Research Initiatives Research Articles

Cryptorchidism and testicular cancer in the dog: unresolved questions and challenges in translating insights from human studies.

Cryptorchidism, the failure of one or both testes to descend into the scrotum, and testicular cancer show a strong correlation in both dogs and humans. Yet, long-standing medical debates persist about whether the location of undescended testes directly causes testicular cancer in humans or if both conditions stem from a common origin. Although testicular cancer is a prevalent disease in dogs, even less is known about its cause and correlation with testicular descent in this species. This review investigates the relation between these two disorders in dogs, drawing insights from human studies, and examines key biomarkers identified thus far. In addition, it explores potential causal links, including the impact of temperature on maturing testicular cells and a potential shared genetic origin. Notably, this literature review reveals significant differences between men and dogs in reproductive development, histological and molecular features of testicular tumors, and the prevalence of specific tumor types, such as Sertoli cell tumors (SCTs) in cryptorchid dogs and germ cell tumors (GCTs) in humans. These disparities caution against using dogs as models for human testicular cancer research and underscore the limitations when drawing comparisons between species. The paper concludes by suggesting specific research initiatives to enhance our understanding of the complex interplay between cryptorchidism and testicular cancer in dogs.

Driving innovation in energy and telecommunications: next-generation energy storage and 5G technology for enhanced connectivity and energy solutions

Driving innovation in energy and telecommunications involves leveraging next-generation energy storage and 5G technology to enhance connectivity and energy solutions. This review explores the intersection of these two domains, highlighting the importance of advancements in energy storage and 5G technology for a sustainable and connected future. Energy storage is crucial for balancing the supply and demand of electricity in modern power systems. Traditional energy storage methods, such as batteries and pumped hydro, have limitations in terms of scalability, efficiency, and cost-effectiveness. Next-generation energy storage technologies, including advanced batteries, hydrogen storage, and thermal storage, offer promising solutions to overcome these limitations. These technologies enable efficient energy storage at scale, facilitating the integration of renewable energy sources like solar and wind into the grid. By storing excess energy generated during periods of low demand, next-generation energy storage systems ensure a reliable and stable power supply, reducing the reliance on fossil fuels and lowering greenhouse gas emissions. In parallel, the evolution of telecommunications technology, particularly the advent of 5G networks, is revolutionizing connectivity and communication. 5G technology offers significantly higher data transfer speeds, lower latency, and increased network capacity compared to its predecessors. These capabilities are essential for supporting emerging technologies such as the Internet of Things (IoT), autonomous vehicles, and smart grids. With 5G-enabled IoT devices, utilities can monitor energy consumption in real-time, optimize grid operations, and detect and respond to faults more efficiently. Moreover, 5G connectivity enhances the efficiency and reliability of energy storage systems by enabling seamless communication between distributed energy resources and grid operators. The convergence of next-generation energy storage and 5G technology presents numerous opportunities for driving innovation in both energy and telecommunications sectors. One of the key areas of innovation is the development of smart energy storage systems equipped with 5G connectivity. These systems can autonomously adjust their operation based on grid conditions, weather forecasts, and energy demand patterns, optimizing energy storage and distribution in real-time. Furthermore, advanced energy management algorithms leveraging artificial intelligence (AI) and machine learning (ML) algorithms can optimize energy usage and storage, further improving the efficiency and reliability of the grid. Another area of innovation lies in the integration of renewable energy resources with 5G-enabled microgrids. Microgrids are localized energy systems that can operate independently or in conjunction with the main grid. By combining renewable energy sources with energy storage and 5G-enabled communication, microgrids can provide reliable, clean, and resilient power to remote or urban areas. These microgrids can also facilitate peer-to-peer energy trading, allowing consumers to buy and sell excess energy within their communities, fostering energy independence and sustainability. Furthermore, advancements in battery technology, such as solid-state batteries and flow batteries, are enhancing the performance and reliability of energy storage systems. Solid-state batteries offer higher energy density, faster charging rates, and improved safety compared to conventional lithium-ion batteries. Flow batteries, on the other hand, provide scalability and long-duration storage capabilities, making them suitable for grid-scale applications. Integrating these advanced battery technologies with 5G-enabled monitoring and control systems enhances the overall resilience and flexibility of the energy infrastructure. In addition to technological advancements, driving innovation in energy and telecommunications requires collaboration among various stakeholders, including policymakers, regulators, industry players, and research institutions. Policies and regulations should incentivize the deployment of next-generation energy storage and 5G infrastructure, promote interoperability standards, and ensure data privacy and security. Public-private partnerships can facilitate the investment and deployment of innovative solutions, while research and development initiatives can spur further technological advancements. Driving innovation in energy and telecommunications through next-generation energy storage and 5G technology is essential for building a sustainable, connected, and resilient future. By leveraging advanced energy storage systems, smart grids, and 5G-enabled communication networks, we can optimize energy usage, reduce carbon emissions, and enhance the reliability and efficiency of our energy infrastructure. Collaboration and investment across various sectors are key to unlocking the full potential of these transformative technologies and achieving a brighter, more sustainable future for generations to come. Keywords: Innovation, Energy, Telecommunications, Next-Generation, 5G technology, Enhanced connectivity.

How should cardiac xenotransplantation be initiated in Japan?

The world's first clinical cardiac xenotransplantation, using a genetically engineered pig heart with 10 gene modifications, prolonged the life of a 57-year-old man with no other life-saving options, by 60days. It is foreseeable that xenotransplantation will be introduced in clinical practice in the United States. However, little clinical or regulatory progress has been made in the field of xenotransplantation in Japan in recent years. Japan seems to be heading toward a "device lag", and the over-importation of medical devices and technology in the medical field is becoming problematic. In this review, we discuss the concept of pig-heart xenotransplantation, including the pathobiological aspects related to immune rejection, coagulation dysregulation, and detrimental heart overgrowth, as well as genetic modification strategies in pigs to prevent or minimize these problems. Moreover, we summarize the necessity for and current status of xenotransplantation worldwide, and future prospects in Japan, with the aim of initiating xenotransplantation in Japan using genetically modified pigs without a global delay. It is imperative that this study prompts the initiation of preclinical xenotransplantation research using non-human primates and leads to clinical studies.

Nonsevere Hemophilia: The Need for a Renewed Focus and Improved Outcomes.

People with nonsevere hemophilia (PWNSH) are phenotypically more diverse than those with severe hemophilia. Perceptions relating to a "nonsevere" phenotype have contributed to fewer research initiatives, fewer guidelines on optimal management, and a lack of standards for surveillance and clinical assessment for affected individuals. In many cases, episodes of abnormal bleeding could, if investigated, have led to earlier diagnosis. Furthermore, the major recent developments in therapy for hemophilia have largely focused on severe disease and, as a group, PWNSH have not been included in many key clinical trials. Benefiting people with severe disease, innovative replacement therapies have generally targeted factor levels that are above those present in a large proportion of PWNSH. Therapeutic advances can lead to improvement in phenotype for people with severe hemophilia over that currently experienced by many PWNSH. As a result, we are approaching a point where PWNSH may, in many countries, have a higher risk of bleeding and restriction in lifestyle than those with severe disease but with more limited therapeutic options. Given the multiple major advances in treatment for people with hemophilia, it is timely to review the aspects of nonsevere disease, to ensure equity in care and management for all individuals with this condition.

Evaluation of diethyl 4-(5-bromo-1H-indol-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate: synthesis, anti-corrosion potential, and biomedical applications

The pursuit of advanced multifunctional compounds has gained significant momentum in recent scientific endeavours. This study is dedicated to elucidating the synthesis, rigorous characterization, and multifaceted applications—encompassing anti-corrosion, antimicrobial, and antioxidant properties—of Diethyl 4-(5-bromo-1H-indol-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate. The 1,4-dihydropyridine derivative was meticulously synthesized through a strategic reaction of ethyl acetoacetate, ammonium acetate, and 5-bromoindole-3-carboxaldehydein the ethanol medium at 60 C. Subsequent spectral validations were conducted using sophisticated techniques, namely FTIR, NMR, and Mass spectrometry, resulting in data that perfectly resonated with the hypothesized chemical structure of the compound. Its anti-corrosive potential was assessed on mild steel subjected to an aggressive acidic environment, employing comprehensive methodologies like gravimetric analysis, Tafel polarization, and EIS. Concurrently, its antimicrobial prowess was ascertained against a spectrum of bacterial and fungal pathogens viz., Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas, Candida albicansandAspergillusniger, leveraging the disc diffusion method and using Gentamicin as a reference standard.The empirical results illustrated a substantial decrement in corrosion rates with ascending concentrations of the organic compound, achieving an apex of anti-corrosive efficacy at 81.89% for a concentration of 2 × 103 M. Furthermore, the compound outperformed Gentamicin in antimicrobial screenings, manifesting superior efficacy against all tested pathogens. The antioxidant potential, quantified using the DPPH free radical scavenging assay against ascorbic acid as a benchmark, was found to have an IC50 value of 113.964 ± 0.076 µg/ml.This comprehensive investigation accentuates the paramount potential of the synthesized dihydropyridine derivative in diverse domains—from industrial applications as a corrosion inhibitor to therapeutic avenues given its pronounced antimicrobial and antioxidant capabilities. The compelling results obtained pave the way for expansive research and development initiatives cantered around this multifaceted compound.Graphical

Development of Competency Standards for Good Hygienic Practices Facilitators to Enhance Food Safety Assurance

This study aims to develop comprehensive competency standards for facilitators implementing Good Hygienic Practices (GHP) in the food industry, particularly to align with the new Codex Alimentarius Standard on Principles of Food Hygiene. Through a literature review approach and drawing inspiration from the Regional Model Competency Standard (RMCS), the research seeks to address existing gaps in GHP training and facilitation. The study emphasizes the importance of consistent and effective implementation of food safety practices by formulating structured competency standards covering areas such as GHP application, risk management, specific hygiene practices, and integration with Hazard Analysis and Critical Control Point (HACCP) systems. These standards are anticipated to significantly enhance food safety standards, reduce the incidence of foodborne diseases, and increase consumer confidence in food products. Furthermore, the study's implications extend to future research and policy initiatives aimed at promoting food safety through professional training and global standardization of practices.

Knowledge, perception, attitude, and practice of complementary and alternative medicine by health care workers in Garki hospital Abuja, Nigeria

BackgroundHealthcare workers are currently making efforts to offer services that cater to the holistic care needs of their patients. Previous studies have shown that some healthcare workers encounter challenges when advising patients about Complementary and Alternative Medicine (CAM), even though its use is widespread. Many health care workers may not have received formal education or training in CAM and consequently are unable to address their patients’ questions about it. This study explored the knowledge, perception, attitude and practice of CAM by healthcare workers in Garki Hospital, Abuja, Nigeria.MethodsThis was an institution-based cross-sectional study, design and a convergent parallel, mixed methods design was used for data collection. Five (5) healthcare workers were purposively selected as participants for the key informant interviews, while two hundred and fifty (250) selected using a simple random sampling method completed the questionnaire. The data collection instruments used were a key informant interview guide and a 35-item self-administered questionnaire. Knowledge was assessed with a 4-item scale with a maximum score of 8. Perceptions and attitudes were assessed using Likert scales with a maximum score of 45 and 20, respectively. Practice was assessed with a 6-item scale with a maximum score of 18. Qualitative data was analysed using framework analysis. Quantitative data was analysed using descriptive and inferential statistics. Data acquired from both methods were integrated to form the findings.ResultsThe average age of respondents for the quantitative study was 34.0 ± 7.8 years, and they were predominantly females (61.2%) with one to ten years of work experience (68.8%). The mean knowledge, perception and attitude scores were 1.94 ± 1.39, 13.08 ± 2.34 and 32.68 ± 6.28, respectively. Multiple linear regression result showed that knowledge (t = 2.025, p = 0.044) and attitude (t = 5.961, p = 0.000) had statistically significant effects on the practice of CAM. Qualitative data revealed that the majority of the participants perceive CAM favourably, provided it is properly introduced into mainstream medicine with evidence of safety and research to prove its efficacy.ConclusionThe study has shown the gaps in knowledge and the practices of CAM by conventional medical practitioners. This has implications for their ability to counsel and refer patients who may require CAM therapies. Policy, research and programmatic initiatives that seek to enhance their knowledge of CAM, and improve collaboration with CAM practitioners are recommended.

Challenges and efforts in managing AI trustworthiness risks: a state of knowledge

This paper addresses the critical gaps in existing AI risk management frameworks, emphasizing the neglect of human factors and the absence of metrics for socially related or human threats. Drawing from insights provided by NIST AI RFM and ENISA, the research underscores the need for understanding the limitations of human-AI interaction and the development of ethical and social measurements. The paper explores various dimensions of trustworthiness, covering legislation, AI cyber threat intelligence, and characteristics of AI adversaries. It delves into technical threats and vulnerabilities, including data access, poisoning, and backdoors, highlighting the importance of collaboration between cybersecurity engineers, AI experts, and social-psychology-behavior-ethics professionals. Furthermore, the socio-psychological threats associated with AI integration into society are examined, addressing issues such as bias, misinformation, and privacy erosion. The manuscript proposes a comprehensive approach to AI trustworthiness, combining technical and social mitigation measures, standards, and ongoing research initiatives. Additionally, it introduces innovative defense strategies, such as cyber-social exercises, digital clones, and conversational agents, to enhance understanding of adversary profiles and fortify AI security. The paper concludes with a call for interdisciplinary collaboration, awareness campaigns, and continuous research efforts to create a robust and resilient AI ecosystem aligned with ethical standards and societal expectations.

Recent trends in reduction of hand arm vibration syndrome for agricultural handheld equipment: A review based on challenges and future directions

A major occupational health risk in the agricultural industry is Hand Arm Vibration Syndrome (HAVS), which is brought on by exposure to vibration from handled machinery. This review thoroughly covers the historical background and prevalence of HAVS in agriculture, highlighting the harm it does to the health and productivity of workers. The goal is to solve the research deficit in this area by concentrating on vibration isolation and dampening approaches. The paper comprehensively examines measurement methods, such as accelerometer-based approaches, strain gauge and force plate methods, wireless sensor networks, for evaluating vibrations related to HAVS. These methods are compared in order to clarify their advantages and disadvantages. Furthermore, engineering controls, isolation mounts, dampers, and smart technologies are included in the categories of shock and vibration reduction solutions based on their efficiency and application. Also covered are human factors that affect vibration reduction. The difficulties in putting reduction strategies into practice are underlined. These difficulties include economic considerations, technological limitations, and user approval. In order to draw useful conclusions, case studies demonstrating effective vibration reduction methods in agricultural contexts are provided. Future directions for reducing HAVS in agriculture include interdisciplinary research opportunities, developing technologies for vibration reduction, and a global approach. This review concludes by highlighting the importance of tackling HAVS, providing insights into real-world applications, and suggesting future research initiatives.

Integrating Open Knowledge and Administrative Management in the Digital Transformation Model of Education Institutions: An Effective Approach

This paper explores the integration of Open Knowledge and Administrative Management into the Digital Transformation Model within educational institutions, focusing on the National Academy of Education Management and three secondary schools in Hanoi. Through a comprehensive methodology involving data collection, analysis, and system development, the study examines the effectiveness of this integrated approach in enhancing educational outcomes. The findings reveal significant improvements in knowledge dissemination, resource allocation, and administrative efficiency following the implementation of the integrated model. By harnessing open knowledge resources and streamlining administrative processes, educational institutions have been able to optimize teaching and learning practices, facilitate collaboration among stakeholders, and promote innovation in education. Furthermore, the study highlights the importance of ongoing research, evaluation, and professional development initiatives to sustain the momentum of this integrated approach. By investing in capacity building, promoting collaboration, and embracing emerging technologies, educational institutions can adapt to the evolving needs of learners and prepare them for success in the digital age. Overall, the integration of Open Knowledge and Administrative Management represents a promising pathway towards educational excellence and equity. Through collective efforts and a commitment to continuous improvement, educational stakeholders can drive meaningful change and empower learners to thrive in an increasingly complex and interconnected world.

Journaling About the Futures- Personal Reflection From the Research “About Time”

The research initiative titled “About Time” undertaken at the Institute of Art, Design + Technology (IADT) in Ireland, sought to develop and assess design-led methods aimed at shaping and influencing attitudes towards the long-term future. The primary focus was influencing behaviours concerning individual futures and the planet. This study encompassed exercises and experiences to explore the intricate connections between past and future, delving into the multidimensional nature of time, art and creativity. Additionally, it aimed to foster positive futures and long-term thinking, reflect on ways to respond to global uncertainty, effect transformative change, and open new dimensions of understanding. The outcome of this research is The Barometer - a template of a journal/sketchbook intended to facilitate deep contemplation of the subject of time and the futures. Filled with creative tasks and prompts, it serves as a vehicle and tool to enhance futures literacy in participants. Seamlessly blending foresight, art, and creativity it extends a playful invitation to engage in reflection, futures thinking, speculation, and world-building. It also serves as a starting point for fostering long-term thinking, by establishing a close emotional connection to future generations, as well as nature connectedness, while addressing the challenges posed by the climate emergency. In this reflection, the author of the study offers insights into the research process, the underlying concept of the journal, and feedback obtained from the test group. The reflection delves into the synergy of creativity and art with future-focused journaling portraying it as a means to enhance futures literacy capabilities. Furthermore, this approach represents a significant stride in fostering sustainable practices and holds the potential to become a robust support tool for resilience, particularly in the face of uncertainties, trauma, and challenging circumstances. Further details: https://pdl.iadt.ie/programme/about-time/

Children with palliative care needs – the landscape of the nordic countries

BackgroundTo strengthen palliative care for children in the Nordic countries, an updated status of current needs, resources, clinical services, education, and research is necessary to align and consolidate future research. A Nordic research collaboration initiative for children with palliative care needs was assembled in 2023. Building on this initiative, this paper presents an overview of pediatric palliative care (PPC) in the Nordic countries’ (a) population characteristics, (b) care models and setting of care, (c) education and training, and (d) research.MethodsThe Nordic initiative researchers collaboratively gathered and assessed available data on the characteristics of PPC within Denmark, Finland, Greenland, Iceland, Norway, the Faroe Islands, Sweden, and Åland. Data were compiled in a matrix with population characteristics, models- and setting of care, education and training, and areas of research in a Nordic context. The findings are narratively and descriptively presented, providing an overview of Nordic PPC.ResultsIn total, the Nordic child population comprises around six million children (0–19 years), of which about 41.200 are estimated to be living with a life-limiting and/or life-threatening condition. Healthcare services are provided through various care models, ranging from specialized care to homecare settings. Overall, there remain few opportunities for education and training with some exceptions. Also, Nordic research within PPC has been shown to be a growing field although much remains to be done.ConclusionThis overview is the first outline of the current PPC in Nordic countries. Although some differences remain important to acknowledge, overall, the strengths and challenges faced within PPC in the Nordic countries are comparable and call for joint action to increase evidence, services, and education to better serve the children, families, and healthcare personnel within PPC. Despite the varying structural premises for PPC, research endeavors aiming to provide evidence in this field seem increasing, timely and relevant for the Nordic countries, as well as the international context.

Cross-Water–Air Optical Wireless Communication Using Orthogonal Time–Frequency Space Modulation

This paper examines the communication difficulties encountered in cross-media wireless optical transmission through simulated research on the utilization of orthogonal time and frequency space (OTFS) modulation technology. Our analysis and comparison demonstrate that OTFS significantly improves the reliability and throughput of data transmission in intricate multipath channel settings. In contrast to conventional orthogonal frequency division multiplexing (OFDM) technology, OTFS displays better resilience and transmission effectiveness. We foresee additional enhancements and progress in OTFS technology to present a sturdier and more efficient resolution for wireless communication, thereby providing valuable perspectives and encouragement for associated research initiatives. Our results underscore the capability of OTFS technology to transform wireless communication systems in demanding multipath channel conditions.

Social Entrepreneurship: Toward Understanding an Emerging Force for the Common Good

Social entrepreneurship combines business innovation with an explicit purpose of positive social and environmental impact, becoming increasingly relevant for analysis from various perspectives. This article presents a systematic review of the literature on social entrepreneurship, aiming to consolidate existing knowledge, identify emerging trends and gaps, and provide an updated guide for researchers and policymakers. The results reveal diverse methodological perspectives, ranging from quantitative research on economic impact and poverty reduction to ethnographies that explore the experiences and strategies of social entrepreneurs. The unique potential of social entrepreneurship to address global challenges is highlighted, necessitating comprehensive strategies to promote it sustainably. Furthermore, education is identified as a fundamental pillar of positive social change due to its role in developing professionals with an entrepreneurial mindset oriented toward social transformation. Finally, the paper emphasizes the need to diversify research lines and initiatives that encourage social impact entrepreneurship in a proactive and innovative manner.     Received: 3 January 2024 / Accepted: 25 April 2024 / Published: 5 May 2024

Technical support as a catalyst for innovation and special project success in oil and gas

In the dynamic landscape of the oil and gas industry, technical support emerges as a pivotal force driving innovation and ensuring the success of special projects. This paper explores the multifaceted role of technical support in this sector, shedding light on its significance in maintaining operational efficiency, safety, and fostering innovation. Amidst the ever-evolving challenges faced by the industry, from fluctuating market demands to stringent regulatory requirements, technical support stands as a cornerstone in navigating complexities and driving progress. Drawing from real-world examples and industry insights, the paper elucidates the challenges and opportunities encountered in fostering innovation within the oil and gas sector. It highlights the critical role of technical support in identifying technological gaps, spearheading research and development initiatives, and facilitating the implementation of innovative solutions. Moreover, the paper delves into the realm of special projects, exploring their importance in driving strategic growth and competitive advantage. It examines the challenges inherent in executing special projects and underscores the indispensable role of technical support in mitigating risks and ensuring successful outcomes. Through a comprehensive analysis of best practices and case studies, the paper elucidates strategies for leveraging technical support as a catalyst for innovation and special project success in oil and gas. It emphasizes the importance of integrating technical support into innovation initiatives, fostering collaboration across multidisciplinary teams, and investing in advanced technologies and expertise. Ultimately, the paper underscores the transformative potential of technical support in shaping the future of oil and gas operations, driving sustainable growth, and fostering resilience in an ever-changing landscape. Keywords:  Technical Support, Catalyst for Innovation, Special Project Success, Oil and Gas.

Scope of Same-sex Marriages in India

This paper thoroughly examines the legal and socio-cultural landscapes surrounding same-sex marriage, delving into both domestic and international perspectives. Through a meticulous review of landmark legal cases, including Navtej Singh Johar v. Union of India and Obergefell v. Hodges, the author elucidates the evolution of jurisprudence concerning LGBTQ+ rights and marriage equality. Furthermore, the interpretation of existing laws within the context of same-sex marriages is scrutinised, highlighting the judicial reasoning and legal arguments that have shaped legal frameworks worldwide. Moreover, this study incorporates insights from a survey conducted by the author to gauge public attitudes towards same-sex marriage. Integrating empirical data with legal analysis generates a nuanced understanding of societal perceptions and challenges. Societal attitudes and stigma, religious perspectives, and the advocacy efforts of LGBTQ+ rights movements are critically examined, shedding light on the complexities inherent in navigating cultural norms and values. Ultimately, this paper underscores the imperative of advancing legal reforms and fostering societal acceptance to ensure the full recognition and protection of the rights of LGBTQ+ individuals. By synthesising legal scholarship, empirical research, and socio-cultural analysis, this study contributes to the ongoing discourse on same-sex marriage. It lays the groundwork for future research and policy initiatives in this vital human rights and social justice area.

224 Influence of gender on animal science research funding from the National Institute of Food and Agriculture

Abstract According to the National Academies of Sciences, Engineering, and Medicine, females and males in science disciplines obtain bachelor of science degrees at or near parity, yet females are not equally represented in academic faculty positions. This is true for agricultural field including the animal sciences. The National Institute of Food and Agriculture (NIFA) administers the Agriculture and Food Research Initiative (AFRI) at USDA, a flagship competitive grants program that fund research, education, and extension efforts with a total appropriation of $455 million in 2023. Our objective was to determine the difference between genders for submission rates (i.e., number of standard and seed grant applications submitted), success rates (i.e., number of grant award/number of applications submitted), and peer reviewers of grant applications in the main animal related AFRI program area priorities. All applications submitted to AFRI programs in animal genomics, reproduction, health, nutrition and growth, and welfare during 2013 to 2022 were evaluated. Gender was assigned to Project Directors (PD) and peer reviewers using first names as input into Gender API software (Gender-API.com; Passau, Germany) with ≥ 95% accuracy and ≥ 20 database occurrences used as quality filters and binary outcomes only (i.e., male or female). Effect of gender on submission rates, success rates, and peer review panel compositions were then analyzed using Pearson’s Chi-squared tests with P ≤ 0.05 considered significant. A total of 3,392 applications were submitted, of which 2,579 (76%) PD genders were assigned and analyzed further. Overall, the proportional submission rate for females was 28% and for males was 72%. Submission rates for females increased (P = 0.0497) over time ranging from 22% in 2013 to 33% in 2021. Submission rates differed by gender across programs (P < 0.0001) and ranged from 22% female in animal reproduction to 48% female in animal welfare. Overall, the funding success rate was 22% and did not differ between genders (P = 0.9826). Success rates did not differ between genders over time (P = 0.4691), but differences among programs approached significance (P = 0.0670). Across 53 panels, 42% of panelists were female; no differences were identified for the proportion of female panelists over time (P = 0.9762) or by program (P = 0.7028). Females submitted less than one-half as many applications as males, but the proportion of submissions by females increased over time. This trend remained consistent despite challenges of relocation of NIFA and COVID-19 during this time. Funding success rates did not differ by gender, but some variation was observed across programs. Overall, the proportion of NIFA panelists who were female exceeded the proportion of applications submitted by females. These results indicate that although differences in gender existed for application submission rate and panel composition, these differences did not impact funding success rate of applications in animal science programs at NIFA, which did not differ between genders.

TwinsMX: Exploring the Genetic and Environmental Influences on Health Traits in the Mexican Population.

TwinsMX registry is a national research initiative in Mexico that aims to understand the complex interplay between genetics and environment in shaping physical and mental health traits among the country's population. With a multidisciplinary approach, TwinsMX aims to advance our knowledge of the genetic and environmental mechanisms underlying ethnic variations in complex traits and diseases, including behavioral, psychometric, anthropometric, metabolic, cardiovascular and mental disorders. With information gathered from over 2800 twins, this article updates the prevalence of several complex traits; and describes the advances and novel ideas we have implemented such as magnetic resonance imaging. The future expansion of the TwinsMX registry will enhance our comprehension of the intricate interplay between genetics and environment in shaping health and disease in the Mexican population. Overall, this report describes the progress in the building of a solid database that will allow the study of complex traits in the Mexican population, valuable not only for our consortium, but also for the worldwide scientific community, by providing new insights of understudied genetically admixed populations.

Medical Education in Bangladesh and the United States: A Comparative Overview

This manuscript presents an overview of Bangladesh medical education system with a brief comparison to the United States. Despite differences in origins and structures, both share similarities and differences in their medical curricula and examination-driven approaches. The paper employs a non-systematic comparative review methodology, gathering information from diverse sources including government websites, educational institutions, and published articles. Medical education in Bangladesh traces its roots back to the mid-20th century, initially influenced by British educational practices. The country now boasts 76 medical colleges—23 public and 53 private—admitting approximately 7,156 students annually for the MBBS degree. The admission process is competitive, with strict eligibility criteria including completion of prerequisite courses and a minimum grade-point average. The five-year MBBS program followed by a one-year clinical internship is a standard pathway in Bangladeshi medical education, with further specialization achieved through fellowship training. In terms of structure, curriculum, and training programs, the Bangladesh medical education system aligns with a lecture-based, examination-focused approach. However, research initiatives are limited due to resource constraints, impacting the quality and quantity of publications. Financially, both public and private medical institutions in Bangladesh charge similar tuition fees ranging from $33,000 to $48,000 USD for the entire MBBS degree, with limited scholarship opportunities. Upon graduation, physicians often opt for private practice, contributing to concerns about retaining qualified medical professionals within the country, particularly in rural areas. Comparatively, the United States has a longstanding history of medical education dating back over two centuries. The American system, encompassing diverse nomenclature for medical schools and varying degrees, presents differences in the application process, structure, and postgraduate training compared to Bangladesh. This comprehensive review highlights the distinctions and commonalities between the medical education systems of the United States and Bangladesh, serving as a resource for prospective students, current practitioners, and residency program directors.

Abstract PO4-16-09: Enhancing Research on Inflammatory Breast Cancer through Count Me In: Assessing the Accuracy of Self-Reported Diagnoses

Abstract Background: Inflammatory breast cancer (IBC) is a rare and aggressive form of breast cancer that relies on clinical identification of specific breast changes for diagnosis, in addition to pathological confirmation of invasive breast cancer. There is a clear need to increase participation of patients with IBC in research to better understand its clinical course and optimal treatment strategy. Count Me In (CMI) is a nonprofit research initiative that enables patients across the United States and Canada to accelerate cancer research by sharing their clinical data and biospecimens. The Metastatic Breast Cancer Project (MBCProject) was the first CMI initiative and is a prospective longitudinal cohort designed to capture these data from patients with metastatic breast cancer. Methods: We reviewed available medical records of patients participating in the MBCProject and who self-reported as having IBC. Records were reviewed by a study team member to identify documentation by a provider of an IBC diagnosis. For records without a documented IBC diagnosis, the clinical symptoms were assessed using a novel quantitative IBC scoring system (Mason G et al. BCRF 2022) currently being validated. Finally, records were also assessed by a physician for final determination of an IBC diagnosis. Records were classified as “concordant” or “not concordant”. Concordant is defined as “review of medical records confirms IBC using the unifying set of specific diagnostic criteria”. We desired the rate of concordant cases to be ≥90%; if ≤ 85% it would be considered as unacceptable to rely solely on patient self-report of IBC diagnosis in future research. Results: We reviewed records of 79 patients participating in the MBCProject who self-identified as having IBC and had medical records collected. Of these, 51 (64.5%) had IBC stated in providers’ notes. Of the remaining 28 patients, 6/28 met criteria for IBC using the new IBC diagnostic criteria, 17/28 didn’t have evidence of IBC based on the records available and 6/28 we were unable to make a final determination due to lack of records at the time of initial diagnosis. In total, 57/79 (72%; 95% CI 61-82%) patients had a concordant diagnosis. Conclusion: Patient self-report registries such as CMI are invaluable for the collection of clinical information and biospecimens for research of patients with rare diseases, however, a self-reported diagnosis of IBC may not be reliable. To improve the accurate identification of IBC, optimization of the questions asked to patients on these registries is warranted. This may include additional screening questions such as specific skin findings and timing of onset of symptoms. Focusing on patients with stage III IBC may also provide a better patient population to test this strategy. Citation Format: Elizabeth Troll, Sean Ryan, Virginia (Ginny) Mason, Mariesa D. Powell, Aditi Hazra, Nikhil Wagle, Mary McGillicuddy, Sara Tolaney, Meredith Regan, Filipa Lynce. Enhancing Research on Inflammatory Breast Cancer through Count Me In: Assessing the Accuracy of Self-Reported Diagnoses [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO4-16-09.