Behavioral Genetic Research Research Articles

C. Robert Cloninger: Mechanisms and conditions by which temperament, character, and personality development can regulate health and well-being

Dr. C. Robert Cloninger's contributions have been foundational in understanding temperament, personality, and their biological and genetic underpinnings. Cloninger explored how temperament, character, and personality traits are influenced by genetic factors and how they predict various psychological disorders, such as alcoholism and personality disorders. His prospective studies involving adoptees reared apart from their biological parents provided crucial insights into the heritability and development of personality traits independent of environmental influences. Moreover, Cloninger's pioneering work in conducting the first genome-wide association and linkage studies of normal personality traits laid the groundwork for subsequent research in psychiatry and behavioral genetics, linking specific genetic profiles to patterns of temperament and personality. He is also the creator of two extensively employed personality assessment instruments: the Tridimensional Personality Questionnaire (TPQ) and the Temperament and Character Inventory (TCI). Dr. Cloninger serves as Director of the Anthropedia Institute and Professor Emeritus at Washington University in St. Louis, where he studies the biopsychosocial foundations of personality that influence health and illness. The Anthropedia Institute is the research branch of the Anthropedia Foundation, a non-profit organization dedicated to the promotion of human well-being through initiatives in health care and education. He served as Wallace Renard Professor of Psychiatry & Genetics, Professor of Psychological and Brain Sciences, and founding Director of the Sansone Center for Well-being at Washington University until July 2019. Dr. Cloninger is a member of the National Academy of Medicine USA, Fellow of the American Academy for Advancement of Science, and an editor of various journals in psychiatry, psychology, and genetics. We are pleased to share Dr. Cloninger's answers to the Genomic Press Interview.

Genetic studies on forensic-psychiatric inpatients? : Clinical, ethical and legal considerations

Research on people deprived of liberty raises serious questions, especially concerning behavioral genetic studies. Does including criminally detained patients with mental disorders in genetic studies lead to again of new knowledge and can this be ethically and legally justified? Evaluation of existing literature and interdisciplinary reflection. After areview of research ethics and legal norms, we consider the benefits and risks of behavioral genetic research, taking the unique situation of test persons deprived of their liberty into account. The fundamental right to freedom of research also justifies foundational research in forensic psychiatry and psychotherapy. The possible future benefits of improving treatment plans must be weighed against the risks resulting from potential data leaks and inappropriate public reception of research results. Then we analyze possible threats to voluntary and informed consent to study participation in more detail by the ethical concept of vulnerability. Alongside problems with grasping complex issues, above all dependencies and power dynamics in the correctional system play apivotal role. Recommendations on the ethical and legal inclusion of this study population are given. Including criminally detained study participants can be ethically and legally justified when autonomous consent is supported by specific organizational and legal procedures and measures, for example via aclear professional and organizational separation of correction and research.

Advancing Diversity in Behavior Genetics: Strategies for Incorporating Undergraduates into Student-Driven Research.

Undergraduate research experiences are crucial for fostering the next generation of behavior genetics researchers. However, incorporating undergraduates into research can be challenging for faculty mentors. In this article, we provide strategies for successfully integrating undergraduates into behavior genetics research based on our experiences mentoring undergraduates in our lab. These strategies include: (1) Practicing reflexivity, specifically an ongoing self-examination and critical self-awareness of personal biases, beliefs, and practices; (2) Implementing an Inclusion, Diversity, Equity, and Access (IDEA) centered approach; (3) empowering students through clear expectations; (4) Providing focused training and mentorship; (5) Aligning research projects with student interests; (6) Assigning meaningful tasks; and (7) Facilitating professional development opportunities. By following these strategies, faculty mentors can cultivate a supportive and inclusive research environment that empowers undergraduates for successful careers in behavior genetics research.

Population descriptors and behavioural genetic research.

Population descriptors and behavioural genetic research.

Are the predictions of phenotypic cognitive scores by polygenic cognitive scores driven by the cognitive complexity of the phenotypic measures? A meta‐analysis

AbstractBackgroundIntelligence is highly heritable and plays an important role in behavioral genetic research. Recent genome‐wide association studies (GWASs) have identified inherited genomic variants that account for a modest portion of the heritability of intelligence. There are many studies where cognitive polygenic scores (PGSs) are used to predict scores on intelligence tests; the resulting rs are all over the place. Various explanations are offered for this high variability in resulting rs, but none of them are convincing.There is another approach, building upon a fundamental finding from intelligence research, namely that the most important difference between intelligence tests is their difference in cognitive complexity. We hypothesize that the predictions of phenotypic cognitive scores by polygenic cognitive scores are a function of the cognitive complexity of the phenotypic cognitive scores.MethodWe carried out a meta‐analysis of studies reporting 1) cognitive polygenic scores (IQ, Cognitive achievement, Educational attainment) and 2) the correlation between cognitive polygenic scores and at least four cognitive test scores. We computed the cognitive complexity of the cognitive tests. We then computed the correlation between 1) the cognitive complexity of the cognitive tests and 2) the correlation between cognitive polygenic scores and at least four cognitive test scores. A strong positive correlation means that the predictions of phenotypic cognitive scores by polygenic cognitive scores are strongly driven by the cognitive complexity of the phenotypic measures.ResultA substantial number of studies were found and many of them were based on a large number of subjects. The studies analyzed so far show large to very large correlations, strongly confirming the hypothesis.ConclusionBased on an analysis of a subset of the studies in the meta‐analysis, cognitive polygenic scores predict most strongly for difficult IQ tests and least strongly for easy IQ tests. So, we conclude that the predictions of phenotypic cognitive scores by polygenic cognitive scores are strongly driven by the cognitive complexity of the phenotypic measures.

The Heritability of Psychopathology Symptoms in Early Adolescence: Moderation by Family Cultural Values in the ABCD Study.

Family cultural values that emphasize support, loyalty, and obligation to the family are associated with lower psychopathology in Hispanic/Latino/a youth, but there is a need to understand the implications of family cultural values for youth development in racially/ethnically heterogeneous samples. This study examined phenotypic associations between parent- and youth-reported family cultural values in late childhood on youth internalizing and externalizing symptoms in early adolescence, and whether family cultural values moderated genetic and environmental influences on psychopathology symptoms. The sample comprised 10,335 children (Mage=12.89 years; 47.9% female; 20.3% Hispanic/Latino/a, 15.0% Black, 2.1% Asian, 10.5% other) and their parents from the Adolescent Brain Cognitive Development (ABCD) Study, and biometric models were conducted in the twin subsample (n = 1,042 twin pairs; 43.3% monozygotic). Parents and youth reported on their family cultural values using the Mexican American Cultural Values Scale at youth age 11-12, and parents reported on youth internalizing and externalizing symptoms using the Child Behavior Checklist at youth ages 11-12 and 12-13. Greater parent- and youth-reported family cultural values predicted fewer youth internalizing and externalizing symptoms. Biometric models indicated that higher parent-reported family cultural values increased the nonshared environmental influences on externalizing symptoms whereas youth-reported family cultural values decreased the nonshared environmental influences on internalizing symptoms. This study highlights the need for behavior genetic research to consider a diverse range of cultural contexts to better understand the etiology of youth psychopathology.

Reinvigoration of a Diversity, Equity, and Inclusion Committee at the Institute for Behavioral Genetics: Student-driven Progress.

Extremist far-right ideologies, including scientifically inaccurate beliefs about race, are on the rise (Mieriņa and Koroļeva 2015; Youngblood 2020); individuals perpetuating such ideologies occasionally cite genetics research, including behavioral genetics research. This highlights the need for behavioral geneticists to actively confront extremist ideology and promote anti-racism. We emphasize the need for Diversity, Equity and Inclusion (DEI) committees within behavioral genetics institutions. DEI committees can lead to: greater awareness of ways in which behavioral genetics has been misused (historically and currently) to harm minoritized communities, increased discussions on conducting ethical behavioral genetics research, and increased collaboration for conducting more diverse behavioral genetics research. We discuss the activities and goals of the student-driven DEI committee at the Institute for Behavior Genetics (IBG). At the same time, we acknowledge we have a long way to go, both as a committee and as a field. Our committee is still in its early stages; we discuss challenges to increasing DEI in the field and present future goals for both IBG and the behavioral genetics community as we explore the process of implementing DEI work.

Testing Environmental Effects on Age at Menarche and Sexual Debut within a Genetically Informative Twin Design.

Life-history-derived models of female sexual development propose menarche timing as a key regulatory mechanism driving subsequent sexual behavior. The current research utilized a twin subsample of the National Longitudinal Study of Adolescent to Adult Health (Add Health; n = 514) to evaluate environmental effects on timings of menarche and sexual debut, as well as address potential confounding of these effects within a genetically informative design. Results show mixed support for each life history model and provide little evidence rearing environment is important in the etiology of individual differences in age at menarche. This research calls into question the underlying assumptions of life-history-derived models of sexual development and highlights the need for more behavior genetic research in this area.

Benefits of hereditarian insights for mate choice and parenting.

Madole & Harden develop some good ideas about how to understand genetic causality more clearly, but they frame the benefits of behavior genetics research at a largely collective level, focused on the pros and cons of different ways to engineer the gene pool or social behavior. This neglects the individual benefits of hereditarian insights for mate choice and parenting.

Behavior genetics and randomized controlled trials: A misleading analogy.

Madole & Harden argue that just as the results of randomized controlled trials (RCTs) represent gains in causal knowledge and are useful, despite their limitations, so too are the findings of human behavior genetics. We argue that this analogy is misleading. Unlike RCTs, the results of human behavior genetics research cannot suggest efficacious interventions, nor point toward future research.

Genetic Mapping of Behavioral Traits Using the Collaborative Cross Resource.

The complicated interactions between genetic background, environment and lifestyle factors make it difficult to study the genetic basis of complex phenotypes, such as cognition and anxiety levels, in humans. However, environmental and other factors can be tightly controlled in mouse studies. The Collaborative Cross (CC) is a mouse genetic reference population whose common genetic and phenotypic diversity is on par with that of humans. Therefore, we leveraged the power of the CC to assess 52 behavioral measures associated with locomotor activity, anxiety level, learning and memory. This is the first application of the CC in novel object recognition tests, Morris water maze tasks, and fear conditioning tests. We found substantial continuous behavioral variations across the CC strains tested, and mapped six quantitative trait loci (QTLs) which influenced these traits, defining candidate genetic variants underlying these QTLs. Overall, our findings highlight the potential of the CC population in behavioral genetic research, while the identified genomic loci and genes driving the variation of relevant behavioral traits provide a foundation for further studies.

A Blueprint for Genetic Determinism

A Blueprint for Genetic Determinism

The next 10years of behavioural genomic research.

The explosion caused by the fusion of quantitative genetics and molecular genetics will transform behavioural genetic research in child and adolescent psychology and psychiatry. Although the fallout has not yet settled, the goal of this paper is to predict the next 10 years of research in what could be called behavioural genomics. I focus on three research directions: the genetic architecture of psychopathology, causal modelling of gene-environment interplay, and the use of DNA as an early warning system. Eventually, whole-genome sequencing will be available for all newborns, which means that behavioural genomics could potentially be applied ubiquitously in research and clinical practice.

Using genetic designs to identify likely causal environmental contributions to psychopathology.

The multifactorial nature of psychopathology, whereby both genetic and environmental factors contribute risk, has long been established. In this paper, we provide an update on genetically informative designs that are utilized to disentangle genetic and environmental contributions to psychopathology. We provide a brief reminder of quantitative behavioral genetic research designs that have been used to identify potentially causal environmental processes, accounting for genetic contributions. We also provide an overview of recent molecular genetic approaches that utilize genome-wide association study data which are increasingly being applied to questions relevant to psychopathology research. While genetically informative designs typically have been applied to investigate the origins of psychopathology, we highlight how these approaches can also be used to elucidate potential causal environmental processes that contribute to developmental course and outcomes. We highlight the need to use genetically sensitive designs that align with intervention and prevention science efforts, by considering strengths-based environments to investigate how positive environments can mitigate risk and promote children's strengths.

Developmental behavioral genetics research on school achievement is missing vulnerable children, to our detriment.

Gene-environment processes tell us how genetic predispositions and environments work together to influence children in schools. One type of gene-environment process that has been extensively studied using behavioral genetics methods is a gene-by-environment interaction. A gene-by-environment interaction shows us when the effect of your context on a phenotype differs depending on your genetic predispositions, or vice versa, when the effect of your genetic predispositions on a phenotype differs depending on your context. Developmental behavioral geneticists interested in children's school achievement have examined many different contexts within the gene-by-environment interaction model, including contexts measured from within children's home and school environments. However, this work has been overwhelmingly focused on WEIRD samples children, leaving us with non-inclusive scientific evidence. This can lead to detrimental outcomes when we overgeneralize this non-inclusive scientific evidence to racialized groups. We conclude with a call to include racialized children in more research samples.

Disassociation of social and sexual partner relationships in a gibbon population with stable one‐male two‐female groups

Adult males living in a one-male multi-female social group are expected to try to monopolize copulations with resident females to increase reproductive fitness. Gibbons have traditionally been described as living in monogamous groups, with the sole resident adult male assumed to sire all of the group's offspring. Here, we used microsatellite analyses and behavioral observations to examine rates of extra-group paternity (EGP) over 16 years in a population of crested gibbons (Nomascus concolor) that form stable and long-term one-male two-female social units. Forty percent of offspring (N = 14) were sired by extra-group males. To understand this high level of EGP, we tested whether inbreeding avoidance was related to EGP. Females who engaged in EGP did not show larger pairwise relatedness with their resident male compared to females who did not engage in EGP. Nevertheless, the standardized heterozygosity of EGP offspring was significantly higher than for offspring sired by the group's resident male. These results provide partial support for the inbreeding avoidance hypothesis. It appears that resident male crested gibbons are unable to monopolize resident females' matings. Our results indicate that long-term social partners are often distinct from sexual partners in this population. Clearly, the breeding system of crested gibbons is more flexible than previously thought, indicating a need for integrating long-term behavioral data and genetic research to re-evaluate gibbon social and sexual relationships derived from concepts of monogamy and pair-bonding.

How the study of digital footprints can supplement research in behavioral genetics and molecular psychology

Studies that apply digital phenotyping and mobile sensing strategies have increased in recent years enabling a better understanding of psychiatric and psychological conditions, as well as neurodegenerative disorders. Although in this context the study of so-called “digital biomarkers” is proliferating, few studies have actually linked digital footprints to biological variables (and when done, the primary focus lay on brain imaging data). It is well established that many psychological phenotypes such as personality, but also psychiatric and neurodegenerative disorders, have a genetic basis – to a different heritability extent. Therefore, in the present opinion article we argue that it is of tremendous importance to also link the field of neurogenetics to the study of digital footprints, as the latter gives myriad insights into human life and in an objective way. The large field of behavioral genetics including the discipline of molecular psychology could profit greatly from focusing more on the actual study of behavior instead of solely relying on self-report data of study participants. In order to push this promising field forward, the present theoretical work presents three exemplary scenarios, highlighting where such a combination of digital and genetic data could be fruitful.

Latent, genetic, and molecular genetic structure of the Wisconsin Card Sorting Test.

The main goal of this study was to explore the latent structure and genetic basis of cognitive processes involved in the Wisconsin Card Sorting Task (WCST) within phenotypic, behavioral genetic, and molecular genetic research paradigms. The sample used in phenotypic and behavioral genetic analyses comprised 468 twins (154 monozygotic and 80 dizygotic twin pairs), while molecular genetic analyses were performed on 404 twins from the same sample. The zygosity of most twin pairs (96.8%) was determined via deoxyribonucleic acid (DNA) analysis of buccal swabs. Trained researchers administered the Wisconsin Card Sorting Test (WCST; Heaton et al., 1993) to the entire sample. A phenotypic factor analysis of WCST variables suggested a single-factor solution. Overall heritability ranged from 0.19 to 0.23 across different measures of the WCST. The presence of a single general genetic factor, which could be identified from different measures of the WCST, indicated the unity of various WCST indicators and the existence of a common basic ability. Performance on the WCST did not reveal significant differences between the three genotypes on catechol-O-methyltransferase (COMT) and dopamine receptor D2 (DRD2). Carriers of the brain-derived neurotrophic factor (BDNF) Met + genotype exhibited better performance in cognitive functions in comparison to the BDNF Met- genotype. This study highlighted similarities in the phenotypic and genetic structures of the WCST, suggesting one general factor underlying different cognitive functions. The BDNF Met + genotype showed significant main effects on different WCST measures. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Behavior genetics research on personality: Moving beyond traits to examine characteristic adaptations

AbstractThis study argues that behavior genetics research on personality should expand beyond universal traits to include characteristic adaptations. Trait research examines broad, decontextualized, and universal domains such as the Five‐Factor Model. Characteristic adaptations are more contextualized than traits, such as goals and life strategies as responses to specific life demands. The study is organized into three sections: (1) a review of the abundance of behavior genetics research on personality traits, which has reached a convergent point at which few further findings are reported beyond the classic distribution of high genetic and non‐shared environmental influences with little to no shared environmental effect; (2) a review of existing behavior genetics research on characteristic adaptations that, although limited in volume, has demonstrated patterns far less consistent than traits; and (3) a discussion on future directions and important limitations to consider in conducting and interpreting behavior genetics research on non‐trait personality. The connection between characteristic adaptations and contextualized life outcomes, the preponderance of homogenous findings on traits, and the sparse yet promising findings of characteristic adaptations, all support the need for behavior genetics research on personality to expand beyond the broad trait level to characteristic adaptations and beyond.

Genetic Data: Potential Uses and Misuses in Marketing

Advances in molecular genetics have led to the exponential growth of the direct-to-consumer genetic testing industry, resulting in the assembly of massive privately owned genetic databases. This article explores the potential impact of this new data type on the field of marketing. Drawing on findings from behavioral genetic research, the authors propose a framework that incorporates genetic influences into existing consumer behavior theory and use it to survey potential marketing uses of genetic data. Applications include business strategies that rely on genetic variants as bases for segmentation and targeting, creative uses that develop consumers’ sense of community and personalization, use of genetically informed study designs to test causal relations, and refinement of consumer theory by uncovering biological mechanisms underlying behavior. The authors further evaluate ethical challenges related to autonomy, privacy, misinformation, and discrimination that are unique to the use of genetic data and are not sufficiently addressed by current regulations. They conclude by proposing an agenda for future research.