Funded Research Program Research Articles

Venous thromboembolism prevention program implementation in a community oncology practice: a cohort study

While national guidelines recommend Venous Thromboembolism (VTE) risk assessment in cancer outpatients and consideration of pharmacologic prophylaxis in high-risk patients, prophylaxis rates are low in community oncology practices. A successful model for guideline implementation (the Vermont Model, VM) is validated in an academic tertiary oncology setting. We undertook an implementation study to determine the success of this model in a multi-site community oncology practice. The study objectives were to: 1) adapt the VM to the community practice setting; 2) implement the adapted VM into practice; and 3) evaluate clinical and implementation outcomes. The study was carried out in three phases: (1) Pre-implementation, a multidisciplinary team addressed the need to adapt the VM to the local context including electronic medical record (EMR) optimisation and clinician education; (2) implementation of the strategies adapted to the local context, informed by VM and adapted based on stakeholder feedback; (3) prospective evaluation of clinical and implementation outcomes at six months after implementation. Following creation of a comprehensive initiation roadmap for the adaptation of VM program to the community practice, 302 cancer outpatients initiating new treatment met inclusion criteria over a 6 month implementation period. VTE risk education was provided to 100% of patients, and 98% (296) of patients received a VTE risk assessment. Of 52 patients (18%) who scored as high risk based on a modified Khorana (Protecht) score, 14 (27%) initiated prophylaxis. Barriers to program adaptation included EMR optimization challenges and practice-level responsibility assignment, time constraints, concern about potential drug interactions, and financial & insurance issues. Implementation of a multidisciplinary VTE prevention model in the community-based oncology setting successfully increased VTE education and risk assessment rates. AC prophylaxis rates were modestly increased, highlighting the need to understand and address barriers to anticoagulant prophylaxis prescribing in this setting. Northern New England Clinical Oncology Society Research Funding Program.

Developing a toolkit to help smaller local authorities establish strong net zero governance in the UK

IntroductionThe Skidmore Review of UK Government's net zero approach highlights a lack of a national framework which establishes local government role, responsibilities and area-based governance arrangements. Although unified political leadership agreed as part of devolution deals has helped some areas to marshal resources and support, the national delivery landscape for net zero remains patchy. This study develops a toolkit to help local areas improve local arrangements.MethodsA mixed methods research approach has been used to develop the toolkit. It incorporates a set of governance models, a method for assessing the values of good governance, a governance improvement process and an illustration of how the toolkit can be employed using three cases where the two-tier public administrative structure applies.ResultsResults from the research process suggest that although change is happening it lacks the coherence and scale needed, with non-urban multiple-tier public administrations getting left behind by their metropolitan, single-tier counterparts creating a credibility and performance gap between political rhetoric and local net zero delivery. This observed inertia highlights the need to change governance processes and practices if public administration is going to deliver its part of net zero effectively outside the UK Metropolitan areas.DiscussionThe gap in support for local government to develop net zero governance arrangements is well recognized in both this research and publicly funded research programmes. This study provides UK local authorities with a simple, effective toolkit, that could potentially help them build strong wider societal relationships that will assist them in playing their full part in the UK reaching net zero.

Research impact assessment: Developing and applying a viable model for the social sciences

Abstract Prompted by research funding agencies and regulatory bodies, universities need to demonstrate and manage the impact of their research. Therefore, models for evaluating research impacts that can be applied quickly and at a reasonable cost are needed. However, the development of these models presents considerable challenges: research impact is multidimensional and can occur over time because of multiple interactions between different agents. Furthermore, impact assessment can demand substantial time and resources. Considering this challenging context, this study proposes a research impact assessment model capable of optimizing benefits and costs. The model was based on a multidimensional impact perspective and an application-oriented way of generating and transmitting knowledge. It was applied to a large teaching and research institution with a predominant role in the social sciences. The assessment involved a survey of the leaders of 133 research projects. The main findings of the application of the assessment model were as follows: first, knowledge production is transitioning from a traditional mode (aimed to impact science) to a new mode (aimed to impact multiple stakeholders); second, project leaders still perceive the prevalence of scientific impact over other types of impact; and third, the survey revealed how certain characteristics of the knowledge production mode relate to (perceived) impact. The viable research impact assessment model was demonstrated to be useful and cost-effective; thus, with adaptations and improvements, it may be used by other institutions, particularly those with internal research funding programs. This article also presents the model’s limitations, suggesting directions for future research.

"Hypertension in Pregnancy Intervention Trial At Term" and "Disproportionate Intrauterine Growth Intervention Trial At Term" Studies.

In 2003, in the context of a national research funding program in which obstetric research was prioritized, several perinatal centers took the initiative to jointly submit a number of applications to the subsidy programs of Effectiveness Research and Prevention of ZonMw. This has led to the funding of the Obstetric Consortium with several projects, including the "Hypertension in Pregnancy Intervention Trial At Term" and the "Disproportionate Intrauterine Growth Intervention Trial At Term" studies. The studies showed that induction of labor for hypertension and growth restriction at term was the appropriate management. Subsequent implementation improved maternal and perinatal outcomes.

The CompactLight Design Study

AbstractCompactLight is a Design Study funded by the European Union under the Horizon 2020 research and innovation funding programme, with Grant Agreement No. 777431. CompactLight was conducted by an International Collaboration of 23 international laboratories and academic institutions, three private companies, and five third parties. The project, which started in January 2018 with a duration of 48 months, aimed to design an innovative, compact, and cost-effective hard X-ray FEL facility complemented by a soft X-ray source to pave the road for future compact accelerator-based facilities. The result is an accelerator that can be operated at up to 1 kHz pulse repetition rate, beyond today’s state of the art, using the latest concepts for high brightness electron photoinjectors, very high gradient accelerating structures in X-band, and novel short-period undulators. In this report, we summarize the main deliverable of the project: the CompactLight Conceptual Design Report, which overviews the current status of the design and addresses the main technological challenges.

Toxicology, environmental chemistry, ecotoxicology, and One Health: definitions and paths for future research

The definitions of toxicology, environmental toxicology, environmental chemistry, environmental risk, and ecotoxicology are closely related and sometimes used as synonyms, whereas One Health is a more recent, complementary concept. This contribution examines the origins of the usages of these terms, explores their interchangeability (whether appropriate or not), and proposes some paths to better define each. The usage of these terms is evolving, and current research and paradigms are progressing toward the integration of broader, more integrative perspectives, such as the One Health approach. One Health is a holistic approach that helps link and integrate work on environmental and human health impacts. Definitions and research should not necessarily strive to segregate human vs. environmentally focused work, and most of the problems are complex and interconnected. Future research endeavors and funding programs must better reflect the multidisciplinary nature of environmental toxicology, and more broadly, One Health research and environmental research must recognize the interrelationships of human health, environmental health, ecotoxicology, and a multitude of geochemical, microbiological, and ecological processes.

The European GO-VIKING project on flow-induced vibrations: overview and current status

Abstract The interaction between cooling fluid and solid structures (rods, tubes) in nuclear power plants may lead to flow-induced vibrations (FIV), causing material fatigue, fretting wear, and eventually loss of component integrity. This can cause further safety issues as well as substantial standstill costs due to longer or unplanned outages. With the growing computational power, the application of modern 3D numerical simulation tools for the accurate prediction of FIV phenomena is rapidly increasing. In 2022, the GO-VIKING (Gathering expertise On Vibration ImpaKt In Nuclear power Generation) project received a grant within the Horizon Europe research and innovation funding program. Sixteen European and two US partners started their collaboration in the field of FIV experiments and analysis. Over four years, the GO-VIKING project investigates FIV phenomena occurring in nuclear reactor cores and steam generators under single- and two-phase flow conditions. The project’s main objectives are to expand the expertise in the field of FIV through generation of new experimental and high-resolution numerical data; development, improvement, and validation of fluid-structure interaction (FSI) methods for FIV evaluation; training stakeholders in the application of these methods; and synthesizing guidelines for the prediction and assessment of FIV phenomena in nuclear reactors. This paper provides an overview of the GO-VIKING objectives, scientific program, as well as of the main scientific achievements in the first project year.

Psychedelics in PERIL: The Commercial Determinants of Health, Financial Entanglements and Population Health Ethics.

The nascent for-profit psychedelic industry has begun to engage in corporate practices like funding scientific research and research programs. There is substantial evidence that such practices from other industries like tobacco, alcohol, pharmaceuticals and food create conflicts of interest and can negatively influence population health. However, in a context of funding pressures, low publicly funded success rates and precarious academic labor, there is limited ethics guidance for researchers working at the intersection of clinical practice and population health as to how they should approach potential financial sponsorship from for-profit entities, such as the psychedelic industry. This article reports on a reflective exercise among a group of clinician scientists working in psychedelic science, where we applied Adams' (2016) PERIL (Purpose, Extent, Relevant harm, Identifiers, Link) ethical decision-making framework to a fictionalized case of corporate psychedelic financial sponsorship. Our analysis suggests financial relationships with the corporate psychedelic sector may create varying degrees of risk to a research program's purpose, autonomy and integrity. We argue that the commercial determinants of health provide a useful framework for understanding the ethics of industry-healthcare entanglements and can provide an important population health ethics lens to examine nascent industries such as psychedelics, and work toward potential solutions.

The Influence of Human Connections and Collaboration on Research Grant Success at Various Career Stages: Regression Analysis.

Documenting the grant acquisition characteristics of a highly selective group of researchers could provide insights into the research and faculty development of talented individuals, and the insights gained to foster such researchers will help university management strengthen their research capacity. This study examines the role of human connections in the success of biomedical researchers in Japanese universities. This study used grant data from the Grants-in-Aid for Scientific Research (GIA) program, the largest competitive research funding program in Japan, to collect information on projects and their implementation systems obtained throughout the participants' careers. Grant success was measured by the number and amounts of the awards obtained while participants occupied the role of principal investigator. Human connections were quantified by the number of projects in which the participants took part as members and were classified by their relationship with the project leader. Data were matched with information on career history, publication performance, and experience of the participants with government-funded programs apart from GIA and were analyzed using univariate and multivariate regression analyses. Early-career interpersonal relationships, as measured using the h-index value of the researchers who provided the participants with their initial experience as project members, had a positive effect on grant success. The experience of contributing to prestigious research programs led by top researchers dramatically increased the cumulative amount of GIA awards received by the participants over time. Univariate logistic regression analyses revealed that more interactions with upper-level researchers resulted in fewer acquisitions of large programs (odds ratio [OR] 0.67, 95% CI 0.50-0.89). Collaboration with peers increased the success rate of ≥2 research grants in large programs in situations in which both the participant and project leader were professors (OR 1.16, 95% CI 1.06-1.26). Tracking the process of research development, we found that collaboration during the periods of 10 to 14 years and 15 to 19 years after completing a doctorate degree determined the size of the project that the participant would obtain-interactions with peer researchers and subordinates during the 10- to 14-year postdegree period had positive effects on ≥2 large-program acquisitions (OR 1.51, 95% CI 1.09-2.09 and OR 1.31, 95% CI 1.10-1.57, respectively), whereas interactions with subordinates during the 15- to 19-year postdegree period also had positive effects (OR 1.25, 95% CI 1.25-1.07). Furthermore, relationships that remained narrowly focused resulted in limited grant success for small programs. Human networking is important for improving an individual's ability to obtain external funding. The results emphasize the importance of having a high-h-indexed collaborator to obtain quality information early in one's career; working with diverse, nonsupervisory personnel at the midcareer stage; and engaging in synergistic collaborations upon establishing a research area in which one can take more initiatives.

Politics of creep: Latent development, technology monitoring, and the evolution of the Schengen Information System

Abstract The Schengen Information System for law enforcement, border control, and judicial cooperation in the European Union has over the years seen a considerable expansion of the amount and types of data stored and its functionalities, as well as its user base. In light of this transformation from a simple information-sharing tool to a full-blown investigative database, there has, however, been surprisingly little public debate and pushback against the growing surveillance and control capacities that the system enables. This article proposes to understand the largely uncontested evolution of the SIS through the concept of ‘creep’, i.e. the incremental, unforeseen, and/or stealthy development of a technological system beyond what it was originally introduced for. More specifically, it retraces how creep has in the case of the SIS been enabled and facilitated through (1) latent development principles, i.e. the rationale of building dormant features into a system that can be activated at a later point in time once technology has sufficiently matured and/or legal foundations have been adopted; and (2) technology monitoring and steering mechanisms, i.e. the continuous assessment of the readiness of key technologies for anticipated updates to the system as well as interventions in publicly funded research programmes.

The American Heart Association at 100: A Century of Scientific Progress and the Future of Cardiovascular Science: A Presidential Advisory From the American Heart Association.

In 1924, the founders of the American Heart Association (AHA) envisioned an international society focused on the heart and aimed at facilitating research, disseminating information, increasing public awareness, and developing public health policy related to heart disease. This presidential advisory provides a comprehensive review of the past century of cardiovascular and stroke science, with a focus on the AHA's contributions, as well as informed speculation about the future of cardiovascular science into the next century of the organization's history. The AHA is a leader in fundamental, translational, clinical, and population science, and it promotes the concept of the "learning health system," in which a continuous cycle of evidence-based practice leads to practice-based evidence, permitting an iterative refinement in clinical evidence and care. This advisory presents the AHA's journey over the past century from instituting professional membership to establishing extraordinary research funding programs; translating evidence to practice through clinical practice guidelines; affecting systems of care through quality programs, certification, and implementation; leading important advocacy efforts at the federal, state and local levels; and building global coalitions around cardiovascular and stroke science and public health. Recognizing an exciting potential future for science and medicine, the advisory offers a vision for even greater impact for the AHA's second century in its continued mission to be a relentless force for longer, healthier lives.

Pathways to a brighter future for Europe

Through the Horizon Europe programme, the European Commission is investing €13.5 billion throughout 2023-24 to support researchers and innovators in Europe in developing novel solutions to key challenges. These include environmental, energy, digital and geopolitical issues. Representing the EU’s main funding programme for research and innovation, Horizon Europe has a budget of €95.5 billion until 2027. The 2023-2024 work programme has around €13.5 billion funding available to help the EU attain its climate, energy and technological goals. The funding will also be used to assist Ukraine, enhance economic sustainability and aid in the recovery from the COVID-19 pandemic. It is also expected to help secure a strengthened research and innovation environment across Europe, with a greater number of researchers and innovators, improved flexibility and funding for selected research facilities. In terms of the allocation of funding, €5.67 billion is earmarked to help achieve crucial climate action targets such as developing ways to lower greenhouse gas emissions and climate change adaptation, while an additional €1.67 billion is allocated to protecting biodiversity. More than €4.5 billion is available to support digital transformation across the EU, supporting the ongoing development of innovations in digital technologies. Nearly â,¬970 million from the EU’s NextGenerationEU programme is dedicated to accelerate the shift to clean energy, including measures to help end the EU’s reliance on Russian fossil fuels in accordance with the European Commission’s REPowerEUPlan.

Human-Centred Machine Learning Approaches for Smart Cultural Heritage Spaces: A Multicontinental Review

The influence of digital technologies on the Cultural Heritage sector has grown as the use of Artificial Intelligence (AI), the Internet of Things (IOT), Virtual Reality (VR) and Augmented Reality (AR) has become more dominant in society. The digitisation of Cultural Heritage content can be seen across many areas of the world such as in the European Union (EU) within projects like meSch and Emotive that were funded under the Horizon 2020 research and innovation funding programme to support personalisation and education. Machine learning techniques have also been utilised in culturally significant work across Asia and Africa in sectors such as education, healthcare, agriculture, and Cultural Heritage with the goal of improving the life and wellbeing of people in these regions. This paper aims to deduce key machine learning techniques that are applicable for smart Cultural Heritage spaces and determine their adherence with the Human-Centred philosophy in selected projects within Africa, Asia, and Europe. The techniques chosen were Collaborative Filtering and Unsupervised Learning and whilst the results indicated that human-centredness was evident there were areas which could be improved to ensure a broad adherence with this philosophical approach.

Research program "City of the Future - Healthy and Sustainable Metropolises"

Urbanization is advancing worldwide and thus, cities are increasingly living spaces for people. Therefore, it is essential to place the health and well-being of city dwellers at the center of urban planning. The research funding program "City of the Future - Healthy and Sustainable Metropolises" from the Fritz and Hildegard Berg Foundation at the German Stiftungszentrum has been providing important inter- and transdisciplinary research impulses on this topic since 2010. Junior research groups at the interfaces of health sciences and other disciplines in the natural and social sciences were funded. One focus of the research program is to enable intensive cooperation with practitioners, in order to reflect upon and work on problems and issues from practice using the best possible scientific methods and to catalyze the transfer of knowledge. The research consortia are accompanied by annual conferences on a wide variety of urban health topics at various venues in Germany. In addition, transdisciplinary networks have been established and further initiatives (e. g., founding of an institute) have been launched. In this paper, the development of the multifaceted research funding program "City of the Future - Healthy and Sustainable Metropolises" is presented, including an outlook into its future development.

Fostering transdisciplinary research for sustainability in the Global South: Pathways to impact for funding programmes

Advancing global sustainable development hinges on strengthening the connections between science, society, and policy, as well as addressing existing science inequalities. Research funding programmes play a pivotal role in this context, but little is known about how they can actively nurture required transformations of the science systems. In this paper, we investigate how science funders can actively promote science-society-policy interactions through transdisciplinary research (TDR) as a means to advance sustainable development in the Global South. Our primary focus is on the research funding programme “LIRA 2030 Africa”. Our research has revealed three closely intertwined pathways for cultivating TDR in this context: (1) Enabling African scientists to lead high-quality TDR projects, (2) empowering African scientists to pursue a career as TDR researchers, and 3) enhancing the context conditions for doing TDR in Africa. By scrutinising the advantages and challenges associated with these pathways and their associated activities, we conclude that fostering TDR in Africa necessitates a multifaceted approach. This approach entails a combination of measures, such as providing research grants, offering TDR and leadership training, fostering networks, developing institutions, and facilitating collaboration across various funders.

Novel proposal of PTO direct-drive linear generator, an Azimuthal Multi-translator Switched Reluctance Machine (AMSRM): mechanical, characterization and performance tests.

Research and development on power take-off (PTO) in wave energy has been gaining relevance in recent years, appearing as a priority in various forums (JCR reports [1], SRIA in wave energy development [2], specific research funding program in WES, etc.).
 The new proposal of a linear electric generator to act as a PTO in wave energy extraction applications has been developed in the European project SEATITAN [3].
 The linear generator is based on a switched reluctance machine type topology in which the magnetic flux is azimuthal. This allows eliminating the yoke, reducing the amount of magnetized material needed and increasing the force density, besides having a cylindrical shape that allows adapting perfectly to the spar of point absorber type WECs.
 The Azimuthal Multi-translator Switched Reluctance Machine (AMSRM) has been developed, designed and a prototype has been manufactured in the project. The prototype is composed of two modules of 35 kN of force and 3 m/s of peak velocity.
 The complete manuscript will detail the testing facility, as well as the tests performed for the static characterization of the force, electrical losses, and air gap achieved during manufacturing, as well as the dynamic characterization of frictional losses and a preliminary setting of force control parameters.
 The dry test facility (figure 1) consists of the necessary electronic converters to conveniently operate the generator and impose a reference force controlling current per generator coil. In addition, an end-stopper is provided to ensure the safety of the tests (this equipment is essential for dynamic tests). For static tests, a load cell for force measurement as well as precision electrical power meters are used.
 
 A test protocol has been defined for each test, as well as an analysis procedure to obtain the required results: for example, for the evaluation of friction, dynamic tests based on a back-and-forth motion with drifting sections are proposed to evaluate the braking force with the generator off at various speeds.
 The description of the test protocol, the raw data obtained, the data analysis carried out, and de results obtained will be presented and detailed in the manuscript, as well as the description of the test-based parameterization of a simplified AMSRM model to be used in the dynamic modeling of WECs. The simplified model has been previously developed and presented in EWTEC 2021.
 [1] D. Magagna, R. Monfardini, and A. Uihlein, “JRC Ocean Energy Status Report 2016 Edition,” 2016
 [2] J. L. Villate et al., “Strategic Research and Innovation Agenda for Ocean Energy,” Etipocean, no. 826033, p. 64, 2020.
 [3] WEDGE GLOBAL, “SeaTitan,” 2018. [Online]. Available: https://seatitan.eu/. [Accessed: 29-Nov-2021].
 [4] Marcos Blanco, Miguel Santos‐Herran, Gustavo Navarro, Jorge Jesus Torres, Jorge Najera, and Luis García-Tabarés, “Simplified model of a novel direct-drive PTO based on an azimuthal linear switched reluctance generator,” 2021.

Assessing the physiological basis for resilience in military personnel.

Military personnel experience training and operational demands that are different from civilian populations, including frequent deployment, exposure to austere environments, and dislocation from family. These unique occupational demands may result in negative impacts on health, performance, and career success. As such, resilience, defined as a system's capacity to resist, recover, recover better, or adapt, to perturbation from a challenge or stressor, is a critical factor in assuring the health and safety of military personnel. In recent years, the Department of Defense (DoD) has funded research programs assessing the physiological basis of resilience. This review will overview research programs, review salient findings from recent studies, and highlight potential future areas of research. Physiological factors influencing or predicting resilience in US military populations, including physical performance, anthropometrics and body composition, nutrition and dietary supplements, and other biomarkers will be highlighted. Finally, this manuscript will detail potential future studies, including interventions, aimed at optimising physiological resilience in military personnel.

Operationalising a large research programme tackling complex urban and planetary health problems: a case study approach to critical reflection

Addressing increasingly urgent global challenges requires the rapid mobilisation of new research groups that are large in scale, co-produced and focussed explicitly on investigating root causes at a systemic level. This requires new ways of operationalising and funding research programmes to better support effective interdisciplinary and transdisciplinary (ID/TD) partnerships between a wide range of academic disciplines and stakeholder groups. Understanding the challenges and approaches that teams can follow to overcome them can come through critical reflection on experiences initiating new research programmes of this nature and sharing of these reflections. We aimed to offer a framework for critical reflection and an overview of how we developed it and to share our reflections on operationalising a newly formed large-scale ID/TD research programme. We present a framework of 10 areas for critical reflection: systems, unknowns and imperfection, ID/TD understanding, values, societal impact, context and stakeholder knowledge, project understanding and direction, team cohesion, decision-making, communications and method development. We reflect on our experience of operationalising the research programme in these areas. Based on this critical examination of our experiences and the processes we adopted, we make recommendations for teams seeking to tackle important and highly complex global challenges, and for those who fund or support such research groups. Our reflections point to an overarching challenge of the structural and institutional barriers to cross-disciplinary research of this nature.

Leveraging AI to investigate the impact of different research funding programs on research outcome

Leveraging AI to investigate the impact of different research funding programs on research outcome

0892 Insomnia and poor sleep efficiency predict cognitive decline among non-demented elderly: findings from the Cretan Aging Cohort

Abstract Introduction Previous cross-sectional studies have shown that insomnia symptoms and objective short sleep are associated with disease severity in patients with Mild Cognitive Impairment (MCI) and Dementia. Our aim was to examine the longitudinal associations between sleep quality/quantity with cognitive progression in non-demented community-dwelling elderly. Methods A sub-sample of 105 participants (77.5% females) from a large population-based cohort in Crete, Greece of 3,140 older adults (>60 years; baseline) were followed up 8 years later (follow-up). All participants underwent neuropsychiatric/neuropsychological evaluation on both phases. At baseline, subjective sleep complaints and objective sleep variables based on 3-day 24 hour actigraphy were assessed. The impact of baseline objective sleep characteristics and/or insomnia (as defined by at least two subjective sleep complaints) on cognitive progression was assessed with univariate and multivariate models controlling for confounders. Results At baseline 50 participants were diagnosed as CNI and 55 as MCI; at follow-up 60 participants (57.1%) displayed clinically significant cognitive deterioration while the remaining showed relatively stable cognitive status. The frequency of persons reporting insomnia symptoms at baseline was higher among those who displayed cognitive deterioration (31.7%) than those in the cognitively stable group (13.3%, p=0.037). Logistic regression analysis showed that participants with insomnia symptoms at baseline, were significantly more likely to deteriorate cognitively at follow-up (p=0.05, OR=2.90). Also, among objective sleep variables added to the model, it was poor sleep efficiency that was associated with cognitive deterioration (p=0.035, OR=3.48). Conclusion More than half of the participants displayed significant cognitive deterioration over 8 years and this decline was predicted by insomnia symptoms and objective poor sleep efficiency at baseline. Improving both quality and quantity of sleep may significantly delay the deterioration of cognitive function in non-demented community-dwelling elderly. Support (if any) National Strategic Reference Framework (NSRF) - Research Funding Program: THALES entitled “UOC-Multidisciplinary network for the study of Alzheimer’s Disease” Grant Cod: MIS 377299 HELLENIC FOUNDATION FOR REASEARCH AND INNOVATION (HFRI)- Research Funding Program: ELIDEK entitled “Sleep Apnea (OSA) and poor sleep as Risk Factors for decreased cognitive performance in patients with Mild Cognitive Impairment: the Cretan Aging Cohort (CAC)”, Grant Cod: HFR1-FM17-4397