Research Excellence Research Articles

Abstract PO5-08-07: Ki-67 Expression in Breast Cancer associated with ATM, BRCA1, BRCA2, CHEK2 and PALB2 Pathogenic Variants

Abstract Background: Germline Pathogenic Variants (PVs) in ATM, BRCA1, BRCA2, CHEK2, and PALB2 are known to increase breast cancer (BCa) risk, but the effect of these PVs on tumor biology is not well-understood. Ki-67 is an established prognostic marker in hormone receptor (HR) positive breast cancer but the distribution of Ki-67 in breast cancer associated with germline PVs is not known. Methods: The study included patients with loco-regional (Stage I-III) HR-positive (ER+ or PR+), HER2-negative invasive ductal or lobular breast cancer evaluated at Mayo Clinic for curative intent treatment between 2012 and 2021. PV carrier status was ascertained in more than two-thirds of cases from germline whole exome sequencing (Regeneron) of patients who participated in a prospective registry at Mayo Clinic. Additional PV carriers were identified through a review of the results of clinical germline genetic testing in electronic medical records aided by natural language processing. Clinically performed Ki-67 values were abstracted from electronic medical records and analyzed as continuous and categorical variables (low: < 20% vs. high: ≥20%). Throughout the timeline of the study, a consistent method for assessment of Ki-67 was utilized at Mayo Clinic, Rochester: Immunohistochemical staining of the Ki-67 antigen in formalin-fixed paraffin-embedded tissue was performed using MIB-1 clone, the scanned slides were reviewed by a technologist and traced areas further analyzed for Ki-67 using Aperio Software. Patients who received neoadjuvant therapy prior to the assessment of Ki-67, with metastatic disease at diagnosis, with PVs in two or more genes of interest, or unknown germline PV or Ki-67 status were excluded from the analysis. Multiple primary tumors in the same patient diagnosed within one year of each other were analyzed independently. The control (non-carrier) group included randomly selected patients from the prospective registry who tested negative for PVs in the five genes over the same time period. Ki-67 values were compared between germline PV carriers and non-carriers in a multivariable logistic regression analysis adjusting for sex, race, age at diagnosis, stage at presentation, and histology of the tumor. Results: A total of 113 HR+/HER2- tumors from 111 PV carriers (ATM: 27, BRCA1: 24, BRCA2: 28, CHEK2: 22, and PALB2:12) along with 431 HR+/HER2- tumors from 422 randomly selected non-carriers were evaluated. The majority (>95%) of patients were non-Hispanic White. Germline PV carriers in each gene were diagnosed at a significantly younger age (P< 0.05) compared to non-carriers. The median Ki-67 value was 12 (Range: 1 to 93) for non-carriers, 16 (Range: 0 to 79) for ATM, 31 (Range: 4 to 86) for BRCA1, 30 (Range: 6 to 80) for BRCA2, 13 (Range: 1 to 38) for CHEK2, and 20 (Range: 3 to 46) for PALB2 PV carriers. In multivariable analysis, compared to non-carriers, we observed significantly higher odds of a high Ki67 value (≥20%) for tumors arising from germline PV carriers in BRCA1 (Odds Ratio (OR): 7.3, 95%CI: 2.3 – 23.3, p< 0.001), BRCA2 (OR: 3.0, 95%CI: 1.2 – 7.4, p=0.02) and PALB2 (OR: 3.9, 95%CI: 1.1 – 14.5, p=0.04). No such relationship was observed with either ATM (OR: 1.1, 95%CI: 0.4 – 2.9, p=0.81) or CHEK2 (OR: 0.8, 95%CI: 0.3 – 2.2, p=0.63). Conclusion: This study reveals that HR+/HER2- tumors in BRCA1, BRCA2, and PALB2 PV carriers have a significantly higher Ki-67 expression compared to non-carriers. These findings have implications for understanding prognosis and endocrine response PV with HR+ breast cancer. Further exploration of the relationships between Ki67 and germline PV status is necessary to personalize systemic therapy options in germline PV carriers. Acknowledgments: Thank you to Regeneron Genetics Center. The study was funded in part by the NIH Specialized Program of Research Excellence in Breast Cancer [P50CA116201] to Mayo Clinic, Mayo Clinic Department of Oncology Small Grants Program, and the Paul Calabresi Program at Mayo Clinic Citation Format: Robert Scheel, Grace Choong, Tara Rao, Nicholas Boddicker, Chunling Hu, Jie Na, Vinod Kaggal, Sean Murphy, Karthik Giridhar, Saba Yasir, Matthew Goetz, Fergus Couch, Siddhartha Yadav. Ki-67 Expression in Breast Cancer associated with ATM, BRCA1, BRCA2, CHEK2 and PALB2 Pathogenic Variants [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO5-08-07.

Overstaying our welcome: On the rise of women's seniority in the academy

AbstractIssues surrounding gender equality are—and should be—front and centre in the water resources community, and other science, technology, engineering and mathematics (STEM) fields. Very necessarily, the focus tends to be on recruitment, offering support for students and early career academics. The leaky pipeline concept used to describe the incremental loss of women from STEM fields with career duration describes a disproportionate loss of senior women, creating a parallel problem where highly qualified, top tier academics are lost from the system after significant financial and personnel investment by institutions. Ultimately, the leaky pipeline undermines the extensive investment of the hydrology and other STEM communities in equity, diversity, inclusion and accessibility (EDIA) recruitment and retention programmes by cutting short career ambitions and the trajectories of diverse top performing individuals, resulting in no net benefit of EDIA policy investments and a lack of diversity with seniority. Addressing this critical gender gap requires the attention and support of the hydrology community of practice with specific focus on generating opportunities for advancement, confronting systemic and structural biases and improving education around allyship. Institutions and professional organizations need to consciously grow diversity in leadership and recognize and outwardly manage the perception of academic excellence around slow research and education that attracts increased diversity. Supporting allyship, reducing competitiveness among community members and reinforcing collaboration will not only attract, but retain, a higher proportion of diversity in the hydrology community, academia and STEM professions in general. It is time for the water resources (and other STEM) communities to demand broader accountability and recognition of the barriers to women, implement and reward more diverse definitions of research excellence, and offer allyship training to the community of practice at large.

Can ChatGPT evaluate research quality?

Abstract Purpose Assess whether ChatGPT 4.0 is accurate enough to perform research evaluations on journal articles to automate this time-consuming task. Design/methodology/approach Test the extent to which ChatGPT-4 can assess the quality of journal articles using a case study of the published scoring guidelines of the UK Research Excellence Framework (REF) 2021 to create a research evaluation ChatGPT. This was applied to 51 of my own articles and compared against my own quality judgements. Findings ChatGPT-4 can produce plausible document summaries and quality evaluation rationales that match the REF criteria. Its overall scores have weak correlations with my self-evaluation scores of the same documents (averaging r=0.281 over 15 iterations, with 8 being statistically significantly different from 0). In contrast, the average scores from the 15 iterations produced a statistically significant positive correlation of 0.509. Thus, averaging scores from multiple ChatGPT-4 rounds seems more effective than individual scores. The positive correlation may be due to ChatGPT being able to extract the author’s significance, rigour, and originality claims from inside each paper. If my weakest articles are removed, then the correlation with average scores (r=0.200) falls below statistical significance, suggesting that ChatGPT struggles to make fine-grained evaluations. Research limitations The data is self-evaluations of a convenience sample of articles from one academic in one field. Practical implications Overall, ChatGPT does not yet seem to be accurate enough to be trusted for any formal or informal research quality evaluation tasks. Research evaluators, including journal editors, should therefore take steps to control its use. Originality/value This is the first published attempt at post-publication expert review accuracy testing for ChatGPT.

Data Resource Profile: The Cancer Public Library Database in South Korea.

This paper provides a comprehensive overview of the Cancer Public Library Database (CPLD), established under the Korean Clinical Data Utilization for Research Excellence project (K-CURE). The CPLD links data from four major population-based public sources: the Korea National Cancer Incidence Database in the Korea Central Cancer Registry, cause-of-death data in Statistics Korea, the National Health Information Database in the National Health Insurance Service, and the National Health Insurance Research Database in the Health Insurance Review & Assessment Service. These databases are linked using an encrypted resident registration number. The CPLD, established in 2022 and updated annually, comprises 1,983,499 men and women newly diagnosed with cancer between 2012 and 2019. It contains data on cancer registration and death, demographics, medical claims, general health checkups, and national cancer screening. The most common cancers among men in the CPLD were stomach (16.1%), lung (14.0%), colorectal (13.3%), prostate (9.6%), and liver (9.3%) cancers. The most common cancers among women were thyroid (20.4%), breast (16.6%), colorectal (9.0%), stomach (7.8%), and lung (6.2%) cancers. Among them, 571,285 died between 2012 and 2020 owing to cancer (89.2%) or other causes (10.8%). Upon approval, the CPLD is accessible to researchers through the K-CURE portal. The CPLD is a unique resource for diverse cancer research to investigate medical use before a cancer diagnosis, during initial diagnosis and treatment, and long-term follow-up. This offers expanded insight into healthcare delivery across the cancer continuum, from screening to end-of-life care.

Mapping philanthropic support of science

While philanthropic support for science has increased in the past decade, there is limited quantitative knowledge about the patterns that characterize it and the mechanisms that drive its distribution. Here, we map philanthropic funding to universities and research institutions based on IRS tax forms from 685,397 non-profit organizations. We identify nearly one million grants supporting institutions involved in science and higher education, finding that in volume and scope, philanthropy is a significant source of funds, reaching an amount that rivals some of the key federal agencies like the NSF and NIH. Our analysis also reveals that philanthropic funders tend to focus locally, indicating that criteria beyond research excellence play an important role in funding decisions, and that funding relationships are stable, i.e. once a grant-giving relationship begins, it tends to continue in time. Finally, we show that the bipartite funder-recipient network displays a highly overrepresented motif indicating that funders who share one recipient also share other recipients and we show that this motif contains predictive power for future funding relationships. We discuss the policy implications of our findings on inequality in science, scientific progress, and the role of quantitative approaches to philanthropy.

A study on poverty among rural women in China

This article mainly studies the issue of poverty among rural women in China. Through actual research and visits to two poverty-stricken counties in Northeast China - Inner Mongolia Autonomous Region, two key poverty-stricken counties in Northwest China - Gansu Province, two key poverty-stricken counties in Southwest China - Guizhou Province, and two severely impoverished counties in East China - Anhui Province, combined with existing excellent research literature, the main characteristics of rural impoverished women in China were finally summarized: the vulnerability, concealment, intergenerational transmission, and persistence of women's poverty The symbiosis of poverty and the derivative nature of poverty ideology. On this basis, this article summarizes the main causes of poverty among impoverished rural women in China: due to illness, education, lack of labor force, constraints of traditional concepts, and geographical factors; At the same time, it clarifies the role of rural women's poverty alleviation in the process of family poverty alleviation in China. Finally, this article outlines the significance of poverty alleviation for impoverished rural women in China from a sustainable perspective: alleviating family conflicts, reducing female crime rates, improving the quality of life for elderly women, effectively limiting intergenerational transmission of poverty, and improving national poverty alleviation effectiveness.

Combinatorial effects of resazomycins and azithromycin against Neisseria gonorrhoeae

Gonorrhea is a sexually transmitted disease caused by the bacterium Neisseria gonorrhoeae. The WHO estimates 87 million new gonococcal infections occur each year making it the second most common sexually transmitted bacterial infection. When left untreated, gonorrhea can cause pelvic inflammatory disease and infertility in women. Treatment is further complicated by the fact that N. gonorrhoeae has acquired resistance to all antibiotics approved for treatment including the gold standard ceftriaxone. One way to address the growing problem of antibiotic resistance is to administer drugs in combination in the hope the two are more effective together than alone. Resazomycins, a novel family of resazurin (Rz) based antibiotics, exhibit antimicrobial activity against N. gonorrhoeae and Francisella tularensis. Here, we used E-test assays to determine if there was a synergistic bactericidal effect between resazomycins and azithromycin, which is commonly used to treat gonorrhea. Multiple clinical isolates of N. gonorrhoeae were more sensitive to azithromycin in the presence of Rz. However, additional testing in a checkerboard assay revealed no synergistic effect between azithromycin and Rz or another resazomycin, resorufin pentyl ether (RPE). Upon further investigation, we determined the conflicting results between the E-test and checkerboard method were due to differences in bacterial load. When the E-test assays were repeated using a lower inoculum of N. gonorrhoeae, increased sensitivity to azithromycin was not observed in the presence of Rz. In the future, we plan to test resazomycins in combination with other antibiotics against N. gonorrhoeae, particularly extensively drug-resistant strains. (This research was made possible by NIH Grant P20GM103434 to the West Virginia IDeA Network for Biomedical Research Excellence and the NASA West Virginia Space Grant Consortium, Grant # 80NSSC20M0055)

Role of LpnA in Francisella tularensis Susceptibility to Resazurin

Francisella tularensis is classified by the Centers for Disease Control and Prevention as a Category A bioterrorism agent due to its low infectious dose, ease of aerosolization, and high mortality rate. Given there is no licensed tularemia vaccine and the possibility of antibiotic-resistant F. tularensis strains, there is an urgent need to develop new treatments against this bacterium. Resazurin (Rz) has bactericidal activity against F. tularensis and other gram-negative bacteria including the human pathogens Neisseria gonorrhoeae and Helicobacter pylori. However, the mechanism of action for Rz has yet to be determined. To identify targets of Rz, we screened for Rz-resistant (Rzr) mutants of F. tularensis LVS. Whole genome sequencing was performed on 42 Rzr isolates and all contained mutations within the coding regions of FTL_0421 and FTL_1504. FTL_0421 encodes for LpnA, the major lipoprotein in F. tularensis. The FTL_0421 mutation in Rzr1 resulted in loss of LpnA expression which correlated with increased sensitivity to osmotic stress. To investigate the individual role of lpnA in Rz-resistance, a deletion mutant (ΔlpnA) was generated using standard molecular genetics techniques. An agar dilution assay was then performed to determine the Rz susceptibility of the ΔlpnA strain. A minimum inhibitory concentration (MIC) of 2.75μg/mL was achieved for the ΔlpnA and the LVS wild-type strain. This data suggests mutation of lpnA alone is not sufficient to confer resistance to resazurin. In the future, we will investigate whether lpnA in combination with other genes like FTL_1504 play a role in resazurin susceptibility in F. tularensis. (Supported by NIH Grant P20GM103434 to the West Virginia IDeA Network for Biomedical Research Excellence & the NASA Space Grant Consortium)

Utilization of Double-Immunofluorescence Microscopy to determine the role of FTL_1199 in erythrocyte invasion by Francisella tularensis.

Francisella tularensis is an intracellular bacterium that is the causative agent of the zoonotic disease, tularemia. F. tularensis invades host erythrocytes during infection, a phenomenon that leads to increased colonization of ticks after a blood meal. To better understand the mechanism of erythrocyte invasion, an RNA-seq analysis was conducted to identify genes whose transcription was affected by the presence of erythrocytes. A putative transcriptional regulator, FTL_1199 was determined to be modulated in the presence of erythrocytes. We hypothesized that this gene may therefore play a role in erythrocyte invasion. Deletion of FTL_1199 resulted in a significant reduction in the invasion of rabbit erythrocytes, and complementation of FTL_1199 restored this strain’s ability to acquire the cytoplasmic space of erythrocytes. These findings were determined by a gentamicin protection assay to quantify erythrocyte invasion. To validate these findings, we conducted double-immunofluorescence microscopy. F. tularensis strains incubated with rabbit erythrocytes to allow for invasion. Cells were probed with anti-F. tularensis antibodies followed by red fluorescent secondary antibodies. Cells were washed and erythrocytes were permeabilized. Bacteria were probed a second time utilizing a green fluorescent secondary antibody. Therefore, intracellular bacteria were only labeled with a singular secondary antibody, while extracellular bacteria were tagged with two secondary antibodies. Intracellular bacterial enumeration showed that deletion of FTL_1199 resulted in a significant reduction of invasion (p = 0.0253), while FTL_1199 complementation to the deletion mutant restored invasion to that of wild type (p = 0.3258). These data demonstrate that FTL_1199 plays an important role in erythrocyte invasion. (Supported by NIH Grant P20GM103434 to the West Virginia IDeA Network for Biomedical Research Excellence, R15HL14735 from NHLBI, and funds from the NASA West Virginia Space Grant Consortium).

Lipidomic analysis by LC-MS/MS of wildtype, mutant and VBNC strains of Francisella tularensis LVS.

Francisella tularensis is one of the many bacteria that can enter a viable but nonculturable state (VBNC). The VBNC state acts as an adaptive strategy that allows for long-term survival of bacteria in unfavorable environments. A defining characteristic of VBNC bacteria is a loss of culturability, making VBNC bacteria difficult to detect in the environment using standard plating assays. Failure to identify VBNC bacteria in the food industry or water distribution centers poses a serious risk to human health. Our preliminary data suggests that lipid metabolism plays a role in VBNC adaptation in F. tularensis. To investigate further, genetic deletion mutants have been constructed from two predicted lipid metabolism genes, FTL_1569 (phosphoglycolate phosphatase) and FTL_1570 (phospholipase D family protein). Lipid extracts were collected from wildtype, mutant and VBNC strains of F. tularensis to determine any lipid species associated with the VBNC state. A single-phase lipid extraction method was used to obtain lipids from F. tularensis cultures grown for 24 hours (culturable) and 336 hours (VBNC). Liquid chromatography with tandem mass spectrometry (LC-MS-MS) and the ThermoFisher Compound Discoverer software were utilized for lipid identification, and comparative analyses. Differences in the lipid profile of wildtype, mutant and VBNC strains of F. tularensis have been identified. (Supported by NIH Grant P20GM103434 to the West Virginia IDeA Network for Biomedical Research Excellence)

Getting from More to Enough: Leveraging Research, Policy, and Clinical Excellence to Grow Palliative Care.

Getting from More to Enough: Leveraging Research, Policy, and Clinical Excellence to Grow Palliative Care.

Support for Research Excellence Award (NIH)

Support for Research Excellence Award (NIH)

Exploring the role of the CapG gene in hypoxia adaptation in Tibetan pigs.

Introduction: The CapG gene, which is an actin-binding protein, is prevalent in eukaryotic cells and is abundantly present in various pathways associated with plateau hypoxia adaptation. Tibetan pigs, which have inhabited high altitudes for extended periods, provide an excellent research population for investigating plateau hypoxia adaptation. Results: This study focused on Tibetan pigs and Yorkshire pigs residing in Nyingchi, Tibet. The blood physiological data of Tibetan pigs were found to be significantly higher than those of Yorkshire pigs, including RBC, HGB, HCT, MCH, and MCHC. The SNP analysis of the CapG gene identified six sites with mutations only present in Tibetan pigs. Notably, the transcription factors at sites C-489T, C-274T, and A-212G were found to be altered, and these sites are known to be associated with hypoxia adaptation and blood oxygen transportation. The mRNA expression of the CapG gene exhibited highly significant differences in several tissues, with the target proteins predominantly higher in the Yorkshire pig compared to the Tibetan pig. Specifically, a notable difference was observed in the lung tissues. Immunohistochemistry analysis revealed high expression levels of CapG proteins in the lung tissues of both Tibetan and Yorkshire pigs, primarily localized in the cytoplasm and cell membrane. Conclusion: The CapG gene plays a significant role in regulating hypoxia adaptation in Tibetan pigs. This study provides a theoretical basis for the conservation and utilization of Tibetan pig resources, the breeding of highland breeds, epidemic prevention and control, and holds great importance for the development of the highland livestock economy.

Measuring research quality in a more inclusive way: Evidence from the UK Research Excellence Framework

Abstract Evidence suggests that common metrics of research quality—e.g. journal publications and citations—are systematically biased against certain groups. But does relying solely on them to evaluate quality lead to lower diversity in academia? In this paper, we start to answer this question by analysing data from the UK’s nationwide research assessment exercise, the Research Excellence Framework. We find that narrowly focussed output-based measures of departmental research quality do indeed negatively correlate with the diversity of departmental staff, while measures of research impact and of the quality of the research environment correlate positively. An aggregate measure that incorporates all three components is therefore likely to better promote staff diversity compared to more narrowly defined output-focused measures. More generally, our results suggest that comprehensive definitions of research quality may be more effective at promoting diversity in academia compared to narrower measures. We further argue that funding decisions informed by broader measures result in more efficient resource allocations across the higher education sector.

RAB32 Ser71Arg in autosomal dominant Parkinson's disease: linkage, association, and functional analyses

Parkinson's disease is a progressive neurodegenerative disorder with multifactorial causes, among which genetic risk factors play a part. The RAB GTPases are regulators and substrates of LRRK2, and variants in the LRRK2 gene are important risk factors for Parkinson's disease. We aimed to explore genetic variability in RAB GTPases within cases of familial Parkinson's disease. We did whole-exome sequencing in probands from families in Canada and Tunisia with Parkinson's disease without a genetic cause, who were recruited from the Centre for Applied Neurogenetics (Vancouver, BC, Canada), an international consortium that includes people with Parkinson's disease from 36 sites in 24 countries. 61 RAB GTPases were genetically screened, and candidate variants were genotyped in relatives of the probands to assess disease segregation by linkage analysis. Genotyping was also done to assess variant frequencies in individuals with idiopathic Parkinson's disease and controls, matched for age and sex, who were also from the Centre for Applied Neurogenetics but unrelated to the probands or each other. All participants were aged 18 years or older. The sequencing and genotyping findings were validated by case-control association analyses using bioinformatic data obtained from publicly available clinicogenomic databases (AMP-PD, GP2, and 100 000 Genomes Project) and a private German clinical diagnostic database (University of Tübingen). Clinical and pathological findings were summarised and haplotypes were determined. In-vitro studies were done to investigate protein interactions and enzyme activities. Between June 1, 2010, and May 31, 2017, 130 probands from Canada and Tunisia (47 [36%] female and 83 [64%] male; mean age 72·7 years [SD 11·7; range 38-96]; 109 White European ancestry, 18 north African, two east Asian, and one Hispanic] underwent whole-exome sequencing. 15 variants in RAB GTPase genes were identified, of which the RAB32 variant c.213C>G (Ser71Arg) cosegregated with autosomal dominant Parkinson's disease in three families (nine affected individuals; non-parametric linkage Z score=1·95; p=0·03). 2604 unrelated individuals with Parkinson's disease and 344 matched controls were additionally genotyped, and five more people originating from five countries (Canada, Italy, Poland, Turkey, and Tunisia) were identified with the RAB32 variant. From the database searches, in which 6043 individuals with Parkinson's disease and 62 549 controls were included, another eight individuals were identified with the RAB32 variant from four countries (Canada, Germany, UK, and USA). Overall, the association of RAB32 c.213C>G (Ser71Arg) with Parkinson's disease was significant (odds ratio [OR] 13·17, 95% CI 2·15-87·23; p=0·0055; I2=99·96%). In the people who had the variant, Parkinson's disease presented at age 54·6 years (SD 12·75, range 31-81, n=16), and two-thirds had a family history of parkinsonism. RAB32 Ser71Arg heterozygotes shared a common haplotype, although penetrance was incomplete. Findings in one individual at autopsy showed sparse neurofibrillary tangle pathology in the midbrain and thalamus, without Lewy body pathology. In functional studies, RAB32 Arg71 activated LRRK2 kinase to a level greater than RAB32 Ser71. RAB32 Ser71Arg is a novel genetic risk factor for Parkinson's disease, with reduced penetrance. The variant was found in individuals with Parkinson's disease from multiple ethnic groups, with the same haplotype. In-vitro assays show that RAB32 Arg71 activates LRRK2 kinase, which indicates that genetically distinct causes of familial parkinsonism share the same mechanism. The discovery of RAB32 Ser71Arg also suggests several genetically inherited causes of Parkinson's disease originated to control intracellular immunity. This shared aetiology should be considered in future translational research, while the global epidemiology of RAB32 Ser71Arg needs to be assessed to inform genetic counselling. National Institutes of Health, the Canada Excellence Research Chairs program, Aligning Science Across Parkinson's, the Michael J Fox Foundation for Parkinson's Research, and the UK Medical Research Council.

정규 창업 강좌와 비정규 창업 강좌 수강생 간 기업가적 역량, 기업가적 태도 및 창업의도 비교 연구

Recently, with active policy support from the central government, the activation of entrepreneurship-friendly academic systems and entrepreneurship education in universities are actively increasing. In particular, the Ministry of Education is actively promoting the revitalization of university-based entrepreneurship in order to connect the research results, technological capabilities, and human capital accumulated by universities as the basis for high value-added technological entrepreneurship in the era of the 4th Industrial Revolution and digital transformation. This study divides the various entrepreneurship courses operated within universities into regular and non-regular entrepreneurship courses and seeks to empirically compare and analyze the entrepreneurial capabilities, entrepreneurial attitudes, and entrepreneurial intentions of each student. Among 390 survey responses from college students, 345 valid questionnaires were used in the study. As a research analysis, SPSS 23 was used for regression analysis, and differences between students were compared through t-test. The main research results are as follows: First, the entrepreneurial competency of entrepreneurship education students was found to have a significant positive effect on their entrepreneurial attitude and intention to start a business. Second, entrepreneurial attitude was found to have a significant mediating effect between entrepreneurial capabilities and entrepreneurial intention. Third, as a result of verifying the differences between students in the types of entrepreneurship courses, there was a significant difference between entrepreneurial capabilities and intention to start a business between students taking regular and non-regular entrepreneurship courses. The implications of this study emphasize the need for continuous expansion of regular entrepreneurship courses through the development of mid- to long-term entrepreneurship education curriculum and subjects within universities, securing excellent instructors and research support, and preparing high-quality syllabuses using various teaching methods.

The Republic of North Macedonia's Research Ranking Platform for Academic Staff and Universities

In the present-day realm of higher education, the integration of open data and machine learning has become a crucial means of improving the evaluation and ranking of research publications by university professors. This research endeavours to address the pressing need for an effective computerized paradigm that combines the collection, analysis, and use of public data in higher education. The main objective is to provide recommendations in the form of informative reports for interested institutions and to rank university professors' scientific works on an open data platform. This research not only contributes to the advancement of educational evaluation methodologies but also responds to the growing importance of open data and machine learning in modern higher education. By automating the assessment of research publications, universities can better track and enhance their academic impact, ultimately fostering a culture of excellence in research and innovation.

Abstract 7315: Collaboration between NIDCR and NCI promotes innovative research in head and neck cancers

Abstract The Oral and Salivary Cancer Biology Program at National Institute of Dental and Craniofacial Research (NIDCR) supports research activities that improve early detection and treatment of cancers of the oral cavity, pharynx, and salivary glands. We promote basic science research on the regulatory pathways and transformation process of pre-cancerous lesions to primary and metastatic tumors, as well as translational science activities to develop novel technologies and therapeutics for the diagnosis, prognosis, and treatment of cancers. NIDCR and National Cancer Institute (NCI) have established long-term collaborations to promote and co-manage awards funded through The Immuno-Oncology Translational Network (IOTN) of the Cancer Moonshot program, Specialized Programs of Research Excellence (SPOREs), and Early Detection Research Network (EDRN) program. NIDCR and NCI have co-developed Notice of Special Interest (NOSI) and Request for Application (RFA) on Advancing Head and Neck Cancer Early Detection Research (AHEAD), which co-funded seven research projects to discover and develop molecular signatures of early detection and diagnosis of HPV positive and negative head and neck cancer (HNC). To further strengthen NIDCR and NCI collaboration, we jointly organized the symposium to promote HNC early detection and biomarker identification at the American Head and Neck Society (AHNS) 11th International Conference on Head and Neck Cancer in July 2023. In addition, NIDCR has organized a symposium to promote HNC research at the 2024 annual meeting of American Association for Dental, Oral, and Craniofacial Research (AADOCR) to celebrate the 75th anniversary of NIDCR. This AADOCR symposium will feature the collaboration between NIDCR with NCI in the Cancer Moonshot program focusing on immunoprevention and immunotherapy, HNC early detection and biomarker research in AHEAD and EDRN, and investigation of HPV positive and negative HNC and clinical translational research under SPORE. At this 2024 AACR annual meeting, NIDCR and NCI program directors will present the collaborations and funding opportunities between NIDCR and NCI, focusing on early cancer detections and biomarker discovery and validation. Collaboration between NIDCR with NCI provides a unique opportunity to promote basic, translational, and clinical research in advancing HNC early detection to benefit cancer patients. Citation Format: Zhong Chen, Wendy Wang. Collaboration between NIDCR and NCI promotes innovative research in head and neck cancers [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 7315.

Legitimizing the interventions recommended in “European Research Area Policy Agenda 2022–2024”

Abstract The EU Directorate General for Research and Innovation’s “European Research Area Policy Agenda: Overview of Actions for the Period 2022–2024” outlines twenty actions to boost research excellence, investment and reform, coordination and support, or green and digital transformation of the academia, in an attempt to create a truly common “European knowledge market.” Filled with strategic planning jargon, the policy specifies the recommended interventions for years to come and with billions of Euros of funding to follow. Using a qualitative critical discourse approach, this study explores policy-making from a linguistic perspective to capture the characteristics of current EU R&I discourse. Language choices have a constitutive role in policy papers due to the discursive capacity for legitimization and subsequent persuasion. The analysis focuses on the persuasive presuppositions induced by certain lexico-grammatical choices, including evaluative and rhetorical devices, and shows how the ERA policy fosters acceptance of a European vision of R&I values.

Large-scale sustainability programming is reshaping research excellence: Insights from a meta-ethnographic study of 12 global initiatives

The growing emphasis on the societal impact of sustainability research has implications for how we understand, measure, and support research excellence. This shift is particularly relevant for international research undertaken through partnerships between collaborators in the global North and South because the reframing of research excellence has implications for developing capacity of Southern-based researchers. Against this backdrop, this study examines twelve large-scale, multi-consortium, transdisciplinary climate resilience research and development programs. We consider how the notions of research excellence are manifested in these programs and how they are consequently shaping the North-South partnerships and research ecosystem in the global South. A meta-ethnographic approach is used to analyse internal and published documents of the programs. In doing so, a continuum of research excellence (spanning knowledge-driven, demand-driven, and societal impact-driven excellence) and its effects on the research ecosystem are shown. We highlight that current capacity support at both individual and institutional levels have not yet caught up with the increasing expectations placed on researchers in these programs to pursue all dimensions of research excellence. This study raises further questions about whether ‘research capacity for impact’ should constitute a defining attribute of an ‘excellent researcher’ for all sustainability researchers in the future.