BackgroundThis study was conducted to assess the knowledge and ongoing practices of plagiarism among the journal editors of Nepal.MethodsThis web-based questionnaire analytical cross-sectional was conducted among journal editors working across various journals in Nepal. All journal editors from NepJOL-indexed journals in Nepal who provided e-consent were included in the study using a convenience sampling technique.A final set of questionnaires was prepared using Google Forms, including six knowledge questions, three practice questions (with subsets) for authors, and four (with subsets) for editors. These were distributed to journal editors in Nepal via email, Facebook Messenger, Viber, and WhatsApp. Reminders were sent weekly, up to three times.Data analysis was done in R software. Frequencies and percentages were calculated for the demographic variables, correct responses regarding knowledge, and practices related to plagiarism. Independent t-test and one-way ANOVA were used to compare mean knowledge with demographic variables. For all tests, statistical significance was set at p < 0.05.ResultsA total of 147 participants completed the survey.The mean age of the participants was found to be 43.61 ± 8.91 years. Nearly all participants were aware of plagiarism, and most had heard of both Turnitin and iThenticate. Slightly more than three-fourths correctly identified that citation and referencing can avoid plagiarism. The overall mean knowledge score was 5.32 ± 0.99, with no significant differences across demographic variables.As authors, 4% admitted to copying sections of others' work without acknowledgment and reusing their own published work without proper citations. Just over one-fifth did not use plagiarism detection software when writing research articles. Fewer than half reported that their journals used authentic plagiarism detection software.Four-fifths of them suspected plagiarism in the manuscripts assigned through their journal. Three out of every five participants reported the plagiarism used in the manuscript to the respective authors. Nearly all participants believe every journal must have plagiarism-detection software.ConclusionsAlthough journal editors' knowledge and practices regarding plagiarism appear to be high, they are still not satisfactory. It is strongly recommended to use authentic plagiarism detection software by the journals and editors should be adequately trained and update their knowledge about it.