In the era of widespread adoption of the new generation of information technology, the crucial development directions for mine site emergency rescue include systematization, precision, intelligence, and diversification. Chinese mines have extensively invested in information technology construction in the field of safety. However, despite these efforts, they still face complex and changing situations following mine disasters. It is often difficult to comprehensively capture all information and devise appropriate rescue plans during the site rescue process. In this context, herein, the scientific connotation of the digital twin system for mine site rescue environment (DTS-MRE) is proposed. Further, its overall architecture, functional characteristics, and key technologies essential for system construction are introduced. The application of DTS-MRE is expected to aid the monitoring, simulation, emulation, coordination, prediction, and control of the entire process of mine emergency rescue governance; increase the success rate of mine emergency rescue; and provide scientific and technological support for mine safety emergency rescue.