The use of synthetic turf has been increasing in professional sports, where evaluation of novel turf designs for mechanical response, consistency, and athlete playability currently requires time-consuming and complex physical testing on physical turf, and more efficient drop-weight impact testing. A variety of drop tests are used to measure the impact response and surface stiffness of synthetic turf, including the Clegg Impact Soil Tester (CIST). Finite element computational models offer an opportunity to assess new turf designs prior to the construction of physical turfs but require validation for a range of turf constructions. In the present study, 14 different synthetic turf designs with varying infill and fibers were constructed and experimentally evaluated using the CIST device. Peak accelerations and acceleration-versus-time responses were measured. The turf constituent materials were mechanically characterized, FE models of all the turfs were created, and the CIST tests were simulated. The peak acceleration from the simulation followed the experimental trend for the wide range of turf designs, with an average difference of 9.7%. When considering conventional turf constructions, the average difference in peak acceleration was 8.8%, indicating the models provided a good prediction of turf impact response and can be used to assess new turf designs virtually, potentially reducing design times and physical test requirements.