This paper presents a new cognitive agent design approach integrating spatial knowledge representation and reasoning in agent-based modeling dedicated to land use simulations. A deep motivation for our agent-centric contribution is the ever-increasing development of spatially explicit agent simulation platforms. We build on this technological evolution and topology theory to endow the agent with human’s spatial representation and reasoning following a Belief–Desire–Intention architecture. A pilot implementation of the methodology with simulation experiments on a hunting model was carried out in GAMA platform to assess agent performances. Simulations display a consistent trend of animal population dynamics and also confirm a high model sensitivity to the integration of spatial knowledge and reasoning in agent-based models of human actor. These results demonstrate a successful implementation and the importance of spatial dimension in the expressive power and the validity of agent-based models. Future research efforts should therefore emphasize on designing human knowledge representation and incorporating learning abilities to improve models efficiency.