This study endeavored to explore on the relationship between inventory management practices and performance of preference groups in Kisii County, Kenya. The specific objectives were: stock replenishment management, just in time management, re-order level management and inventory description management. The study was anchored on various theories relevant. This study adopted descriptive survey research design. The target population was 1036 respondents’ from 210 prequalified preference groups within Kisii County and a sample size of 104 of the population was established from three stratus. The study equally distributed the sample size equally on all the constituencies of Kisii County. Reliability was tested of 10% (10) respondents using Cronbach alpha index at 0.7 while validity was tested by correlation coefficient. This was above the required before proceeding to the field for data correction. All the predictor variables displayed above average or positive relationship with performance of preference groups. Reliability test results for the variables track your activity management, daily inventory count management, manage out-of-stock product management, clear inventory description management and performance was above the threshold of >0.7. With adequate validity and reliability the instrument were clearly drafted and precisely fit to collect data. The researcher recommends that preference groups were really being affected by inventory management practices. Also the research concludes that the four specific objectives had greater impact on preference groups in Kisii County, Kenya. The study further recommends a review of Public Procurement to provide supportive regulatory framework which was establish an independent body that was to facilitate continuous capacity developments of the disadvantages groups and establish mechanism for regular compliance audit since the current regulation is not clear on action to be taken on non-compliance