Repetitive Bursts Research Articles

Comparative analysis of the impact of repetitive transcranial magnetic stimulation and burst transcranial magnetic stimulation at different frequencies on memory function and neuronal excitability of mice

Transcranial magnetic stimulation (TMS) as a non-invasive neuroregulatory technique has been applied in the clinical treatment of neurological and psychiatric diseases. However, the stimulation effects and neural regulatory mechanisms of TMS with different frequencies and modes are not yet clear. This article explores the effects of different frequency repetitive transcranial magnetic stimulation (rTMS) and burst transcranial magnetic stimulation (bTMS) on memory function and neuronal excitability in mice from the perspective of neuroelectrophysiology. In this experiment, 42 Kunming mice aged 8 weeks were randomly divided into pseudo stimulation group and stimulation groups. The stimulation group included rTMS stimulation groups with different frequencies (1, 5, 10 Hz), and bTMS stimulation groups with different frequencies (1, 5, 10 Hz). Among them, the stimulation group received continuous stimulation for 14 days. After the stimulation, the mice underwent new object recognition and platform jumping experiment to test their memory ability. Subsequently, brain slice patch clamp experiment was conducted to analyze the excitability of granulosa cells in the dentate gyrus (DG) of mice. The results showed that compared with the pseudo stimulation group, high-frequency (5, 10 Hz) rTMS and bTMS could improve the memory ability and neuronal excitability of mice, while low-frequency (1 Hz) rTMS and bTMS have no significant effect. For the two stimulation modes at the same frequency, their effects on memory function and neuronal excitability of mice have no significant difference. The results of this study suggest that high-frequency TMS can improve memory function in mice by increasing the excitability of hippocampal DG granule neurons. This article provides experimental and theoretical basis for the mechanism research and clinical application of TMS in improving cognitive function.

Pain tolerance and the thresholds of human sensory and motor axons to single and repetitive bursts of kilohertz-frequency stimulation.

Transcutaneous electrical stimulation with repetitive bursts of a kilohertz carrier frequency is thought to be less painful than conventional pulsed currents by reducing the sensitivity of pain receptors. However, no purported benefit has been shown unequivocally. We compared the effects of carrier-frequency stimulation and conventional stimulation on pain tolerance and the thresholds for sensory and motor axons in twelve participants. The ulnar nerve was stimulated transcutaneously with a conventional single pulse and 5 and 10kHz carrier-frequency waveforms that had 5 and 10 pulses, respectively, when delivered in bursts of ∼1ms duration. Phase durations were adjusted across waveform types to match the total charge for a given current amplitude. Single bursts of stimulation were delivered from 1mA up until no longer tolerable. This was repeated with repetitive bursts of stimulation at 20Hz for 1s. Participants tolerated higher current amplitudes with both carrier-frequency waveforms than conventional stimulation, with repetitive bursts more painful than single bursts. However, compared to conventional stimulation, carrier-frequency waveforms required more current to produce sensory and motor-threshold responses and to obtain a maximal motor response (Mmax). When the current at pain tolerance was normalised to the current at Mmax, participants tolerated lower stimulus intensities with carrier-frequency waveforms than conventional stimulation. These findings indicate that there is little to no benefit in using carrier-frequency waveforms to minimise the discomfort from electrical stimulation as the increase in stimulus intensity at pain tolerance is more than offset by reduced effectiveness in the activation of sensory and motor axons. KEY POINTS: Transcutaneous electrical stimulation with repetitive bursts of a kilohertz carrier-frequency waveform is thought to be less painful than conventional pulsed currents. For ulnar nerve stimulation, when stimulus waveforms were matched for total phase charge, participants tolerated higher current amplitudes with carrier-frequency stimulation than conventional stimulation. However, compared to conventional stimulation, carrier-frequency waveforms required more current to produce a threshold response in both sensory and motor axons and to produce a maximal motor response (Mmax). When current at pain tolerance was normalised to current at Mmax, participants tolerated lower stimulus intensities with carrier-frequency waveforms than conventional stimulation. Carrier-frequency waveforms provide little to no benefit in minimising the discomfort from transcutaneous electrical stimulation as the increase in stimulus intensity at pain tolerance is more than offset by reduced effectiveness in activating sensory and motor axons.

Numerical simulation of deuterium retention in tungsten under ELM-like conditions

Retention of hydrogen isotopes (HI) in plasma-facing components (PFCs) is a crucial process influencing the operation of a fusion device. The dynamics of HI retention is mainly determined by irradiation conditions of PFCs. These conditions can change due to the onset of fast transient events, such as edge-localised modes (ELMs). The development of ELMs results in repetitive short-term plasma bursts on PFCs, affecting the exposure regime. In this work, the effect of ELM-like loads on the fuel retention is numerically analysed using a one-dimensional diffusion model, implemented in the FESTIM code. As a representative simulation case, the deuterium (D) retention in tungsten (W) is considered with the geometry and inter-ELM exposure conditions relevant for large fusion devices. Temporal dependencies of heat and particle fluxes during intra-ELM stages are accounted for by applying the free-streaming model for an ELM filament transport. The simulations were conducted for three inter-ELM exposure regimes with various properties of transient loads, D trapping sites, and D recombination rates. Compared to the ELM-free irradiation, the onset of transients is shown to mainly reduce the D retention rate because of significant material heating induced by the arrival of energetic ELMy particles. This relative difference can decrease if the material is characterised by strong trapping sites or limited desorption from a surface. The findings also demonstrate that additional heating during transients provides conditions for a faster D migration into the bulk. In addition, we discuss the possibility of using ELM-average loads to obtain quick assessments of the D content. The approach is shown to be applicable for the case of small ELMs and is used to derive the analytical expressions for the D distribution in W within the steady-state approximation.

Multiscale interaction underlying 2022 concurrent extreme precipitation in Pakistan and heatwave in Yangtze River Valley

Unprecedentedly extreme precipitation occurred in Pakistan (PAK), and mega heat waves persisted along the Yangtze River Valley (YRV) from July to August 2022. Using the advanced multiscale window transform-based canonical transfer attribution framework, we quantitatively delineated intra-scale and inter-scale interactions leading to record-breaking spatially concurrent extremes in 2022 and comprehensively revealed differences in dynamic processes affecting extreme events in July and August. The basic flow scale window lost the available potential energy (APE), and through APE canonical transfers to the intraseasonal-scale and synoptic-scale windows, the inter-scale dynamic processes and barotropic instability of the basic flow scale preserved the concurrent extreme in July. In August, the eruptive synoptic-scale kinetic energy convergence provided dynamic conditions for the sinking motion of the YRV and its advection to PAK from the Indian Ocean. Consequently, the interaction between high- and low-frequency processes drove atmospheric circulation in summer, but the high-frequency process in August played a vital role in extreme events. Additionally, the heat source in the tropical western-central Pacific is considered one of the key drivers for localized repetitive bursts of energy. This study emphasizes both the interactions between multiple scales of atmospheric dynamics and reveals the driving mechanisms behind the impacts of warming on extreme events, linking the external forcing issue with the free problem of atmospheric internal instability.

Experiment study of m/n = 1/1 mode saturation level in high-βp discharge on the EAST tokamak

The saturated internal kink mode with m/n = 1/1 has been observed in the H-mode discharge of the experimental advanced superconducting tokamak, characterized by high βP and weak magnetic shear in the core. This observation was made using a combination of soft x-ray imaging and electron cyclotron emission diagnostics. It was noted that the repetitive bursting of m/n = 1/1 internal mode (large amplitude, short bursting duration) transitions into a long-lasting continuous one (small amplitude, constant frequency), when βp> 2.2 in H-mode, a much shorter bursting duration, transitioning into a long-lasting continuous one, with smaller amplitude and a constant frequency. Conversely, for typical βp< 1.5 in L/I discharge, the frequency of m/n = 1/1 mode decreases with time, associated with local poloidal electron diamagnetism drift velocity. The benign m/n = 1/1 mode in high βp has an amplitude much smaller than one in L-mode for high βP stabilization effect. By adjusting the power deposition of electron cyclotron resonance heating, it is found that the saturation level of m/n = 1/1 mode is independent of the local electron temperature gradient in H-mode discharge. It underscores that the flat current and, hence, weak magnetic shear are crucial factors influencing the saturation level of the m/n = 1/1 mode for both the off-axis electron cyclotron current driving current-dominant and off-axis bootstrap current-dominant cases. Furthermore, the outward movement with growth of the m/n = 1/1 mode in the process of L-H mode transition and the characteristic time of this process are close to the current diffusion time.

Distinctive gastrointestinal motor dysfunction in patients with MNGIE.

Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a rare mitochondrial disease caused by mutations in TYMP, encoding thymidine phosphorylase. Clinically it is characterized by severe gastrointestinal dysmotility associated with cachexia and a demyelinating sensorimotor polyneuropathy. Even though digestive manifestations are progressive and invariably lead to death, the features of gastrointestinal motor dysfunction have not been systematically evaluated. The objective of this study was to describe gastrointestinal motor dysfunction in MNGIE using state-of-the art techniques and to evaluate the relationship between motor abnormalities and symptoms. Prospective study evaluating gastrointestinal motor function and digestive symptoms in all patients with MNGIE attended at a national referral center in Spain between January 2018 and July 2022. In this period, five patients diagnosed of MNGIE (age range 16-46 years, four men) were evaluated. Esophageal motility by high-resolution manometry was abnormal in four patients (two hypoperistalsis, two aperistalsis). Gastric emptying by scintigraphy was mildly delayed in four and indicative of gastroparesis in one. In all patients, small bowel high-resolution manometry exhibited a common, distinctive dysmotility pattern, characterized by repetitive bursts of spasmodic contractions, without traces of normal fasting and postprandial motility patterns. Interestingly, objective motor dysfunctions were detected in the absence of severe digestive symptoms. MNGIE patients exhibit a characteristic motor dysfunction, particularly of the small bowel, even in patients with mild digestive symptoms and in the absence of morphological signs of intestinal failure. Since symptoms are not predictive of objective findings, early investigation is indicated.

Predictive Power of Interictal Epileptiform Discharges in Fitness-to-Drive Evaluation.

This study aimed to evaluate and predict the effects of interictal epileptiform discharges (IEDs) on driving ability using simple reaction tests and a driving simulator. Patients with various epilepsies were evaluated with simultaneous EEGs during their response to visual stimuli in a single-flash test, a car-driving video game, and a realistic driving simulator. Reaction times (RTs) and missed reactions or crashes (miss/crash) during normal EEG and IEDs were measured. IEDs, as considered in this study, were a series of epileptiform potentials (>1 potential) and were classified as generalized typical, generalized atypical, or focal. RT and miss/crash in relation to IED type, duration, and test type were analyzed. RT prolongation, miss/crash probability, and odds ratio (OR) of miss/crash due to IEDs were calculated. Generalized typical IEDs prolonged RT by 164 ms, compared with generalized atypical IEDs (77.0 ms) and focal IEDs (48.0 ms) (p < 0.01). Generalized typical IEDs had a session miss/crash probability of 14.7% compared with a zero median for focal and generalized atypical IEDs (p < 0.01). Long repetitive bursts of focal IEDs lasting >2 seconds had a 2.6% miss/crash probabilityIED. Cumulated miss/crash probability could be predicted from RT prolongation: 90.3 ms yielded a 20% miss/crash probability. All tests were nonsuperior to each other in detecting miss/crash probabilitiesIED (zero median for all 3 tests) or RT prolongations (flash test: 56.4 ms, car-driving video game: 75.5 ms, simulator 86.6 ms). IEDs increased the OR of miss/crash in the simulator by 4.9-fold compared with normal EEG. A table of expected RT prolongations and miss/crash probabilities for IEDs of a given type and duration was created. IED-associated miss/crash probability and RT prolongation were comparably well detected by all tests. Long focal IED bursts carry a low risk, while generalized typical IEDs are the primary cause of miss/crash. We propose a cumulative 20% miss/crash risk at an RT prolongation of 90.3 ms as a clinically relevant IED effect. The IED-associated OR in the simulator approximates the effects of sleepiness or low blood alcohol level while driving on real roads. A decision aid for fitness-to-drive evaluation was created by providing the expected RT prolongations and misses/crashes when IEDs of a certain type and duration are detected in routine EEG.

Functional connectivity explains how neuronavigated TMS of posterior temporal subregions differentially affect language processing

Background“Wernicke's area” is most often used to describe the posterior superior temporal gyrus (STG) and refers to a region traditionally thought to support language comprehension. However, the posterior STG additionally plays a critical role in language production. The purpose of the current study was to determine to what extent regions within the posterior STG are selectively recruited during language production. Methods23 healthy right-handed participants completed an auditory fMRI localizer task, resting-state fMRI and underwent neuronavigated TMS language mapping. We applied repetitive TMS bursts during a picture naming paradigm to probe speech disruptions of different categories (anomia, speech arrest, semantic paraphasia and phonological paraphasia). We combined an in-house built high precision stimulation software suite with E-field modeling to map the naming errors to cortical regions and revealed a dissociation of language functions within the temporal gyrus. Resting state fMRI was used to explain how E-field peaks of different categories differentially affected language production. ResultsPeaks for phonological and semantic errors were found in the STG while those for anomia and speech arrest were located in the MTG. Seed-based connectivity analysis revealed a local connectivity pattern for phonological and semantic errors, while anomia and speech arrest seeds resulted in a larger network between IFG and posterior MTG. ConclusionsOur study provides important insights into the functional neuroanatomy of language production and might help to increase the current understanding of specific language production difficulties on a causal level.

Application of athletics equipment in sprinting training of rugby players

Aim – to justify the use of athletics exercises in the sprint training of rugby players. Methods: theoretical methods of pedagogical research. Results and discussion. The modern game of rugby requires a player, regardless of his role and position on the field in the game, to be prepared to execute short, repetitive bursts of running at high intensity. It has been established that the structure of the sprint of rugby players is similar to the actions of a sprinter who has to perform a run from the start or an instant powerful acceleration in motion. The results of the analysis of the scientific and methodological literature and pedagogical modeling showed that in order to improve the rugby player's sprinting performance, the physical training coach should include in the training program plyometric exercises, fast squats with a barbell, towing a sled and exercises aimed at improving the technique of sprinting. It is these practical and scientifically proven means in the field of athletics that determine the impact on the structure of sprinting abilities of rugby players, identical to the sprinting characteristics of a player on the field. Conclusions. It has been established that rugby players need the ability to perform powerful quick movements in accordance with the structure inherent in short-distance runners. Therefore, there is an opportunity to build a sprint training program using exercises and training methodology for short-distance runners. Sprinting exercises should be selected taking into account the powerful short sprints that are inherent in the actions of a rugby player during the game. At the same time, the need for readiness for their serial implementation should be taken into account. Therefore, it is promising to develop a methodology for applying elements of sprinter training in the construction of sprint training for rugby players.

Experimental X-ray emission doses from GHz repetitive burst laser irradiation at 100 kHz repetition rate

Experimental X-ray emission doses from GHz repetitive burst laser irradiation at 100 kHz repetition rate

Investigating datasets with high IRIS burst prevalence

Context. Approximately 0.01% of all Si IV 1394 Å spectra sampled in 2013 and 2014 by the Interface Region Imaging Spectrograph (IRIS) have IRIS burst profiles. However, these events are not evenly distributed across datasets with 19.31% of these spectra being identified in only six (of more than 3500) rasters. Aims. Here, we investigate five of these six datasets, with the aim of understanding why they contain so many IRIS burst profiles. This research will help guide future targeted analyses of IRIS bursts. Methods. We analyse five datasets sampled by the IRIS satellite, studying both Si IV 1394 Å spectra and 1400 Å filter slit-jaw imager (SJI) data. IRIS burst profiles are identified through the use of an automated algorithm. Additionally, we study co-spatial line-of-sight photospheric magnetic field maps sampled by the Solar Dynamics Observatory’s Helioseismic and Magnetic Imager (SDO/HMI) instrument. Results. The majority of identified IRIS burst profiles (12 401 out of 13 904) found in the five datasets analysed here were localised to seven small regions in the time-distance domain (temporal durations of &lt; 4 h and spatial lengths of &lt; 12″ along the slit). The SJI data co-spatial to these regions contained long-lived or repetitive compact brightenings, matching the defined properties of UV bursts, which remained close to the IRIS slit throughout their evolutions. The IRIS burst profiles were not limited to the brightest pixels in the fields of view (FOVs) nor did they comprise the majority of bright (&gt; 500 DN/s) pixels. These IRIS burst profiles occurred co-spatial to evolving (e.g., cancelling) opposite polarity magnetic fields where magnetic reconnection is thought to be possible. Conclusions. More than 10% of the IRIS burst profiles identified during the entirety of 2013 and 2014 are contained in just seven small regions in the time-distance domain where long-lived (lifetimes &gt; 10 min) or repetitive UV bursts occurred along the axis of the IRIS slit.

Spatio-temporal changes in degassing behavior at Stromboli volcano derived from two co-exposed SO2 camera stations

Improving volcanic gas monitoring techniques is central to better understanding open-vent, persistently degassing volcanoes. SO2 cameras are increasingly used in volcanic gas studies, but observations are commonly limited to one single camera alone viewing the volcanic plume from a specific viewing direction. Here, we report on high frequency (0.5 Hz) systematic measurements of the SO2 flux at Stromboli, covering a 1-year long observation period (June 2017-June 2018), obtained from two permanent SO2 cameras using the same automated algorithm, but imaging the plume from two different viewing directions. Our aim is to experimentally validate the robustness of automatic SO2 camera for volcano monitoring and to demonstrate the advantage of using two co-exposed SO2 camera stations to better capturing degassing dynamics at open-vent volcanoes. The SO2 flux time-series derived from the two SO2 camera stations exhibit good match, demonstrating the robustness of the automatic SO2 camera method. Our high-temporal resolution SO2 records resolve individual Strombolian explosions as transient, repetitive gas bursts produced by the sudden release of over pressurized gas pockets and scoriae. Calculations show that explosive degassing activity accounts for ∼10% of the total SO2 emission budget (dominated by passive degassing) during mild regular open-vent activity. We show that the temporal variations of the explosive SO2 flux go in tandem with changes in total SO2 flux and VLP seismicity, implicating some commonality in the source processes controlling passive degassing and explosive activity. We exploited the spatial resolution of SO2 camera to discriminate degassing at two distinct regions of the crater area, and to minimize biases due by the station position respect to the target plume. We find that the SO2 fluxes from southwest-central (SWCC) and northeast (NEC) crater areas oscillate coherently but those from the NEC are more sensitive to the changes in the volcanic intensity. We interpret this as due to preferential gas/magma channeling into the structurally weaker north-eastern portion of the crater terrace in response to increasing supply rate of buoyant, bubble-rich magma in the shallow plumbing system.

Evaluation of the Novel Automated Anti-Tachycardia Pacing Algorithm Successfully Terminating Sustained Monomorphic Ventricular Tachycardia in an Electrophysiology Study.

We report the usefulness of novel automated anti-tachycardia pacing (ATP) for ventricular tachycardia (VT) termination evaluated in an electrophysiology study. This intrinsic, automated ATP with an implanted cardiac resynchronization therapy-defibrillator successfully terminated the sustained VT, which had not been suppressed by repetitive burst pacing from the electrode catheter. The reproduction of programed pacing of the automated ATP by a right ventricular electrode catheter was effective in terminating VT, and this termination was absolute and reproducible. Further detailed assessment in an electrophysiology study could highlight the algorithm of the automated ATP and its possible benefit in terminating the reentrant VT.

Spatiotemporal Distribution of Electrically Evoked Spinal Compound Action Potentials During Spinal Cord Stimulation

ObjectivesRecent studies using epidural spinal cord stimulation (SCS) have demonstrated restoration of motor function in individuals previously diagnosed with chronic spinal cord injury (SCI). In parallel, the spinal evoked compound action potentials (ECAPs) induced by SCS have been used to gain insight into the mechanisms of SCS-based chronic pain therapy and to titrate closed-loop delivery of stimulation. However, the previous characterization of ECAPs recorded during SCS was performed with one-dimensional, cylindrical electrode leads. Herein, we describe the unique spatiotemporal distribution of ECAPs induced by SCS across the medial-lateral and rostral-caudal axes of the spinal cord, and their relationship to polysynaptic lower-extremity motor activation. Materials and MethodsIn each of four sheep, two 24-contact epidural SCS arrays were placed on the lumbosacral spinal cord, spanning the L3 to L6 vertebrae. Spinal ECAPs were recorded during SCS from nonstimulating contacts of the epidural arrays, which were synchronized to bilateral electromyography (EMG) recordings from six back and lower-extremity muscles. ResultsWe observed a triphasic P1, N1, P2 peak morphology and propagation in the ECAPs during midline and lateral stimulation. Distinct regions of lateral stimulation resulted in simultaneously increased ECAP and EMG responses compared with stimulation at adjacent lateral contacts. Although EMG responses decreased during repetitive stimulation bursts, spinal ECAP amplitude did not significantly change. Both spinal ECAP responses and EMG responses demonstrated preferential ipsilateral recruitment during lateral stimulation compared with midline stimulation. Furthermore, EMG responses were correlated with stimulation that resulted in increased ECAP amplitude on the ipsilateral side of the electrode array. ConclusionsThese results suggest that ECAPs can be used to investigate the effects of SCS on spinal sensorimotor networks and to inform stimulation strategies that optimize the clinical benefit of SCS in the context of managing chronic pain and the restoration of sensorimotor function after SCI.

Generation, breakdown and responses of ATP in the carotid body

Purinergic signaling involving adenosine triphosphate (ATP) acting on P2X2/3 receptors modulates physiological carotid body (CB) afferent discharge and chemoreflex activation however, the upregulation of P2X3 receptors on petrosal sensory neurons is partly responsible for aberrant CB tonicity and hyperreflexia, and the increase in blood pressure in the Spontaneously Hypertensive rat (SHR). The enhanced chemoreflex occurs prior to the onset of hypertension and elevated CB activity is thought to contribute to the underlying pathophysiology of the disease but the exact mechanisms remain unclear. We hypothesize that there is greater release of ATP and/or decreased ATP breakdown in the pre‐hypertensive SHR CB compared with that in the Wistar rat, and this evokes an increase in the chemoreflex response and subsequent activation of the sympathetic nervous system. We performed three studies. (i) Using digital droplet PCR (ddPCR), we measured mRNA expression levels of enzymes involved in the breakdown of ATP in CBs extracted from male 4‐week‐old prehypertensive SHR and Wistar rats; these included: ectonucleotide pyrophosphatase/phosphodiesterase 1‐3 (Enpp1‐3), ectonucleoside triphosphate diphosphohydrolase 2‐3 (Entpd2‐3), and ecto‐5’‐nucleotidase (Nt5e). (ii) We quantified ATP release from CBs in vitro during baseline conditions and during cyanide‐evoked ATP release using a colorimetric assay (213‐579‐1 ‐ Millipore), comparing between male 4‐week‐old pre‐hypertensive SHR and Wistar rats. (iii) In an in situ working heart‐brainstem preparation of 4‐week‐old Wistar rats, simultaneous recordings were made from phrenic (PN), hypoglossal (HN), recurrent laryngeal (RLN), abdominal (ABN), and thoracic sympathetic nerves (tSNA). The peripheral chemoreceptors were stimulated with either potassium cyanide (KCN 20‐100 μL, 0.04%) or ATP at varying concentrations (10‐100 µL, 50 µM ‐ 2 mM) delivered via the internal carotid artery. In whole CB extracts, ddPCR revealed increased Enpp2‐3 and Nt5e expression (p&lt;0.05) in pre‐hypertensive SHRs relative to Wistar rats suggesting greater capacity to break down ATP in the pre‐hypertensive SHR CB. There were no differences in the expressions of Enpp1 or Entpd2‐3 between rat strains. However, the amount of ATP released from the CB in both baseline and during cyanide stimulation was two‐fold greater in the pre‐hypertensive SHR (P&lt;0.05). Stimulation of the CB with KCN evoked hyperpnoea, bradycardia and sympathoexcitation at all doses. In contrast, CB injection of low dose ATP increased PN rate with little effect on tSNA, whereas higher doses induced apnea accompanied by repetitive burst discharge of post‐inspiratory activity in the RLN with tonic elevations in the discharge of both ABN and tSNA. In sum, despite the upregulation of several ATP degrading enzymes in the CBs of the SHR, CB release of ATP is higher in this species. We hypothesize that the increase in ATP release in the SHR CB drives the CB hyperexcitability and that the shift towards an upregulation of ATP degrading enzymes even prior to the development of hypertension is compensatory to oppose the increase in ATP signaling. The dose‐dependent effect of exogenous ATP at supraphysiological levels evoking greater CB‐mediated expiratory and sympathetic outflow in the Wistar rat mimics aspects of pathophysiological CB chemoreflex signaling in the SHR.

Rapid Bursts of Magnetically Gated Accretion in the Intermediate Polar V1025 Cen

Abstract Magnetically gated accretion has emerged as a proposed mechanism for producing extremely short, repetitive bursts of accretion onto magnetized white dwarfs in intermediate polars (IPs), but this phenomenon has not been detected previously in a confirmed IP. We report the 27 day TESS light curve of V1025 Cen, an IP that shows a remarkable series of 12 bursts of accretion, each lasting for less than 6 hours. The extreme brevity of the bursts and their short recurrence times (∼1–3 days) are incompatible with the dwarf-nova instability, but they are natural consequences of the magnetic gating mechanism developed by Spruit and Taam to explain the Type II bursts of the accreting neutron star known as the Rapid Burster. In this model, the accretion flow piles up at the magnetospheric boundary and presses inward until it couples with the star’s magnetic field, producing an abrupt burst of accretion. After each burst, the reservoir of matter at the edge of the magnetosphere is replenished, leading to cyclical bursts of accretion. A pair of recent studies applied this instability to the suspected IPs MV Lyr and TW Pic, but the magnetic nature of these two systems has not been independently confirmed. In contrast, previous studies have unambiguously established the white dwarf in V1025 Cen to be significantly magnetized. The detection of magnetically gated bursts in a confirmed IP therefore validates the extension of the Spruit and Taam instability to magnetized white dwarfs.

Critical role of rhythms in prefrontal transcranial magnetic stimulation for depression: A randomized sham-controlled study.

Repetitive transcranial magnetic stimulation (rTMS) is an alternative treatment for depression, but the neural correlates of the treatment are currently inconclusive, which might be a limit of conventional analytical methods. The present study aimed to investigate the neurophysiological evidence and potential biomarkers for rTMS and intermittent theta burst stimulation (iTBS) treatment. A total of 61 treatment‐resistant depression patients were randomly assigned to receive prolonged iTBS (piTBS; N = 19), 10 Hz rTMS (N = 20), or sham stimulation (N = 22). Each participant went through a treatment phase with resting state electroencephalography (EEG) recordings before and after the treatment phase. The aftereffects of stimulation showed that theta‐alpha amplitude modulation frequency (f am) was associated with piTBS_Responder, which involves repetitive bursts delivered in the theta frequency range, whereas alpha carrier frequency (f c) was related to 10 Hz rTMS, which uses alpha rhythmic stimulation. In addition, theta‐alpha amplitude modulation frequency was positively correlated with piTBS antidepressant efficacy, whereas the alpha frequency was not associated with the 10 Hz rTMS clinical outcome. The present study showed that TMS stimulation effects might be lasting, with changes of brain oscillations associated with the delivered frequency. Additionally, theta‐alpha amplitude modulation frequency may be as a function of the degree of recovery in TRD with piTBS treatment and also a potential EEG‐based predictor of antidepressant efficacy of piTBS in the early treatment stage, that is, first 2 weeks.

Kv2.1 Potassium Channels Regulate Repetitive Burst Firing in Extratelencephalic Neocortical Pyramidal Neurons

Abstract Coincidence detection and cortical rhythmicity are both greatly influenced by neurons’ propensity to fire bursts of action potentials. In the neocortex, repetitive burst firing can also initiate abnormal neocortical rhythmicity (including epilepsy). Bursts are generated by inward currents that underlie a fast afterdepolarization (fADP) but less is known about outward currents that regulate bursting. We tested whether Kv2 channels regulate the fADP and burst firing in labeled layer 5 PNs from motor cortex of the Thy1-h mouse. Kv2 block with guangxitoxin-1E (GTx) converted single spike responses evoked by dendritic stimulation into multispike bursts riding on an enhanced fADP. Immunohistochemistry revealed that Thy1-h PNs expressed Kv2.1 (not Kv2.2) channels perisomatically (not in the dendrites). In somatic macropatches, GTx-sensitive current was the largest component of outward current with biophysical properties well-suited for regulating bursting. GTx drove ~40% of Thy1 PNs stimulated with noisy somatic current steps to repetitive burst firing and shifted the maximal frequency-dependent gain. A network model showed that reduction of Kv2-like conductance in a small subset of neurons resulted in repetitive bursting and entrainment of the circuit to seizure-like rhythmic activity. Kv2 channels play a dominant role in regulating onset bursts and preventing repetitive bursting in Thy1 PNs.

Chirping ion cyclotron emission (ICE) on NSTX-U

We report here on the discovery on NSTX-U of a qualitatively new type of non-thermal emission from plasmas in the ion-cyclotron frequency range (ICE). This new type of ICE is weakly damped, γdamp/ω ICE ≈ 0.14%, low order eigenmodes, excited by a fast ion population radially located near an internal transport barrier. The ICE appears as repetitive bursts with durations of ≈1 ms, and the bursts exhibit frequency chirps upwards and/or downwards with maximum δf/f ≈ 1%. We refer to this chirping ICE as ch-ICE. The bursts are longer than the typical ICE bursts of ≈100 μs reported previously for NSTX and NSTX-U, for simplicity, NSTX(-U). The chirping resembles that seen in modeling of weakly unstable fast particle driven instabilities (cf, Berk et al 1997 Phys. Lett. A 234 213). These data also provide some preliminary indications of non-linear coupling between the ch-ICE harmonics. Despite extensive experimental and theoretical studies of ICE, theoretical understanding of ICE remains qualitative at best. The detailed experimental observations of ICE from NSTX(-U) find a wide variation in the ICE characteristics. The new observations of ch-ICE presented here, combined with the characteristics of ICE on NSTX(-U) previously reported (Fredrickson et al 2019 Phys. Plasmas 26 032111), could guide the development of more complete theoretical models of ICE.

E‐POP Observations of Suprathermal Electron Bursts in the Ionospheric Alfvén Resonator

AbstractUtilizing the suprathermal electron imager onboard the e‐POP satellite, we performed a statistical study of groups of repetitive suprathermal electron bursts (STEBs) with 52 events (each with ≥3 STEBs) during 21 e‐POP orbits. The STEBs are observed on both the day side and night side, and within a wide range of geomagnetic latitudes, from 64° to 78°. We interpret these data as temporally varying signatures; we suggest the repetition is due to the ionospheric Alfvén resonator (IAR), since the statistical time separation of adjacent STEBs in the satellite frame is 0.5–1.5 s, which is consistent with the characteristic period of the IAR. Furthermore, the STEBs are associated with low‐frequency magnetic field perturbations. The statistical occurrence of repetitive STEBs shows a preference toward postnoon and midnight sectors at high magnetic latitudes. We also present one example event of four successive STEBs associated with auroral rays in conjugate imagery. The repetition period of STEBs is similar to the oscillation period of magnetic fields observed by Enhanced Polar Outflow Probe (e‐POP). One of the STEBs in an example event exhibits “normal” dispersion (high energy particles with field‐aligned pitch angle arriving first) and the adjacent STEB exhibits “inverse” dispersion (low energy particles with broad pitch angles arriving first). With a test particle simulation, we propose one possible explanation of inverse dispersion in terms of a suprathermal electron population and a downward‐propagating parallel electric field.