Repetition Of Pseudowords Research Articles

The impact of phonological short-term memory impairment on verbal repetition in the logopenic variant of primary progressive aphasia

ABSTRACT The logopenic variant of primary progressive aphasia (lvPPA) is characterized mainly by anomia, production of phonological errors, and impairment in repetition of sentences. The functional origin of these language impairments is mainly attributed to the breakdown of phonological short-term memory. The present study examined the effects of phonological short-term memory impairment on language processing in lvPPA. In two studies, 11 participants with lvPPA and 11 healthy control participants were presented with repetition tasks in which the type and length of stimuli and the mode of administration were manipulated. Study 1 aimed to examine the influence of length and lexicality (words vs. pseudowords) on immediate and delayed repetition, whereas Study 2 aimed to examine the influence of length, syntactic complexity (nominalized vs. pronominalized sentences), and serial position on immediate sentence repetition. Study 1 showed that participants’ performance with lvPPA was impaired only on immediate repetition of five-syllable pseudowords and on delayed repetition of words and pseudowords. Study 2 showed that participants’ performance with lvPPA was impaired in the repetition of nominalized sentences where a recency effect was observed. Repetition of pronominalized sentences was also impaired in the lvPPA group. This study provides additional support for arguments regarding phonological short-term memory as a cause of language impairment in lvPPA. Clinically, the results of the study suggest that instruments for assessing repetition ability in lvPPA should include not only lists of short or long nominalized sentences, but also delayed repetition of words and pseudowords and pronominalized sentences.

The syllable as a fundamental sub-lexical unit in phonological paraphasias: evidence from Spanish-speaking aphasic patients

ABSTRACT Background Considering that the syllable is a well-defined unit in the Spanish language, we assume that it could be analyzed at the core of phonological paraphasias. Aims Identify if the characteristics of the Spanish syllable system are reflected in the production of phonological errors among Spanish-speaking aphasic patients. Methods & Procedures Twenty-four Spanish-speaking aphasic patients with different aetiology, severity, and type of aphasia participated in the study. We designed Word and Pseudoword Repetition Tasks controlling for stimuli length, syllable structure frequency, and syllable position. Outcomes & Results The production of paraphasias evidences an effect of syllable complexity and syllable frequency, since the CV syllable structure which is the simplest but also the most common one in Spanish, was more resistant to errors. Stimulus length and stimuli lexicality effects were evident since monosyllabic stimuli and words (opposed to pseudowords) triggered fewer errors, respectively. Also, we observed an interaction of length/lexicality, where polysyllabic pseudowords were related to a higher number of errors. Finally, results revealed a strong correlation between the relative frequency of syllable structures in Spanish and the percentage of syllable structures in phonemic paraphasias. Conclusions The repetition of words and pseudowords by these Spanish-speaking aphasic patients confirm that their phonological errors are related to the syllabic system of the Spanish language. This finding has implications when assessing Spanish-speaking aphasic patients.

Dissociating the functional roles of arcuate fasciculus subtracts in speech production.

Recent tractography and microdissection studies have shown that the left arcuate fasciculus (AF)-a fiber tract thought to be crucial for speech production-consists of a minimum of 2 subtracts directly connecting the temporal and frontal cortex. These subtracts link the posterior superior temporal gyrus (STG) and middle temporal gyrus (MTG) to the inferior frontal gyrus. Although they have been hypothesized to mediate different functions in speech production, direct evidence for this hypothesis is lacking. To functionally segregate the 2 AF segments, we combined functional magnetic resonance imaging with diffusion-weighted imaging and probabilistic tractography using 2 prototypical speech production tasks, namely spoken pseudoword repetition (tapping sublexical phonological mapping) and verb generation (tapping lexical-semantic mapping). We observed that the repetition of spoken pseudowords is mediated by the subtract of STG, while generating an appropriate verb to a spoken noun is mediated by the subtract of MTG. Our findings provide strong evidence for a functional dissociation between the AF subtracts, namely a sublexical phonological mapping by the STG subtract and a lexical-semantic mapping by the MTG subtract. Our results contribute to the unraveling of a century-old controversy concerning the functional role in speech production of a major fiber tract involved in language.

A functional dissociation of the left frontal regions that contribute to single word production tasks

Controversy surrounds the interpretation of higher activation for pseudoword compared to word reading in the left precentral gyrus and pars opercularis. Specifically, does activation in these regions reflect: (1) the demands on sublexical assembly of articulatory codes, or (2) retrieval effort because the combinations of articulatory codes are unfamiliar? Using fMRI, in 84 neurologically intact participants, we addressed this issue by comparing reading and repetition of words (W) and pseudowords (P) to naming objects (O) from pictures or sounds. As objects do not provide sublexical articulatory cues, we hypothesis that retrieval effort will be greater for object naming than word repetition/reading (which benefits from both lexical and sublexical cues); while the demands on sublexical assembly will be higher for pseudoword production than object naming.We found that activation was: (i) highest for pseudoword reading [P>O&W in the visual modality] in the anterior part of the ventral precentral gyrus bordering the precentral sulcus (vPCg/vPCs), consistent with the sublexical assembly of articulatory codes; but (ii) as high for object naming as pseudoword production [P&O>W] in dorsal precentral gyrus (dPCg) and the left inferior frontal junction (IFJ), consistent with retrieval demands and cognitive control.In addition, we dissociate the response properties of vPCg/vPCs, dPCg and IFJ from other left frontal lobe regions that are activated during single word speech production. Specifically, in both auditory and visual modalities: a central part of vPCg (head and face area) was more activated for verbal than nonverbal stimuli [P&W>O]; and the pars orbitalis and inferior frontal sulcus were most activated during object naming [O>W&P]. Our findings help to resolve a previous discrepancy in the literature, dissociate three functionally distinct parts of the precentral gyrus, and refine our knowledge of the functional anatomy of speech production in the left frontal lobe.

Repetición de pseudopalabras en trastorno específico del lenguaje

Numerosas hipótesis explicativas apoyan la existencia de limitaciones en el bucle fonológico de las personas con Trastorno Específico del Lenguaje (TEL). La repetición de pseudopalabras es una tarea sensible a la capacidad del bucle fonológico dentro de la memoria de trabajo, puesto que esta repetición provoca que el niño tenga que mantener de forma temporal la información fonológica, para más tarde reproducirlo. El objetivo principal de este trabajo es aportar información novedosa acerca de las diferencias en los resultados entre niños con desarrollo típico y trastornos del lenguaje ante una tarea de repetición de pseudopalabras donde los estímulos han sido controlados estrictamente a nivel fonológico. En este estudio participaron un total de 36 niños de entre 7 y 12 años: 18 niños con desarrollo típico y 18 con diagnóstico previo de TEL. Para llevar a cabo dicho estudio se elaboró una prueba de repetición de pseudopalabras controlando variables, como son la longitud, frecuencia, composición, acentuación y repeticiones de cada sílaba. Los resultados obtenidos demuestran que los niños con TEL se muestran más sensibles a las variables de longitud, frecuencia y la interacción entre estas. De igual forma, los datos han demostrado que la posición en la que aparece una sílaba infrecuente juega un papel importante, provocando mayores errores en los niños con desarrollo típico (DT) cuando la sílaba infrecuente se encuentra en última posición. Los datos obtenidos ponen en manifiesto la necesidad de continuar analizando de manera sistemática la interacción entre las variables longitud y frecuencia. Además, se comentan las implicaciones de cara al diagnóstico clínico.

Rise Time Perception, Phonological Processing, and Reading in Brazilian Portuguese-Speaking Schoolchildren

Background/Aims: Studies of people with dyslexia have pointed to the ability to perceive the amplitude envelope rise time (“beat” perception) as a possible cause of phonological processing (PhP) difficulties in this population. However, there are very few studies about the relationships between such skills in the non-dyslexic school population. Methods: We investigated the influence of the beat perception ability on PhP and reading skills of 93 Brazilian Portuguese-speaking schoolchildren from the 3rd to the 5th year, with data on reading, phonological awareness (PhA), lexical access, phonological operational memory, and perception of amplitude envelope rise time. To verify the possible effects of age, gender, and school grade on the tasks in the study, we directly included these variables in the models. Results: Modeling structural equations showed that beat perception did not influence PhP or reading skills, but only the tasks of repetition of words and pseudowords. These tasks may be related because of the demand for phonological working memory necessary to perform the beat perception task rather than a possible connection between this and phonological abilities, as reported in the literature. Conclusion: We suspect beat perception could be of relevance only for subjects with altered reading and/or a deficit in PhP. Further studies will indicate whether the rise time of the amplitude envelope is an essential acoustic clue only for those individuals whose PhA ability is not fully present.

Rethinking the Neural Basis of Prosody and Non-literal Language: Spared Pragmatics and Cognitive Compensation in a Bilingual With Extensive Right-Hemisphere Damage.

Above and beyond the critical contributions of left perisylvian regions to language, the neural networks supporting pragmatic aspects of verbal communication in native and non-native languages (L1s and L2, respectively) have often been ascribed to the right hemisphere (RH). However, several reports have shown that left-hemisphere activity associated with pragmatic domains (e.g., prosody, indirect speech, figurative language) is comparable to or even greater than that observed in the RH, challenging the proposed putative role of the latter for relevant domains. Against this background, we report on an adult bilingual patient showing preservation of pragmatic verbal skills in both languages (L1: Spanish, L2: English) despite bilateral damage mainly focused on the RH. After two strokes, the patient sustained lesions in several regions previously implicated in pragmatic functions (vast portions of the right fronto-insulo-temporal cortices, the bilateral amygdalae and insular cortices, and the left putamen). Yet, comparison of linguistic and pragmatic skills with matched controls revealed spared performance on multiple relevant tasks in both her L1 and L2. Despite mild difficulties in some aspects of L2 prosody, she showed no deficits in comprehending metaphors and idioms, or understanding indirect speech acts in either language. Basic verbal skills were also preserved in both languages, including verbal auditory discrimination, repetition of words and pseudo-words, cognate processing, grammaticality judgments, equivalent recognition, and word and sentence translation. Taken together, the evidence shows that multiple functions of verbal communication can be widely spared despite extensive damage to the RH, and that claims for a putative relation between pragmatics and the RH may have been overemphasized in the monolingual and bilingual literature. We further discuss the case in light of previous reports of pragmatic and linguistic deficits following brain lesions and address its relation to cognitive compensation in bilingual patients.

Effects of working memory intervention on students with reading comprehension difficulties

ABSTRACT Purpose: to investigate the effectiveness of a working memory-based intervention proposal for reading comprehension. Methods: 43 children divided into two groups according to their performance in a reading comprehension test - G1: children with reading comprehension difficulty; G2: children with no difficulties. All the children were evaluated regarding reading, writing, sentence reading comprehension, and phonological working memory - PWM (repetition of pseudo-words and digits). After this evaluation, children from G1 participated in an intervention program (15 meetings) that stimulated the PWM. Following the intervention, all the children were reevaluated. The results were compared intra- and intergroup, and pertinent statistical tests were applied, by adopting the significance level lower than 0.05%. Results: after the intervention program, the children of G1 showed a significant improvement in all tests. In the intergroup analysis, at the time of evaluation, G1 was different from G2 in reading, writing and reading comprehension. In the reevaluation, G1 equaled G2 in reading and got closer to G2 in writing and reading comprehension. Conclusion: PWM training brought benefits to children with academic difficulties. Thus, these strategies could be used in the classroom, aiming to promote learning.

Early undernutrition as a cause of changes in phonological processing skills

ABSTRACT Purpose: to determine whether undernutrition in the first years of life affects the phonological awareness skills, the phonological working memory and the school performance of children. Methods: the participants were children with a history of moderate/severe undernutrition during their first years of life (G1) who achieved nutritional recovery (n = 15). The performance of G1 in different cognitive tasks (phonological awareness at the syllable and phoneme level, phonological working memory - repetition of digits and pseudowords, and reading, writing and arithmetic activities) was compared to that of children with school difficulties (G2) (n = 15) and without school difficulties (G3) (n = 15), all eutrophic ones. Results: the performance of G1 was worse than that of the other two groups in all tasks evaluated (mean score of G1, G2 and G3 and p-values: phonological awareness: 31, 41, 57 - 0.01; repetition of direct order digits: 18, 23, 28 - 0.001; writing: 4, 10, 22 - 0.001; reading: 26, 45, 65-0.001; arithmetic: 4, 7, 11- 0.001). Conclusion: the results demonstrate that undernutrition affected the cognitive development, causing changes in important cognitive skills for the development of written language.

Brain Signatures of New (Pseudo-) Words: Visual Repetition in Associative and Non-associative Contexts.

The contribution of two different training contexts to online, gradual lexical acquisition was investigated by event-related potentials (ERPs) elicited by new, word-like stimuli. Pseudowords were repeatedly preceded by a picture representing a well-known object (semantic-associative training context) or by a hash mark (non-associative training context). The two training styles revealed differential effects of repetition in both behavioral and ERPs data. Repetition of pseudowords not associated with any stimulus gradually enhanced the late positive component (LPC) as well as speeded lexical categorization of these stimuli, suggesting the formation of episodic memory traces. However, repetition under the semantic-associative context caused higher reduction in N400 component and categorization latencies. This result suggests the facilitation in the lexico-semantic processing of pseudowords as a consequence of their progressive associations to picture-concepts, going beyond the visual memory trace that is generated under the non-associative context.

Comparative analysis of cognitive-linguistic evaluation in normal hearing schoolchildren and users of cochlear implants.

When children becom cochlear implant users, they have already had the opportunity to develop phonological skills; however, it is possible that they miss sound information during speech and, consequently, present difficulties in competences associated with the learning of reading and writing. The study sample consisted of 11 normal hearing children aged 7-10 years and a right-ear cochlear implant user enrolled in the 3rd grade of Elementary School. The Cognitive-Linguistic Assessment protocol was used to evaluate the study participants. Data were transcribed and analyzed using descriptive statistics. The following sub-tests presented the highest percentage of children with superior performance: alphabet in sequence (82%), reading of pseudo-words (82%), syllable segmentation (73%), word repetition (82%), copying of shapes (72%), and rapid naming (100%).The cochlear implant user presented superior performance in all the sub-tests except for word repetition, in which average performance was observed. In the rhythm sub-test, none of the normal hearing children presented superior performance, and the cochlear implant user performed poorly. It was possible to observe that the condition of being a cochlear implant user is not the only determinant for a child's school failure. There are issues that go beyond auditory integrity, because some normal hearing children performed poorly in sub-tests such as repetition of pseudo-words, rhythm, and alliteration. The cochlear implant user presented a cognitive-linguistic profile very similar to those of his hearing peers.

Music and Dyslexia: A New Musical Training Method to Improve Reading and Related Disorders.

Numerous arguments in the recent neuroscientific literature support the use of musical training as a therapeutic tool among the arsenal already available to therapists and educators for treating children with dyslexia. In the present study, we tested the efficacy of a specially-designed Cognitivo-Musical Training (CMT) method based upon three principles: (1) music-language analogies: training dyslexics with music could contribute to improve brain circuits which are common to music and language processes; (2) the temporal and rhythmic features of music, which could exert a positive effect on the multiple dimensions of the “temporal deficit” characteristic of some types of dyslexia; and (3) cross-modal integration, based on converging evidence of impaired connectivity between brain regions in dyslexia and related disorders. Accordingly, we developed a series of musical exercises involving jointly and simultaneously sensory (visual, auditory, somatosensory) and motor systems, with special emphasis on rhythmic perception and production in addition to intensive training of various features of the musical auditory signal. Two separate studies were carried out, one in which dyslexic children received intensive musical exercises concentrated over 18 h during 3 consecutive days, and the other in which the 18 h of musical training were spread over 6 weeks. Both studies showed significant improvements in some untrained, linguistic and non-linguistic variables. The first one yielded significant improvement in categorical perception and auditory perception of temporal components of speech. The second study revealed additional improvements in auditory attention, phonological awareness (syllable fusion), reading abilities, and repetition of pseudo-words. Importantly, most improvements persisted after an untrained period of 6 weeks. These results provide new additional arguments for using music as part of systematic therapeutic and instructional practice for dyslexic children.

Dementia Apraxia Test (DATE): A Brief Tool to Differentiate Behavioral Variant Frontotemporal Dementia from Alzheimer's Dementia Based on Apraxia Profiles.

Standardized praxis assessments with modern, empirically validated screening tests have substantially improved clinical evaluation of apraxia in patients with stroke. Although apraxia may contribute to early differential diagnosis of Alzheimer's dementia (AD) and behavioral variant frontotemporal dementia (bvFTD), no comparable test is readily available to clinicians for this purpose to date. To design a clinically useful apraxia test for the differentiation of AD and bvFTD. 84 test items pertaining to twelve praxis subdomains were evaluated for their efficacy to discriminate between patients with bvFTD (n = 24), AD (n = 28), and elderly healthy controls (HC; n = 35). Items were then selected based on discriminative value and psychometric properties. Items indicative of mild AD comprised spatially complex imitation of hand and finger postures and to a lesser degree, pantomime of common object-use. Buccofacial apraxia including imitation of face postures, emblematic face postures, and repetition of multisyllabic pseudowords differentiated bvFTD from HC and AD. The final test version consisting of 20 items proved highly efficient for the discrimination of biologically confirmed dementia patients from HC (sensitivity 91% , specificity 71%) but also for differential diagnosis of bvFTD and AD (sensitivity 74% , specificity 93%). Assessment of praxis profiles effectively contributes to diagnosis and differential diagnosis of AD and bvFTD. The Dementia Apraxia Test (DATE) is a brief and easy to administer cognitive tool for dementia assessment, has a high inter-rater reliability (Cohen's κ= 0.885) and demonstrates content validity.

Phonological short-term memory in logopenic variant primary progressive aphasia and mild Alzheimer's disease

It has been argued that individuals with logopenic variant primary progressive aphasia (lvPPA) have an impairment of the phonological loop, which is a component of the short-term memory (STM) system. In contrast, this type of impairment is not thought to be present in mild typical Alzheimer's disease (AD). Thus, one would predict that people with lvPPA would score significantly lower than a matched AD group on tasks that require phonological STM. In the current study, an lvPPA group was compared with a mild AD group that was matched on age, education, and general cognitive functioning. For a subset of the tasks that involved pseudowords, the AD and lvPPA groups were compared to a healthy control group that was matched on age and education. The lvPPA group was more impaired than the AD group on all of the tasks that required phonological STM, including the pseudoword tasks, but there were no significant differences between these groups on tasks that required visuospatial STM. Compared to the healthy controls, the lvPPA group performed significantly worse on the repetition and reading of pseudowords, while the AD group did not differ significantly from the controls on these tasks. These findings are consistent with the hypothesis that phonological STM is impaired in lvPPA.

Phonological working memory and reading in students with dyslexia.

Purpose: To investigate parameters related to fluency, reading comprehension and phonological processing (operational and short-term memory) and identify potential correlation between the variables in Dyslexia and in the absence of reading difficulties.Method: One hundred and fifteen students from the third to eighth grade of elementary school were grouped into a Control Group (CG) and Group with Dyslexia (GDys). Reading of words, pseudowords and text (decoding); listening and reading comprehension; phonological short-term and working memory (repetition of pseudowords and Digit Span) were evaluated.Results: The comparison of the groups showed significant differences in decoding, phonological short-term memory (repetition of pseudowords) and answers to text-connecting questions (TC) on reading comprehension, with the worst performances identified for GDys. In this group there were negative correlations between pseudowords repetition and TC answers and total score, both on listening comprehension. No correlations were found between operational and short-term memory (Digit Span) and parameters of fluency and reading comprehension in dyslexia. For the sample without complaint, there were positive correlations between some parameters of reading fluency and repetition of pseudowords and also between answering literal questions in listening comprehension and repetition of digits on the direct and reverse order. There was no correlation with the parameters of reading comprehension.Conclusion: GDys and CG showed similar performance in listening comprehension and in understanding of explicit information and gap-filling inference on reading comprehension. Students of GDys showed worst performance in reading decoding, phonological short-term memory (pseudowords) and on inferences that depends on textual cohesion understanding in reading. There were negative correlations between pseudowords repetition and TC answers and total score, both in listening comprehension.

Transcranial Direct Current Stimulation improves word production in Conduction Aphasia: Electroencephalographic and behavioral evidences

A Conduction Aphasic patient, RH, with many difficulties at the level of phonological output, was subjected to Transcranial Direct Current Stimulation (tDCS) therapy six months after suffering a stroke. Fifteen daily sessions were administered (five days per week). The treatment led to a better intra-hemispheric electrical coherence and inter-hemispheric balance, as shown by the quantitative EEG analysis. Transcranial Direct Current Stimulation therapy was shown to be effective in inhibiting irregular activation of the right hemisphere, offering the healthy areas of the left hemisphere the possibility of reassuming their linguistic processing abilities. Also, the number of errors in picture naming and repetition of words and pseudowords dropped considerably following treatment. The recovery was greater for long stimuli and was not affected by semantic or lexical variables such as familiarity. These results suggest that the Phonological Output Buffer, a mechanism dedicated to the maintenance, ordering and production of phoneme strings, was the processing stage modified by the treatment.

Sensory-to-motor integration during auditory repetition: a combined fMRI and lesion study

The aim of this paper was to investigate the neurological underpinnings of auditory-to-motor translation during auditory repetition of unfamiliar pseudowords. We tested two different hypotheses. First we used functional magnetic resonance imaging in 25 healthy subjects to determine whether a functionally defined area in the left temporo-parietal junction (TPJ), referred to as Sylvian-parietal-temporal region (Spt), reflected the demands on auditory-to-motor integration during the repetition of pseudowords relative to a semantically mediated nonverbal sound-naming task. The experiment also allowed us to test alternative accounts of Spt function, namely that Spt is involved in subvocal articulation or auditory processing that can be driven either bottom-up or top-down. The results did not provide convincing evidence that activation increased in either Spt or any other cortical area when non-semantic auditory inputs were being translated into motor outputs. Instead, the results were most consistent with Spt responding to bottom up or top down auditory processing, independent of the demands on auditory-to-motor integration. Second, we investigated the lesion sites in eight patients who had selective difficulties repeating heard words but with preserved word comprehension, picture naming and verbal fluency (i.e., conduction aphasia). All eight patients had white-matter tract damage in the vicinity of the arcuate fasciculus and only one of the eight patients had additional damage to the Spt region, defined functionally in our fMRI data. Our results are therefore most consistent with the neurological tradition that emphasizes the importance of the arcuate fasciculus in the non-semantic integration of auditory and motor speech processing.

Phonological and visuospatial processing in lvPPA and mild AD

Phonological and visuospatial processing in lvPPA and mild AD

Increased Facilitatory Connectivity from the Pre-SMA to the Left Dorsal Premotor Cortex during Pseudoword Repetition

Previous studies have demonstrated that the repetition of pseudowords engages a network of premotor areas for articulatory planning and articulation. However, it remains unclear how these premotor areas interact and drive one another during speech production. We used fMRI with dynamic causal modeling to investigate effective connectivity between premotor areas during overt repetition of words and pseudowords presented in both the auditory and visual modalities. Regions involved in phonological aspects of language production were identified as those where regional increases in the BOLD signal were common to repetition in both modalities. We thus obtained three seed regions: the bilateral pre-SMA, left dorsal premotor cortex (PMd), and left ventral premotor cortex that were used to test 63 different models of effective connectivity in the premotor network for pseudoword relative to word repetition. The optimal model was identified with Bayesian model selection and reflected a network with driving input to pre-SMA and an increase in facilitatory drive from pre-SMA to PMd during repetition of pseudowords. The task-specific increase in effective connectivity from pre-SMA to left PMd suggests that the pre-SMA plays a supervisory role in the generation and subsequent sequencing of motor plans. Diffusion tensor imaging-based fiber tracking in another group of healthy volunteers showed that the functional connection between both regions is underpinned by a direct cortico-cortical anatomical connection.

Articulation-based sound perception in verbal repetition: a functional NIRS study

Verbal repetition is a fundamental language capacity where listening and speaking are inextricably coupled with each other. We have recently reported that the left inferior frontal gyrus (IFG) harbors articulation-based codes, as evidenced by activation during repetition of meaningless speech sounds, i.e., pseudowords. In this study, we aimed at confirming this finding and further investigating the possibility that sound perception as well as articulation is subserved by neural circuits in this region. Using functional near-infrared spectroscopy (fNIRS), we monitored changes of hemoglobin (Hb) concentration at IFG bilaterally, while subjects verbally repeated pseudowords and words. The results revealed that the proportion of oxygenated hemoglobin (O2Hb) over total Hb was significantly higher at the left IFG during repetition of pseudowords than that of words, replicating the observation by functional MRI and indicating that the region processes articulatory codes for verbal repetition. More importantly for this study, hemodynamic modulations were observed at both IFG during passive listening without repetition to various sounds, including natural environmental sounds, animal vocalizations, and human non-speech sounds. Furthermore, the O2Hb concentration increased at the left IFG but decreased at the right IFG for both speech and non-speech sounds. These findings suggest that both speech and non-speech sounds may be processed and maintained by a neural mechanism for sensorimotor integration using articulatory codes at the left IFG.