Abstract In the field of electric motor maintenance, this study introduces a transformative approach by inte-grating entropy-based algorithms with machine learning for enhanced multi-class fault detection. Employing Shannon, Renyi, and Tsallis entropy algorithms on standard fault detection measure-ments, the research significantly advances predictive maintenance strategies through a robust, ear-ly-indication, system-agnostic analysis. Detailed examination is conducted, comparing results de-rived from datasets that include statistical features (excluding entropy) against the proposed entro-py-based datasets, when applied to a Multi-Layer Perceptron Classifier. Optimization of the MLPC and all compared algorithms’ hyperparameters is done using the state-of-the-art Optuna tool to dynamically explore each search space, ensuring that each methodology performs adequately in a timely fashion while allowing for adaptation. The results showcase significant enhancement in clas-sification accuracy of diverse electric motor operational states, facilitating the differentiation be-tween healthy and various levels of fault conditions under assorted load scenarios. Computational analyses reveal favorable results related to execution time and memory overhead, thereby support-ing the practicality in operations constrained by memory resources. Validation of the approach is achieved through laboratory experiments on a purpose-built test bench. Versatility of entropy-based measures through their proposed utilization in diverse fault indications is achieved by a demonstration in the field of mechanical fault detection with a focus on bearing faults through well-respected datasets.