Renal Solitary Fibrous Tumor Research Articles

Renal Solitary Fibrous Tumor With Müllerian Cysts: A Novel Differential Diagnosis for Biphasic Renal Neoplasms.

Solitary fibrous tumor is an uncommon mesenchymal neoplasm, initially described in the pleura and infrequently found in the kidney. It is characterized by haphazardly arranged spindle cells, staghorn vasculature, coexpression of CD34 and signal transducer and activator of transcription 6 (STAT6), and a NAB2::STAT6 gene fusion. We report a 64-year-old woman who presented with a 2.5 cm multilocular cystic renal mass. On microscopic examination, the tumor consisted of a spindle cell component closely intermingled with ciliated and hemorrhagic epithelial cysts. The spindle cell component was positive for CD34, B-cell lymphoma 2 (BCL2), and STAT6, confirming the diagnosis of a solitary fibrous tumor. The epithelial cysts expressed keratin 7, PAX8, BCL2, estrogen receptor 1, and progesterone receptor, indicative of Müllerian cysts. The occurrence of solitary fibrous tumor in the kidney is extremely rare, and its association with Müllerian cysts has not been previously reported in the kidney. This morphologic variant has a striking similarity with biphasic renal neoplasms, especially with mixed epithelial and stromal tumors and angiomyolipoma with epithelial cysts. This report describes a novel renal solitary fibrous tumor subtype within this differential and underscores clinical and pathological distinctions of biphasic renal neoplasms.

Early rare recurrence of a huge renal solitary fibrous tumor: Case report and review of literature

Early rare recurrence of a huge renal solitary fibrous tumor: Case report and review of literature

Renal Solitary Fibrous Tumor - A Case Report

A renal solitary fibrous tumor (SFT) is an unusual and especially rare entity. Preoperative diagnosis is usually difficult, but it remains of favorable prognosis. In this study, the authors report a case of a 33-year-old Moroccan man with a history of left pyelolithotomy who presented with a 19 cm left renal mass associated with two kidney stones in the lower calyx. He underwent an open radical nephrectomy, and pathology revealed a renal SFT. To the best of our knowledge, our patient is the first case of renal SFT with a history of urolithiasis and presenting with concomitant ipsilateral calculi. Radical nephrectomy is still the cornerstone gold standard therapy for patients with large renal tumors, especially for rare tumors with no proper protocol.

A case of incidentally discovered solitary fibrous tumor of the kidney: A case study.

Solitary fibrous tumor (SFT) is a rare neoplasm of mesenchymal origin. The kidney represents an unusual location for SFT and the diagnosis and treatment of renal SFT remains challenging. The present study reports the case of a right kidney SFT incidentally discovered in a 52-year old woman. Radiological findings from computed tomography and magnetic resonance imaging were not specific but highly suspect for a malignant neoplasm. The definitive diagnosis relied on histological examination and immunohistochemical staining for CD34 and signal transducer and activator of transcription 6.

Malignant Renal Solitary Fibrous Tumor With Two Local Recurrences and Distant Pulmonary Metastasis

Malignant Renal Solitary Fibrous Tumor With Two Local Recurrences and Distant Pulmonary Metastasis

Clinicopathological characteristics of renal solitary fibrous tumor: A single institution experience.

To analyze the clinical characteristics, treatment modalities and outcomes of adult renal solitary fibrous tumors (SFT) treated at a single institution. Demographic, diagnostic, surgical, and pathological findings of patients who had undergone radical nephrectomy (RN) due to renal SFT were collected from the database of a single institution and were retrospectively reviewed. Ten patients (6 men and 4 women) were diagnosed with renal SFT in our institution between January 1, 2000 and December 31, 2016. The mean age was 50.9 ± 8.2 years (range, 38–63 years). Of the 10 patients, 6 were asymptomatic, 2 presented with flank pain, 1 presented with abdominal discomfort, and 1 presented with haematuria. Computed tomography scans were obtained for all patients. Open RN was performed on 6 patients, and laparoscopic RN was performed on 4 patients. The mean tumor size was 10.23 ± 4 cm (range, 5.3–19 cm). Pathological diagnosis revealed that the tumors in 8 patients were benign, while those in the other 2 patients were malignant renal SFT. No recurrence occurred during a mean follow-up period of 47.3 ± 21.5 months (range, 16–85 months). Renal SFT is extremely rare, and its diagnosis may be challenging because of a lack of typical imaging manifestations. RN is a safe treatment modality for benign or low-grade malignant renal SFT, ensuring favorable outcomes.

A benign mimicker of renal cell carcinoma: A case report

We report a rare case of benign renal solitary fibrous tumor in a 40-year old male who presented with a vague fullness and dragging sensation on right lumber region. Computed tomography showed large heterogeneously enhancing solid cystic leision arising from upper pole right kidney for which radical nephrectomy was done. On histopathological examination the diagnosis of solitary fibrous tumor of kidney was made.

Renal solitary fibrous tumor: a case report

目的 探讨肾孤立性纤维瘤的临床表现、影像学及病理学特征，深化对其诊断及治疗的认识。 方法 回顾性分析1例影像学表现为肾盂肿瘤的肾孤立性纤维瘤患者的临床资料，结合相关文献复习，探讨肾孤立性纤维性肿瘤的临床表现、影像学特征、病理诊断、手术及预后。 结果 本例患者术前诊断为右肾盂肿瘤，先行右输尿管肾盂镜检及病变活检术，术中见右肾盂中下部有一占位。术后3 d出现右腰部剧烈疼痛及肉眼血尿，行后腹腔镜右肾输尿管全长切除加膀胱部分切除术，术后病理报告：肾孤立性纤维性肿瘤。现随访14个月，未见复发及转移。 结论 肾孤立性纤维瘤较为罕见，其中个别病例影像学可表现为肾盂肿瘤，缺乏特异的临床症状，术前诊断困难，易误诊，输尿管镜检是有效的鉴别手段，确定诊断需结合病理学及免疫组织化学的相关结果。

Solitary Fibrous Tumor of the Kidney Developing Local Recurrence.

Solitary fibrous tumor (SFT) of the kidney is a rare entity and usually displays a favorable prognosis. We herein report a second case of renal SFT developing local recurrence. A 50-year-old man was referred to our hospital because of a left renal mass. An abdominal CT detected a large renal tumor and radical nephrectomy was performed with a possible diagnosis of renal cell carcinoma. The resected tumor size was measured at 17 × 11 × 8 cm. Grossly, necrosis was observed in central lesion of the tumor but hemorrhage was not observed. Microscopically, the tumor consisted of spindle-shaped cells with scant cytoplasm accompanied by hyalinized collagenous tissue, which displayed hemangiopericytomatous patterns. The cellularity was normal and nuclear pleomorphism was not observed. Ki-67 labeling index was less than 3%. The pathological diagnosis of SFT was made without obvious malignant findings. Three years after the surgery, a follow-up CT scan detected a mass lesion in the tumor bed. Surgical resection was performed and the resected tumor was compatible with local recurrence of the SFT without obvious malignant findings. Renal SFT should be carefully monitored even in the absence of obvious malignant findings.

A huge malignant solitary fibrous tumor of kidney: case report and review of the literature

Virtual slidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1603694556107408.Solitary fibrous tumor (SFT) is a spindle cell neoplasm that rarely occurs in the kidney. Malignant SFT of the kidney is particularly rare. Here, we report a 66-year old woman with a right flank mass that has been proved clinically and radiographically. Grossly, the largest diameter of the mass were measured up to 23 cm, was poorly circumscribed. Approximately 80% of the neoplasm consisted of hyperchromatic and pleomorphic spindled cells surrounding staghornlike blood vessels. Tumor cells frequently had mitoses and necrosis. However, the remainder of the mass was composed of haphazard, storiform or short fascicular arrangements of spindle cells in a loose myxoid to fibrous stroma. Immunohistochemically, we observed diffusely strong CD34 staining and an 85% Ki-67 proliferative index. The tumor partly showed negative CD34 and a 20% proliferative index. To our knowledge, this is the largest malignant renal SFT in the reported literatures and shows an obviously high proliferative index.

De novo malignant solitary fibrous tumor of the kidney

The kidney is a relatively infrequent site for solitary fibrous tumor (SFT). Among the previously reported cases, only two cases of malignant renal SFT developing via dedifferentiation from a pre-existing benign SFT have been reported. Here we reported a case of de novo malignant renal SFT clinically diagnosed as renal cell carcinoma in a 50-year-old woman. The tumor was circumscribed but unencapsulated and showed obvious hemorrhagic necrosis. Microscopically, the tumor was composed of patternless sheets of alternating hypercellular and hypocellular areas of spindle cells displaying mild to moderate nuclear atypia, frequent mitoses up to 8 per 10 high power fields, and a 20% Ki-67 proliferative index. Immunohistochemical studies revealed reactivity for CD34, CD99 and vimentin, with no staining for all other markers, confirming the diagnosis of SFT. No areas of dedifferentiation were seen after extensive sampling. Based on the pathologic and immunohistochemical features, a diagnosis of de novo malignant renal SFT was warranted. Our report expands the spectrum of malignant progression in renal SFTs. Even though this patient has been disease-free for 30 months, long-term follow-up is still mandatory.

Solitary Fibrous Tumor of the Kidney - A Report of Two Cases with Review of Literature -

Solitary fibrous tumor (SFT) is a benign mesenchymal neoplasm usually occurring in the pleura. Kidney is one of the rarest sites for SFT. We report here on two cases of renal SFT found in 30-year-old and 33-year-old men with review of the literatures. Both cases manifested as well-enhanced solid masses in kidney and radical nephrectomies were done. The tumors consisted of bland-looking spindle cells arranged in short, ill-defined fascicles and storiform pattern with characteristic hemangiopericytoma-like blood vessels. The tumor cells were strongly positive for CD34 and CD99, focally positive for bcl-2, and negative for cytokeratin and human melanoma black-45 on immunohistochemical stainings. Possibility of SFT should be considered in the differential diagnosis of a renal mass which consists of benign-looking spindle cells and hemangiopericytomatous blood vessels. Immunohistochemical staining for CD34 is essential to confirm the renal solitary fibrous tumor.

Multiple primary carcinomas of thyroid and kidney coexisting with renalsolitary fibrous tumor: report of a case

患者女,35岁.因左髋部疼痛1年,加剧3个月于2008年4月入院.患者于2007年3月不慎扭伤后出现左髋部疼痛,左腹股沟处有轻压痛,伴轻微跛行,未重视.2007年12月自觉左髋部疼痛加重,在当地医院行X线检查,左髋臼上方见鹅蛋大小骨质缺损.边缘欠光整,遂行左髂骨肿瘤活检.病理经外院会诊意见为:左髂骨转移性神经内分泌癌,癌组织中度分化,富于血窦,形成多个脉管和腺泡样结构,倾向甲状腺滤泡癌.后行PET/CT检查结果提示左髂骨恶性肿瘤及右侧甲状腺腺瘤可能性.随后患者在当地医院行3次羟基喜树碱、足叶乙甙及顺铂(HEP方案)联合重组人血管内皮抑制素(恩度)化疗。