Objective:This review shows the history of inventions of devices, hygiene products, and methods of dissolution and removal of pus, sulfur plugs, blood crusts, and plaque.Material and Methods:The search for inventions was carried out in the databases, such as Google Patent, Google Scholar, Scopus, and PubMed. The key words used in this search were as follows: toothbrushes, toothpicks, toothpastes, plaque, cleaning products for teeth and dentures, teeth whiteners and dentures, bleach bruises and blood stains, pus, sulfur plugs, and pus solvents. A total of 24 inventions were evaluated for review.Results:In recent years, hygiene products that quickly dissolve and bleach pus, sulfur plugs, blood stains, and plaque because of alkaline saponification of protein–lipid complexes and cold boiling inside the biological masses have been invented. Such an action has a heated above 37°C supersaturated sodium bicarbonate solutions containing hydrogen peroxide in moderate concentrations and gaseous oxygen under excessive pressure. Cold boiling inside the dense biological masses occurs under the action of catalase and/or due to the normalization of internal pressure in the solution.Conclusion:Alkalinity, hyperthermia, and hyperoxygenation of solutions with high internal pressure optimize whitening of teeth and dentures because of alkaline saponification and cold boiling.