The study addressed the environmental concerns arising from industrial activities, such as mining, by focusing on the Candelaria-Santa Cruz region. Nickel mining in the region has raised issues related to water quality and sedimentation patterns. Employing the Modified Universal Soil Loss Equation (MUSLE) model, sediment yield computations were conducted, with consideration on factors like bare soil coverage, slope characteristics, and precipitation rates. The results emphasize the need for sustainable land management practices to mitigate adverse effects. The research covers a 10,000-ha area, simulating overburden removal scenarios ranging from 100 ha to 5,847.78 ha, and assesses sediment yield implications under different precipitation rates. The study also determines optimal relative growth rates and plant cover densities for progressive rehabilitation, highlighting the potential for effective erosion control. The findings underscore the significant impact of mining on sediment yield and water quality, prompting the call for comprehensive monitoring, calibration, and validation of the MUSLE model to guide informed decision-making and promote sustainable practices in the region. This research highlights the crucial role of integrated approaches in understanding and mitigating the consequences of resource exploitation on the environment and local communities.