Objective: To assess the clinical features and the surgery outcomes of chronic otitis media with cholesteatoma. Subjects and method: A retrospective, descriptive study was conducted on fifty-six patients underwent a surgery to remove cholesteatoma at the Ear, Nose and Throat (ENT) Department at 108 Military Central Hospital from January 2019 to September 2023. Result: Most of patients presented at the late stage with years of clinical symptoms: Otorrhea (92.9%), hearing loss (100%). One-third of the subjects had a severe to profound hearing loss. 89.3% had scutum and ossicles erosion on CT scan images. Cholesteatoma was found at epitympanum location most of the time (83.9%). Incus was the most likely to be eroded ossicle (83.9%). No significant hearing improvement was found postoperatively. No complications and no recurrences in a long-term follow up. Conclusion: Although most of patients presented at the late stage, our micro-surgery for cholesteatoma removal still had favorable outcomes.