327 Background: Delayed assessment of diagnostic imaging (DI) significant actionable findings (AFs) at an oncological center prompted the creation of a safety net system which used technological advancements to improve communication amongst radiologists and patient-facing providers. Significant AFs is an unexpected radiology finding that is not considered imminently life-threatening but for which follow-up action is recommended within a determined timeframe. Due to the robust nature of DI reports significant AFs can be overlooked. The Actionable Finding Vigilance Unit (AFVU) was created to provide a safety net system for the flow of information. Methods: Operationalizing the AFVU required a multidisciplinary approach consisting of executive stakeholders in Patient Safety, Quality, Radiology, and Information Technology amongst others. A list of 24 AFs was created. Stakeholders met weekly to formalize a strategy and execute the planned intervention. Essential elements included: identifying significant AFs for monitoring, obtaining provider buy-in, creating a digital dashboard within the electronic health record, developing a structured DI report for enhanced communication of findings, and implementing registered nurses team for monitoring. The plan – do- study- act methodology was applied. Results: Over a ten-month period, there were a total of 819 findings. 353 significant AFs associated with the pre-determined list for monitoring. Approximately 29% (102/352) required escalation from the AFVU. Patients without a primary physician in the cancer center were considered a vulnerable population. These patients often sought care via the emergency department and were under the oversight of the AFVU. Total volume of significant AFs for this population consisted of 466 findings, 8 % (36/466) required escalation by the AFVU. Conclusions: Utilization of an electronic health record with the capacity to issue immediate electronic notifications to providers, coupled with a digital dashboard for the monitoring all significant AF reported, does create a safety net for providers and patients. The electronic communication of significant AFs is further enhanced using human interaction for case review and follow up. Data highlights the benefit of harmonizing technology with clinician knowledge and workflow as instrumental in promoting safety and reducing risk in healthcare.