This paper presents a hybrid cell evaluated genetic algorithm (CEGA) for optimization of the dedicated remanufacturing system with simulation. The paper first summarizes the special characteristics and problems of the dedicated remanufacturing. The paper then proposes a simulation model with a prioritized stochastic batch arrival mechanism, considering factors that affect the total profit. Based on the simulation model, the CEGA algorithm is developed to optimize the production planning and control policies for dedicated remanufacturing. A case study is provided based on the remanufacturing facility located at Austin, USA