Enhanced understanding of extreme events is essential for comprehensive risk assessment promoting informed decision-making and early warning to ensure the resilience against challenges imposed by changing climate. This study proposes a novel multi-module integration framework for the comprehensive evaluation of future flood risk in the Greater Pamba River basin, Kerala, India. The integrative modelling framework is developed by assembling a Cellular Automata-Markov Chain (CAMC) based and Use/Land Cover (LULC) projections, Reliability Ensemble Averaging (REA) of Global Climate Model (GCM) rainfall projections, Bayesian approach-based population projection, and spatial analysis of projected infrastructure and Digital Elevation Models (DEMs). By seamlessly interweaving the associated datasets, we illustrate the intricacies of flood vulnerability, exposure, and frequency across multiple return periods (2, 5, 10, and 100, 200 and 500 year) leading to the creation of diagnostic and prognostic high-resolution flood risk maps. The resultant flood analytics and analyses shown that around 36 % of the villages/municipalities and between 70 and 80 % of the critical facilities like schools, hospitals, and flood relief camps are falling under high-risk zones, for the 100-year return period flood. This finding is in line with Kerala's devastating flood episode in 2018, which exhibited characteristics of a nearly 100-year return period flood. In light of a changing climate, population growth, and shifting landscapes, these approaches provide a roadmap for more informed decision-making and adaptive flood risk management measures.