Relaxant Research Articles

The impact of pillow height on neck muscle activity: a pilot study.

Muscle relaxation in the neck during sleep is crucial for achieving quality sleep, and varying pillow heights can significantly influence the myoelectric activity of the neck muscles. This study aims to investigate the effects of different pillow heights on neck muscle activity, with the goal of providing evidence-based recommendations for pillow selection. A total of 15 asymptomatic participants in this study, aged 18 to 30, were assigned to three groups based on pillow height: height 1 (0.5*Shoulder width), height 2 (1.0*Shoulder width), and height 3 (1.5*Shoulder width). Electromyography (EMG) was employed to measure muscle activity in the sternocleidomastoid and trapezius muscles during lateral sleeping positions. Sleep comfort was evaluated using a 100mm visual analog scale (VAS). Statistical analysis was conducted using ANOVA to assess the differences in muscle activity and comfort levels across the various pillow heights. The muscle activation levels revealed that both the sternocleidomastoid and trapezius muscle exhibited the lowest EMG activity in the height 2 (p < 0.001). In contrast, the sternocleidomastoid muscle recorded the highest activation, demonstrating significantly greater average electromyography (AEMG) and integrated electromyography (iEMG) at height 1 (p < 0.001). Meanwhile, the trapezius muscle showed the highest AEMG at height 3 (p < 0.001). Additionally, height 2 was identified as the most comfortable option when compared to height 1 and 3 (p < 0.001). This study concludes that varying pillow heights are linked to neck muscle activity and sleep comfort. These findings underscore the importance of an appropriate pillow height to maintain a healthy cervical spine and promote restful sleep.

A Death Too Fast - Suxamethonium Chloride Poisoning: A Case Report

Introduction: Suxamethonium chloride (SUX) is a short acting depolarizing muscle relaxant commonly used for medical procedures to induce respiratory paralysis. The case report aims to highlight the important postmortem findings associated with SUX poisoning. Case report: A female adult health-care worker in her thirties was found dead in her bedroom at home. There were two empty ampoules of IV/IM Suxamethonium Chloride 100 mg/2 ml found next to the body. Results: The autopsy revealed an adult female with multiple needle injection marks. Gross examination of the lungs showed markedly congested lungs and froth in the airways. The liver showed foci of petechial haemorrhages and confluent haemorrhages. Other internal organs showed diffuse vascular congestion. Microscopically, significant pathological changes were seen in the lungs and kidneys with areas of pulmonary infarction and acute tubular necrosis. SUX was not detected from the toxicological analysis. Correlating the circumstantial evidence at the scene of death, autopsy and microscopic findings, the cause of death was certified as SUX poisoning. Conclusions: We wished to demonstrate the autopsy and histopathological findings associated with acute SUX poisoning culminating in death due to respiratory paralysis.

Detection and Identification of New Chlorphenesin Carbamate Metabolites in Human Urine and Metabolomic Characterization Using Liquid Chromatography-Q Exactive-HF-Orbitrap-Mass Spectrometry.

Chlorphenesin carbamate is a skeletal muscle relaxant, and one of its metabolites is 4-chlorophenoxyacetic acid (4-CPA), which is included on the Prohibited List of the World Anti-Doping Agency (WADA). The non-prohibited substance, chlorphenesin carbamate, as a potential source of 4-CPA, needs to be identified more strongly in doping control protocols. In this paper, the metabolism of chlorphenesin carbamate in human urine was studied. Ten volunteers were recruited to take chlorphenesin carbamate tablets orally, and urine samples were collected before and after being tested. The urine samples were detected by liquid chromatography-Q Exactive HF orbitrap mass spectrometry (LC-Q Exactive HF-MS) in full MS and full MS-ddMS2 scanning modes. Based on accurate molecular formulae determination and fragmentation pattern analysis by mass spectrometry, a total of 29 chlorphenesin carbamate metabolites were found, comprising 18 newly identified metabolites and 11 previously reported metabolites. There were five potential metabolic processes listed: hydroxylation, amide hydrolysis, C-oxidation, O-glucuronidation, sulfation, and their combinations. Chlorphenesin carbamate and the 29 metabolites were compared for their detection windows, and the findings indicated that the two recently reported metabolites, M9 and M10, had longer detection windows than the metabolites documented by the WADA. These metabolites are anticipated to be long-lasting biomarkers for the detection of chlorphenesin carbamate intake. By analyzing the results of metabolomic profiling, it was found that the metabolites with significant changes were mainly related to histidine metabolism and β-alanine metabolism pathways. This paper provides a comprehensive report on the metabolic profile of urinary chlorphenesin carbamate and reveals a point of view the changes in the metabolic in the human body, which is conducive to supporting the detection of chlorphenesin carbamate and meclofenoxate for doping control, as well as a better understanding of the mechanism of action of chlorphenesin carbamate as a drug.

Layanan Konseling Kelompok : Penerapan Teknik Relaksasi Otot Progresif untuk Mengatasi Stress Belajar Siswa SLTP

The purpose of this research is to (1) provide an overview of how progressive muscle relaxation techniques and group counseling services affect student learning stress, (2) provide an overview of students' learning stress levels both before and after progressive muscle relaxation technique treatment, and (3) determine How progressive muscle relaxation techniques affect student learning stress. This type of quantitative research, pre-experimental with a one group pretest-posttest design approach, consisting of one treatment group. The research sample was 15 class VIII Tahfidz students who were identified as experiencing learning stress. Data collection was obtained using observation and the student learning stress scale, then analyzed using the Shapiro - Wilk test analysis which is used to test the normality of data distribution in a sample, especially in small to medium samples. The results showed that (1) students used the progressive muscle relaxation technique for learning stress in accordance with procedures that had been designed with several implementation stages, (2) the level of student learning stress before using the progressive muscle relaxation technique was high, and the level of student learning stress after using it Progressive muscle relaxation technique is low, and (3) Progressive muscle relaxation technique has the effect of helping students reduce learning stress. The results of this study indicate that the application of progressive muscle relaxation techniques can significantly reduce students' learning stress levels, providing empirical evidence that group counseling interventions are effective in improving students' psychological well-being.

Botulinum toxin treatment of refractory vaginismus: a prospective study.

Vaginismus is a common sexual dysfunction. A few studies have indicated that botulinum neurotoxin type A (BoNTA) can help treat refractory vaginismus by alleviating muscle tension. However, such studies did not use standardized methodology and BoNTA dosage. The aim is to evaluate the efficacy of intravaginal BoNTA injection in treating refractory vaginismus. Also, we intended to assess the effectiveness and safety of modest doses, that is, 100 to 200 IU of submucosal BoNTA injections. A prospective study was conducted in an outpatient surgical center over 18 months. Twenty patients aged 29 to 49 years (mean, 30.9 years) with refractory vaginismus were enrolled. All patients had been sexually inactive at the time of treatment. All participants had received various treatments such as psychotherapy, vaginal dilatator therapy, muscle relaxants, and lubricants with no relief. A dose of 100 to 200 IU of BoNTA was injected submucosally in the lateral sides of the bulbospongiosus, pubococcygeus, and puborectalis muscle areas. The patients were followed over 4 months posttreatment. Nineteen patients (95%) achieved satisfactory intercourse by the end of the 4-month follow-up period. A repeat BoNTA injection was not required as there were no recurrences. None of the participants reported adverse effects. A small sample size and lack of a control group. Injecting submucosally modest BoNTA doses is an effective and safe treatment for refractory vaginismus. When conventional therapies fail, BoNTA can be used to lessen muscle contraction, alleviate pain, and facilitate dilator treatments. Our standardized protocol, which involves a careful submucosal injection technique, can minimize risks and make the procedure easy to perform for daily practice.

The Effect of Progressive Muscle Relaxation on Blood Pressure Reduction as An Effort to Prevent Emergencies in Hypertensive Patients

The Effect of Progressive Muscle Relaxation on Blood Pressure Reduction as An Effort to Prevent Emergencies in Hypertensive Patients

Vertebral osteoporotic fractures: differential diagnosis, therapeutic approaches

Osteoporotic vertebral fractures (OVF) are a severe complication of osteoporosis associated adverse outcomes, acute and chronic pain syndrome. If vertebral fractures (deformities) are detected, osteoporosis is diagnosed regardless of bone mineral density and the 10-year absolute fracture risk scale of the Fracture Risk Assessment Tool, but subject to the exclusion of other metabolic osteopathies. The article presents differential diagnosis of OVF with osteopathies such as osteomalacia, tumors or metastatic lesions of the spine, Paget»s disease, myeloma, hyper parathyroid osteodystrophy, post-traumatic vertebral deformities, Scheuermann-Mau disease. Differential diagnosis between different types of osteopathies is based on features of the clinical picture, history, changes in laboratory parameters (calcium, phosphorus, alkaline phosphatase, parathyroid hormone, vitamin D3 and on data from X-ray of the skeleton examination. It is necessary to take into account conditions under which the vertebral fracture occurred, its localization, prevalence, peculiarities of changes in bone structures, presence or absence of osteoporotic background, degenerative-dystrophic changes in the spine. The tactics of managing the patients with OVF is determined by the time after the fracture, its severity, nature of the pain syndrome and includes non-drug and medical measures. Among non-pharmaceutical measures in the acute period of OVF, there are unloading of the spinal column, use of a corset, and physical therapy. Medical measures are aimed at pain relief using injectable and oral forms of nonsteroidal anti-inflammatory drugs, central acting muscle relaxants and anti-osteoporotic therapy. Dexketoprofen (Dexalgin) is the first-line drug for relief of acute pain in OVF which has a rapid and pronounced analgesic effect. For the anti-osteoporotic therapy, the drugs of choice are parenteral bisphosphonates, denosumab and teriparatide.

Progressive Muscle Relaxation As An Effort To Reduce Pain Intensity In Cervical Cancer Sufferers

Progressive Muscle Relaxation As An Effort To Reduce Pain Intensity In Cervical Cancer Sufferers

Ultrasound guided evaluation of muscle wasting in critically ill patients

BackgroundMuscle wasting constitutes a frequent complication in critical illness and may be most prevalent in chronic critical illness as inpatients with prolonged ICU length of stay.ObjectiveTo evaluate the incidence and percentage of muscle wasting estimated by ultrasonography during ICU stay in patients with sepsis and receiving medications as corticosteroids, muscle relaxant, and certain antibiotics during ICU stay and hospital stay.Patients and methodsWe enrolled 90 patients diagnosed with sepsis who were admitted to ICU at Kasr Alainy Hospital were subdivided in to 3 groups: Group 1 consists of 30 patients receiving steroids. Group 2 consists of 30 patients receiving antibiotic causing muscle wasting in the form of aminoglycosides. Group 3 consists of 30 patients receiving neuromuscular blocking agents (muscle relaxants) for any indication in ICU.ResultsOur study included 90 patients, with mean age 50.44 ± 6.79 years, with male % 60%, APACHE II score 7.16 ± 3.59, SOFA score 7.16 ± 3.59, results showed there was a significant decline in QMT on both right and left sides as well as RFCSA on both right and left sides when compared with baseline starting from the 3rd day of ICU admission till the end of the study period (15th day of ICU admission) (P < 0.001). Patients who received muscle relaxant had significantly higher QMT% and RFCSA% wasting when compared to patients who received aminoglycosides (P < 0.001) and when compared to patients who received steroids (P < 0.001). Patients who received aminoglycosides had significantly higher QMT% and RFCSA% wasting compared to patients who received steroids (P < 0.001). There was a significant negative correlation between Horowitz index with right side QMT% wasting (r = − 0.557; P < 0.001), left side QMT% wasting (r = − 0.444; P < 0.001), right side RFCSA% wasting (r = − 0.638; P < 0.001), and left side RFCSA% wasting (r = − 0.621; P < 0.001). Right side QMT% wasting positively correlated with WBCs (r = 0.254; P = 0.016). There was a significant positive correlation between SOFA score with right side QMT% wasting (r = 0.308; P = 0.003) and left side QMT% wasting (r = 0.285; P = 0.006). There was a significant positive correlation between SOFA score with right side RFCSA% wasting (r = 0.210; P = 0.003) and left side RFCSA% wasting (r = 0.303; P = 0.004).ConclusionUltrasound showed significant reduction in QMT and RFCSA from the baseline in patients with sepsis starting from the 3rd day of admission. Patients who received muscle relaxant had the highest incidence of muscle wasting (QMT% wasting and RFCSA% wasting). Patients who received steroids reported the least percentage of muscle wasting.

Assessing the Optimal Dose of Mivacurium for Modified Rapid Sequence Intubation in Emergency Surgical Settings: A Randomized, Double-Blind Trial

Background: Modified rapid sequence intubation (RSI) is crucial in emergency surgery, particularly for patients with a full stomach, as it allows for the administration of general anesthesia (GA). Objectives: This work aimed to evaluate mivacurium effectiveness and optimal dose in modified RSI. Methods: This randomized double-blind study involved 100 patients, aged between 20 - 60 years, of both sexes, with the American Society of Anesthesiologists physical status classification of I - III, who were undergoing emergency surgery under GA. Patients were randomized into two equal groups and received mivacurium in a dose of 0.3 mg/kg in group M1 or 0.4 mg/kg in group muscarinic-2 (M2). Results: Intubating conditions were significantly better in group M2 than in group M1. The onset of adequate muscle relaxation was significantly earlier in group M2 than in group M1 (P &lt; 0.001). At the third minute, mean arterial blood pressure recordings were significantly lower in group M2 (P = 0.04) than in group M1. The recovery time was significantly longer in group M2 than in group M1 (P &lt; 0.001). Conclusions: Mivacurium in a 0.4 mg/kg dose resulted in more favorable intubating conditions during RSI and a more profound, earlier onset of muscle relaxation, but with a longer recovery time compared to the 0.3 mg/kg dose.

O USO DE ACUPUNTURA NO TRATAMENTO DE EQUINOS COM LAMINITE: REVISÃO DE LITERATURA

Acupuncture is explored as an alternative treatment for laminitis in horses, a condition that compromises the health and well-being of these animals due to intense pain and inflammation in the hooves. Originating from Traditional Chinese Medicine, acupuncture stands out for its ability to modulate pain and reduce inflammation by stimulating specific points on the body that promote analgesia, muscle relaxation, and improved circulation in affected tissues. This practice complements conventional treatment, reducing the need for analgesics and anti-inflammatory drugs, aiding in the animal’s clinical stabilization. The review presented in this paper highlights the importance of acupuncture in treating laminitis in horses, addressing relevant issues for veterinarians. In addition to promoting pain relief and improving blood circulation, this technique has anti-inflammatory and immunomodulatory effects that can be especially useful in managing laminitis. The study reveals acupuncture as a promising therapeutic resource that when complementing conventional treatment reduces the need for medication and minimizes side effects, benefiting the animals’ quality of life. The review aims to provide professionals comprehension about the efficacy and limitations of this practice, supporting clinical decision-making and proposing an integrative approach that enhances outcomes in the treatment of laminitis.

Efficient Reversal of Neuromuscular Blocking Agent-Induced Biological Functions and Side Effects by an Extended Biphen[3]arene Carboxylate.

Neuromuscular blocking agents (NMBAs) are widely administered during anethesia to prevent the patient from moving and optimize surgical conditions. Timely reversal of the muscle relaxation state induced by NMBAs at the end of surgery is necessary to recover autonomous respiration and muscle function. Herein, an extended biphen[3]arene carboxylate (ExBP3C) was designed and synthesized by a supramolecular sequestration approach as a reversal agent with high efficiency and generality against several representative NMBAs. ExBP3C exhibited robust host-guest complexation toward atracurium, rocuronium, vecuronium, pancuronium, and gallamine with an association constant of up to 108 M-1. A series of in vitro and in vivo safety tests preliminarily demonstrated that this synthetic macrocycle had good biocompatibility. Compared to sugammadex, post-treatment by an equivalent dose of ExBP3C could produce a more efficient reversal function. Additionally, a single dose of such a reversal agent was also able to completely recover overdose atracurium-induced heart rate abnormalities within 2 min.

Our experience in providing anesthesia during surgical interventions for necrotizing enterocolitis

Necrotizing enterocolitis (NEC) is one of the most common serious acquired diseases of the gastrointestinal tract, both in full-term and premature infants, and is associated with a high risk of complications and high mortality. Anesthetic management for necrotizing enterocolitis in newborns during surgery is a complex task and is still relevant, since the future fate of the patient depends on adequacy of the anesthesia used. Purpose of the study: Optimization of anesthesia during surgery in newborns for necrotizing enterocolitis. Material and research methods: The study was conducted in surgical clinics of the Azerbaijan Medical University. The paper presents the results of treatment of 96 patients based on the assessment of clinical indicators of preoperative preparation, anesthesiological care, and the study of central hemodynamics in newborns operated on for necrotizing enterocolitis. Newborns were divided into 2 groups depending on the method of anesthesia used: group I with general anesthesia and group II with general anesthesia using caudal anesthesia. Results: The results of this study showed that effective interruption of nociceptive impulses from the surgical site through caudal blockade and sufficient sedation can prevent pronounced activation of the body's neurohumoral reactions to surgical stress under conditions of balanced regional anesthesia, and it was also revealed that the modern muscle relaxant rocuronium bromide allows the concept of multicomponent anesthesia to be implemented, causing complete relaxation of the striated muscles during surgery, which helps to effectively block pathological reactions in response to surgical stress.

Skeletal Muscle Relaxants and Their Impact on Intracranial Pressure in Neurosurgery

Skeletal Muscle Relaxants and Their Impact on Intracranial Pressure in Neurosurgery

Nanotechnology in Pain Management.

Chronic pain is a debilitating condition that affects millions of patients worldwide, contributing to a high disease burden and millions of dollars in lost wages, missed workdays, and healthcare costs. Opioids, NSAIDs, acetaminophen, gabapentinoids, muscle relaxants, anticonvulsants, and antidepressants are the most used medications for chronic pain and carry significant side effects, including gastric bleeding, hepatotoxicity, stroke, kidney damage, constipation, dizziness, and arrhythmias. Opioids in particular carry the risk of long-term dependence, drug tolerance, and overdose. In 2022, 81,806 people died from opioid overdose in the United States alone. Alternative treatments for chronic pain are critically needed, and nanotechnology has emerged as a promising means of achieving effective long-term analgesia while avoiding the adverse side effects associated with conventional pharmacological agents. Nanotechnology-based treatments include liposomes, Poly Lactic-co-Glycolic Acid (PLGA) and other polymeric nanoparticles, and carbon-based polymers, which can help mitigate those adverse side effects. These nanomaterials can serve as drug delivery systems that facilitate controlled release and drug stability via the encapsulation of free molecules and protein-based drugs, leading to longer-lasting analgesia and minimizing side effects. In this review, we examine the role of nanotechnology in addressing concerns associated with conventional chronic pain treatments and discuss the ongoing efforts to develop novel, nanotechnology-based treatments for chronic pain such as nanocapacitor patches, gene therapy, the use of both viral and non-viral vectors, CRISPR, and scavengers.

TMEM16A Antagonism: Therapeutic Potential with Desensitization of β-agonist Responsiveness in Asthma.

The efficacy of β-agonists in asthma is severely limited by β-adrenoceptor desensitization which results in poorly managed symptoms and refractory bronchoconstriction. Thus, there is a need to identify novel therapeutic pathways and to clarify the relationship between novel therapeutics and functional β-adrenoceptor responsiveness. We have previously demonstrated that acute antagonism of the calcium activated chloride channel, transmembrane member 16A (TMEM16A), relaxes airway smooth muscle (ASM). We sought to determine the efficacy and role of TMEM16A antagonism in the context of desensitization β - adrenoceptor responsiveness. For these studies, we exposed murine tracheal rings on wire myography and precision cut lung slices to contractile mediators in the presence or absence of TMEM16A antagonists and β-agonists with or without prior β-adrenoceptor desensitization. Contractile studies were also performed with human tracheal and bronchial ASM. Finally, the ability of TMEM16A antagonism to prevent desensitization of β2-adrenoceptor-induced cyclic AMP synthesis was measured in human ASM cells. From these studies we demonstrate that acute TMEM16A antagonism is effective in relaxing β-agonist desensitized ASM in central and peripheral murine ASM and human ASM. Furthermore, we demonstrate that chronic pretreatment with TMEM16A antagonists prevents functional desensitization of β-agonist responsiveness in mouse and human upper airways and prevents desensitization of β-agonist-mediated cyclic AMP production in human ASM cells. Taken together, the present study demonstrates a favorable therapeutic profile of TMEM16A antagonism for airway smooth muscle relaxation despite functional desensitization of β-agonist responsiveness which may be a novel therapeutic approach in the face of β-adrenoceptor tachyphylaxis.

Impact of Liver Disease on Use of Muscle Relaxants in Anesthesia: A Comprehensive Review

Impact of Liver Disease on Use of Muscle Relaxants in Anesthesia: A Comprehensive Review

Magnesium and Zinc as Vital Micronutrients Enhancing Athletic Performance and Recovery – a Review

Introduction and Aim of the ReviewMagnesium and zinc are vital for cellular metabolism and maintaining homeostasis, playing a particularly significant role for athletes. Magnesium, which is largely stored in bones and muscles, is essential for protein synthesis. Zinc, a critical trace element found in muscle and bone tissue, participates in over 300 enzymatic reactions, acts as an antioxidant and making both minerals crucial for physical performance. This study aims to explore the physiological role of magnesium (Mg) and zinc (Zn) in the context of athletic performance and to examine their impact on energy metabolism, muscle function, protein synthesis and potential benefits of Mg and Zn supplementation for improving athletic outcomes and post-exercise recovery. MethodsA comprehensive review of scientific literature was conducted through a thorough search of the PubMed database to explore the latest findings on the utility of magnesium and zinc in sports. Only articles in English were considered. Current KnowledgeThe review results indicate that Mg and Zn play critical roles in energy metabolism, muscle and immune system health. Mg deficiency can impair muscle function and reduce endurance, while its supplementation supports muscle relaxation, cardiovascular health, and respiratory efficiency. Although required in small amounts, Zn is indispensable for enzymatic activity, protein synthesis, hormonal balance, and muscle recovery, making it vital for post-exercise recovery and immune response modulation. ConclusionsAvailable data suggest that Mg and Zn supplementation may positively influence athletic performance, energy metabolism, and recovery post-exercise, though further research is needed to establish specific supplementation guidelines. This review provides a foundation for developing supplementation strategies aimed at enhancing athletic performance and supporting healthy recovery.

Psychological Interventions for Insomnia in Patients with Cancer: A Scoping Review.

Insomnia is a frequent and distressing symptom with limited treatment in patients with cancer. Among the available treatments for insomnia, psychological interventions are some of the most assessed. While studies and reviews show promise of interventions improving insomnia in patients with cancer, inconsistent approaches to operationalizing and measuring insomnia combined with the heterogeneity of available treatments render comparisons and synthetization difficult. This review sought to rigorously synthesize psychological interventions for patients with cancer and insomnia by describing current therapies, identifying gaps in the literature, and offering supportive interventions. A comprehensive search of five databases-Ovid MEDLINE, Ovid Embase, Ovid PsycInfo, EBSCO CINAHL Plus with Full Text, and Cochrane Library-was conducted through 1 August 2024. The review included randomized trials and non-inferiority trials evaluating psychological interventions for patients with various types of cancers. Twenty-one studies were included, and study quality ranged from good to excellent, according to the PEDro scale. The current evidence supports the use of cognitive behavioral therapy (CBT) to treat insomnia over and above psychoeducation alone, mindfulness-based stress reduction, Brief Behavioral Therapy, the Benson Relaxation Technique, progressive muscle relaxation, mindfulness meditation, mind-body bridging, and home-based psychological nursing. Digital, minimal, and internet-based intervention modalities are effective, though professional-delivered CBT proved most effective. CBT remains the most effective psychological intervention for insomnia in this population. Challenges exist regarding the implementation of CBT, so further research is warranted to identify the best psychological interventions for specific settings and subsets of patients with cancer.

Alexithymia, Inner Thinking Patterns, and Perceptions of Mental Health Therapy Strategies Among Autistic Adults.

Autistic adults are at high risk for mental health challenges, yet there has been limited research on mental health interventions for this population. Individual differences in how thoughts and emotions are perceived may directly relate to the success of specific therapy strategies. This study examined whether alexithymia and inner thinking patterns relate to helpfulness and ease of use of mental health therapy strategies among autistic adults. Participants (n = 269 autistic adults, ages 21-77) completed questionnaires assessing alexithymia, inner thinking patterns (i.e., self-talk, verbal thinking, visual thinking), and experiences with mental health therapy strategies. Ordinal logistic regressions were used to examine associations between alexithymia, inner thinking, and perceived helpfulness and ease of use of therapy strategies. Autistic adults with greater alexithymia found cognitive strategies more difficult to use, while those with greater frequency of self-talk found them easier to use. By contrast, autistic adults with greater visual thinking found guided imagery strategies easier to use. There were no associations between alexithymia or inner thinking and perceived helpfulness or ease of use of behavioral strategies (exposure, behavioral activation), mind-body relaxation strategies (deep breathing, progressive muscle relaxation), or mindfulness meditation. The findings suggest that some mental health strategies may be more difficult to implement for some autistic adults, depending on individual thinking profiles. However, alexithymia and inner thinking patterns were unrelated to the perceived helpfulness of mental health strategies. Overall, this highlights the importance of providing individualized supports and accommodations to optimize mental health therapy for autistic adults.