We investigate the presence of thermodynamic instabilities in compressed asymmetric baryonic matter, reachable in high energy heavy ion collisions, and in the cold β-stable compact stars. To this end we study the relativistic nuclear equation of state with the inclusion of Δ-isobars and require the global conservation of baryon and electric charge numbers. Similarly to the low density nuclear liquid-gas phase transition, we show that a phase transition can occur in dense asymmetric nuclear matter and it is characterized by both mechanical instability (fluctuations on the baryon density) and by chemical-diffusive instability (fluctuations on the electric charge concentration). Such thermodynamic instabilities can imply a very different electric charge fraction Z/A in the coexisting phases during the phase transition and favoring an early formation of Δ− particles with relevant phenomenological consequences in the physics of the protoneutron stars and compact stars. Finally, we discuss the possible co-existence of very compact and very massive compact stars in terms of two separate families: compact hadronic stars and very massive quark stars.