Background and Aim: The adipokines leptin and adiponectin, mainly produced in adipose tissue, are involved in energy homeostasis and insulin sensitivity. Lower adiponectin and higher leptin correlate with older childhood and adult adiposity, while the relationship in young children is less clear. Higher prenatal heavy metals and lower nonessential metals have been associated with childhood adiposity, but it is unclear if prenatal metals influence childhood adipokines. Methods: Six nonessential (As, Ba, Cd, Cs, Hg, Pb) and four essential (Mg, Mn, Se, Zn) metals were measured in first trimester red blood cells from pregnant participants in the Boston MA-area Project Viva cohort. Blood leptin and adiponectin were measured in early-childhood (N=527-526; mean 3.3 (SD 0.3) years), mid-childhood (N=426; 8.0 (0.8) years), and early-adolescence (N=477; 13.1 (0.9) years). Linear regression and quantile g-computation models estimated associations between individual and mixtures of metals and adipokines, adjusting for confounders. Results: Mean (SD) leptin was 1.9 (1.9) ng/ml in early-childhood, 5.6 (6.8) ng/ml in mid-childhood and 11.9 (14.7) ng/ml in early-adolescence. Mean (SD) adiponectin was 22.4 (5.5) μg/ml in early-childhood, 15.7 (8.5) μg/ml in mid-childhood and 6.4 (2.8) μg/ml in early-adolescence. A doubling in arsenic was associated with lower adiponectin at the early-childhood visit (β=-0.40 μg/ml, 95% CI: -0.73, -0.07), while cesium was associated with higher leptin at the early-adolescence visit (β=2.76 ng/mL, 95% CI: 0.22, 5.30). In mixture analyses, adjusting for metals not in the mixture, a quartile increase in nonessential metal mixture was associated with lower adiponectin (β=-0.18 μg/ml, 95% CI: -0.33, -0.03) at the mid-childhood visit. Conclusions: Our findings suggest that certain prenatal metals are associated with adipokines in childhood, which might influence cardiometabolic risk. Future work will evaluate if adipokines mediate associations of prenatal metals with adiposity and cardiometabolic risk. Keywords: Heavy metals, Mixtures analysis, Children's environmental health