Reproductive activity is an activity that involves both male and female and this activity is encouraged by certain factors like social, economic and political. These factors should be favourable for reproductive activity to occur. Reproduction is a seamless process that occur when two opposite partner agree, and desire to have children. The aim of the study is to investigate Effects of Socio-Economic Factors on Reproductive Activity Among Women in South-East, Nigeria. This was a cross-sectional study involving 480 women who were within the age of 18 to 47 years. A well-structured questionnaire was administered to participants. Each participant had one questionnaire to fill appropriately and independently after instructions were given to them by the Research Assistants. The study lasted for a period of 4 months. The results of the study revealed that, the educational qualification of respondents also indicated that 80(16.67%) has primary education, 100(20.83%) secondary education while 300(62.50%) had tertiary education. The marital statuses of the respondents also showed that 300(62.50%) were married, 100(20.83) single, while 80(16.67%) were divorced. 300(72.92%) of the respondents have health centre in their community whereas 350(62.50) said the health centres are not functioning. Also, 300(62.50%) of the participants have not visited the health centre. 380(79.17) of the respondents said no access road to the health centre. The study revealed that 60(12.50%) of participants had money to access hospital while 420(87.50%) did not and 460(95.83%) do not have the desire to get pregnant.