To assess the impact of the COVID-19 pandemic on young people's functioning, relationships, and well-being, four systematic reviews were put together to shed light on school experiences, family and peer relationships, and civic engagement during the pandemic. The reviews presented research findings on the protective role of several personal and contextual resources including intrinsic motivation, self-efficacy, family, school, peer, and community support, as well as the harming effect of risk factors, such as poor mental health, COVID-19-related stressors, and technological challenges, thus highlighting the significant role of both personal and contextual factors in adolescent development and well-being. Equally important, the research findings collectively suggested an ecological perspective of the determining factors, although the focus was largely on factors in immediate contexts (family, school, peers, and local community). Adopting a more holistic approach that also considers factors in other ecological contexts (e.g., partnership between immediate contexts, the influence of cultural values and norms along with educational and developmental transitions) can be crucial in addressing the specific needs of young people across diverse contexts and cultures during a pandemic and in general. In addressing their needs, the ever-growing digital space of young people can be utilized to connect them to services and supportive networks in their contexts including distal ones.