This work deals with fluid-structure interaction (FSI), one of the emerging areas of numerical simulation and calculation. This research shows a numerical study investigating heat transfer enhancement and fluid-structure interaction in a circular finned tube by using alumina nanofluid as a working fluid with a typical twisted tape that has a twisting ratio of 1.85. The studied nanofluid volumes of fraction are φ=0, 3, 5 % under conditions of laminar and turbulent flow. The solution for such problems is based on the relations of continuum mechanics and is mostly done with numerical methods. FSI occurs when the flow of fluid influences the properties of a structure or vice versa. It is a computational challenge to deal with such problems due to complexity in defining the geometries, nature of the interaction between a fluid and solid, intricate physics of fluids and requirements of computational resources. CFD investigations were made based on the numerical finite volume techniques to solve the governing three-dimensional partial differential equations to get the influence of inserted twisted tape and concentration of nanofluid on heat transfer enhancement, friction loss, average Nusselt number, velocity profile, thermal performance factor characteristics, and two-way interaction in a circular tube at laminar and turbulent flow. The governing continuity, momentum and energy transfer equations are solved using Ansys Fluent and Transient Structural. The simulation results show that the deformations of two-way coupling fluctuate from side to side, with 0.004 mm, as maximum amplitude, located at the typical twisted tape center. Heat transfer dissipation improved by adding fins and as Reynolds numbers increase the heat transfer behavior increases.