Numerous reinforced concrete (RC) structures are exposed to aggressive environments, such as chloride, mainshock and aftershock. These environmental and extreme loads have the potential to increase the seismic risks during structure's service life. This study introduces a practical probabilistic methodology to estimate the seismic risk of corroded RC frame subjected to mainshock-aftershock sequences. In this methodology, a time-variant modeling strategy is used to simulate the geometrical and mechanical properties of structural degraded materials. The Bayesian updating theorem is employed to calibrate the demand models, which are then used to estimate the fragilities and confidence intervals considering the model uncertainties. A Copula-based approach is conducted to generate joint probability of mainshock and aftershock intensities and the seismic hazard of the mainshock-aftershock scenario. Finally, the seismic risk and associated confidence intervals are estimated by integrating over all mainshock and aftershock intensities levels. A typical corroded RC frame structure is used to illustrate the proposed methodology. The results show that the contribution of corrosion and aftershock would lead a 10 times higher seismic risks compared to scenarios considering only mainshock damage. It is necessary to account for the influence of both corrosion and aftershock in seismic design.