Energy Regulation Research Articles

Carbon Capture Storage dalam Pengelolaan Barang Milik Negara

Climate change has gained prominence following the 2015 Paris Agreement, which aims to limit global temperature rise to below 2 degrees Celsius, with efforts to keep it under 1.5 degrees Celsius. This agreement stresses the importance of collective action to reduce greenhouse gas emissions and build resilience against climate impacts. In June 2023, the global average surface temperature reached a record high, with subsequent months also setting heat records. Mitigating global warming's adverse effects, such as rising temperatures and extreme weather changes, requires significant reductions in greenhouse gas emissions. Efforts in the energy sector have led to a decrease in CO2 emissions from 40.6 million tons in 2018 to 127.67 million tons in 2023. These efforts include enhancing energy efficiency, transitioning to renewable energy, and implementing carbon capture and storage (CCS) technologies In Indonesia, CCS regulations are outlined in Minister of Energy and Mineral Resources Regulation No. 2 of 2023. CCS involves the capture, transport, injection, and permanent storage of carbon emissions. The management of state-owned assets related to CCS falls under the Ministry of Finance Regulation No. 140/PMK.06/2020, which addresses the transfer, utilization, and valuation of upstream oil and gas assets. This paper discusses the role of state asset management in the implementation of CCS in Indonesia, examining current regulations, challenges, and future prospects.

Renovating Post-First-Energy-Regulation Housing: Achieving Nearly Zero-Energy buildings under typical and extreme warm conditions in a temperate European city

Decarbonising the built environment is essential for achieving the 2050 European objectives. Multi-family buildings comprise nearly half of Europe’s building stock, yet there is no regulation mandating all housing renovations to be Nearly Zero-Energy Buildings (NZEBs). This paper highlights the role of NZEB renovation for residential buildings constructed between the first energy regulations, after the first oil crisis, and the EPBD 2002 implementation (post-first-energy-regulation housing), as a pivotal factor towards energy transition. In Spain, this period (1980–2006) encompasses approximately 45% of existing dwellings. A case study was conducted in a city with a Cfb temperate climate, focusing on the most representative residential typology of the target period: the linear block. The study evaluates its current state and defines potential measures to meet NZEB requirements, achieving zero consumption when renovation of thermal envelope is combined with heat recovery systems, heat pumps, and PV panels.This research is based on energy simulations for two climate scenarios: the typical meteorological year (TMY, official series 1970–2000) and the most extreme warm year (EWY, 2022) in Spain. Results indicate active cooling systems are necessary for NZEB renovations in Spanish Cfb climates. Furthermore, low-temperature radiators significantly reduce heating consumption, while splits are the most suitable cooling systems. This study shows Spain is not adequately preparing its housing stock to face climate change, as most typical renovation works are based on official weather files that need updating to reflect harsher summer conditions. Finally, the study aims to encourage new policies and enhance existing regulations to address rising temperatures and heatwaves.

MicroRNA-34a-5p regulates agouti-related peptide via krüppel-like factor 4 and is disrupted by bisphenol A in hypothalamic neurons

Obesity is a complex disease marked by increased adiposity and impaired metabolic function. While diet and lifestyle are primary causes, endocrine-disrupting chemicals (EDCs), such as bisphenol A (BPA), significantly contribute to obesity. BPA, found in plastic consumer products, accumulates in the hypothalamus and dysregulates energy homeostasis by disrupting the neuropeptide Y (NPY)/agouti-related peptide (AgRP) and pro-opiomelanocortin (POMC) neurons.However, the precise molecular mechanisms of how BPA disrupts neuropeptide expression remains unclear. We hypothesized that microRNAs (miRNAs), which regulate approximately 60% of the human protein-coding genome and are crucial for hypothalamic energy regulation, may mediate the effects of BPA on Agrp. Using the TargetScanMouse 8.0 and DIANA microT bioinformatics tools, we identified miR-501-5p as a potential miRNA that directly regulates Agrp and the miR-34 family as miRNAs that indirectly regulate Agrp through its transcription factor krüppel-like factor 4 (KLF4). We found that in an immortalized NPY/AgRP-expressing cell line, mHypoE-41, miR-501-5p unexpectedly upregulated Agrp, while miR-34a-5p reduced Klf4 and Agrp mRNA levels. Serum starvation reduced miR-34a-5p levels and elevated Agrp mRNA levels, suggesting a potential role in AgRP regulation. Inhibiting the miR-34a-5p interaction with the Klf4 3′UTR using a specific target site blocker prevented the downregulation of both Klf4 and Agrp, suggesting miR-34a-5p alters Agrp mRNA levels via regulation of KLF4. BPA treatment increased Agrp and Klf4 expression while simultaneously decreasing miR-34a-5p levels, indicating miR-34a-5p may play a role in BPA-mediated dysregulation of Agrp. Overall, this study highlights indirect miRNA-based regulation of Agrp, which can also be dysregulated by obesogens, such as BPA.

Socially driven negative feedback regulates activity and energy use in ant colonies.

Despite almost a century of research on energetics in biological systems, we still cannot explain energy regulation in social groups, like ant colonies. How do individuals regulate their collective activity without a centralized control system? What is the role of social interactions in distributing the workload amongst group members? And how does the group save energy by avoiding being constantly active? We offer new insight into these questions by studying an intuitive compartmental model, calibrated with and compared to data on ant colonies. The model describes a previously unexplored balance between positive and negative social feedback driven by individual activity: when activity levels are low, the presence of active individuals stimulates inactive individuals to start working; when activity levels are high, however, active individuals inhibit each other, effectively capping the proportion of active individuals at any one time. Through the analysis of the system stability, we demonstrate that this balance results in energetic spending at the group level growing proportionally slower than the group size. Our finding is reminiscent of Kleiber's law of metabolic scaling in unitary organisms and highlights the critical role of social interactions in driving the collective energetic efficiency of group-living organisms.

Novel Interacting Partners of MGP-40, a Chitinase-Like Protein in Buffalo Mammary Epithelial Cells.

Mammary Gland Protein-40 (MGP-40), also known as chitinase-3-like protein 1 (CHI3L1), is involved in critical biological processes such as inflammation, tissue remodeling, and cell proliferation, especially during the involution phase of the mammary gland. This study aimed to explore the molecular mechanisms of MGP-40 by identifying its novel interacting partners in buffalo mammary epithelial cells (BuMECs). Stable overexpression of MGP-40 in BuMECs was achieved through transfection with the pCIneo-MGP-40 vector, followed by G418 selection and confirmation by Western blot analysis. To identify interacting proteins, Co-immunoprecipitation (Co-IP) of BuMEC lysate using an anti-YKL-40 antibody was performed, and the eluted proteins were analyzed using SDS-PAGE and mass spectrometry (MALDI-TOF/TOF). The analysis revealed several interacting proteins, including synaptotagmin-like 3, Ras-related Rab19, RIB34A-like protein with coiled coils, and ATP synthase subunit g. These interacting partners suggest that MGP-40 is involved in crucial cellular processes like vesicle trafficking, cytoskeletal organization, and energy metabolism, extending its known functions in inflammation and tissue remodeling. Notably, the interactions with synaptotagmin-like 3 and Rab proteins emphasize MGP-40's potential role in vesicular transport, essential for milk production in mammary epithelial cells, while the association with ATP synthase subunit g links MGP-40 to energy regulation during lactation. These findings provide preliminary insights into the potential roles of MGP-40 in mammary gland physiology, particularly in cellular processes such as vesicle trafficking and energy metabolism. Further studies, including in vivo validation, are essential to confirm these interactions and clarify their relevance to mammary gland function and pathology.

Hydrogen fuel cell energy regulators based on Boost DC-DC converters with switched capacitors

A new principle for constructing small-sized capacitor DC-DC regulators that provide energy-efficient conversion and multi-zone energy regulation of hydrogen fuel cells is proposed. It consists in converting the energy of their current into the energy of a constant voltage source with further alternating changes in its low-voltage regulation subranges. It is carried out by discretely changing the number of resonant chains of a step-up capacitor DC-DC converter in combination with a smooth change in the charge level of its first chain using a low-power classic PWM constant voltage regulator. Improving the energy properties of the regulator is achieved by multi-zone regulation and soft switching of transistors in the power circuit of the capacitor DC-DC converter. The energy properties of the proposed regulator have been studied. It is shown that with an increase in the number of resonant chains in the capacitor DC-DC converter, there is a tendency for the controller efficiency to increase. For the various regulator circuits considered in the work, the regulating characteristics were obtained and a comparative assessment of their efficiency was carried out. A comparative analysis of energy and design properties proves the significant advantage of a circuit using a Boost PWM constant voltage regulator.

HUVECs-derived exosomes increase neovascularization and decrease limb necrosis in hindlimb ischemia

Chronic limb-threatening ischemia (CLTI) is the most severe manifestation of peripheral arterial disease (PAD) and imposes a significantly high burden due to its high risk of mortality and amputation. Revascularization is the first-line treatment for CLTI; however, the amputation rate remains high, and approximately one-third of patients are not eligible for this treatment. Therefore, there is an urgent need for more effective therapeutic strategies. The aim of this study was to investigate the effects and mechanisms of human umbilical vein endothelial cells (HUVECs)-derived exosomes on neovascularization and the degree of necrosis in a hindlimb ischemia model and to study the biological processes underlying their mechanisms. This is an in vivo experimental study with a post-test-only control group design. Forty BALB/c mice were randomized to receive injections of exosomes, conditioned media, and phosphate-buffered saline (PBS) one day after unilateral double ligation. A sham-operated group was also included as a control. Capillary density, arteriole lumen diameter, and histopathological necrosis were measured after seven days, while clinical necrosis was observed daily. MicroRNA profiling, in silico analysis, and transcriptomic analysis of vascular endothelial growth factor (VEGF) mRNA expression were performed to determine the possible biological processes. No amputation was found in the exosome group, as well as in the conditioned media and sham-operated groups, compared to three out of seven mice (43%) in the PBS group. The capillary density was higher in the exosome than in the PBS group (p=0.026). The arteriole lumen diameter in the exosome group was larger than in the PBS (p=0.033) and sham-operated (p=0.034) groups. The scores of clinical necrosis and histopathological necrosis in the exosome group were lower than the PBS group (p=0.005), while the histopathological necrosis scores were also lower but statistically insignificant. In silico analysis showed improvement in neovascularization and necrosis, possibly through energy regulation, PI3K/AKT and TGF-β activation, the ubiquitin-proteasome system, and tyrosine kinases receptors. HUVEC exosomes were associated with lower VEGF mRNA expression, which may indicate a more effective compensatory mechanism under ischemic conditions. The exosome group had the lowest VEGF mRNA expression compared to other groups, although the difference was not statistically significant. This study highlights that HUVECs-derived exosomes improve neovascularization and decrease necrosis in a hindlimb ischemia mice model, potentially by modulating several possible mechanisms.

The Effect of Bio-Electromagnetic Energy Regulation Therapy on Erectile Dysfunction in Patients with Multiple Sclerosis: A Triple-Blind Randomized Clinical Trial

The Effect of Bio-Electromagnetic Energy Regulation Therapy on Erectile Dysfunction in Patients with Multiple Sclerosis: A Triple-Blind Randomized Clinical Trial

GRAF1 deficiency leads to defective brown adipose tissue differentiation and thermogenic response.

Adipose tissue, which is crucial for the regulation of energy within the body, contains both white and brown adipocytes. White adipose tissue (WAT) primarily stores energy, while brown adipose tissue (BAT) plays a critical role in energy dissipation as heat, offering potential for therapies aimed at enhancing metabolic health. Regulation of the RhoA/ROCK pathway is crucial for appropriate specification, differentiation and maturation of both white and brown adipocytes. However, our knowledge of how this pathway is controlled within specific adipose depots remains unclear, and to date a RhoA regulator that selectively controls adipocyte browning has not been identified. Our study shows that GRAF1, a RhoGAP, is highly expressed in metabolically active tissues, and closely correlates with brown adipocyte differentiation in culture and in vivo. Mice with either global or adipocyte-specific GRAF1 deficiency exhibit impaired BAT maturation and compromised cold-induced thermogenesis. Moreover, defects in differentiation of human GRAF1-deficient brown preadipocytes can be rescued by treatment with a Rho kinase inhibitor. Collectively, these studies indicate that GRAF1 can selectively induce brown adipocyte differentiation and suggest that manipulating GRAF1 activity may hold promise for the future treatment of diseases related to metabolic dysfunction.

A Coordinated Bidding Strategy of Wind Power Producers and DR Aggregators Using a Cooperative Game Approach

The purpose of this paper is to analyze the profitability of wind energy and demand response (DR) resources participating in the energy and frequency regulation markets. Since wind power producers (WPPs) must reduce their output to provide up-regulation and DR aggregators (DRAs) have to purchase additional power to facilitate down-regulation, this may result in revenue loss. If WPPs coordinate with DRAs, these two costs could be reduced. Thus, it would be profitable for WPPs and DRAs to form a coalition to participate in the regulation market. To better utilize the frequency response characteristics of wind and DR resources, this paper proposes a cooperation scheme to optimize the bidding strategy of the coalition. Furthermore, cooperative game theory methods, including Nucleolus- and Shapley-value-based models, are employed to fairly allocate additional benefits among WPPs and DRAs. The uncertainties associated with wind power and the behavior of DR customers are modeled through stochastic programming. In the optimization process, the decision-maker’s attitude toward risks is considered using conditional value at risk (CVaR). Case studies demonstrate that the proposed bidding strategy can improve the performance of the coalition and lead to higher benefits for both WPPs and DRAs. Specifically, the expected revenue of the coordinated strategies increased by 12.1% compared to that of uncoordinated strategies.

Why the Construction Trades Have a Valuable Role in Meeting the Climate Challenge

The construction industry accounts for 18 per cent of Canada’s greenhouse gas emissions. There is extensive evidence that this can be reduced significantly by implementing aggressive net zero building practices. However, the way the industry is organized impedes this achievement because it fails to promote the development of a broadly based, highly qualified, climate-literate workforce. Successful low carbon construction requires enhancement of workers’ knowledge, skills, and competencies because it requires much higher energy performance standards than traditional construction practice. Yet the industry remains wedded to the current system of low-bid, low-quality construction to cut costs. The organization of much construction work reflects a Taylorist approach, with extensive piecework and subcontracting that relies heavily on precarious, unskilled, and semi-skilled workers. Most employers avoid investing in trades training, leaving it to governments, unions, and individual workers to fund workforce development. Committed to a deregulated market with minimal government interference in their profit-making activities, many contractors oppose tougher building and energy regulations while lobbying against higher labour standards, occupational certification requirements, and union organizing. To meet their net zero targets, governments must recognize that market forces are inadequate to create the well-trained, highly skilled workforce needed. Major policy interventions are required to force industry to make the necessary changes in vocational education and training (vet) and employment practices – changes designed to upskill the construction workforce and give workers and unions a greater voice in shaping climate-informed building practice.

Optically Transparent Complex-Amplitude Metasurface for Full-Space Manipulation of Frequency-Multiplexed Holographic Imaging.

Restricted by the physical properties of materials, most traditional metasurfaces (MSs) cannot achieve transparent stealth in the visible spectrum. Although some metasurfaces for holography have been designed, there is no standard method for evaluating the advancement of wavefront manipulation under different design algorithms. Here, a complex-amplitude metasurface with optical transparency (OT) and full-space manipulation is presented in the millimeterwave band. Through frequency multiplexing, two holographic images "HOLO" and "GRAM" with high quality are designed, achieving the signal-to-noise ratios of 14.6 and 14.4 dB, respectively. The 64 × 64 bilayered metasurface consists of glass and poly(ethylene terephthalate) (PET) substrates and three metallic mesh layers. By change of the opening size and oriented angle of split rings, phase and amplitude modulations are independently realized. Besides, a new method is provided to assess the superiority of the metasurface holography system for near-field energy regulation. The prototype was fabricated using micro-nano-technology and tested. Two holographic images were experimentally demonstrated and show good agreement with theoretical calculations and simulated results. With the advantages of OT and full-space complex-amplitude customization, the proposed metasurface holograms for frequency-multiplexed may find prospective application aspects in target perception, multichannel data storage and encryption, and many other related fields.

BS O02 - Impact of Bariatric surgery on Obesity Indices and Reproductive Hormones: A Prospective Study in Morbidly Obese Women

Abstract Background Obesity, defined by a BMI of 30 kg/m² or higher, is influenced by genetics, socio-economic, and cultural factors. Genetic predispositions affect metabolism and energy regulation, while environmental factors like sedentary lifestyles and poor food environments worsen obesity. Obesity disrupts hormonal balances, impacting sex hormone levels and menstrual cycles, leading to infertility in women. This hormonal imbalance affects oocyte quality and ovulation. Bariatric surgery offers significant weight loss and metabolic improvements, enhancing reproductive hormone profiles and insulin sensitivity. Our study explores how sleeve gastrectomy affects BMI and hormone levels, aiming to understand its impact on obesity management and reproductive health. Method This prospective observational study examines the effects of laparoscopic sleeve gastrectomy on reproductive hormones and ovarian function in 32 morbidly obese women, adhering to Helsinki Declaration ethics. Participants, aged 18-50 with no menopause or chronic illness, consented to the study. Exclusions included those with polycystic ovary syndrome, recent reproductive organ surgery, or recent infertility medications. The study assessed changes in BMI, antral follicles, anti-Müllerian hormone, and reproductive hormones before surgery and at 6 and 12 months post-surgery. Blood samples and transvaginal ultrasounds were conducted preoperatively and at 6 and 12 months postoperatively to monitor outcomes. Results The study involved participants with an average age of 33 and a mean BMI of 42.12. Significant changes were observed post-sleeve gastrectomy at 6 and 12 months (p < 0.001). At 6 months, BMI decreased by 9.24 units, AMH levels dropped from 3 to 2.5 ng/mL, and antral follicle counts in both ovaries declined. By 12 months, BMI decreased by 16.47 units, AMH levels fell to 2 ng/mL, and antral follicle counts further reduced. Hormonal changes included increases in FSH, LH, and estradiol, while SHBG levels rose, and free testosterone levels decreased significantly. Conclusion Individual hormone responses to weight loss and surgery necessitate personalized obesity treatments. Tailoring surgical approaches and care to hormonal profiles can optimize outcomes and reduce complications. Monitoring AMH levels post-surgery can offer insights into reproductive effects, aiding clinical management and counseling for women with obesity-related infertility. We highlight the significant impact of sleeve gastrectomy on physiological parameters in obese individuals, especially regarding reproductive health and metabolic regulation. The findings enhance understanding of the changes associated with bariatric surgery and its potential benefits for metabolic and reproductive health.

In vivo detection of spectral reflectance changes associated with regulated heat dissipation mechanisms complements fluorescence quantum efficiency in early stress diagnosis.

Early stress detection of crops requires a thorough understanding of the signals showing the very first symptoms of the alterations in the photosynthetic light reactions. Detection of the activation of the regulated heat dissipation mechanism is crucial to complement passively induced fluorescence to resolve ambuiguities in energy partitioning. Using leaf spectroscopy, we evaluated the capability of pigment spectral unmixing to calculate the fluorescence quantum efficiency (FQE) and simultaneously retrieve fast absorption changes in a drought and nitrogen deficiency experiment with tomato. In addition, active fluorescence measurements and pigment analyses of xanthophylls, carotenes and chlorophylls were conducted. We observed notable responses in noninvasive proximal sensing-retrieved FQE values under stress, but as expected, these alone were not enough to identify the constraints in photosynthetic efficiency. Reflectance-based detection of the 535-nm peak absorption change was able to complement FQE and indicate the activation of regulated heat dissipation for both stress treatments under growing light conditions. However, further complexity in the light harvesting energy regulation needs to be accounted for when considering additional light stress. Our results underscore the potential of complementary in vivo quantitative spectroscopy-based products in the early and nondestructive stress diagnosis of plants, marking the path for further applications.

Metabolism and Clinical Significance of Triglycerides

Triglycerides, the principal form of fat storage in animals and humans, are essential in view of their roles in energy metabolism and regulation. Indeed, they have been ascribed very vital functional significance in a plethora of physiological processes, which extends to energy storage, metabolic signaling, and disease pathology. Biochemistry and metabolism of triglycerides is a multivaried area of science that includes different mechanisms that control synthesis, storage, and utilization in organisms. For many years, the issue of triglycerides and their relationship to cardiovascular disease (CVD) has been one of the central themes of research. Elevated triglyceride levels frequently associate with an elevated cardiovascular risk, but the situation is complex and multifaceted at all. It has now been reported that triglycerides could act not only as a biomarker regarding cardiovascular risk but also play an actual part in the fostering of cardiovascular disorders. The present literature review juxtaposes key findings on triglyceride metabolism, thereby underlining implications for health and disease, with the end to identify works currently associating triglyceride implications in cardiovascular health, and further to explore determinants of triglyceride levels gap that warrant further investigation.

Design and application of a novel Improved Fire Hawk Optimization technique-tuned ANFIS for optimal regulation of energy of a composite microgrid system

Design and application of a novel Improved Fire Hawk Optimization technique-tuned ANFIS for optimal regulation of energy of a composite microgrid system

Enhanced thermal performance of phase change mortar using multi-scale carbon-based materials

Incorporating phase change material (PCM) into construction materials is an effective method for modifying building energy regulations throughout their service life. However, the effectiveness of PCM is constrained by its low thermal conductivity, highlighting the need for efficient enhancement methods. This study introduces thermally conductive carbon-based additions at both the nano-scale and meso-scale with different shapes, including carbon nano-tube (CNT), carbon black nano-particle (CB), and carbon fibre (CF) in PCM mortar. The mixed hydrated inorganic salt serves as the core PCM, while expanded perlite acts as the supporting material for the stable PCM composite, based on the presented research. The multi-scale additions establish thermal conduction pathways that improve temperature regulation performance. The modified samples exhibited a temperature difference of 2.2 °C and a time lag of up to 20 min under natural cooling conditions. Notably, CB positively influenced thermal conductivity, while CNT demonstrated an unexpected minor reduction. The enhancement in thermal conductivity increased with the content of CB, reaching an optimal enhancement of 18 %, except at a CNT content of 0.5 %. Conversely, both CB and CNT consistently improved thermal diffusivity. Furthermore, the compressive strength of the modified samples was significantly enhanced by up to 24 % compared to PCM mortar without carbon modifications. The modification method proposed in this study significantly improves both the thermal and mechanical properties of PCM mortar.

Snake Venom in Anticancer Drug Development: Potential Targets and Current Perspectives

Many animals active secretions have been used to create novel medications to treat ailments such as hypertension and cancer. Snake venom toxins have made major contributions to treating various medical disorders. There have been several research studies that have been published characterizing and clarifying snake venom's anti-cancer potential. Cancer treatment is one of the primary applications for protein peptides and enzymes derived from various animal species. When separated, several of these proteins, peptides, and enzymes from snake venom and assessed may bind selectively to cancer cell membranes, influencing migration and invasion. These cells proliferation Some of the chemicals discovered in snake venom have a high potential. Cystatin-rich snake venom influences tumor invasion and metastasis. A non-cholinesterase Arginine ester hydrolase enzyme in snake venom reported to have increased sensitivity to chemotherapy and radiotherapy in animal models. Snake thrombin-like enzymes, are serine proteases found in snake venom that causes haemostasis and hypofibrinogenemia. Cancer-associated fibroblasts was reported to have role in quiescence and also prevents cancer cell migration, in addition to downregulating the epithelial-mesenchymal transitioning. Collagen Tumor-associated hyaluronic acid (HA) and hyaluronidase (HAase) was crucial for tumor growth and metastasis promotion. Phospholipases are enzymes that break down phospholipids, which are key components of cell membranes are involved in cancer cell migration, invasion and metastasis. AMP-activated protein kinase (AMPK), a metabolic protein plays a crucial role in energy regulation and cell survival and studies reported its role in tumour suppression. The components of snake venom and its potential as a cancer-fighting agent, we summarised the key findings in this review.

GC-MS uncovers unique metabolic markers of drug-resistant epilepsy in capillary but not venous dried blood spots

This study compared the effectiveness of capillary dried blood spots (DBS) versus venous DBS in detecting metabolic changes related to drug-resistant epilepsy (DRE). DBS samples were collected from 142 epilepsy patients (58 drug-resistant, 84 drug-responsive) via venipuncture or fingerstick capillary sampling. Metabolomic analysis using gas chromatography-mass spectrometry compared DBS metabolite profiles between the two groups. While venous DBS profiles showed no distinct patterns, capillary DBS profiles revealed clustering patterns in principal components analysis, with the first two principal components explaining 14.5 %, and 13.5 % of the total variance, respectively. Orthogonal PLS-DA confirmed group discrimination (R2Y=0.989, Q2=0.742). Drug-resistant patients exhibited elevated capillary DBS levels of glutamine, pyruvic acid, and serine, and decreased palmitic acid compared to drug-responsive patients. Pathway analysis revealed disruptions in amino acid metabolism, neurotransmission, and cellular energy regulation. Elevated glutamine levels may contribute to an imbalance between excitatory glutamate and inhibitory GABA neurotransmission, key factors in epileptogenesis and drug resistance. Capillary DBS, likely enriched with arterial blood supply to the brain, appears to better capture central nervous system metabolic disturbances compared to venous DBS containing systemic contributions. This minimally invasive capillary DBS approach offers effective metabolic profiling of brain conditions like DRE, for monitoring disease progression and treatment response, enhancing personalized patient management in epilepsy.

Assessment of heating degree-days factor (HDDF) for building-oriented climate zoning in Türkiye

ABSTRACT In this study, a novel heating degree-days factor (HDDF) is proposed to determine the optimum facade design for buildings in Türkiye as a function of both cooling degree-days (CDD) and heating degree-days (HDD) data. For this purpose, the HDDF (HDD/(HDD+CDD)) is defined as the ratio of the heating degree-days of a region to the total heating and cooling degree-days. Firstly, the HDDF values of all provinces in Türkiye are calculated by using meteorological data from 81 meteorological stations covering the period 1991–2022, and HDDF performance is evaluated. Then, the building-oriented climate zoning is realized based on the HDDF values. Moreover, historical trends of monthly and yearly average HDD, CDD, and HDDF values are revealed and yearly HDD, CDD, and HDDF maps were created using the ArcGIS program. According to the results, HDDF values in Türkiye varied between 0.4519 and 0.9998, and HDDF values between 0.9 ≤ HDDF ≤ 1 cover 46 out of 81 cities in the country and span a broad area across the country. The findings suggest that if global warming continues at the current rate, cooling energy demand in the residential sector will dramatically increase in the future, while heating energy demand will fall in Türkiye. This indicates that domestic energy consumption regulations would require modification. The building-oriented climate zoning resulting from this study is unique to Türkiye and can aid engineers, architects, and policymakers in building energy efficiency programs, studies, regulations, and standards.