Regular Moderate-intensity Physical Activity Research Articles

Effect of a 12-Week Walking Program Monitored by Global Physical Capacity Score (GPCS) on Circulating Cell-Free mtDNA and DNase Activity in Patients with Irritable Bowel Syndrome.

Irritable bowel syndrome (IBS) involves low-grade mucosal inflammation. Among the various approaches capable of managing the symptoms, physical activity is still under investigation. Despite its benefits, it promotes oxidative stress and inflammation. Mitochondria impacts gut disorders by releasing damage-associated molecular patterns, such as cell-free mtDNA (cf-mtDNA), which support inflammation. This study evaluated the effects of a 12-week walking program on the cf-mtDNA and DNase in 26 IBS and 17 non-IBS subjects. Pro- and anti-inflammatory cytokines were evaluated by ELISA. Digital droplet PCR was used to quantify cf-mtDNA; DNase activity was assessed using a single radial enzyme diffusion assay. PCR-RFLP was used to genotype DNASE1 rs1053874 SNP. Significantly lower IL-10 levels were found in IBS than in non-IBS individuals. Exercise reduced cf-mtDNA in non-IBS subjects but not in IBS patients. DNase activity did not correlate with the cf-mtDNA levels in IBS patients post-exercise, indicating imbalanced cf-mtDNA clearance. Different rs1053874 SNP frequencies were not found between groups. The study confirms the positive effects of regular moderate-intensity physical activity in healthy subjects and its role in cf-mtDNA release and clearance. Walking alone might not sufficiently reduce subclinical inflammation in IBS, based on imbalanced pro- and anti-inflammatory molecules. Prolonged programs are necessary to investigate their effects on inflammatory markers in IBS.

Özellikli Çocuk Gruplarıyla Doğa Etkinlikleri

Spending more time outdoors improves children's social and cognitive development, physical activity, and vision. Regular moderate-intensity physical activity is linked to many health benefits, including a reduced risk of high blood pressure, obesity, heart disease, stroke, cancer, and depression. Besides physical health indicators, physical activity has also been associated with higher academic and cognitive performance, and higher self-esteem. Since children's outdoor activities are primarily in public areas, there is a need for improvement studies to make these areas suitable for all children, including special child groups, and to supervise them. There are some special preparations and points to be considered during the activity when nature activities are desired to be held with child groups with chronic diseases such as epilepsy, diabetes, asthma, autism, or with atopic structure. With this review, we wanted to share some of the information needed to ensure that nature activities start and end happily with both special and healthy child groups.

Should cardiac rehabilitation programmes be specifically targeting sedentary time?

Abstract Funding Acknowledgements Type of funding sources: None. Background / Introduction Structured exercise classes and advice regarding regular moderate intensity physical activity are well-established components of cardiac rehabilitation (CR). Sedentary behaviour, refers to activities typically sitting or lying that do not substantially increase energy expenditure above resting, and increasing evidence suggests adults should limit their sedentary time to less than 9 hours/day as such behaviour with increased cardiovascular and all-cause mortality with additional benefits likely gained sitting less than 6-8 hours/day. Nonetheless sedentary behaviours are often overlooked or are only partially assessed via self-report in CR programmes. Due to covid restrictions (lockdown, social distancing, suspension of face-to-face CR programmes) there is concern that sedentary time may further increase in this population. Thus, it may be important to effectively monitor and target sedentary time, alongside traditional advice, to minimise its negative health impacts. Purpose Can a CR programme, adapted to remote delivery due to covid, objectively measure sedentary behaviour in a way that is feasible in every day practice and acceptable to patients? Methods Consecutive cardiovascular patients attending an initial assessment (via telephone or video) on the Our Hearts Our Minds Programme for Cardiovascular Health between December 2020 and February 2021 were asked to wear activPAL (PAL technologies Ltd., Glasgow, UK), a triaxial accelerometer, on their thigh for 7 days to measure the postural aspect of sedentary behaviour. On return of the monitor, the data was analysed using proprietary algorithms (intelligent activity classification) generating a report summarising time spent sitting, prolonged sitting, step count average, number of sit to stand transitions, moderate intensity activity minutes, most sedentary time(s) of the day and percentages spent in these activities. This personalised report was shared with the patient and their goals in terms of sedentary behaviour and physical activity were discussed and agreed. Results 59 referrals were received between mid December 2020 and February 2021, of which 52 had an initial virtual assessment. Of these, 50 patients accepted an activPAL (96% response rate). Mean age 62.6 years. The output from the activPal is shown in table 1. The average sitting time overall was 9 hours 36 minutes. The breakdown in proportions sitting for extended periods of time are detailed in table below Conclusion 2/3 of cardiovascular patients attending CR had levels of sitting time greater than what is recommended following their IA. Measuring sedentary time beyond self-report in CR programmes using activPal was feasible in a CR programme with 96% of consecutive patients wearing and returning activPAL. Repeat analysis at end of programme will show if use of this data results in reduction of same .

First-generation Ethiopian immigrants and beliefs about physical activity

PurposeWhile several studies have examined the attitudes, perceptions and beliefs of physical activity in different immigrant groups, little is known in this area among the first-generation Ethiopian immigrant population who lives in the USA. The purpose of this paper is to explore the behavioral, normative and control beliefs of physical activity among first-generation Ethiopian immigrants living in the DC-Metro area.Design/methodology/approachThe study used semi-structured interviews, focus group discussions and unobtrusive observation. Three structural themes and six textural themes were identified from the three forms of data collections. Qualitative data analysis including topics, categories and pattern analysis were conducted using phenomenological techniques.FindingsFindings highlighted similarities to the theory of planned behavior with regard to attitudes, subjective norms and perceived behavioral control. Consistent with the literature, several salient behavioral determinants of physical activity that could affect participants’ decision-making were identified in the current pilot study. Increased longevity, mental well-being, improved sleep and improved metabolism were listed as the most common benefits of physical activity. Lack of time, family responsibility, neighborhood safety, location of the gym, lack of awareness and social and economic stressors were the major barriers to engage in physical activity. Implications for service providers and future research are discussed.Practical implicationsThis study supported the need for future research into the social aspects of physical activity, as well as barriers to physical activity, including time, family responsibility, culture, income and neighborhood safety.Originality/valueTo the best of the authors’ knowledge, this is the first study exploring the behavioral, normative and control beliefs of physical activity among first-generation Ethiopian immigrants. To understand the beliefs, desires and barriers to physical activity in this population subgroup, the authors examined the behavioral, normative and control beliefs of regular moderate-intensity physical activity using the theory of planned behavior as a conceptual framework. As health education researchers, it is their responsibility to develop theory-driven policies and interventions to promote a healthy lifestyle among these underserved populations.

The importance of physical activity in the regulation of anti-viral immunity

The paper reviews the current data on the effect and role of varying intensity physical activity in the prevention of various respiratory virus infections, including influenza virus and SARS-CoV-2 coronavirus. The paper discusses the effect of varying intensity physical activity on antiviral immunity, cellular and cytokine responses to respiratory virus infections, physical activity influence on vaccination effectiveness and the role of regular moderate intensity physical activity in the prevention of viral infection in patients with obesity, overweight, diabetes and other metabolic disorders. The paper analyzes physical activity role in the prevention of SARS-CoV-2 infection, as well as in the conditions of self-isolation and quarantine.

How Sickle Cell Disease Impairs Skeletal Muscle Function: Implications in Daily Life.

Sickle cell disease (SCD) is the most frequent life-threatening genetic hemoglobinopathy in the world and occurs due to the synthesis of abnormal hemoglobin S (HbS). hemoglobin S-containing red blood cells (RBC) are fragile, leading to hemolysis and anemia, and adhere to the endothelium, leading to hemorheological and hemodynamical disturbances. In its deoxygenated form, HbS may polymerize, leading to sickling of red blood cells and potentially to vasoocclusive crises. Recent findings observed that SCD patients demonstrate significant skeletal muscle remodeling and display reduced muscle functional capacities, contributing to exercise intolerance and poor quality of life. Although acute high-intensity exercise is not recommended for SCD patients because it may increase the risk of sickling, regular moderate-intensity physical activity could have beneficial effects on skeletal muscle and more generally on the well-being of SCD patients. This article reviews the literature regarding the impact of the disease on muscular tissue characteristics and function, as well as the corresponding implications for SCD patients' quality of life.

Cardiometabolic risks, lifestyle health behaviors and heart disease in Filipino Americans.

Cardiovascular disease is the leading cause of death among all racial and ethnic populations in the USA. Cardiovascular risks and cardioprotective factors have been disparately estimated among Asian American subpopulations. The study's purpose was to describe the cardiometabolic risks and lifestyle health behaviors associated with cardiovascular disease, considering age and gender, in Filipinos, the second largest Asian American population. Secondary analysis was conducted of behavioral (smoking, walking, body mass index and soda, fast food and fruit/vegetable consumption), cardiometabolic (hypertension and diabetes) and heart disease variables in the 2011-2012 California Health Interview Survey. The metropolitan sample of Filipino American adults included 57.3% women and had a mean age of 47.9 ± 18.3 years ( n = 555). Among the sample, 7.4% had heart disease, 38.9% had hypertension, 16.6% had diabetes, 12.4% smoked cigarettes, 83.2% were insufficiently active, 54.2% were overweight/obese, 21.8% routinely ate fast food, 13.2% routinely drank soda and 90.3% did not meet the fruit/vegetable consumption recommendation. Age (unadjusted odds ratio [OR] = 1.0, p < 0.0001), hypertension (unadjusted OR = 4.8, p < 0.0001) and diabetes (unadjusted OR = 3.3, p = 0.001) were associated with heart disease. Hypertension was the single greatest heart disease risk, controlling for diabetes, age and gender (adjusted OR = 3.1, p = 0.006). Primary and secondary prevention and treatment of hypertension should be paramount, along with promotion of glucose control, regular moderate-intensity physical activity, weight management and increased fruit and vegetable consumption in the Filipino American population. A multidisciplinary, chronic care model that is population-specific, emphasizes integrated, comprehensive care and provides linkages between primary healthcare and community resources is recommended for practice.

Telomere Length in Elite Athletes.

The authors investigated LTL differences between young elite athletes (n = 61, 54% men, age [mean ± SD] 27.2 ± 4.9 y) and healthy nonsmoker, physically inactive controls (n = 64, 52% men, 28.9 ± 6.3 y) using analysis of variance (ANOVA). Elite athletes had, on average, higher LTL than control subjects, 0.89 ± 0.26 vs 0.78 ± 0.31, P = .013 for the group effect, with no significant sex (P = .995) or age effect (P = .114). The results suggest that young elite athletes have longer telomeres than their inactive peers. Further research might assess the LTL of elite athletes of varying ages compared with both age-matched active and inactive individuals.

Physical activity and sedentary behavior in Belgium (BNFCS2014): design, methods and expected outcomes.

BackgroundThere is strong evidence to indicate that regular moderate intensity physical activity is associated with health benefits. Furthermore, sedentary behavior has been related with an increased risk for all-cause mortality. The accurate measurement of physical activity and sedentary behavior is therefore vital to evaluate their health impact and provide evidence for the development of public health recommendations. This paper describes the methodology used for assessing physical activity and sedentary behavior in the Belgian population in the context of the Belgian National Food Consumption Survey 2014 (BNFCS2014).ResultsData about physical activity and sedentary behavior were collected as part of the cross-sectional BNFCS2014 between February 2014 and May 2015. A nationally-representative sample of children (3–9 years) and adolescents (10–17 years) were asked to wear an accelerometer (Actigraph® GT3X) during their waking hours for 7 consecutive days. Data were recorded in 15-second epochs and respondents with at least 2 valid week days (i.e., 10 h of wear-time) and 1 valid week-end day (i.e., 8 h of wear-time) were retained for the analyses. The Evenson cut points were used to assess the time spent in each physical activity intensity level: sedentary, low, moderate and vigorous. Complementary, diaries were provided to register the activities performed when the accelerometer was removed; these activities were added to the measures provided by the accelerometers. In addition, age-specific self-reported questionnaires (ToyBox and FPAQ) were completed to provide contextual information about the type of activities performed. Due to financial constraints, physical activity in adults (18–64 years) was assessed and described through the self-reported International Physical Activity Questionnaire (IPAQ long version) only.ConclusionData were collected in the context of the BNFCS2014 to provide a comprehensive picture of the physical activity and sedentary behavior in the Belgian population, with a special focus on children (3–9 years) and adolescents (10–17 years). Levels of physical activity and sedentary behavior can be compared to international guidelines and analyzed according to several background variables, such as age, gender, Body Mass Index, education level and region. Such results are aimed to underpin future policies in the field of physical activity.

The effects of oral hydrolytic enzymes and flavonoids on inflammatory markers and coagulation after marathon running: study protocol for a randomized, double-blind, placebo-controlled trial

BackgroundRegular moderate intensity physical activity positively influences the immune system with a lower incidence of upper respiratory tract infections (URTI) and lower levels of pro-inflammatory markers. However, marathon running due to its strenuous and prolonged nature results in immune perturbations with a major increase in pro-inflammatory markers and subsequent increased incidence of URTI. Furthermore, marathon running results in muscle damage and changes in hemostasis that promote a pro-thrombotic state.Naturally occurring hydrolytic enzymes and flavonoids have antioxidant, anti-inflammatory and fibrinolytic effects, and may serve as countermeasures to exercise-induced inflammation, immune dysfunction and URTI.The aim of this study is to determine whether the ingestion of oral hydrolytic enzymes and flavonoids before and after a marathon attenuates post-race muscle damage and inflammation, counters pro-thrombotic changes in hemostasis and decreases URTI incidence.Methods/designThe Enzy-MagIC-study ( Enzy mes, Ma rathon runnin G , I nflammation, C oagulation) is a randomized, double-blind, placebo-controlled, monocenter phase I trial. 160 healthy males (age 20-65 years) will be randomized to receive either placebo or treatment (Wobenzym, MUCOS Pharma, Berlin, Germany) which contains the hydrolytic enzymes (bromelain, trypsin) and the flavonoid rutoside. One week before the marathon race, participants will begin daily ingestion of the investigational product (3×4 tablets). Intake will be continued for two weeks after the race (3×2 tablets per day). Clinical and laboratory measures will be collected 5-weeks and 1-week before the race, and immediately-, 24-h, 72-h, and 2 weeks after the race. The primary endpoint is the influence of the treatment on the pre-to-post marathon race plasma concentration change of the inflammatory marker interleukin-6 (IL-6). Secondary endpoints include the effect of treatment on salivary IgA concentration and the frequency of upper respiratory tract infections (URTI) for two weeks post-marathon as determined by the Wisconsin Upper Respiratory Symptom Survey (WURSS-24). Furthermore, changes of muscular and rheological parameters will be measured before and after the marathon race.DiscussionWe hypothesize that marathon-induced inflammatory perturbations and the incidence of subsequent URTI, muscular damage, and changes of hemostasis can be positively influenced by the anti-edematous, anti-inflammatory, antioxidant, and fibrinolytic effects of oral hydrolytic enzymes and flavonoids (Wobenzym).Trial registrationClinicalTrials.gov Identifier: NCT01916408

Predictors of Physical Inactivity Among Elderly Malaysians

Physical inactivity is the fourth leading risk factor for global mortality. Regular moderate-intensity physical activity has significant benefits for health. To determine the socioeconomic predictors of physical inactivity among elderly Malaysian population. A nationwide community-based survey was conducted among 4831 respondents aged ≥60 years with a face-to-face questionnaire. The prevalence of physical inactivity among the elderly was 88.0%, highest in respondents aged older than 80 years (95.4%), females (90.1%), other Bumiputra (92.2%), earning household income less than RM1000 (87.9%), and residing in urban locality (88.4%). In the multivariate model, the predictors of physical inactivity were only sex, ethnicity, locality, and age group (adjusted odds ratio = 1.3-3.6). The predictors of physical inactivity can identify the risk factors to develop policies that will reduce the public health burden of noncommunicable diseases.

121 TELOMERE ATTRITION IS ATTENUATED IN ULTRA-MARATHON RUNNERS

Background: Leukocyte telomere length is a marker of biological ageing and its shortening is associated with cardiovascular disease. Engagement in regular moderate-intensity physical activity is a recognised method of cardiovascular disease prevention. However, it is not clear whether repeated exposure to ultra-strenuous physical exercise is beneficial long-term and whether it may attenuate biological ageing. Methods: We compared leukocyte telomere length in context of inflammation and endothelial dysfunction between 67 male ultra-marathon runners and 67 age-, sex- and BMI-matched apparently healthy controls. Genomic DNA was extracted from peripheral blood and leukocyte telomere length was measured by quantitative polymerase chain reaction assays. Adhesion molecules (sICAM-1, sE-selectin) and inflammatory markers (IL-6, C-reactive protein) concentrations were measured in 67 ultra-marathon runners by quantitative sandwich enzyme immunoassay technique, high-sensitive immunoassay and ultra-sensitive double antibody sandwich ELISA, respectively. Results: Adjusted (for age, BMI, blood pressure and lipids) leukocyte telomere length was approximately 13.8% greater in the ultra-marathon runners than in the controls (P<0.001). This translates into approximately 32.9 years difference in age-related telomere length attrition. There was a strong negative linear correlation between sICAM-1 and leukocyte telomere length in the ultra-marathon runners (r=-0.33; P=0.007) and this association retained its statistical significance after adjustment for age, BMI, blood pressure and lipids in multiple regression (P=0.026). Conclusion: Prolonged, intense physical exercise may attenuate cellular ageing possibly through a protective effect on endothelial function.

Antenatal physical activity: Investigating the effects on postpartum depression

Engaging in regular moderate-intensity physical activity has been demonstrated as a successful treatment modality for both major and minor depression and as effective as pharmacologic treatments. However, less is known about the use of antenatal physical activity as a preventive modality for depression during the perinatal period. The objective of the present study was to determine if there is an association between antenatal physical activity and PPD. A cross-sectional study using the 2007-2008 Pregnancy Risk Assessment Monitoring System (PRAMS) data from Colorado and North Carolina (N = 6026) was conducted. PRAMS self-reported data are from a large randomized sample collected by the CDC that assesses maternal demographic, socio-economic, and prepregnancy and perinatal behaviors. Multivariable logistic regression was used to examine the relationship between antenatal sedentary behavior and PPD. Upon adjusting for maternal age, education, race, marital status, parity, stress, smoking, drinking, and prenatal care utilization, women who did not engage in antenatal physical activity were 1.34 times more likely to screen positive for PPD than women who exercised 5 or more days per week [OR 1.34; 95% CI: (1.04, 1.74); p = 0.03]. These findings suggest that not engaging in antenatal exercise may be associated with an increase risk of PPD. Further research is warranted to better understand the effects of antenatal sedentary behavior on PPD and the potential use of physical activity as a preventive modality for PPD.

Physical activity mass media campaigns and their evaluation: a systematic review of the literature 2003-2010

Internationally, mass media campaigns to promote regular moderate-intensity physical activity have increased recently. Evidence of mass media campaign effectiveness exists in other health areas, however the evidence for physical activity is limited. The purpose was to systematically review the literature on physical activity mass media campaigns, 2003-2010. A focus was on reviewing evaluation designs, theory used, formative evaluation, campaign effects and outcomes. Literature was searched resulting in 18 individual adult mass media campaigns, mostly in high-income regions and two in middle-income regions. Designs included: quasi experimental (n = 5); non experimental (n = 12); a mixed methods design (n = 1). One half used formative research. Awareness levels ranged from 17 to 95%. Seven campaigns reported significant increases in physical activity levels. The review found that beyond awareness raising, changes in other outcomes were measured, assessed but reported in varying ways. It highlighted improvements in evaluation, although limited evidence of campaign effects remain. It provides an update on the evaluation methodologies used in the adult literature. We recommend optimal evaluation design should include: (1) formative research to inform theories/frameworks, campaign content and evaluation design; (2) cohort study design with multiple data collection points; (3) sufficient duration; (4) use of validated measures; (5) sufficient evaluation resources.

Evidence-based policy and practice of physical activity in Australia: Awareness and attitudes of attendees at a national physical activity conference (the PAPPA study)

evidence that regular moderate-intensity physical activity confers substantial health benefits has been available for more than a decade. Recent studies suggest that the availability of evidence is in itself insufficient for the development of evidence-based public policy and that comprehensive translation mechanisms are needed. This paper explores the current sources of information about effective interventions among physical activity professionals, their awareness and uptake of evidence reviews, their use of the national physical activity network AusPANet and their beliefs about evidence-based policy and practice in physical activity. this Physical Activity Policy and Practice in Australia (PAPPA) study reports data from a survey of 115 key physical activity professionals attending the Sixth National Physical Activity Conference in Adelaide, Australia, October 2007. Respondents answered questions about awareness and use of evidence sources and about their beliefs regarding policy and practice in physical activity. only 37% of respondents could accurately identify the main policy messages on 'physical activity and health' as defined in the seminal US Surgeon General's report; 48% reported using the current 'Be Active Australia' national strategic framework on more than two occasions; and just over 35% reported using the most recent national evidence synthesis 'Getting Australia Active II'. the study identifies gaps in knowledge about physical activity and health, gaps in understanding contemporary policy and gaps in translation strategies. Notwithstanding the possible limitations of evidence reviews and syntheses as a determinant of policy and practice, it is apparent that the dissemination of physical activity guidelines and evidence summaries has been less than optimal in Australia.

Evidence based policy and practice of physical activity in Australia: Awareness and attitudes of attendees of a national physical activity conference (the PAPPA study)

Issue addressed: Evidence that regular moderate-intensity physical activity confers substantial health benefits has been available for more than a decade. Recent studies suggest that the availability of evidence is in itself insufficient for the development of evidence-based public policy and that comprehensive translation mechanisms are needed. This paper explores the current sources of information about effective interventions among physical activity professionals, their awareness and uptake of evidence reviews, their use of the national physical activity network AusPANet and their beliefs about evidence-based policy and practice in physical activity. Methods: This Physical Activity Policy and Practice in Australia (PAPPA) study reports data from a survey of 115 key physical activity professionals attending the Sixth National Physical Activity Conference in Adelaide, Australia, October 2007. Respondents answered questions about awareness and use of evidence sources and about their beliefs regarding policy and practice in physical activity. Results: Only 37% of respondents could accurately identify the main policy messages on 'physical activity and health' as defined in the seminal US Surgeon General's report; 48% reported using the current 'Be Active Australia' national strategic framework on more than two occasions; and just over 35% reported using the most recent national evidence synthesis 'Getting Australia Active II'. Conclusions: The study identifies gaps in knowledge about physical activity and health, gaps in understanding contemporary policy and gaps in translation strategies. Notwithstanding the possible limitations of evidence reviews and syntheses as a determinant of policy and practice, it is apparent that the dissemination of physical activity guidelines and evidence summaries has been less than optimal in Australia.

Endurance exercise and DNA stability: Is there a link to duration and intensity?

It is commonly accepted that regular moderate intensity physical activity reduces the risk of developing many diseases. Counter intuitively, however, evidence also exists for oxidative stress resulting from acute and strenuous exercise. Enhanced formation of reactive oxygen and nitrogen species may lead to oxidatively modified lipids, proteins and nucleic acids and possibly disease. Currently, only a few studies have investigated the influence of exercise on DNA stability and damage with conflicting results, small study groups and the use of different sample matrices or methods and result units. This is the first review to address the effect of exercise of various intensities and durations on DNA stability, focusing on human population studies. Furthermore, this article describes the principles and limitations of commonly used methods for the assessment of oxidatively modified DNA and DNA stability. This review is structured according to the type of exercise conducted (field or laboratory based) and the intensity performed (i.e. competitive ultra/endurance exercise or maximal tests until exhaustion). The findings presented here suggest that competitive ultra-endurance exercise (>4h) does not induce persistent DNA damage. However, when considering the effects of endurance exercise (<4h), no clear conclusions could be drawn. Laboratory studies have shown equivocal results (increased or no oxidative stress) after endurance or exhaustive exercise. To clarify which components of exercise participation (i.e. duration, intensity and training status of subjects) have an impact on DNA stability and damage, additional carefully designed studies combining the measurement of DNA damage, gene expression and DNA repair mechanisms before, during and after exercise of differing intensities and durations are required.

Acute moderate-intensity exercise in middle-aged men has neither an anti- nor proinflammatory effect

Strenuous exercise induces an initial pro- and subsequent anti-inflammatory response, and it has been suggested that this may be one of the ways that regular exercise reduces chronic inflammation and therefore the risk of cardiovascular disease. However, public health recommendations emphasize moderate-intensity physical activity, and it is important to understand whether moderate-intensity exercise has a similar anti-inflammatory effect. Twelve sedentary male volunteers (age 54 +/- 4 yr) completed two main trials, moderate-intensity exercise and rest (30 min at 50% maximal oxygen uptake vs. sitting, respectively). There were no significant changes in circulating neutrophils, lymphocytes, monocytes, or serum interleukin-6, interleukin-10, and C-reactive protein concentration over the 7 days following exercise. Similarly, lymphocyte adhesion to cultured endothelial cells and heme oxygenase-1 (HO-1) expression in lymphocytes and monocytes were not affected by walking at any time point. These results suggest that the long-term anti-inflammatory and antiatherogenic effects of regular moderate-intensity physical activity must be explained by something other than a profound net anti-inflammatory response to each exercise bout since a single bout of walking did not lead to a change in various markers of inflammation or lymphocyte adherence to cultured endothelial cells.

A Single Bout Of Moderate Intensity Exercise Has Neither A Pro- Nor Anti-inflammatory Effect

The long-term anti-inflammatory and anti-atherogenic effects of regular physical activity may be due to the transient responses elicited by each bout of exercise. PURPOSE: To determine whether a 30-min walk at a moderate intensity induces a pro- or anti- inflammatory response and alters lymphocyte adhesion. METHODS: Twelve inactive male volunteers (age 54 ± 4 y, body mass 87 ± 9 kg, VO2 max 34.4 ± 3.9 ml.kg-1.min-1) completed two main trials, one exercise (30 min at 50% VO2 max) and one rest (30 min quiet sitting), separated by at least seven days. A baseline venous blood sample was collected prior to exercise or rest and then immediately post-trial (0 h), 2 h, 24 h, 48 h, 72 h and 168 h after each trial. Mononuclear cells were isolated from the blood and lymphocyte adhesion to cultured endothelial cells (HMEC-1) stimulated with 0.1 ng.ml-1 tumor necrosis factor-α was assessed. Lymphocyte and monocyte Heme Oxygenase-1 (HO-1) protein expression was determined by flow cytometry. Serum Interleukin-6 (IL-6) and C-reactive protein (CRP) were measured by ELISA. Data were analysed using a two-way repeated measures ANOVA. RESULTS: The intensity of the exercise performed by the volunteers was 53 ± 2% VO2 max (equivalent to 5.2 ± 0.7 METs). Over the seven days following exercise there was no significant change in circulating neutrophils, lymphocytes, monocytes or serum IL-6 and CRP concentration. Similarly, lymphocyte adhesion to cultured endothelial cells and HO-1 expression in lymphocytes and monocytes was not affected by walking at any time point. CONCLUSION: These results suggest that the long-term anti-inflammatory and anti-atherogenic effects of regular moderate intensity physical activity are unlikely to be due to the profound effect of each exercise bout since a single bout of walking did not lead to a detectable change in systemic markers of inflammation (pro- and anti-inflammatory) or lymphocyte adherence to cultured endothelial cells. The anti-inflammatory and anti-atherogenic effect of regular physical activity is either the result of very subtle changes associated with each exercise bout or due to other changes that accumulate when exercise is performed over weeks and months. Supported by The British Heart Foundation.

Mental Illness and Physical Activity: Therapists’ Beliefs and Practices

The scientific evidence for the effectiveness of regular moderate-intensity physical activity in alleviating anxiety and depression symptoms is well documented [1–3]. Low-risk exercise programmes s...