Superior Temporal Sulcus Region Research Articles

Auditory cortical connectivity in humans.

To understand auditory cortical processing, the effective connectivity between 15 auditory cortical regions and 360 cortical regions was measured in 171 Human Connectome Project participants, and complemented with functional connectivity and diffusion tractography. 1. A hierarchy of auditory cortical processing was identified from Core regions (including A1) to Belt regions LBelt, MBelt, and 52; then to PBelt; and then to HCP A4. 2. A4 has connectivity to anterior temporal lobe TA2, and to HCP A5, which connects to dorsal-bank superior temporal sulcus (STS) regions STGa, STSda, and STSdp. These STS regions also receive visual inputs about moving faces and objects, which are combined with auditory information to help implement multimodal object identification, such as who is speaking, and what is being said. Consistent with this being a "what" ventral auditory stream, these STS regions then have effective connectivity to TPOJ1, STV, PSL, TGv, TGd, and PGi, which are language-related semantic regions connecting to Broca's area, especially BA45. 3. A4 and A5 also have effective connectivity to MT and MST, which connect to superior parietal regions forming a dorsal auditory "where" stream involved in actions in space. Connections of PBelt, A4, and A5 with BA44 may form a language-related dorsal stream.

Brain Metabolic Profile in Presymptomatic GRN Carriers Throughout a 5-Year Follow-up.

GRN variants are a frequent cause of familial frontotemporal dementia (FTD). Monitoring disease progression in asymptomatic carriers of genetic variants is a major challenge in delivering preventative therapies before clinical onset. This study aimed to assess the usefulness of fluorodeoxyglucose (FDG)-PET in identifying metabolic changes in presymptomatic GRN carriers (PS-GRN+) and to trace their longitudinal progression. Participants were longitudinally evaluated over 5 years in a prospective cohort study focused on GRN disease (Predict-PGRN). They underwent cognitive/behavioral assessment, plasma neurofilament measurement, brain MRI, and FDG-PET. Voxel-wise comparisons of structural and metabolic imaging data between 2 groups were performed for each time point. Longitudinal PET changes were evaluated with voxel-wise comparisons and the metabolic percent annual changes method. The association of regional brain metabolism with plasma neurofilament and cognitive changes was analyzed. Among the 80 individuals enrolled in the study, 58 (27 PS-GRN+ and 31 noncarriers) were included in the analyses. Cross-sectional comparisons between PS-GRN+ and controls found a significant hypometabolism in the left superior temporal sulcus (STS) region (encompassing the middle and superior temporal gyri), approximately 15 years before the expected disease onset, without significant cortical atrophy. The longitudinal metabolic decline over the following 5 years peaked around the right STS in carriers (p < 0.001), without significantly greater volume loss compared with that in controls. Their estimated annualized metabolic decrease (-1.37%) was higher than that in controls (-0.21%, p = 0.004). Lower glucose uptake was associated with higher neurofilament increase (p = 0.003) and lower frontal cognitive scores (p = 0.014) in PS-GRN+. This study detected brain metabolic changes in the STS region, preceding structural and cognitive alterations, thus contributing to the characterization of the pathochronology of preclinical GRN disease. Owing to the STS involvement in the perception of facially communicated cues, it is likely that its dysfunction contributes to social cognition deficits characterizing FTD. Overall, our study highlights brain metabolic changes as an early disease-tracking biomarker and proposes annualized percent decrease as a metric to monitor therapeutic response in forthcoming trials.

The human posterior parietal cortex: effective connectome, and its relation to function.

The effective connectivity between 21 regions in the human posterior parietal cortex, and 360 cortical regions was measured in 171 Human Connectome Project (HCP) participants using the HCP atlas, and complemented with functional connectivity and diffusion tractography. Intraparietal areas LIP, VIP, MIP, and AIP have connectivity from early cortical visual regions, and to visuomotor regions such as the frontal eye fields, consistent with functions in eye saccades and tracking. Five superior parietal area 7 regions receive from similar areas and from the intraparietal areas, but also receive somatosensory inputs and connect with premotor areas including area 6, consistent with functions in performing actions to reach for, grasp, and manipulate objects. In the anterior inferior parietal cortex, PFop, PFt, and PFcm are mainly somatosensory, and PF in addition receives visuo-motor and visual object information, and is implicated in multimodal shape and body image representations. In the posterior inferior parietal cortex, PFm and PGs combine visuo-motor, visual object, and reward input and connect with the hippocampal system. PGi in addition provides a route to motion-related superior temporal sulcus regions involved in social interactions. PGp has connectivity with intraparietal regions involved in coordinate transforms and may be involved in idiothetic update of hippocampal visual scene representations.

Transcranial Direct Current Stimulation on the Left Superior Temporal Sulcus Improves Social Cognition in Schizophrenia: An Open-Label Study.

BackgroundPatients with schizophrenia show impairments of social cognition, which cause poor real-world functional outcomes. Transcranial direct current stimulation (tDCS) delivered to frontal brain areas has been shown to partially alleviate disturbances of social cognition. In this study, we aimed to determine whether multisession tDCS targeting the superior temporal sulcus (STS), a brain region closely related to social cognition, would improve social cognitive performance in patients with schizophrenia.MethodsThis was an open-label, single-arm trial to investigate the benefits and safety of multisession tDCS over the left STS. Fifteen patients received tDCS (2 mA × 20 min) two times per day for 5 consecutive days. Anodal and cathodal electrodes were placed over the left STS and right supraorbital regions, respectively. Assessments with the Social Cognition Screening Questionnaire (SCSQ), the Hinting Task (HT), the Brief Assessment of Cognition in Schizophrenia (BACS), and the Positive and Negative Syndrome Scale (PANSS) were conducted at baseline and 1 month after the final stimulation.ResultsSignificant improvements were found on theory of mind, as measured using the SCSQ (d = 0.53) and the HT (d = 0.49). These changes on social cognition were not correlated with those of neurocognition, as measured using the BACS or psychotic symptoms, as measured using the PANSS. There were no adverse events of serious/moderate levels attributable to tDCS.ConclusionThese results suggest that administration of multisession tDCS with anode stimulation targeting the left STS provides a novel strategy to improve functional outcomes in patients with schizophrenia.Ethics StatementThe National Center of Neurology and Psychiatry Clinical Research Review Board (CRB3180006) approved this study.Trial RegistrationThis study was registered within the Japan Registry of Clinical Trials (jRCTs032180026).

Perceptual Uncertainty Alternates Top-down and Bottom-up Fronto-Temporal Network Signaling during Response Inhibition.

Response inhibition is a primary executive control function that allows the withholding of inappropriate responses, and requires appropriate perception of the external environment to achieve a behavioral goal. It remains unclear, however, how response inhibition is achieved when goal-relevant information involves perceptual uncertainty. Twenty-six human participants of both sexes performed a go/no-go task where visually presented random-dot motion stimuli involved perceptual uncertainties. The right inferior frontal cortex (rIFC) was involved in response inhibition, and the middle temporal (MT) region showed greater activity when dot motions involved less uncertainty. A neocortical temporal region in the superior temporal sulcus (STS) specifically showed greater activity during response inhibition in more perceptually certain trials. In this STS region, activity was greater when response inhibition was successful than when it failed. Directional effective connectivity analysis revealed that, in more coherent trials, the MT and STS regions showed enhanced connectivity to the rIFC, whereas in less coherent trials, the signal direction was reversed. These results suggest that a reversible fronto-temporal functional network guides response inhibition and perceptual decision-making under perceptual uncertainty, and in this network, perceptual information in the MT is converted to control information in the rIFC via STS, enabling achievement of response inhibition.SIGNIFICANCE STATEMENT Response inhibition refers to withholding inappropriate behavior and is important for achieving goals. Often, however, decision must be made based on limited environmental evidence. We showed that successful response inhibition is guided by a neocortical temporal region that plays a hub role in converting perceived information coded in a posterior temporal region to control information coded in the PFC. Interestingly, when a perceived stimulus becomes more uncertain, the PFC supplements stimulus encoding in the temporal regions. Our results highlight fronto-temporal mechanisms of response inhibition in which conversion of stimulus-control information is regulated based on the uncertainty of environmental evidence.

Electrophysiological evidence of global structure-from-motion processing of biological motion in 6-month-old infants

Understanding the actions of others is a fundamental and important skill for navigating our social world. A striking example of how our visual system is sensitive to others’ actions is the phenomenon of biological motion (BM), in which the visual system encodes socially relevant information regarding action from as few as a dozen point-lights of motion. Previous studies have demonstrated that infants can discriminate between BM and other types of actions. However, there is a lack of electrophysiological evidence outlining the exact point of time within the first year of life when global structure-from-motion processing of BM emerges. We herein show a clear event-related potential (ERP) response related to the global structure-from-motion processing of a coherent human point-light walker in 6-month-old infants. We introduced a novel experimental paradigm composed of two stimuli phases to extract a single ERP component related to the global structure-from-motion processing of a coherent human point-light walker. Furthermore, we demonstrated that an enhanced single ERP component observed at approximately 482–586 ms following the onset of the stimulus of a coherent human point-light walker was larger than that of a spatially scrambled point-light walker in 6-month-old infants. These findings suggest that 6-month-old infants can process the global structure-from-motion information of a coherent human point-light walker, which may involve the posterior part of the superior temporal sulcus region. The current findings further refine the recently outlined developmental theory of BM processing.

A paleo-neurologic investigation of the social brain hypothesis in frontotemporal dementia.

The social brain hypothesis posits that a disproportionate encephalization in primates enabled to adapt behavior to a social context. Also, it has been proposed that phylogenetically recent brain areas are disproportionally affected by neurodegeneration. Using structural and functional magnetic resonance imaging, the present study investigates brain-behavior associations and neural integrity of hyperspecialized and domain-general cortical social brain areas in behavioral variant frontotemporal dementia (bvFTD). The results revealed that both structure and function of hyperspecialized social areas in the middle portion of the superior temporal sulcus (STS) are compromised in bvFTD, while no deterioration was observed in domain general social areas in the posterior STS. While the structural findings adhered to an anterior-posterior gradient, the functional group differences only occurred in the hyperspecialized locations. Activity in specialized regions was associated with structural integrity of the amygdala and with social deficits in bvFTD. In conclusion, the results are in line with the paleo-neurology hypothesis positing that neurodegeneration primarily hits cortical areas showing increased specialization, but also with the compatible alternative explanation that anterior STS regions degenerate earlier, based on stronger connections to and trans-neuronal spreading from regions affected early in bvFTD.

Intelligibility of audiovisual sentences drives multivoxel response patterns in human superior temporal cortex

Regions of the human posterior superior temporal gyrus and sulcus (pSTG/S) respond to the visual mouth movements that constitute visual speech and the auditory vocalizations that constitute auditory speech, and neural responses in pSTG/S may underlie the perceptual benefit of visual speech for the comprehension of noisy auditory speech. We examined this possibility through the lens of multivoxel pattern responses in pSTG/S. BOLD fMRI data was collected from 22 participants presented with speech consisting of English sentences presented in five different formats: visual-only; auditory with and without added auditory noise; and audiovisual with and without auditory noise. Participants reported the intelligibility of each sentence with a button press and trials were sorted post-hoc into those that were more or less intelligible. Response patterns were measured in regions of the pSTG/S identified with an independent localizer. Noisy audiovisual sentences with very similar physical properties evoked very different response patterns depending on their intelligibility. When a noisy audiovisual sentence was reported as intelligible, the pattern was nearly identical to that elicited by clear audiovisual sentences. In contrast, an unintelligible noisy audiovisual sentence evoked a pattern like that of visual-only sentences. This effect was less pronounced for noisy auditory-only sentences, which evoked similar response patterns regardless of intelligibility. The successful integration of visual and auditory speech produces a characteristic neural signature in pSTG/S, highlighting the importance of this region in generating the perceptual benefit of visual speech.

Live agent preference and social action monitoring in the macaque mid-superior temporal sulcus region

Mentalizing, the ability to infer the mental states of others, is a cornerstone of adaptive social intelligence. While functional brain mapping of human mentalizing has progressed considerably, its evolutionary signature in nonhuman primates remains debated. The discovery that the middle part of the macaque superior temporal sulcus (mid-STS) region has a connectional fingerprint most similar to the human temporoparietal junction (TPJ)-a crucial node in the mentalizing network-raises the possibility that these cortical areas may also share basic functional properties associated with mentalizing. Here, we show that this is the case in aspects of a preference for live social interactions and in a theoretical framework of predictive coding. Macaque monkeys were trained to perform a turn-taking choice task with another real monkey partner sitting directly face-to-face or a filmed partner appearing in prerecorded videos. We found that about three-fourths of task-related mid-STS neurons exhibited agent-dependent activity, most responding selectively or preferentially to the partner's action. At the population level, activities of these partner-type neurons were significantly greater under live-partner compared to video-recorded-partner task conditions. Furthermore, a subset of the partner-type neurons responded proactively when predictions about the partner's action were violated. This prediction error coding was specific to the action domain; almost none of the neurons signaled error in the prediction of reward. The present findings highlight unique roles of the macaque mid-STS at the single-neuron level and further delineate its functional parallels with the human TPJ in social cognitive processes associated with mentalizing.

Exploring the Benefits of Doll Play Through Neuroscience.

It has long been hypothesized that pretend play is beneficial to social and cognitive development. However, there is little evidence regarding the neural regions that are active while children engage in pretend play. We examined the activation of prefrontal and posterior superior temporal sulcus (pSTS) regions using near-infrared spectroscopy while 42 4- to 8-year-old children freely played with dolls or tablet games with a social partner or by themselves. Social play activated right prefrontal regions more than solo play. Children engaged the pSTS during solo doll play but not during solo tablet play, suggesting they were rehearsing social cognitive skills more with dolls. These findings suggest social play utilizes multiple neural regions and highlight how doll play can achieve similar patterns of activation, even when children play by themselves. Doll play may provide a unique opportunity for children to practice social interactions important for developing social-emotional skills, such as empathy.

Increased Right Posterior STS Recruitment Without Enhanced Directional-Tuning During Tactile Motion Processing in Early Deaf Individuals.

Upon early sensory deprivation, the remaining modalities often exhibit cross-modal reorganization, such as primary auditory cortex (PAC) recruitment for visual motion processing in early deafness (ED). Previous studies of compensatory plasticity in ED individuals have given less attention to tactile motion processing. In the current study, we aimed to examine the effects of early auditory deprivation on tactile motion processing. We simulated four directions of tactile motion on each participant’s right index finger and characterized their tactile motion responses and directional-tuning profiles using population receptive field analysis. Similar tactile motion responses were found within primary (SI) and secondary (SII) somatosensory cortices between ED and hearing control groups, whereas ED individuals showed a reduced proportion of voxels with directionally tuned responses in SI contralateral to stimulation. There were also significant but minimal responses to tactile motion within PAC for both groups. While early deaf individuals show significantly larger recruitment of right posterior superior temporal sulcus (pSTS) region upon tactile motion stimulation, there was no evidence of enhanced directional tuning. Greater recruitment of right pSTS region is consistent with prior studies reporting reorganization of multimodal areas due to sensory deprivation. The absence of increased directional tuning within the right pSTS region may suggest a more distributed population of neurons dedicated to processing tactile spatial information as a consequence of early auditory deprivation.

Predicting Performances on Processing and Memorizing East Asian Faces from Brain Activities in Face-Selective Regions: A Neurocomputational Approach.

For more than two decades, a network of face-selective brain regions has been identified as the core system for face processing, including occipital face area (OFA), fusiform face area (FFA), and posterior region of superior temporal sulcus (pSTS). Moreover, recent studies have suggested that the ventral route of face processing and memory should end at the anterior temporal lobes (i.e., vATLs), which may play an important role bridging face perception and face memory. It is not entirely clear, however, the extent to which neural activities in these face-selective regions can effectively predict behavioral performance on tasks that are frequently used to investigate face processing and face memory test that requires recognition beyond variation in pose and lighting, especially when non-Caucasian East Asian faces are involved. To address these questions, we first identified during a functional scan the core face network by asking participants to perform a one-back task, while viewing either static images or dynamic videos. Dynamic localizers were effective in identifying regions of interest (ROIs) in the core face-processing system. We then correlated the brain activities of core ROIs with performances on face-processing tasks (component, configural, and composite) and face memory test (Taiwanese Face Memory Test, TFMT) and found evidence for limited predictability. We next adopted an multi-voxel pattern analysis (MVPA) approach to further explore the predictability of face-selective brain regions on TFMT performance and found evidence suggesting that a basic visual processing area such as calcarine and an area for structural face processing such as OFA may play an even greater role in memorizing faces. Implications regarding how differences in processing demands between behavioral and neuroimaging tasks and cultural specificity in face-processing and memory strategies among participants may have contributed to the findings reported here are discussed.

Processing communicative facial and vocal cues in the superior temporal sulcus

Facial and vocal cues provide critical social information about other humans, including their emotional and attentional states and the content of their speech. Recent work has shown that the face-responsive region of posterior superior temporal sulcus (“fSTS”) also responds strongly to vocal sounds. Here, we investigate the functional role of this region and the broader STS by measuring responses to a range of face movements, vocal sounds, and hand movements using fMRI. We find that the fSTS responds broadly to different types of audio and visual face action, including both richly social communicative actions, as well as minimally social noncommunicative actions, ruling out hypotheses of specialization for processing speech signals, or communicative signals more generally. Strikingly, however, responses to hand movements were very low, whether communicative or not, indicating a specific role in the analysis of face actions (facial and vocal), not a general role in the perception of any human action. Furthermore, spatial patterns of response in this region were able to decode communicative from noncommunicative face actions, both within and across modality (facial/vocal cues), indicating sensitivity to an abstract social dimension. These functional properties of the fSTS contrast with a region of middle STS that has a selective, largely unimodal auditory response to speech sounds over both communicative and noncommunicative vocal nonspeech sounds, and nonvocal sounds. Region of interest analyses were corroborated by a data-driven independent component analysis, identifying face-voice and auditory speech responses as dominant sources of voxelwise variance across the STS. These results suggest that the STS contains separate processing streams for the audiovisual analysis of face actions and auditory speech processing.

The perception of gloss: A comparison of three methods for studying intentionally polished bone tools

Polished bone and stone tools are well known from many archaeological contexts. In use-wear studies, polish is usually characterised by the degree of surface roughness, or more subjectively by its visual appearance. Visual appearances, however, may be deceptive, and the scale of analysis of traditional surface roughness studies is often too fine to consider the overall visual effect of a polished surface. Here I consider three techniques for characterising modified bone surfaces and assess the correlation between surface roughness and gloss. My results show that softer contact materials generally produce higher gloss values than harder materials, but within these two broad categories results are more complex. Based on these experimental results a trial assessment is presented of archaeological bone tools from assorted Holocene sites. The ability to perceive and appreciate polished surfaces is linked to developments in the superior temporal sulcus region of the human brain, which is the same region in which our ability to perceive shapes and colour developed. Deliberately polished bone tools from Pleistocene contexts therefore have the potential to provide insights into cognitive developments in our species. The specular reflectance or gloss of a polished surface provides a quantifiable and repeatable measure, more suitable than surface roughness analysis, for characterising deliberate polish, although a combined approach is advocated.

Developmental changes in visual responses to social interactions

Recent evidence demonstrates that a region of the posterior superior temporal sulcus (pSTS) is selective to visually observed social interactions in adults. In contrast, little is known about neural responses to social interactions in children. Here, we used fMRI to ask whether the pSTS is ‘tuned’ to social interactions in children at all, and if so, how selectivity might differ from adults. This was investigated in the pSTS, along with several other socially-tuned regions in neighbouring temporal cortex: extrastriate body area, face selective STS, fusiform face area, and mentalizing selective temporo-parietal junction.Both children and adults showed selectivity to social interaction within right pSTS, while only adults showed selectivity on the left. Adults also showed both more focal and greater selectivity than children (6–12 years) bilaterally. Exploratory sub-group analyses showed that younger children (6–8), but not older children (9–12), are less selective than adults on the right, while there was a continuous developmental trend (adults > older > younger) in left pSTS. These results suggest that, over development, the neural response to social interactions is characterized by increasingly more selective, focal, and bilateral pSTS responses, a process that likely continues into adolescence.

Developmental Differences in Cortical Activation During Action Observation, Action Execution and Interpersonal Synchrony: An fNIRS Study.

Interpersonal synchrony (IPS) is an important everyday behavior influencing social cognitive development; however, few studies have investigated the developmental differences and underlying neural mechanisms of IPS. functional near-infrared spectroscopy (fNIRS) is a novel neuroimaging tool that allows the study of cortical activation in the presence of natural movements. Using fNIRS, we compared cortical activation patterns between children and adults during action observation, execution, and IPS. Seventeen school-age children and 15 adults completed a reach to cleanup task while we obtained cortical activation data from bilateral inferior frontal gyrus (IFG), superior temporal sulcus (STS), and inferior parietal lobes (IPL). Children showed lower spatial and temporal accuracy during IPS compared to adults (i.e., spatial synchrony scores (Mean ± SE) in children: 2.67 ± 0.08 and adults: 2.85 ± 0.06; temporal synchrony scores (Mean ± SE) in children: 2.74 ± 0.06 and adults: 2.88 ± 0.05). For both groups, the STS regions were more activated during action observation, while the IFG and STS were more activated during action execution and IPS. The IPS condition involved more right-sided activation compared to action execution suggesting that IPS is a higher-order process involving more bilateral cortical activation. In addition, adults showed more left lateralization compared to the children during movement conditions (execution and IPS); which indicated greater inhibition of ipsilateral cortices in the adults compared to children. These findings provide a neuroimaging framework to study imitation and IPS impairments in special populations such as children with Autism Spectrum Disorder.

Free viewing of talking faces reveals mouth and eye preferring regions of the human superior temporal sulcus

During face-to-face communication, the mouth of the talker is informative about speech content, while the eyes of the talker convey other information, such as gaze location. Viewers most often fixate either the mouth or the eyes of the talker's face, presumably allowing them to sample these different sources of information. To study the neural correlates of this process, healthy humans freely viewed talking faces while brain activity was measured with BOLD fMRI and eye movements were recorded with a video-based eye tracker. Post hoc trial sorting was used to divide the data into trials in which participants fixated the mouth of the talker and trials in which they fixated the eyes. Although the audiovisual stimulus was identical, the two trials types evoked differing responses in subregions of the posterior superior temporal sulcus (pSTS). The anterior pSTS preferred trials in which participants fixated the mouth of the talker while the posterior pSTS preferred fixations on the eye of the talker. A second fMRI experiment demonstrated that anterior pSTS responded more strongly to auditory and audiovisual speech than posterior pSTS eye-preferring regions. These results provide evidence for functional specialization within the pSTS under more realistic viewing and stimulus conditions than in previous neuroimaging studies.

Diagnosis of Attention Deficit Hyperactivity Disorder by Using MR Imaging and Radiomics: A Potential Tool for Clinicians.

Diagnosis of Attention Deficit Hyperactivity Disorder by Using MR Imaging and Radiomics: A Potential Tool for Clinicians.

Representations of naturalistic stimulus complexity in early and associative visual and auditory cortices

The complexity of sensory stimuli has an important role in perception and cognition. However, its neural representation is not well understood. Here, we characterize the representations of naturalistic visual and auditory stimulus complexity in early and associative visual and auditory cortices. This is realized by means of encoding and decoding analyses of two fMRI datasets in the visual and auditory modalities. Our results implicate most early and some associative sensory areas in representing the complexity of naturalistic sensory stimuli. For example, parahippocampal place area, which was previously shown to represent scene features, is shown to also represent scene complexity. Similarly, posterior regions of superior temporal gyrus and superior temporal sulcus, which were previously shown to represent syntactic (language) complexity, are shown to also represent music (auditory) complexity. Furthermore, our results suggest the existence of gradients in sensitivity to naturalistic sensory stimulus complexity in these areas.

Pathways for smiling, disgust and fear recognition in blindsight patients

The aim of the present review is to discuss the localization of circuits that allow recognition of emotional facial expressions in blindsight patients. Because recognition of facial expressions is function of different centers, and their localization is not always clear, we decided to discuss here three emotional facial expression – smiling, disgust, and fear – whose anatomical localization in the pregenual sector of the anterior cingulate cortex (pACC), anterior insula (AI), and amygdala, respectively, is well established. We examined, then, the possible pathways that may convey affective visual information to these centers following lesions of V1. We concluded that the pathway leading to pACC, AI, and amygdala involves the deep layers of the superior colliculus, the medial pulvinar, and the superior temporal sulcus region. We suggest that this visual pathway provides an image of the observed affective faces, which, although deteriorated, is sufficient to determine some overt behavior, but not to provide conscious experience of the presented stimuli.