The main stages in the development of the “B2B” module of a regional digital platform for collaboration of supply chain participants and other stakeholders have been identified in order to manage regional supply chains and develop import substitution policies. Algorithms have been developed for making management decisions on the feasibility of supporting import substitution projects within the “B2B” module of the regional digital platform, which will accelerate the transition of business entities to the production of competitive innovative products in the domestic market, which will help ensure economic security and increase the competitiveness of the territory. The study was carried out with financial support from the Belarusian Republican Foundation for Basic Research (BRFFR Nauka M G23M-029 grant).