Aim. To develop a model of interrelation of factors and tools for increasing the region’s investment potential, aimed at accelerating the processes of achieving technological sovereignty in key sectors of the Russian economy by increasing the efficiency of regional investment policy on its basis.Objectives. To study the main approaches to understanding the essence and role of technological sovereignty; to group the key factors and tools for managing the region’s investment potential, to give their generalizing characteristic; to develop an algorithmic model of the relationship between factors and tools for increasing the region’s investment potential; to identify the main discussion aspects in understanding the essence and objectives of managing the level of investment potential of the region and technological sovereignty of the national economy.Methods. The principles and approaches of general scientific methods of scientific cognition: historical, logical, comparison, dialectical, system approach, structural-functional analysis, qualitative analysis and synthesis served as the methodological basis of the research.Results. Purposeful management of factors of the region’s investment potential allows to use its objective and potential advantages as an object of investment investments more effectively. In this regard, it seems reasonable to use a complex algorithmic model of interrelation of factors and tools to increase the investment potential of the region. The model proposed by the authors includes three groups of factors and related tools for the analysis of investment potential, as well as a block of generalizing tools for its comprehensive development. Technological sovereignty in modern conditions to a greater extent acquires the role of an effective protective mechanism of national identity and subjectivity for the states facing the problems generated by the external environment. The task of ensuring technological sovereignty today is a rational response to the rapidly changing world order, in which opportunities for free trade and international cooperation are no longer guaranteed in equal proportions to the countries concerned, which becomes a significant factor in their global vulnerability; it is an opportunity for more active development of national scientific and production potential, which will contribute to a relative equalization of the existing imbalances in the levels of technological development with the international community; is the first priority need to take into account long-term systemic effects, rather than current economic benefits, when making decisions on the conscious rejection or priority development of certain competencies, technological niches, types of production at the national and regional levels.Conclusions. High dynamism due to fierce competition in the technological sphere requires from federal and regional government bodies systematic systematic work aimed at ensuring a high level of investment attractiveness of key sectors and segments of the economy. Strengthening the role and attention to the issues of investment policy management due to the achieved level of investment potential both at the level of individual regions and industries, and the country as a whole, is now associated not only with current economic interests, but also with the strategic priorities of national identity and preservation of statehood. At the national level, it is necessary to form and regularly adjust the list of critical products and technologies, key industries that require continuous development while maintaining a leading rate of investment in research and development in order to create demanded and competitive products and services on their basis.