The article examines the importance of implementing an organizational and economic mechanism to stimulate innovative processes in the industrial complex in order to achieve significant socio-economic benefits. In the context of industrial development with a focus on innovation, special attention is paid to the creation of new jobs, especially in areas requiring high qualifications and scientific knowledge. The implementation of a special organizational and economic management mechanism is necessary for effective management and stimulation of innovative activity in the regional economy. This mechanism must coordinate, interact and effectively implement policies and strategies aimed at supporting innovation, control the location of resources and support innovative enterprises. The article discusses various approaches to understanding the economic mechanism, including functional and structural approaches, and also examines its role in coordinating the actions of economic agents to achieve common goals and ensure sustainable development of the economy. The article explores the organizational and economic mechanism for managing the industrial complex of the region with the aim of diversifying economic activities and increasing overall competitiveness. Regional governance covers the coordination and integration of various aspects such as economic development, infrastructure and social welfare. The article discusses the principles of inclusiveness, participation and subsidiarity in the context of managing a regional industrial complex, and also examines the main components of the organizational and economic management mechanism. The proposed management scheme is based on stimulating innovative activity through the market aspect, resource block, financial component, motivational block and the development of production and innovation infrastructure. The article examines a systematic approach to managing the regional industrial sector in order to stimulate innovation in the economy. The importance of analyzing the economic situation and potential of the industrial sector is highlighted as a priority step. Next, methods for defining goals and objectives, developing a regional innovation strategy, developing policy and regulatory frameworks, financing and investment, developing production and innovation infrastructure, cooperation and partnerships, digitalization and developing a culture of innovation are discussed. The authors emphasize the need for interaction between multiple participants in the industrial sector and propose an organizational and economic mechanism for managing the industrial complex of the region to stimulate innovation, develop scientific and technical potential and ensure economic growth.