Ring Region Research Articles

Development of Potent and Selective Inhibitors of Methylenetetrahydrofolate Dehydrogenase 2 for Targeting Acute Myeloid Leukemia: SAR, Structural Insights, and Biological Characterization.

Methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 (MTHFD2), a pivotal mitochondrial enzyme in one-carbon metabolism, is significantly upregulated in various cancers but minimally expressed in normal proliferating cells. In contrast, MTHFD1, which performs similar functions, is predominantly expressed in normal cells. Therefore, targeting MTHFD2 with selective inhibitors holds promise for a broader therapeutic window with reduced toxicity and fewer side effects. This study identified selective 2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl ureido-based derivatives through systematic chemical modifications and SAR studies. Structural biology investigations revealed substitutions in the phenyl ring and tail region modulate potency and selectivity toward MTHFD2. Additionally, a comprehensive cell screening platform revealed acute myeloid leukemia cells with FLT3 internal tandem duplication mutations are particularly sensitive to these inhibitors. Furthermore, synergistic effects were observed when combining potential compounds with Alimta. Compound 16e emerged as a leading candidate, demonstrating superior inhibition and selectivity for MTHFD2, favorable pharmacokinetics, and potent antitumor efficacy in MOLM-14 xenograft models.

An unexpected retained metallic intraocular foreign body.

This case report aims to describe a rare case of asymptomatic retained metallic intraocular foreign body (IOFB) in the retina with reduced full-field electroretinography (ff-ERG) in a Chinese woman. This is a clinical investigation of a patient who unexpectedly presented with a metallic IOFB at the superior-temporal region of the left eye ring during a brain computed tomography. Her best-corrected visual acuity was 20/20 in both eyes. The dilated fundus photograph of the left eye revealed a metallic IOFB in the retina. She reported no ocular symptoms. A diagnosis of asymptomatic metallic IOFB was made definitely. The subsequent ff-ERG demonstrated subnormal amplitudes of dark and light adaption in the left eye, whereas responses were normal in the right eye. Our findings suggest the application of ff-ERG has important benefits for evaluating the visual function in patients with retained IOFB.

Systematic Review on Seismic Hazards in the Coastal Regions of the Pacific Ring of Fire

Systematic Review on Seismic Hazards in the Coastal Regions of the Pacific Ring of Fire

Hard Particle Mask Electrochemical Machining of Micro-Textures

The efficient and cost-effective preparation of masks has always been a challenging issue in mask-based electrochemical machining. In this paper, an electrochemical machining process of micro-textures is proposed using hard particle masks such as titanium and zirconia particles. Numerical simulations were conducted to analyze the formation mechanisms of micro-protrusion structures with insulating and conductive hard particle masks, followed by experimental verification of the process. The results indicate that when the hard particles are electrically insulating, metal material preferentially dissolves at the center of the particle gap, and the dissolution then expands over time in depth and towards the particle contact points. Conversely, using the conductive particles as the masks, such as titanium particles, dissolution initially occurs in a ring region centered at the contact point between the hard particle and the anode, with a radius approximately one-quarter of the chosen particle’s diameter (200 μm), and then continues to expand outward.

DAYA SAING KOPI ARABIKA DI MASA PANDEMI

During the COVID-19 pandemic, most of the export-oriented Arabica coffee plantations experienced production and productivity constraints due to decreased maintenance costs; besides, export opportunities were constrained by regulations issued by several countries requiring the product to be sterile from the COVID-19 virus. export. Based on the above phenomenon, this study aims to analyze the impact of the COVID-19 pandemic on Arabica coffee agribusiness, especially the profitability and competitiveness of Arabica coffee during the pandemic. The method used to select the area is the production center area around Mount Ijen, the Ijen Ring Region. The research is descriptive, combined research (mixed methods), and the method of collecting data uses primary and secondary data, as well as purposive sampling and incidental sampling with observation and interviews. The analysis tool uses competitiveness and policy with PAM (Policy Analysis Matrix). Arabica coffee during the pandemic is still profitable both financially (privately) and economically (socially), has great competitiveness and export opportunities, and is indicated to be able to compete with similar commodities, both imported and domestic products.

Molecular dynamics-based targeted adsorption of hazardous substances from rubberized asphalt VOCs by UiO-67

The interplay among UiO-67 and rubberized-asphalt components has been examined according to its molecular scale. The adhesion kinetics of UiO-67 to VOCs molecules in asphalt was modeled. The binding energy, radial distribution function (RDF), solubility parameters (SP), mean square displacement (MSD) and other parameters among UiO-67 to rubberized-asphalt components were evaluated in depth. The Sorption module was simulated the adsorption behavior of UiO-67 on 12 malodorous gases and 5 primary carcinogens. In combination with GC-MS results, the conjugative bonds and target attachment mechanisms for UiO-67 with VOCs were clarified. It was indicated that the binding energy among UiO-67 to the components were all negative. The radial distribution of asphalt was characterized as proximally ordered and remotely disordered. The ΔSP was less than 1.6, which was indicated that UiO-67 could be compatible with asphalt. The overall inhibition effect of UiO-67 on a group of carcinogens was exceeded 70 %. The presence of conjugation effect was allowed the adsorption sites of vinyl chloride and 1,3 butadiene to occur at high densities within the benzenoid. The concentration reduction of UiO-67 for hydrogen sulfide, carbon disulfide, and dimethyl sulfide was more than 80 %. The higher polarity was predisposed substances such as hydrogen sulfide and isobutanol to interact with the non-benzene ring region of UiO-67.

Investigating the role of solvents in modulating glass transition and dynamic mechanical characteristics of polystyrene film

This study investigates how different solvents impact the glass transition and dynamic mechanical properties of polystyrene (PS) films. Using FTIR spectroscopy, it analyzes solvent-induced variations in molecular vibrations, particularly in the phenyl ring region. Results show solvent-specific effects on the 750 cm-1 peak, associated with the "meta-substituted aromatic ring," influencing phenyl ring vibrations. DSC analysis highlights solvent effects on the glass transition temperature (Tg), revealing complexities in PS films prepared with chloroform, tetrahydrofuran (THF), and toluene. Varied Tg behavior suggests solvent-driven structural modifications and gradual solvent removal. Dynamic Mechanical Analysis (DMA) demonstrates solvent-dependent changes in storage modulus, loss modulus, and tan δ, indicating solvent polarity role in polymer chain dynamics. Toluene-induced plasticization reduces Tg and increases creep compliance, revealing PS film sensitivity to solvents. These findings stress solvent selection importance in tailoring thermal and mechanical properties of polymer films for specific applications.

Deformation and microstructure radial gradient evolution of AZ31 magnesium alloy bar during three-roll skew rolling

AZ31 magnesium alloy bar with radial gradient microstructure was prepared by three-roll skew rolling process (TRS), and achieving an excellent combination of ductility and strength. To elucidate the formation mechanism of this gradient microstructure, the deformation behavior during rolling was analyzed through experiments and simulations. The simulation results indicated that the metal flow of the bar in a spatial helical trajectory during rolling, with the trajectory inclination angle gradually decreasing from the center to the surface, promoting dynamic recrystallization in the surface and near-surface regions. The radial equivalent strain decreased from 1.5 at the surface to 0.01 at the center, and the shear strain decreased from 0.051 at the surface to 0.00012 at the center. Experimental results showed that the grain size of the bars decreased from 49.77 µm at the center to 19.72 µm at the surface, and the tensile twin volume fraction decreased from 34.1 % to 19.4 %. Dynamic recrystallization predominantly occurred in the outer ring region of the bars, while significant {10−12} tensile twin activation was observed in the central region, with twin-induced dynamic recrystallization observed at the twin boundaries. Mechanical property tests demonstrated that the gradient structure endowed the bars with a favorable combination of strength and elongation, with hardness significantly increasing from 50 HV at the center to 90 HV at the surface. This indicates that the three-roll skew rolling technology effectively promotes dynamic recrystallization at the surface, and the resulting gradient microstructure achieves an excellent combination of strength and plasticity in magnesium alloy bars.

Effectiveness of RF ablation and cementoplasty in enhancing functional capacity in pelvic malignant bone metastases.

Pelvic and sacral bone metastases cause significant morbidity. The primary aim of the study is to thoroughly evaluate the increase in functional capacity resulting from combined RF ablation and cementoplasty surgery applied to malignant bone metastases of the pelvic bones. Twenty patients who underwent RF ablation and cementoplasty for malign pelvic bone and sacrum metastases between January 2014 and December 2021 were retrospectively identified. The inclusion criteria were having a life expectancy of more than 1month, being > 18years old, and having at least 1 month of follow-up. The Visual Anlogue Scale (VAS) pain, Karnofsky Performance Status (KP), and Musculoskelatal Tumor Society (MSTS) scores were calculated. VAS pain values decreased, and KP values increased postoperatively (p = 0.006 and p = 0,013). There was no statistically significant increase in MSTS (p > 0.05). The correlation relationships between lesion filling ratio and VAS pain, KP, and MSTS scores were not statistically significant (p > 0.05). Cement leakage was observed in 5 patients (25.0%), and no symptoms related to this leakage were observed. The pelvic region, given its close proximity to blood vessels, nerves, and joint areas, along with the distinct challenges associated with its surgery, requires separate evaluation. In studies evaluating applications in the isolated pelvic ring region, as in our study, functional gains have been most comprehensively assessed in this study, demonstrating that the procedure results in significant functional improvements.

Revealing Gas Inflows Toward the Galactic Central Molecular Zone

We study the gas inflows toward the Galactic Central Molecular Zone (CMZ) based on the gas morphological and kinematic features from the Milky Way Imaging Scroll Painting in the region of l = 1.°2–19.°0 and ∣b∣ ≲ 3.°0. We find that the near dust lane appears to extend to l ∼ 15°, in which the end of the large-scale gas structure intersects with the 3 kpc ring at a distance of ∼5 kpc. Intriguingly, many filamentary molecular clouds (MCs), together with the bow-like/ballistic-like clouds and continuous CO features with notable velocity gradient, are finely outlined along the long structure. These MCs also have relatively large velocity dispersions, indicating the shocked gas generated by local continuous accretion and thus the enhanced turbulence along the entire gas structure. We suggest that the ∼3.1–3.6 kpc-long CO structure originates from the accretion molecular gas driven by the Galactic bar. The gas near the bar end at the 3 kpc ring region becomes an important reservoir for the large-scale accreting flows inward to the CMZ through the bar channel. The inclination angle of the bar is estimated to be ϕ bar = 23° ± 3°, while the pattern speed of the bar is Ωbar ≲ 32.5 ± 2.5 km s−1 kpc−1. The total mass of the whole near gas lane is about 1.3 ± 0.4 × 107 M ⊙ according to the calculated X CO ∼ 1.0 ± 0.4 × 1020 cm−2(K km s−1)−1 from the large-scale 12CO and 13CO data and the complementary H i data. We revisit the gas inflow rate as a mean value of 1.1 ± 0.3 M ⊙ yr−1, which seems to be comparable to the outflow's rate of the Galactic nuclear winds after applying the updated lower X-factor above.

Molecular-atomic scale insights into polymer-asphalt interactions induced by the oxidation of reactive oxygen species via computational simulation and multifield microscopy characterization

The objective of this study is to investigate the intermolecular interactions between polymers and asphalt components due to the oxidation of reactive oxygen species (ROS). Quantum chemistry (QC) and molecular dynamics (MD) were employed to simulate the molecular properties and intermolecular interactions between SBS and asphalt components during ROS aging. Multifield optical microscopy was utilized to analyze the microstructural characteristics and validate intermolecular interactions of SBS and asphalt components during ROS aging. The results show that asphaltenes have the most uneven electrostatic potential (ESP) distribution, followed by resins and aromatics, while saturates exhibit the most uniform ESP distribution. ROS aging leads to a more uneven ESP distribution and a higher polarity for HiMA molecules, especially for asphaltenes and resins with increased formation of polar functional groups. SBS and saturates exhibit small energy gaps and electronic softness, indicating good resistance to ROS oxidation, whereas asphaltenes and resins are prone to free radical oxidation reactions with ROS. The potential ROS oxidation site of asphaltenes and resins are mainly distributed in benzene ring regions and heteroatoms, while that of SBS are primarily located at the polybutadiene chains. The interactions between SBS and asphalt components are primarily driven by van der Waals forces. However, the hydrogen bonding appears after ROS aging, enhancing the intermolecular interactions. The interaction energies of SBS-asphaltenes and SBS-resins are significantly enhanced, and the intermolecular distances are shortened as ROS aging progresses. Multifield microscopy observation reveals that the development of bee structures in polymer regions is significantly faster than that in asphalt regions, indicating a significantly enhanced adsorption of asphaltenes by polymers after ROS aging. This is attributed to the uneven charge distribution, increased polarity, and enhanced reactivity of asphaltenes and SBS due to ROS aging. This study contributes to a molecular-atomic-level understanding of the intermolecular interactions between polymers and asphalt components during ROS aging.

The Wnt/β-catenin/TCF/Sp5/Zic4 Gene Network That Regulates Head Organizer Activity in Hydra Is Differentially Regulated in Epidermis and Gastrodermis.

Hydra head formation depends on an organizing center in which Wnt/β-catenin signaling, that plays an inductive role, positively regulates Sp5 and Zic4, with Sp5 limiting Wnt3/β-catenin expression and Zic4 triggering tentacle formation. Using transgenic lines in which the HySp5 promoter drives eGFP expression in either the epidermis or gastrodermis, we show that Sp5 promoter activity is differentially regulated in each epithelial layer. In intact animals, epidermal HySp5:GFP activity is strong apically and weak along the body column, while in the gastrodermis, it is maximal in the tentacle ring region and maintained at a high level along the upper body column. During apical regeneration, HySp5:GFP is activated early in the gastrodermis and later in the epidermis. Alsterpaullone treatment induces a shift in apical HySp5:GFP expression towards the body column where it forms transient circular figures in the epidermis. Upon β-catenin(RNAi), HySp5:GFP activity is down-regulated in the epidermis while bud-like structures expressing HySp5:GFP in the gastrodermis develop. Sp5(RNAi) reveals a negative Sp5 autoregulation in the epidermis, but not in the gastrodermis. These differential regulations in the epidermis and gastrodermis highlight the distinct architectures of the Wnt/β-catenin/TCF/Sp5/Zic4 network in the hypostome, tentacle base and body column of intact animals, as well as in the buds and apical and basal regenerating tips.

Rapid and cost-effective quantitative analysis of arsenic in drinking water using surface-enhanced Raman spectroscopy

A rapid, cost-effective, and sample-preparation-free approach is proposed for the quantitative detection of arsenic in drinking water, using surface-enhanced Raman spectroscopy (SERS). This fabrication entailed comprehensive optimization of chemically synthesized silver colloidal nanoparticles, focusing on parameters such as centrifugation time and speed to attain maximal nanoparticle concentration while mitigating interference from trisodium citrate and other chemical agents. Subsequently, SERS substrates were fabricated by depositing a concentrated drop of colloidal silver nanoparticles onto hydrophobic silicon substrates using the drop-coating technique. The drying process induced a coffee-ring effect, resulting in a pronounced spatial variation of nanoparticle concentration, with significantly higher densities observed in the peripheral ring regions compared to the central regions of the substrate. These regions possess the ability to enhance the Raman spectrum of arsenic, enabling the detection of arsenic at concentrations as low as 50 ppb. This method can prove highly valuable for initial field analyses of drinking water.

Fatigue life analysis of scraper conveyor chain ring under different chain speeds and loads

This study aims to explore how different chain speeds and loads impact the fatigue life of the scraper conveyor chain ring. To achieve this, the study validates the reliability of a coupled simulation involving multi-body dynamics and the discrete element method. It also acquires time-varying tension load spectra under various operational conditions. The research evaluates the effects of distinct chain speeds and loads on parameters such as chain tension, vibration acceleration in the Y and Z-directions of the chain ring. Furthermore, finite element simulation is employed to examine stress distribution changes and fatigue life trends within the three-chain ring structure. The findings demonstrate that Y and Z-direction vibration accelerations of the chain ring correlate positively with the load. Additionally, the vibration acceleration in the Y-direction correlates positively with the chain speed. Across different chain speeds and loads, the maximum equivalent stress in the chain ring exhibits dynamic variations mirroring the load spectrum. Within the elastic deformation range of the chain ring, the highest stress within the transition region correlates linearly with chain tension. Load has a greater effect on the fatigue life of chain rings than chain speed. The fatigue life within the transition region of the chain ring decreases exponentially with increasing load at a constant chain speed. Conversely, at a constant load, chain ring life correlates positively with chain speed. Specifically, the fatigue life of the chain ring in LS 22 amounts to 32.64 days. When both chain speed and load are adjusted by 25%, the chain ring's lifespan reduces by 51.66% during simultaneous increments and increases by 39.26% with concurrent reductions in speed and load.

Longitudinal manipulation of local nonseparability in vector beams.

The inherent nonseparability of vector beams presents a unique opportunity to explore novel optical functionalities, expanding new degrees of freedom for optical information processing. In this Letter, we introduce a novel, to the best of our knowledge, method for tailoring the local nonseparability along the propagation axis of vector beams. Employing higher-order Bessel vector beams, the longitudinal control over the local nonseparability is achieved through targeted amplitude modulation of constituent orthogonal polarization components within the main ring region. Experimental demonstrations of diverse longitudinal nonseparability profiles corroborate the efficacy and versatility of our approach, opening avenues for further exploration of the nonseparability manipulation in vector beams.

Optimal fusion of features from decomposed ultrasound RF data with adaptive weighted ensemble classifier to improve breast lesion classification

Early diagnosis plays a crucial role in successful treatment of breast tumors and reduced mortality. In this study, considering the complementary advantages between features and combined with the improvement of classifiers, fusion of optimal complexity and texture features from decomposed ultrasound radio frequency (RF) data is proposed to improve breast lesion classification performance. In this method, three complexity features and four texture features were extracted from the ring regions of interest for breast lesions in all decomposed RF sub-images and their combinations. Selection techniques based on analysis of feature relevance, redundancy, and interaction (FRRI) were used to determine the optimal feature sets (FS–FRRI). Finally, three classifiers with the best performance (weighted k-nearest neighbor, bagged tree, Gaussian Naive Bayes (NB)) were selected based on FS-FRRI. The three classifiers were integrated using the bagging method, and each classifier was adaptively weighted according to the genetic algorithm during the integration to classify breast lesions. The proposed method was evaluated using the Open Access Series of Breast Ultrasonic Data, with 10-fold cross-validation. The experimental results demonstrated that optimal performance was obtained by the FS–FRRI-based adaptive weighted ensemble classifier, with an accuracy of 97%, a sensitivity of 99%, a specificity of 96%, and an area under the receiver operating curve value of 0.97. Fusion of optimal complexity and texture features from decomposed ultrasound RF data with an adaptive weighted ensemble classifier can help improve breast lesion classification performance, which has great potential to assist clinicians in accurate diagnosis of breast lesions.

Studies on the effects of preheated β-lactoglobulin on the physicochemical properties of theaflavin-3,3′-digallate and the interaction mechanism

Teaflavin-3,3′-digallate (TFDG) is a sensory and health benefit substance in tea beverage, but is usually eliminated during processing due to the formation of tea cream by binding with proteins. In order to retain the TFDG, β-lactoglobulin (β-LG) was used to bind with TFDG and avoid the formation of tea cream. The results of physicochemical tests and entropy weight-TOPSIS showed that the best β-LG-TFDG dispersion (TFDG concentration: 0.468 g/L) had low particle size (37.29 nm), high electrical potential (−32.43 mv), high transmittance (88.52%), and strong antioxidant activity (84.82%), when the preheated temperature of β-LG was 85 °C and the molar ratio was 1:2. The multispectral experiment results showed that TFDG interacted with β-LG via static quenching, and preheated treatment of β-LG enhanced the interaction between β-LG and TFDG. CD spectroscopy suggested that TFDG induced slight changes in the secondary structure of β-LG. The results of molecular dynamics showed that preheated treatment leading in the changes in tertiary structure of β-LG, opening of key ring region of β-LG and exposing the active cavities of β-LG, which enhances the intermolecular forces between TFDG and β-LG. What's more, molecular docking was proved that preheated treatment of β-LG enhances the hydrophobic interactions and hydrogen bonds, which dominated the interaction between TFDG and β-LG. The results proposed in this research could further reducing tea cream formation and improving the healthy and sensory performances of tea beverage by using preheated β-LG without preserving both the tea pigments and the active nutrients.

The smallest structures in Saturn’s rings from UVIS stellar occultations

On the largest scales Saturn’s rings are often thought of as axisymmetric annuli varying only radially in optical depth with exceptions of spiral waves and eccentric ringlets. But on scales smaller than a few tens of km yet still larger than the largest common ring particles, the assumption of azimuthal symmetry breaks down. Structures such as “straw” in the troughs of density waves, partial gaps around propeller moonlets, and ephemeral particle aggregates such as self-gravity wakes are responsible for the predominant variations in optical depth. During the 13 year Cassini mission, the Ultraviolet Imaging Spectrograph (UVIS) high speed photometer (HSP) measured 80 stellar chord occultations of Saturn’s main rings. In the vicinity of the minimum ring plane radius of each chord, the occultation line-of-sight slewed across the ring plane tangent to the Keplerian motion of the ring particles. These occultations measured ultraviolet light in the wavelength range 110–190 nm with 1- or 2-ms ms integration times, providing optical depth measurements with resolution comparable to the Fresnel scale of ∼10 m in the frame co-moving with the local Keplerian speed. These high-resolution chord occultations reach their minimum ring radii over a broad range of radial locations within Saturn’s main rings and resolve non-axisymmetric structures in a wide variety of ring regions. We measure the azimuthal length scales and optical depth profiles of “ghosts”, or azimuthally limited gaps with radial scales less than 30 m (Baillié et al., 2013), in the C ring plateaus. We measure the length scale of transparent gaps and self-gravity wakes in the peaks and troughs of spiral density waves. We present optical depth profiles which resolve axisymmetric waves in the A and B rings and constrain the azimuthal length scale over which the waves remain axisymmetric to ∼1000 km. We combine autocorrelation length scales from stellar occultations which cut across the minimum ring radius of a chord occultation with line-of-sight trajectories from other occultations which are not tangent to the rings to constrain the morphology of the azimuthally and temporally averaged mesoscale structures at that ring radius. 2D autocorrelation profiles from stellar occultations show self-gravity wakes and axisymmetric waves often coexisting.

Influence mechanism of impingement and film on the flow and heat transfer of turbine outer ring with composite cooling structure under different operating parameters

Two typical turbine outer rings with impingement-film composite cooling structure and single film cooling structure are selected as the research object, the mechanism of temperature ratio (τ = 1.2 ∼ 1.6), blowing ratio (M = 0.7 ∼ 3.0) and Mach number (Ma = 0.2 ∼ 0.8) on the flow and heat transfer of the two outer rings under engineering application is explored, which serves as a foundation for designing turbine outer ring cooling of aero-engine with different thermal load characteristics. It is indicated that compared to single film cooling, impingement-film composite cooling improves the cooling performance on the outer ring surface, while also effectively reduces the localized regions of low cooling property, enhancing the even distribution of cooling effectiveness. In the impingement-film composite cooling structure, film cooling is the primary factor determining the cooling property of outer ring. Among the influencing factors, Mach number has the greatest impact (64 % ∼ 83 %), followed by blowing ratio. Under different temperature ratios, film cooling accounts for approximately 80 % of the cooling property. At high blowing ratio, impingement-film composite cooling outperforms single film cooling in terms of cooling enhancement and effectiveness. Increasing blowing ratio (0.7 ∼ 2.0) enhances the cooling contribution of impingement in composite cooling, while the cooling contribution remains constant at 18 % as the blowing ratio enhances from 2.0 to 3.0. When Mach number increases, impingement-film composite cooling experiences a smaller decrease in cooling effectiveness compared to single film cooling, leading to better cooling uniformity. At high Mach number, impingement cooling effectively mitigates the decreasing cooling trend in the middle region of the outer ring. Additionally, the proportion of cooling performance in composite cooling increases, thereby reducing the adverse impact of the sharp decrease in film cooling property with elevating Mach number on the overall performance of composite cooling.

Ultrasound detection based on optical tapered-knot resonator sensor

In this work, we propose and experimentally demonstrated an optical ultrasound sensor based on tapered knot resonator (TKR) structure for ultrasound sensing. The sensor is fabricated by tapering a knotted single mode fiber (SMF), forming ring region and tapered region of TKR sensor. Higher order modes are excited and the mode interference is effectively enhanced. By simulating and analyzing transmission spectrum of TKR sensors with different diameter of ring region and different length of taper length, the diameter of ring region and the length of tapered region are optimized as 2 cm and 5 mm, respectively. We constructed the ultrasound detection experimental system, and the experimental results show that the TKR sensor performs high response characteristics for continuous ultrasound from 25 kHz to 305 kHz, and have a high signal-to noise ratio (the maximal calculated SNR is 37.89 dB). Moreover, the TKR sensor shows low temperature sensitivity of 6.64 pm/°C. The proposed TKR sensor has stable structure, wide ultrasound response range, and easily fabrication method, which shows potential application value in the field of high sensitivity ultrasound testing.