Event Abstract Back to Event Roller Coaster Scanning Revealed a New Type of Dendritic Spike Balazs Rozsa1*, Gergely Katona1, Attila Kaszas1, Gergely Turi1, Balazs Chiovini1, Norbert Hajos1, Gabor Tamas2 and Sylvester E. Vizi1 1 Institute of Experimental Medicine, Hungarian Academy of Sciences, Hungary 2 Research Group for Cortical Microcircuits of the Hungarian Academy of Sciences, Hungary Previous studies have shown that nonlinear dendritic integration mediated by layers of independent local integrators may increase the computational power of neurons. More recently it has been demonstrated that an artificially compartmentalized spatiotemporal pattern of glutamate photochemical activation (MNI-glutamate uncaging) induces local nonlinear regenerative voltage events, dendritic spikes in pyramidal neurons. However, it is currently unknown whether the connectivity of the brain is able to provide the required number and coincidence of synaptic inputs to induce dendritic spikes at physiological conditions. Using a new rapid 3D imaging technique optimized for dendritic imaging we showed that on thicker slice preparation where the hippocampal network activity is more preserved, synchronous spontaneous inputs are able to induce N-methyl-D-aspartate (NMDA)-spikes on interneuron dendrites. This form of regenerative activity on interneurons has not been shown previously. Conference: 12th Meeting of the Hungarian Neuroscience Society, Budapest, Hungary, 22 Jan - 24 Jan, 2009. Presentation Type: Poster Presentation Topic: Research on the cerebral cortex and related structures Citation: Rozsa B, Katona G, Kaszas A, Turi G, Chiovini B, Hajos N, Tamas G and Vizi SE (2009). Roller Coaster Scanning Revealed a New Type of Dendritic Spike. Front. Syst. Neurosci. Conference Abstract: 12th Meeting of the Hungarian Neuroscience Society. doi: 10.3389/conf.neuro.01.2009.04.219 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 09 Mar 2009; Published Online: 09 Mar 2009. * Correspondence: Balazs Rozsa, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary, rozsabal@koki.hu Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Balazs Rozsa Gergely Katona Attila Kaszas Gergely Turi Balazs Chiovini Norbert Hajos Gabor Tamas Sylvester E Vizi Google Balazs Rozsa Gergely Katona Attila Kaszas Gergely Turi Balazs Chiovini Norbert Hajos Gabor Tamas Sylvester E Vizi Google Scholar Balazs Rozsa Gergely Katona Attila Kaszas Gergely Turi Balazs Chiovini Norbert Hajos Gabor Tamas Sylvester E Vizi PubMed Balazs Rozsa Gergely Katona Attila Kaszas Gergely Turi Balazs Chiovini Norbert Hajos Gabor Tamas Sylvester E Vizi Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.