Reflex Movements Research Articles

Testing Visual Function by Assessment of the Optomotor Reflex in Glaucoma.

Optomotor response/reflex (OMR) is a fast and efficient first-in-line visual screening method, especially for rodents. It has the potential to evaluate both the scotopic and photopic visions of nonrestrained animals through tracking head movement, providing a quantitative estimate of visual functions. In restrained animals, optokinetic response (OKR), compensatory eye movements for visual shifts in the surroundings, is utilized. Both OMR and OKR capitalize on an individual's innate reflex to stabilize images for the purpose of capturing clear vision. The two reflexes have similar reliability when evaluating stimulus luminance, contrast, spatial frequency, and velocity. They have emerged as powerful tools to evaluate the efficacy of pharmacological treatments and phenotypes of subjects undergoing study. With OMR and OKR accurately assessing visual acuity (VA) as well as contrast sensitivity (CS), the gold standards for measuring clinical vision, they provide reliable and easily accessible results that further eye and brain research. These methods of sight evaluation have been used in multiple animal models, particularly mice and zebrafish. Through OMR assays, these animal models have been utilized to investigate retinal degenerative diseases, helping researchers differentiate between worsening stages. Alongside tests such as optical coherence tomography (OCT), OMR provides confirmation of visual status, where increased OMR function often correlates with improved visual status. OMR has continued to be used outside of glaucoma in various retinal diseases, such as retinitis pigmentosa (RP), diabetic retinopathy, and age-related macular degeneration.In this chapter, we will introduce the concept and application of visual stimulus-induced head or eye reflex movement in different animal species and experimental models of eye diseases, such as glaucoma and other neurodegenerative disorders, and in patients with glaucoma.

Acute effects of local vibration inducing tonic vibration reflex or illusion of movement on maximal wrist force production.

Local vibration (LV) mainly stimulates primary afferents (Ia) and can induce a tonic vibration reflex (TVR) and an illusion of movement. This study aimed to evaluate the effect of these two phenomena on maximal voluntary isometric contraction (MVIC) capacity. LV (80 Hz) was applied to the wrist flexor muscles in two randomized experiments for 6 min. LV conditions were adjusted to promote either TVR (visual focus on the vibrated wrist) or ILLUSION [hand hidden, visual focus on electromyographic activity of the flexor carpi radialis muscle (FCR)]. Mechanical and electromyographic (EMG) responses of the FCR and extensor carpi radialis muscles were recorded during MVIC in flexion and extension and during electrically evoked contractions at supramaximal intensity. Measurements were performed before (10 min and just before) and after (0 and 30 min) LV protocol. An increase in FCR EMG was observed during LV in the TVR condition (+340%) compared with the illusion condition (P = 0.003). In contrast, the movement illusion was greater in the ILLUSION condition (assessed through subjective scales) (P = 0.004). MVIC was reduced in flexion only after the TVR condition ([Formula: see text], all P < 0.034). Moreover, the decrease in force was correlated with the amount of TVR recorded on the FCR muscle (r = -0.64, P = 0.005). Although potentiated doublets of each muscle did not evolve differently between conditions, a decrease was observed between the first and the last measure. In conclusion, when conducting research to assess maximal strength, it is necessary to have better control and reporting of the phenomena induced during LV.NEW & NOTEWORTHY The maximal force production of the vibrated muscle is reduced after 6 min of LV only in TVR condition. Furthermore, the amount of TVR is negatively correlated with this force decrease. When measuring the effects of LV on maximal force production, it is important to control and report any phenomena induced during vibration, such as TVR or movement illusion, which can be achieved by recording EMG activity of vibrated muscle and quantifying illusion.

LMC-driven Anisotropic Boosts in Stream–Subhalo Interactions

Dark matter subhalos are predicted to perturb stellar streams; stream morphologies and dynamics can, therefore, constrain the mass distribution of subhalos. Using FIRE-2 simulations of Milky Way–mass galaxies, we demonstrate that the presence of an LMC analog significantly changes stream–subhalo encounter rates. The LMC analog brings in many subhalos, increasing encounter rates for streams near the massive satellite by 10%–40%. Additionally, the LMC analog displaces the host from its center of mass (inducing reflex motion), which causes a north–south asymmetry in the density and radial velocity distributions of subhalos. This asymmetry, combined with the presence of LMC-analog subhalos, causes encounter rates at the same distance to vary by 50%–70% across the sky, particularly in regions opposite the LMC analog. Furthermore, the LMC analog induces a density wake in the host's dark matter halo, further boosting the encounter rates near the LMC analog. We also explore how stream orbital properties affect encounter rates, finding up to a 50% increase for streams moving retrograde to the LMC analog’s orbit in the opposite quadrant. Finally, we report the encounter rates for Milky Way streams within the context of our simulations, both with and without the presence of an LMC analog. The dependence of encounter rates on stream location, orbit, and their position relative to the LMC has important implications for where to search for streams with spurs and gaps in the Milky Way.

Identifying tinnitus in mice by tracking the motion of body markers in response to an acoustic startle.

Rodent models of tinnitus are commonly used to study its mechanisms and potential treatments. Tinnitus can be identified by changes in the gap-induced prepulse inhibition of the acoustic startle (GPIAS), most commonly by using pressure detectors to measure the whole-body startle (WBS). Unfortunately, the WBS habituates quickly, the measuring system can introduce mechanical oscillations and the response shows considerable variability. We have instead used a motion tracking system to measure the localized motion of small reflective markers in response to an acoustic startle reflex in guinea pigs and mice. For guinea pigs, the pinna had the largest responses both in terms of displacement between pairs of markers and in terms of the speed of the reflex movement. Smaller, but still reliable responses were observed with markers on the thorax, abdomen and back. The peak speed of the pinna reflex was the most sensitive measure for calculating GPIAS in the guinea pig. Recording the pinna reflex in mice proved impractical due to removal of the markers during grooming. However, recordings from their back and tail allowed us to measure the peak speed and the twitch amplitude (area under curve) of reflex responses and both analysis methods showed robust GPIAS. When mice were administered high doses of sodium salicylate, which induces tinnitus in humans, there was a significant reduction in GPIAS, consistent with the presence of tinnitus. Thus, measurement of the peak speed or twitch amplitude of pinna, back and tail markers provides a reliable assessment of tinnitus in rodents.

Acute toxicity of mercury to freshwater cultured milkfish Chanos chanos: Clinical symptoms and lethal concentration assessment

The increasing use of mercury in the industrial sector poses significant risks to freshwater ecosystems and aquatic organisms. Milkfish (Chanos chanos), a widely consumed species, is now being reared in freshwater environments, raising concerns about mercury bioaccumulation and food safety. This study aimed to determine the median lethal mercury concentration for milkfish at 96 hours (LC50) in freshwater using an experimental approach and probit analysis. Five mercury concentrations were tested: 0 (control), 0 .110 mg Hg/L, 0.195 mg Hg/L, 0.347 mg Hg/L, and 0.618 mg Hg/L. The results indicated that mercury is highly toxic to milkfish, with a 96-hour LC50 of 0.147 mg Hg/L. Clinical symptoms observed included loss of reflex movements, irregular swimming, frequent surfacing with widened mouth and operculum openings, convulsions, and ventilation of the ram before mortality. These findings highlight the acute toxicity of mercury in freshwater milkfish and underscore the potential health risks associated with mercury contamination in aquaculture systems.

Behaviour Hallmarks in Alzheimer's Disease 5xFAD Mouse Model.

The 5xFAD transgenic mouse model widely used in Alzheimer's disease (AD) research recapitulates many AD-related phenotypes with a relatively early onset and aggressive age-dependent progression. Besides developing amyloid peptide deposits alongside neuroinflammation by the age of 2 months, as well as exhibiting neuronal decline by the age of 4 months that intensifies by the age of 9 months, these mice manifest a broad spectrum of behavioural impairments. In this review, we present the extensive repertoire of behavioural dysfunctions in 5xFAD mice, organised into four categories: motor skills, sensory function, learning and memory abilities, and neuropsychiatric-like symptoms. The motor problems, associated with agility and reflex movements, as well as balance and coordination, and skeletal muscle function, typically arise by the time mice reach 9 months of age. The sensory function (such as taste, smell, hearing, and vision) starts to deteriorate when amyloid peptide buildups and neuroinflammation spread into related anatomical structures. The cognitive functions, encompassing learning and memory abilities, such as visual recognition, associative, spatial working, reference learning, and memory show signs of decline from 4 to 6 months of age. Concerning neuropsychiatric-like symptoms, comprising apathy, anxiety and depression, and the willingness for exploratory behaviour, it is believed that motivational changes emerge by approximately 6 months of age. Unfortunately, numerous studies from different laboratories are often contradictory on the conclusions drawn and the identification of onset age, making preclinical studies in rodent models not easily translatable to humans. This variability is likely due to a range of factors associated with animals themselves, housing and husbandry conditions, and experimental settings. In the forthcoming studies, greater clarity in experimental details when conducting behavioural testing in 5xFAD transgenic mice could minimise the inconsistencies and could ensure the reliability and the reproducibility of the results.

Understanding Abnormal Examination Findings During Concussion Recovery: A Retrospective Chart Review.

Physical examination findings in athletes with sport-related concussion (SRC) are not well described in the literature. The objective of this study was to describe physical examination findings during the first month following concussion in athletes, with a focus on the effect of sex, age, and time since injury. This was a retrospective electronic medical record (EMR) review of physical examination findings in 500 patients aged 6-24 who were initially seen within 15 days of SRC at a multidisciplinary outpatient academic concussion clinic between 2017 and 2019. A standardized concussion examination built in the EMR recorded mental status, cranial nerve, vestibulo-ocular motor screen, and balance findings for all patients. The primary outcome was the frequency of abnormal examination findings during the first 30 days postinjury, which was further analyzed by sex, age, and time since injury using mixed logistic regression models. The most common abnormal examination findings overall were eyes-closed single-leg stance, vestibular-ocular reflex, visual motion sensitivity, the neck examination, and eyes-closed tandem stance. Abnormal findings were more frequent in female athletes for vestibular ocular reflex and visual motion sensitivity. The frequency of abnormal findings increased with age for vestibulo-ocular reflex, visual motion sensitivity, the neck examination, convergence testing, and eyes-open single-leg stance, whereas abnormalities decreased in frequency with age for eyes-open tandem stance and tandem gait. The frequency of abnormal findings generally decreased with time over the first 4 weeks following injury. A comprehensive physical examination is pivotal for evaluation of athletes with concussion. These findings highlight high-yield components of the concussion examination and support use of these examination components as injury markers. Future work should investigate associations between physical examination findings and postconcussion symptoms and recovery outcomes. This retrospective cohort study provides Class IV evidence that neurologic examination with specifically designed clinical tests are helpful for diagnosis of traumatic brain injury in young athletes at age 6-24.

The radial variation of the LMC-induced reflex motion of the Milky Way disc observed in the stellar halo

ABSTRACT We measure the kinematic signature arising from the Milky Way (MW) disc moving with respect to the outer stellar halo, which is observed as a dipole signal in the kinematics of stellar halo tracers. We quantify how the reflex motion varies as a function of Galactocentric distance, finding that (i) the amplitude of the dipole signal increases as a function of radius, and (ii) the direction moves across the sky. We compare the reflex motion signal against a compilation of published models that follow the MW–LMC interaction. These models show a similar trend of increasing amplitude of the reflex motion as a function of distance, but they do not reproduce the direction of the disc motion with respect to the stellar halo well. We also report mean motions for the stellar halo as a function of distance, finding radial compression in the outer halo and non-zero prograde rotation at all radii. The observed compression signal is also present in MW–LMC models, but the rotation is not, which suggests that the latter is not induced by the LMC. We extensively validate our technique to measure reflex motion against idealized tests. We discuss prospects for directly constraining the mass and orbital history of the LMC through the impact on the motion of the MW stellar disc, and how the modelling of the reflex motion can be improved as more and better data become available.

IVOMS: Instrumented Vestibular / Ocular motor screen in healthy controls and mild traumatic brain injury

Objective Vestibular/ocular deficits occur with mild traumatic brain injury (mTBI). The vestibular/ocular motor screening (VOMS) tool is used to assess individuals post-mTBI, which primarily relies upon subjective self-reported symptoms. Instrumenting the VOMS (iVOMS) with technology may allow for more objective assessment post-mTBI, which reflects actual task performance. This study aimed to validate the iVOMS analytically and clinically in mTBI and controls.Methods Seventy-nine people with sub-acute mTBI (<12 weeks post-injury) and forty-four healthy control participants performed the VOMS whilst wearing a mobile eye-tracking on a one-off visit. People with mTBI were included if they were within 12 weeks of a physician diagnosis. Participants were excluded if they had any musculoskeletal, neurological or sensory deficits which could explain dysfunction. A series of custom-made eye tracking algorithms were used to assess recorded eye-movements.Results The iVOMS was analytically valid compared to the reference (ICC2,1 0.85–0.99) in mTBI and controls. The iVOMS outcomes were clinically valid as there were significant differences between groups for convergence, vertical saccades, smooth pursuit, vestibular ocular reflex and visual motion sensitivity outcomes. However, there was no significant relationship between iVOMS outcomes and self-reported symptoms.Conclusion The iVOMS is analytically and clinically valid in mTBI and controls, but further work is required to examine the sensitivity of iVOMS outcomes across the mTBI spectrum. Findings also highlighted that symptom and physiological issue resolution post-mTBI may not coincide and relationships need further examination.

Learning capabilities to resolve tilt-translation ambiguity in goldfish.

Spatial orientation refers to the perception of relative location and self-motion in space. The accurate formation of spatial orientation is essential for animals to survive and interact safely with their environment. The formation of spatial orientation involves the integration of sensory inputs from the vestibular, visual, and proprioceptive systems. Vestibular organs function as specialized head motion sensors, providing information regarding angular velocity and linear acceleration via the semicircular canals and otoliths, respectively. However, because forces arising from the linear acceleration (translation) and inclination relative to the gravitational axis (tilt) are equivalent, they are indistinguishable by accelerometers, including otoliths. This is commonly referred to as the tilt - translation ambiguity, which can occasionally lead to the misinterpretation of translation as a tilt. The major theoretical frameworks addressing this issue have proposed that the interpretation of tilt versus translation may be contingent on an animal's previous experiences of motion. However, empirical confirmation of this hypothesis is lacking. In this study, we conducted a behavioral experiment using goldfish to investigate how an animal's motion experience influences its interpretation of tilt vs. translation. We examined a reflexive eye movement called the vestibulo-ocular reflex (VOR), which compensatory-rotates the eyes in response to head motion and is known to reflect an animal's three-dimensional head motion estimate. We demonstrated that the VORs of naïve goldfish do not differentiate between translation and tilt at 0.5 Hz. However, following prolonged visual-translation training, which provided appropriate visual stimulation in conjunction with translational head motion, the VORs were capable of distinguishing between the two types of head motion within 3 h. These results were replicated using the Kalman filter model of spatial orientation, which incorporated the variable variance of process noise corresponding to the accumulated motion experience. Based on these experimental and computational findings, we discuss the neural mechanism underlying the resolution of tilt-translation ambiguity within a context analogous to, yet distinct from, previous cross-axis VOR adaptations.

Astrometric detection of a Neptune-mass candidate planet in the nearest M-dwarf binary system GJ65 with VLTI/GRAVITY

The detection of low-mass planets orbiting the nearest stars is a central stake of exoplanetary science, as they can be directly characterized much more easily than their distant counterparts. Here, we present the results of our long-term astrometric observations of the nearest binary M-dwarf Gliese 65 AB (GJ65), located at a distance of only 2.67 pc. We monitored the relative astrometry of the two components from 2016 to 2023 with the VLTI/GRAVITY interferometric instrument. We derived highly accurate orbital parameters for the stellar system, along with the dynamical masses of the two red dwarfs. The GRAVITY measurements exhibit a mean accuracy per epoch of 50−60 ms in 1.5 h of observing time using the 1.8 m Auxiliary Telescopes. The residuals of the two-body orbital fit enable us to search for the presence of companions orbiting one of the two stars (S-type orbit) through the reflex motion they imprint on the differential A–B astrometry. We detected a Neptune-mass candidate companion with an orbital period of p = 156 ± 1 d and a mass of mp = 36 ± 7 M⊕. The best-fit orbit is within the dynamical stability region of the stellar pair. It has a low eccentricity, e = 0.1 − 0.3, and the planetary orbit plane has a moderate-to-high inclination of i &gt; 30° with respect to the stellar pair, with further observations required to confirm these values. These observations demonstrate the capability of interferometric astrometry to reach microarcsecond accuracy in the narrow-angle regime for planet detection by reflex motion from the ground. This capability offers new perspectives and potential synergies with Gaia in the pursuit of low-mass exoplanets in the solar neighborhood.

Measuring precise radial velocities on individual spectral lines

Context. Radial velocities (RVs) of stars contain both the Doppler reflex motion of potential planetary companions and the drowning and sometimes imitating effect of stellar activity. To separate the two, previous efforts have sought proxies that only trace the activity signals, yet the sub-meter-per-second floor required for the detection of Earth-like planets remains difficult to break. Aims. In this work, we analyze a sample of 12 G- to early M-type stars in order to investigate the feasibility of detecting a differential effect of stellar activity with photospheric depth, as traced by the spectral line-forming temperature, for observations with different sampling and noise levels. Methods. We computed the average line formation temperature for each point in the observed wavelength grids using the spectral synthesis code PySME. The final line selection was curated to exclude blended and poorly synthesized lines. We thereafter computed the convective blueshift (CB) of the line cores of our master spectra (composed of the stacked individual spectra of each star). Finally, we extracted RV time series for certain intervals of formation temperature using a template-matching approach. Results. We find the CB to follow a linear relation with the formation temperature of the line cores, and the CB slope to be steeper with increasing effective temperature. For the RV time series derived for different intervals of formation temperature, we find the RVs of line parts formed at higher temperatures, close to the spectral continuum, to be generally correlated with the S index, and the RVs of line parts formed at cooler temperatures, close to the spectral line cores, to be generally anti-correlated, especially for stars with low noise levels and significant variations over their magnetic cycles. Conclusions. RVs of line parts formed in the coolest 25% of the line-forming temperature range appear to be a strong tracer of stellar activity over the magnetic cycle for several stars. By detrending the total RV time series with a multi-linear combination of residuals of RVs measured at different temperature ranges and the S index, the RV scatter can be decreased to a greater extent than with the S index alone.

Facial disgust in response to touches, smells, and tastes.

Disgust serves to defend the body from the entry of toxins and disease. Central to this function is a strong relationship with the proximate senses of smell, taste, and touch. Theory suggests that distinct and reflexive facial movements should be evoked by gustatory and olfactory disgusts, serving to impede bodily entry. While this hypothesis has received some support from facial recognition studies, whether smell and taste disgusts actually produce distinct facial responses, is unknown. Moreover, there has been no assessment of the facial response evoked by contact with disgusting objects. To address these issues, this study compared facial responses to touch, smell, and taste disgusts. Sixty-four participants were asked to touch, smell, and taste disgust-evoking and neutral control stimuli, and rate them on disgust, on two occasions-first, while they were video recorded and second, with facial electromyography (EMG) applied (measuring levator labii and corrugator supercilii activity). Videos were coded for facial expressions by humans and for facial action units (FAUs) by machines. Self-report data confirmed the disgust stimuli as highly disgusting. Comparison of the overall pattern of FAUs evoked by touch, smell, and taste disgusts, indicated two distinct facial disgusts for the proximate senses-a chemosensory and a tactile-disgust face. The nose wrinkle and upper lip raise were central to all facial disgusts, indicating their centrality to the disgust face. Several facial disgusts appear to exist, each with different functional goals. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Reflexive and voluntary saccadic eye movements as biomarker of Huntington's Disease.

Subtle abnormalities in the preclinical stage of Huntington's Disease (HD) can be detected using saccadic eye movement assessment reflecting disease progression. This study was aimed to evaluate abnormalities in saccade parameters in asymptomatic carriers and symptomatic HD patients at various stages of HD. The study enrolled 104 participants, including 14 asymptomatic carriers of HTT mutations, 44 symptomatic HD patients, and 46 control subjects. HD severity was measured using the Unified Huntington's Disease Rating Scale Total Motor Score (UHDRS-TMS) and Total Functional Capacity Scale (TFC). The evaluation of rapid eye movements (reflexive saccades, anti-saccades, memory-guided saccades) was carried out using 'Saccadometer Research'. Measures of reflexive and volitional saccades did not differ between the asymptomatic carriers and controls. Significant latency prolongation and increased physiological variability of latency times, as well as higher error rates among HD patients, were found in all saccade tasks (p < 0.001) compared to the controls. Abnormalities in saccade parameters were more pronounced in the advanced stages of the disease. Latency of saccades and error rate of volitional saccades correlated with the UHDRS-TMS and TFC scores. The saccade parameters in asymptomatic HD carriers with a long time to disease development were similar to those in the control group. Saccade abnormalities appeared in symptomatic patients at the beginning of the disease, and correlated with HD severity.

Unusual refractive anomaly in Alport syndrome with lenticonus: A challenging case

Herein, we report a 15-year-old male with Alport syndrome, exhibiting hemorrhagic nephritis, hearing loss, and a 1-year history of poor distance visual acuity. Slit-lamp examination revealed bilateral anterior lenticonus, with unremarkable findings in other ocular structures. Unusual reflex movements were observed during retinoscopy, characterized by distinct central and annular reflexes yielding objectively an intraeye discrepancy of 12 D. Similar to the objective findings, a pair of subjective findings for each eye was obtained and each pair resulted almost equal visual acuity. However, small pupil size veiled plus error and final prescription was myopic.

Development of Human-Size Swallowing Robot

The number of patients with swallowing disorders is increasing according to the aging of society, although swallowing plays a significant role in the dietary process. The process of swallowing includes a very fast reflexive motion; there are difficulties in analyzing its mechanism even with the latest medical imaging technologies. In recent years, a simulator, named “Swallow Vision®,” has been developed from medical images such as MRI and CT to clearly visualize swallowing motion. It enables us to understand the kinesiology and analyze the motion of organs in swallowing. By using kinematic data obtained from this simulator and referring to medical knowledge, we develop a robotic simulator that has the potential to mimic human swallowing motion. The robot is able to perform tongue depressor and pharynx contraction to swallow food bolus. A performance evaluation is conducted to determine whether it is possible to swallow food bolus properly or where the bolus remains when failing.

Synergy of Muscle and Cortical Activation through Vojta Reflex Locomotion Therapy in Young Healthy Adults: A Pilot Randomized Controlled Trial.

Vojta Therapy is a neurorehabilitation therapy that allows to activate reflex movement patterns. The scientific literature has shown its ability to generate muscle contractions. The activation of brain neural networks has also been proven. However, the relationship between these processes has not yet been demonstrated. For this reason, the aim of this study is to verify brain activation produced by recording with near-infrared spectroscopy and its relationship with muscle activation produced in the abdominal muscles recorded with surface electromyography. A total sample of 27 healthy subjects over 18 years of age was recruited. An experimental study on a cohort was conducted. Two experimental conditions were considered: stimuli according to the Vojta protocol, and a control non-stimuli condition. Abdominal muscle activation was measured using surface electromyography, and the activation of the motor cortex was assessed with near-infrared spectroscopy. In relation to the oxygenated hemoglobin concentration (HbO), an interaction between the stimulation phase and group was observed. Specifically, the Vojta stimulation group exhibited an increase in concentration from the baseline phase to the first resting period in the right hemisphere, contralateral to the stimulation area. This rise coincided with an enhanced wavelet coherence between the HbO concentration and the electromyography (EMG) signal within a gamma frequency band (very low frequency) during the first resting period. The results underscore the neurophysiological effects on the brain following tactile stimulation via Vojta Therapy, highlighting increased activity in pivotal areas essential for sensory processing, motor planning, and control. This activation, particularly evident in the Vojta stimulation group, aligns with previous findings, suggesting that tactile stimuli can not only evoke the intention to move but can also initiate actual muscle contractions, emphasizing the therapy's potential in enhancing innate locomotion and rolling movements in patients with neurological disorders.

Transmembrane Channel-Like (Tmc) Subunits Contribute to Frequency Sensitivity in the Zebrafish Utricle.

Information about dynamic head motion is conveyed by a central "striolar" zone of vestibular hair cells and afferent neurons in the inner ear. How vestibular hair cells are tuned to transduce dynamic stimuli at the molecular level is not well understood. Here we take advantage of the differential expression pattern of tmc1, tmc2a, and tmc2b, which encode channel subunits of the mechanotransduction complex in zebrafish vestibular hair cells. To test the role of various combinations of Tmc subunits in transducing dynamic head movements, we measured reflexive eye movements induced by high-frequency stimuli in single versus double tmc mutants. Wefound that Tmc2a function correlates with the broadest range of frequency sensitivity, whereas Tmc2b mainly contributes to lower-frequency responses. Tmc1, which is largely excluded from the striolar zone, plays a minor role in sensing lower-frequency stimuli. Our study suggests that the Tmc subunits impart functional differences to the mechanotransduction of dynamic stimuli.Significance Statement Information about dynamic head movements is transmitted by sensory receptors, known as hair cells, in the labyrinth of the inner ear. The sensitivity of hair cells to fast or slow movements of the head differs according to cell type. Whether the mechanotransduction complex that converts mechanical stimuli into electrical signals in hair cells participates in conveying frequency information is not clear. Here we find that the transmembrane channel-like 1/2 genes, which encode a central component of the complex, are differentially expressed in the utricle and contribute to frequency sensitivity in zebrafish.

The Effect of Motor Relearning Program on Daily Living Activity and Dynamic Balance in Non-Hemorrhagic Post Stroke Hemiparese Patients at Grandmed Lubuk Pakam Hospital

Stroke is a functional disorder of the brain that can occur suddenly or abruptly with focal or global neurological signs that can last 24 hours or more (if no surgery or death occurs) without any signs of non-vascular causes, which include signs of subarachnoid hemorrhage, intracerebral hemorrhage, ischemia or cerebral infarction. This can cause disturbances in vital brain functions such as coordination disorders, balance disorders, posture control disorders, sensation disorders and movement reflex disorders, thereby reducing the ability to carry out daily living activities and balance disorders. The motor relearning program method is a program for retraining specific motor controls by avoiding unnecessary or wrong movements that involve cognitive processes, the application of motor and psychological science, training, understanding of nervous anatomy and physiology and is not based on the theory of normal development (neuro development). The research aims to determine the effect of the motor relearning program on daily living activities and dynamic balance disorders in post-stroke patients. The method used in this research is a quasi experiment with one group pretest and post test design. The research sample consisted of 9 people. The samples will be observed and adjusted to the specified criteria so that they do not cause problems. Each respondent was measured 2 (two) times, namely before and after the intervention. Test the hypothesis using the Wilcoxon test. The research results obtained a value of p = 0.000 (p=&lt;0.05), which means there is a significant influence of the motor relearning program intervention on daily living activities and dynamic balance disorders in post-stroke patients. The results of this research can be concluded that the motorbike relearning program can improve daily living activities and dynamic balance disorders in patients after non-hemorrhagic stroke. It is hoped that the results of this research can contribute to health services for the community in overcoming the problems of daily living activities and dynamic balance disorders in post-stroke patients.

The Food-Crushing Reflex and Its Inhibition

Anterior tooth (ANT) contacts induce a short-latency reflex inhibition of the human jaw-closing muscles. The jaw is a rigid class 1 lever for pinpoint targeting muscle force into a single bite point, the pivoting food particle. Seesaw reflex movements around the food particle fulcrum multiply the food-crushing force. Unpredictable jolts of reaction force caused by food crushing are subjected to the rostral ANT and caudally to the two articulate ends of the jaw triangle. The compression/distraction strains of food crushing must be monitored and inhibited by withdrawal reflexes. The mesencephalic ganglion (Vmes), neural myelin sheath, and muscle stretch receptors evolved subsequently to the advent of jaws to improve the velocity of proprioceptive and withdrawal reflexes. In mammalians, the spindles of the taut motor units, stretched by the food fulcrum, send excitatory monosynaptic feedback for the efferent neurons of the respective ipsilateral muscle units via the Vmes. In the Vmes, the spindle-input-mediating afferent neurons are coupled with another source of afferent feedback, which is also excitatory, from the back tooth (BAT) mechanoreceptors. The two sources of excitatory pulses are summated and targeted for the efferent neurons to boost the stretched and taut motor units. Likewise, the afferent feedback from the ANT mechanoreceptors is also coupled in the Vmes with concomitant feedback from spindles. The ANT output, however, is inhibitory to negate the excitatory feedback from the stretched jaw muscle units. The inhibitory feed from the anterior teeth temporarily blocks the excitatory potential of the masticatory motor efferent neurons to protect the anterior teeth and jaw joints from inadvertent strains. The inhibitory inputs from the anterior teeth alternate with the excitatory inputs from the BAT to determine which jaw-closing muscle units are activated or inhibited at any given instant of food crushing. The Vmes exists in all jawed vertebrates, and its evolution was probably motivated by demands for the control of bite force. The monosynaptic unilateral food-crushing excitatory and inhibitory reflexes (UFCRs) override the coexisting bilaterally executed feed for the jaw muscles from the central nervous system. The hypothesis proposed in this study is that the Vmes-mediated UFCRs combine neural inputs from tooth contacts with concomitant feedback from the muscle stretch receptors for the control of the mammalian food-crushing bite force.