The detection of concealed water-conducting structures is essential for preventing water inrush disasters. Aiming to mitigate the limitations inherent in using any single technique, a comprehensive approach that combines integrated mining geophysical exploration, hydrogeological drilling, and hydrochemical exploration (GDH) is proposed for the exploration of concealed water-conducting structures. By conducting a thorough analysis of the background geological data obtained through surface exploration, potentially concealed water-conducting structures can be predicted. Then, a combination of the seismic reflection method (SRM) and mine transient electromagnetic method (MTEM) can be used to detect the location and water-bearing properties of the target structures. Afterwards, the target drilling areas are defined by the anomalies detected by the integrated mine geophysical technique, and the drilling method can directly acquire the hydrogeological information of water-conducting structures and verify the results of the geophysical methods. By means of hydrochemical analysis, inrush water sources and their runoff conditions can be identified, and the spatial relationship betweenof the source aquifers and mining space can be determined; hence, the properties, scale, and configuration of the water-conducting structures can finally be evaluated. Employing a water-conducting fault in a mine as a case study, we verified that the integrated method overcomes the limitations and possible biases of each method, providing a multiple-method solution that can accurately detect concealed water-conducting structures to help prevent water inrush disasters.