The present paper provides engineering estimates for plastic J-integral and crack opening displacement (COD) of a non-idealized axial through-wall crack (TWC) in pipes based on detailed 3-dimensional finite element (FE) analyses. The behaviors of plastic J-integral and COD of a non-idealized axial TWC in typical pressurized pipes in nuclear power plants were systematically investigated. The FE model and analysis procedure employed in this study were verified by comparing the present FE results with the limited existing solutions for pipes with an idealized axial TWC. Based on the FE results, the new plastic influence functions, h1 and h2, which include the effect of a non-idealized TWC on plastic J-integral and COD, are provided as tabular solutions. By employing the plastic influence functions, plastic J-integral and COD of a non-idealized axial TWC along crack front can be directly predicted based on GE/EPRI method. In the present paper, plastic J-integral and COD estimates based on the reference stress concept have also been suggested. Finally, the estimated results were compared with elastic-plastic FE results by using actual stress-strain data and Ramberg-Osgood constants for TP 316 stainless steel. In addition, the engineering estimates proposed in this study were extended to estimating the creep fracture mechanics parameters at elevated temperature. Based on Norton and RCC-MRx creep models, C*-integral and creep COD rate values predicted from the present engineering solutions were validated by comparing with creep FE results. The results provided in this paper demonstrate that the present estimates can be applied to calculating plastic J-integral and COD, C*-integral, and creep COD rate of a non-idealized axial TWC.