The New Madrid Seismic Zone (NMSZ) in the central United States is a seismically active intraplate region composed of two fault segments: the Reelfoot and Cottonwood Grove fault segments. It has witnessed several major earthquakes, including a devastating 1811–1812 earthquake sequence of three ~M7 events. Nearly 200 years later, earthquakes still continue today in this complex seismic zone. This seismic zone is located in a domain with higher hydrological load than surrounding regions, which may play a crucial role in seismicity modulation. However, the hydrological unloading or loading-induced seismicity modulation and the underlying earthquake dynamics on this stable plate interior remain equivocal. Our study demonstrates that increased climate variability and drought-induced hydrological unloading can be potential drivers for the crustal stress change in the upper Mississippi embayment and seismicity modulation in the NMSZ. The seismicity rate associated with the Reelfoot fault segment shows ~60% increase during drought-induced prolonged drier periods, linked to La Niña cycles, than during the relatively wetter periods. However, such a feature is lacking for the seismicity associated with the Cottonwood Grove fault segment. We argue that the near-lithostatic pore pressure condition explicitly on the Reelfoot fault segment leads to an increase in the amplitude of the velocity perturbation, making this fault segment more susceptible to seismicity modulation on a multi-annual or annual time scale by the resonance destabilization process.
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