Reduction In Disability Research Articles

Utilizing a Defined Multiphase, Multispecialty Perioperative Pathway to Achieve Functional Recovery after Surgery

This article emphasizes the need for a personalized approach in managing older cancer patients, highlighting the importance of a multidisciplinary team that tailors treatment to the patient's specific health conditions and goals. The objective is to balance positive oncological outcomes with the restoration of independence, reduction of disabilities and enhancement of quality of life. Functional recovery is central to treatment decisions as disability can impact cancer patients more than the prognosis itself. The paper stresses the value of frailty screening tools, nutritional assessment and physical evaluation which help predict postoperative outcomes and guide clinical management. It advocates for comprehensive preoperative evaluations, including geriatric assessments, to prevent both undertreatment and overtreatment. Multimodal prehabilitation can improve postoperative outcomes, reduce healthcare costs, and help older patients remain engaged in society. The article concludes by recommending a patient-centered, individualized approach to optimize functional recovery and alleviate the economic burden on healthcare systems.

Combined Oxygen–Ozone and Porcine Injectable Collagen Therapies Boosting Efficacy in Low Back Pain and Disability

Background/Objectives: Intervertebral disc degeneration is the most common cause of low back pain (LBP), and lumbosciatica is a major challenge to healthcare systems worldwide. For years, ozone therapy has been used with excellent results in intervertebral disc disease and in patients with LBP. In vitro studies have demonstrated the positive action of porcine collagen in extracellular matrix remodeling and homeostasis. These tissue changes, associated with LBP, may suggest an indication for combined ozone/collagen treatment in patients with LBP. However, no studies have been reported regarding this combination of treatments. Methods: The present work compared retrospective data of two treatment groups (each of 10 LBP patients): (A) oxygen–ozone therapy (OOT) vs. (B) OOT plus porcine collagen type 1 injections (COL I). Pain intensity and physiological function were assessed by the numerical rating scale (NSR) method. The Roland–Morris questionnaire was used to assess disability. Patient data were acquired before, during, and at the six-month follow-up. Significant differences were assessed by ANOVA and Student’s t-test. Results: The analyses revealed significant statistical differences comparing the two arms, where the (OOT+COL I) treatment demonstrated a booster efficacy in pain (a reduction of 62% vs. 35%), while the questionnaire revealed a reduction in disability (70% vs. 31%). Conclusions: Therefore, this combination therapy (oxygen–ozone plus porcine injectable collagen) might be a promising approach for the management of patients with LBP.

Feasibility, acceptability, and fidelity of remote-delivered abbreviated mindfulness-based cognitive therapy interventions for patients with migraine and depressive symptoms.

This study was an open-label single-arm clinical trial evaluating the fidelity, feasibility, acceptability, and clinical signal of abbreviated mindfulness-based cognitive therapy (MBCT-brief) delivered either via telephone (MBCT-T) or by video conferencing (MBCT-V) for people with migraine and comorbid depressive symptoms. Migraine is commonly comorbid with elevated depressive symptoms. MBCT reduces depressive symptoms and shows promise to reduce migraine-related disability. An abbreviated and remotely delivered version of MBCT could increase access to care. People with migraine and elevated depressive symptoms were recruited from a large urban health system. Participants were assigned in blocks of eight to receive an evidence-based MBCT-brief treatment, including eight weekly group classes and home practice delivered via telephone (MBCT-T) or video (MBCT-V); MBCT-T was randomly selected for the first block. Sessions were recorded and coded for treatment fidelity. Feasibility was assessed via session attendance (primary), homework completion, recruitment rate, and survey completion rate. Acceptability was assessed via the eight-item Client Satisfaction Questionnaire (CSQ-8; primary), the Credibility/Expectancy Questionnaire (CEQ), the System Usability Scale (SUS), and items assessing survey acceptability. Participants completed the Headache Disability Inventory (HDI) and Quick Inventory of Depressive Symptomatology-Self Report 16-item (QIDS-SR16) at baseline, mid-treatment, and post-treatment. Feasibility and acceptability rates were compared to a priori benchmarks. Participants (n = 16) were all female with a mean (standard deviation [SD]) age of 45 (13) years, the majority of whom identified as White (13/16, 81%) and non-Hispanic (14/16, 88%). The intervention met the a priori criteria set for therapist fidelity to treatment protocol (mean [SD] MBCT-Treatment Acceptability and Competence Scale Adherence score 2.9 [0.2]), feasibility (mean [SD] session attendance was 7.9/8 [0.3]), and acceptability (mean [SD] CSQ-8 score 28.8 [3.3]) for the entire sample and for each treatment arm. The usability of the remote-delivery system was high across study participants (mean [SD] SUS score 84.8 [11.0]). Survey procedures were broadly deemed acceptable, with at least 80% participants either endorsing "Agree" or "Strongly Agree" across all items. Using Wilcoxon tests, we observed significant reductions in both the HDI (pre-treatment median [interquartile range] score 63 [40, 70] vs. post-treatment 36 [26, 54], p = 0.004) and the QIDS-SR16 (pre-treatment median [interquartile range] score 8 [5, 13] vs. post-treatment 4 [3, 6], p = 0.003). We found that remotely delivered MBCT-brief for migraine and depressive symptoms was feasible and acceptable to patients in both the telephone and video modalities. Intervention was associated with significant post-treatment reductions in headache-related disability and depressive symptomatology, findings that must be interpreted cautiously in the absence of a control group.

Improvements in Forward Bending Are Related to Improvements in Pain and Disability During Cognitive Functional Therapy for People With Chronic Low Back Pain.

OBJECTIVE: To investigate whether improvements in forward bending were related to improvements in pain and disability in people with chronic low back pain (CLBP) who were undergoing Cognitive Functional Therapy (CFT). DESIGN: Longitudinal observational study. METHODS: Two hundred and sixty-one participants with CLBP received CFT. Forward bending was assessed at each treatment session over 13 weeks (an average of 4.3 timepoints per participant [range, 1-8]). Spinal range of motion (ROM) and velocity were recorded using 2 inertial measurement units located at T12 and S2. Participants reported (1) average pain intensity (0-10 scale) (pain) and (2) pain-related activity limitation (Roland Morris Disability Questionnaire [disability]) via online questionnaires at 0, 3, 6, and 13 weeks. Multivariate multilevel models were used to evaluate associations between individual rates of change over time for 3 spinal movement measures (trunk velocity, trunk ROM, lumbar ROM) and pain/disability. RESULTS: Strong correlations were observed for increased trunk velocity with reduced pain (r = -0.81; 95% CI: -0.98, -0.05) and with reduced disability (r = -0.77; 95% CI: -0.95, -0.22). Moderate correlations were observed between increased trunk ROM with reduced pain (r = -0.37; 95% CI: -0.67, 0.04) and with reduced disability (r = -0.32; 95% CI: -0.6, 0.03). There was no evidence of association between changes in lumbar ROM and pain (r = -0.46; 95% CI: -0.90, 0.44) or disability (r = -0.01; 95% CI: -0.56, 0.55). CONCLUSION: Reductions in pain and disability were strongly correlated with increased trunk velocity in people with CLBP who were undergoing CFT. These findings are consistent with CFT that explicitly trains "nonprotective" spinal movement. J Orthop Sports Phys Ther 2024;54(11):721-731. Epub 7 October 2024. doi:10.2519/jospt.2024.12727.

Development of an Integrated Physiotherapy Treatment Protocol for Desk Job Personals: A Pilot Research

Objectives: To develop an Integrated validated Physiotherapy Treatment Protocol for Desk Job personnel along with an assessment of its effectiveness. Methods: The research was conducted utilizing a mixed-method methodology. Interviews with thirty computer professionals (having more than five years of experience) and a thorough in-depth literature research were conducted to identify various symptoms which are commonly seen among computer professionals. Search engines such as Ovid MEDLINE, Cochrane Library, Pubmed, and EBSCO CINAHL were used with terms such as Neck Problems in Computer Professionals(cs), Treatment Techniques used in Cervical Spondylitis, and Motor or Sensory issues in Computer Professionals. The treatment protocol was created with the help of identified symptoms and validated using the Delphi technique. After the protocol was developed, a randomized control trial was conducted with thirty samples in each group. A developed and validated regimen was provided to the participants. Findings: Item level CVI ranges from 0.79 to 1. The Kappa results demonstrated the protocol's strong content validity, which ranged from 0.79 to 1. In comparison to day 1, there was a decline in both groups' scores of NDI and NPRS on day 30, and there was an even more noticeable decrease on day 60. The experimental group showed a much greater reduction in neck pain and disability when compared to the control group. Novelty: The study has focussed on a new category of occupational health issues, namely computer-related health issues, for which there is no established set of Physiotherapy Protocol that can either prevent or treat the issues. Keywords: Numeric Pain Rating Scale (NPRS), Neck Disability Index (NDI), Content Validity Ratio (CVR) and Content Validity Index (CVI), Integrated Physiotherapy Treatment Protocol (IPTP)

A new approach to Health Benefits Package design: an application of the Thanzi La Onse model in Malawi.

An efficient allocation of limited resources in low-income settings offers the opportunity to improve population-health outcomes given the available health system capacity. Efforts to achieve this are often framed through the lens of "health benefits packages" (HBPs), which seek to establish which services the public healthcare system should include in its provision. Analytic approaches widely used to weigh evidence in support of different interventions and inform the broader HBP deliberative process however have limitations. In this work, we propose the individual-based Thanzi La Onse (TLO) model as a uniquely-tailored tool to assist in the evaluation of Malawi-specific HBPs while addressing these limitations. By mechanistically modelling-and calibrating to extensive, country-specific data-the incidence of disease, health-seeking behaviour, and the capacity of the healthcare system to meet the demand for care under realistic constraints on human resources for health available, we were able to simulate the health gains achievable under a number of plausible HBP strategies for the country. We found that the HBP emerging from a linear constrained optimisation analysis (LCOA) achieved the largest health gain-∼8% reduction in disability adjusted life years (DALYs) between 2023 and 2042 compared to the benchmark scenario-by concentrating resources on high-impact treatments. This HBP however incurred a relative excess in DALYs in the first few years of its implementation. Other feasible approaches to prioritisation were assessed, including service prioritisation based on patient characteristics, rather than service type. Unlike the LCOA-based HBP, this approach achieved consistent health gains relative to the benchmark scenario on a year- to-year basis, and a 5% reduction in DALYs over the whole period, which suggests an approach based upon patient characteristics might prove beneficial in the future.

Effects of MLS Laser on pain, function, and disability in chronic non-specific low back pain: A double-blind placebo randomized-controlled trial.

Among non-pharmacological interventions, Multiwave Locked System (MLS) Laser therapy has been used in patients with several musculoskeletal pathologies and in combination with other therapeutical interventions. The effects of sole MLS therapy on pain and function in patients with chronic non-specific low-back pain are unknown. The objective of this study was to investigate the effects of MLS Laser therapy on pain, function, and disability in patients with chronic non-specific low back pain in comparison to a placebo treatment group. Forty-five patients were randomized into two groups: the MLS Laser group and the Sham Laser group, undergoing 8 sessions of either a MLS Laser therapy or a Sham Laser therapy, respectively. At the beginning of the therapy (T0), at the end of the therapy (T1), and 1 month after the end of therapy (T2) patients were assessed for low back pain (by means of a VAS scale), function (by means of kinematic and electromyographic assessment of a forward bending movement) and self-reported disability (by means of the Roland-Morris and Oswestry Disability questionnaires). There was a significant reduction of pain and disability in both groups at T1 and T2 in comparison with T0. At T2 patients in the MLS group showed a significantly lower pain in comparison with patients in the Sham group (VAS = 2.2 ± 2 vs. 3.6 ± 2.4; p< 0.05). No differences between the two groups were found for function and disability. Both MLS Laser and Sham Laser therapies lead to a significant and comparable reduction in pain and disability in patients with chronic non-specific low back pain. However, one month after treatment, MLS Laser therapy has been found to be significantly more effective in reducing pain as compared to sham treatment.

Unveiling citicoline's mechanisms and clinical relevance in the treatment of neuroinflammatory disorders.

Citicoline, a compound produced naturally in small amounts in the human body, assumes a pivotal role in phosphatidylcholine synthesis, a dynamic constituent of membranes of neurons. Across diverse models of brain injury and neurodegeneration, citicoline has demonstrated its potential through neuroprotective and anti-inflammatory effects. This review aims to elucidate citicoline's anti-inflammatory mechanism and its clinical implications in conditions such as ischemic stroke, head trauma, glaucoma, and age-associated memory impairment. Citicoline's anti-inflammatory prowess is rooted in its ability to stabilize cellular membranes, thereby curbing the excessive release of glutamate-a pro-inflammatory neurotransmitter. Moreover, it actively diminishes free radicals and inflammatory cytokines productions, which could otherwise harm neurons and incite neuroinflammation. It also exhibits the potential to modulate microglia activity, the brain's resident immune cells, and hinder the activation of NF-κB, a transcription factor governing inflammatory genes. Clinical trials have subjected citicoline to rigorous scrutiny in patients grappling with acute ischemic stroke, head trauma, glaucoma, and age-related memory impairment. While findings from these trials are mixed, numerous studies suggest that citicoline could confer improvements in neurological function, disability reduction, expedited recovery, and cognitive decline prevention within these cohorts. Additionally, citicoline boasts a favorable safety profile and high tolerability. In summary, citicoline stands as a promising agent, wielding both neuroprotective and anti-inflammatory potential across a spectrum of neurological conditions. However, further research is imperative to delineate the optimal dosage, treatment duration, and underlying mechanisms. Moreover, identifying specific patient subgroups most likely to reap the benefits of citicoline as a new therapy remains a critical avenue for exploration.

Effects of oral steroid sparing immunosuppressive drugs in long term maintenance treatment of chronic inflammatory demyelinating polyradiculoneuropathy.

Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an acquired treatable autoimmune disorder. Due to limited availability and affordability of IV immunoglobulins and therapeutic plasma exchange in Pakistan, oral immunosuppressive drugs (ISDs) are used despite limited role in literature. The study aimed to determine the response to ISDs in CIDP patients by assessing the frequency of remission, reduction of disability using a neuropathy related disability score called Inflammatory Neuropathy Cause and Treatment score (or INCAT score), as well as reduction in steroid maintenance dose. The retrospective observational study of six months duration (May to October, 2020) was carried out in Aga Khan University Hospital, Karachi, Pakistan. Medical record of all the patients with idiopathic CIDP taking oral ISDs in last five years was selected which included bio-data, clinical signs and symptoms, medication details, and INCAT scores. Descriptive statistics were described i.e. frequency, percentages, mean/standard deviation using Microsoft Excel v.2021. Out of thirteen patients, Azathioprine was used in nine, Mycophenolate mofetil in two and Cyclosporine in two, with remission (INCAT score improvement ≥ 1) achieved in eight, one and zero patients respectively. Duration of ISDs ranged from three to twenty-four months (average 15.8 months). Patients with monoclonal paraproteinemia and prior exposure to ISDs had a poor response to the introduction of subsequent ISDs. The study describes preliminary experience of the potential role of relatively cheaper and more convenient oral ISDs (especially Azathioprine) as an alternative or sparing agent to first line agents for CIDP and sets the stage for larger scale studies and randomized controlled trials.

Does Pain Explain Trends in Disability? An Analysis of Middle-Aged and Older U.S. Adults, 2002-2018.

This article investigates the role of pain in disability trends in the United States, within the context of recent unfavorable disability trends and the concurrent rise in pain. We conducted a 2-part analysis using National Health Interview Survey data from 2002 to 2018 for U.S. adults aged 45-84. First, we assessed how changes in the prevalence of 5 site-specific types of pain (headaches/migraines, joint, low back, neck, and facial/jaw pain) associated with disability trends. Second, we used self-reported causes of disability and examined whether there has been a change in the proportion of individuals who attribute their disability to 1 of 5 chronic or acute painful conditions. The 5 site-specific types of pain, individually and collectively, were significantly associated with increases in disability. If site-specific chronic pain had not increased during the study period, the trend for functional limitations would have been 40% lower, and that for activity limitations would have shown a slight decline instead of an increase. Attributions of functional limitations to painful conditions increased by 23% during the 2002-2018 period, representing an additional 9.82 million Americans experiencing pain-attributable disability. Arthritis/rheumatism, back/neck problems, and other musculoskeletal/connective conditions were the primary sources of pain-related disability. Our research provides the first systematic, national examination of how pain is contributing to disability trends in the United States. The findings have implications for disability reduction policies and shed light on the far-reaching consequences of pain for overall population health.

Patent foramen ovale and migraine: prevalence, pathogenetic relationship and impact of PFO closure

Background. Migraine is a chronic neurovascular disease with high prevalence (12-15% of the population) and social significance [1]. Pathogenesis of migraine has not been clear. Some studies report an association between migraine and the presence of a patent foramen ovale (PFO) and right-to-left shunt [2, 3, 4]. Introduction. The objectives of this study were to clarify the prevalence and clinical characteristics of migraine, as well as the effect of endovascular PFO closure on the course of migraine in a cohort of patients who suffered ischemic stroke (IS) by paradoxical embolism due to PFO. Material and methods. We examined 97 patients from 18 to 50 y.o. (average age 32.29 ± 2.19 years, women 70.8%) with IS due to PFO in The Research Center of Neurology since January 2018 until October 2023. All patients were assessed for migraine, characteristics of headaches and the impact of migraine on social adaptation. Endovascular surgery was performed in 61 patients. The data from a dynamic examination of 24 patients with migraine were assessed before and after PFO closure. Results. Among a cohort of IS due to PFO patients, the prevalence of migraine was 39.2% (migraine with aura - 55%, migraine without aura - 45%), the ratio of women to men was 1.9:1. The frequency of headaches was 4 [1;7] days per month. Six months after PFO closure, patients with migraine showed a significant decrease in the frequency of headaches from 4 [2; 24] up to 2 [1;5] days per month (p=0.009); reduction in pain intensity from 7 [7; 9] to 3 [3; 7] points according to VAS (p=0.0001); reduction of disability from 20 [6; 89] to 17 [2; 26] points (p=0.019) according to the MIDAS. Conclusion. The present study confirmed the high prevalence of migraine in the PFO cohort. PFO closure led to decrease in frequency and intensity of headaches and decrease of migraine’s impact on social adaptation.

Integrating Chiropractic Care and Tai Chi Training for the Treatment of Chronic Nonspecific Neck Pain in Nurses: A Single-Arm Mixed-Methods Pilot Trial.

Objectives: Chronic nonspecific neck pain (CNNP) is prevalent among health care workers, with particularly high rates among nurses. Nurses experiencing CNNP often report decreased job satisfaction, increased absenteeism, and reduced productivity. In recent years, nonpharmacologic approaches have gained attention as effective treatments for the management of CNNP, with exercise and manual therapies representing two of the most common. Early evidence shows that multimodal treatments may be more effective than unimodal strategies. The purpose of this current study was to assess the feasibility and observe the clinical outcomes of combined multimodal chiropractic care (MCC) and Tai Chi (TC) for CNNP in nurses. Methods: A single-arm mixed-methods pilot trial was conducted including 16 weeks of MCC and TC in nurses with self-reported CNNP. Feasibility outcomes were recruitment, retention, and adherence to the interventions. Clinical outcomes of interest included neck pain and related disabilities. Secondary outcomes of interest were functional, affective, and work-related performance. Qualitative interviews were also conducted. Results: Of the 59 screened, 36 met the eligibility criteria, and 21 were enrolled. The retention rate was 71.4%, and adherence rates were 85.3% for MCC and 62.5% for TC classes. Multiple pain and disability-related outcomes exhibited modest improvement from baseline to 16-week follow-up. Qualitative analysis identified six emergent themes: (1) neck pain being an inherent part of nursing, (2) nurses push through their pain, (3) MCC relieves pain and is instructive for preventing pain, (4) TC provides overall relaxation, (5) both interventions increased body awareness and improved posture, and (6) scheduling difficulties were a key obstacle for participating. Conclusions: Observed reductions in neck pain and disability suggest the potential utility of combined MCC and TC interventions for managing CNNP. Along with qualitative feedback regarding facilitators and barriers to participation, the findings support and inform a future randomized trial evaluating the combined benefits of MCC and TC for CNNP in nurses. Clinical Trial Registration #NCT06523036.

The impact of electrotherapy on the quality of life of patients suffering from chronic migraine and cervicalgia

Objective. To evaluate the effect of electrotherapy on quality of life in patients with chronic migraine and neck pain. Material and methods. The study included 45 patients with chronic migraine and neck pain, divided into two groups: the first group (n=25) received treatment with transcutaneous electrical nerve stimulation (TENS), the second group (n=20) received botulinum toxin type A injections PREEMPT scheme. The results were assessed using the MIDAS, HIT-6 and NDI questionnaires before the start of treatment and one month after it began. Results. The use of electrotherapy caused a greater reduction in disability and improved quality of life compared to botulinum toxin. The data obtained indicate the high effectiveness of electrotherapy and the need for its further use in clinical practice to improve the condition of patients with chronic migraine and neck pain.

Effect of Extracorporeal Shock Wave Therapy in Conjunction with Kinetic Chain Based Exercises on Pain, Kinesiophobia, and Functional Outcome in Chronic Subacromial Pain Syndrome Participants -A Case Series

Background and Objectives: Chronic Subacromial Pain Syndrome (CSAPS) is a common condition characterized by persistent shoulder pain and functional limitations. Despite existing non-operative treatments, patients often experience chronic pain, fear of movement (kinesiophobia) and impact shoulder function. The primary objective of this study is to evaluate the effects of extracorporeal shock wave therapy in conjunction with kinetic chain-based exercises on pain, kinesiophobia, and shoulder functional outcomes in individuals with CSAPS. Methodology: This case series included ten participants with unilateral shoulder pain lasting at least three months. Participants received extracorporeal shock wave therapy biweekly for six weeks alongside a structured kinetic chain exercise program. Outcome measures included the Numeric Pain Rating Scale for pain, the Tampa Scale for fear of movement, and the Shoulder Pain and Disability Index for functional assessment. Pre- and post-intervention data were analyzed using paired t-tests to determine statistical significance. Results and Discussion: Statistically significant improvements (p&lt;0.05) were observed after the intervention. The average NPRS score reduced from 7.5±0.84 to 1.90±0.99, showing a significant reduction in pain. The SPADI scores exhibited a significant improvement, decreasing from 66.79±9.48 to 51.90±8.90, indicating a reduction in both shoulder pain and disability. The TSK scores decreased from 48.10±3.03 to 37.60±4.47, indicating a decrease in kinesiophobia. Conclusion: The combination of ESWT and kinetic chain exercises resulted in significant enhancements in pain reduction, reduction in fear of movement, and improvement in shoulder function. This demonstrates the potential effectiveness of this integrated strategy in controlling CSAPS.

Impact of Trunk Stabilization Training on Cricketers with Chronic Non-Specific Low Back Pain

Background: The endeavour of this study was to check the impact of trunk stabilization training on cricketers suffering from chronic non-specific low back pain. Objectives: The objectives of the study was to examine the effects of trunk stabilizing exercises in cricketers with chronic low back pain for the change in level of pain, disability and improvement of endurance of trunk muscles. Methods: The related literature was searched and reviewed for the efficacy of interventions, reliability and validity of outcome measures. Quasi-experimental approach was chosen for conducting the study with pre-intervention and post-intervention evaluation of the outcomes. Convenient sampling and random allocation in to groups were used to select and assign the sample that comprised of 15 subjects in each groups out of total sample size of 30. Standardized tools such as VAS for evaluating the pain, modified Oswestry LBP disability questionnaire for evaluating disability trunk stabilization exercises to check improvement of endurance of trunk muscles were utilized. Trunk stabilization exercises with warm up, stretching and cool down were given to group A (experimental group). Hitting pads and back care advice was given in the form of a leaflet to the group B (control group). Results: The data were analysed with help of SPSS version 21. Paired t-test was done for intra group analysis and un-paired t-test for intergroup analysis. The results of the study suggested that there was significant difference between the difference in mean values of pain, disability and endurance between the group-A&amp;B. The findings also suggested that there was significant difference within group-A and group-B for pain, disability and endurance. Conclusion: This study concluded that on both groups, the significant reductions were seen in pain, disability and endurance of subjects after 8 weeks of intervention. However, there was more reduction in pain, disability and endurance in group-A (experimental group)

Functional and Radiological Outcomes Following Arthroscopic-Assisted Reduction and Fixation of Intra-Articular Distal Radius Fractures

Abstract Background: Intra-articular distal radius fractures (DRFs) are prevalent injuries that are usually difficult to treat and rehabilitate. These injuries may be associated with ligamentous injuries or intra-articular loose fragments. This study aims to assess the functional and radiological results of using arthroscopic-assisted reduction and fixation, which offers direct visualization of the joint surface, evaluation of intra-articular ligaments, and removal of loose fragments, potentially enhancing recovery outcomes. Patients and Methods: This quasi-experimental interventional study evaluated the functional and radiological outcomes of arthroscopic-assisted reduction and fixation for intra-articular DRFs. The study included 26 patients who met specific inclusion criteria, and data collection involved preoperative assessment, patient preparation, operative measures, postoperative care, and follow-up evaluations using various scoring systems. Results: The range of motion showed a significant (P &lt; 0.001) improvement over the study duration: flexion increased from 42.81° ± 11.81° at 6 weeks to 54.23° ± 14.95° at 12 months, and extension improved from 56.88° ± 13.28° to 68.38° ± 13.43°. In addition, there was a significant reduction in disability and wrist-related symptoms, as indicated by improvements in the Disabilities of the Arm, Shoulder, and Hand (DASH) scores (6 weeks: 25.80 ± 15.85 vs. 12 months: 5.27 ± 8.61; P &lt; 0.01) and Patient-Rated Wrist Evaluation (PRWE) scores at the same follow-up intervals (6 weeks: 46.04 ± 22.49 vs. 12 months: 9.54 ± 12.03; P &lt; 0.001). Chronic illness and injuries like triangular fibrocartilage complex tears affected outcomes negatively. Age, ulnar variance, and palmar tilt were significantly correlated with DASH and PRWE scores. Conclusion: Arthroscopic-assisted reduction and fixation for intra-articular DRFs resulted in favorable outcomes regarding the range of motion, disability, and wrist-related symptoms. Further research and long-term follow-up studies are recommended to validate the positive outcomes of arthroscopic-assisted reduction and fixation for intra-articular DRFs, compare it with other surgical approaches, and assess its economic implications.

The Application of Spinal Manipulation Results in Alterations in Thalamic Neural Metabolite among Patients Experiencing Nonspecific Chronic Low Back Pain

Abstract Background: In patients diagnosed with nonspecific chronic low back pain (NCLBP), discernable discrepancies in pain perception have been observed. This study endeavors to assess alterations in left thalamic metabolites in patients with NCLBP following spinal manipulation, utilizing proton magnetic resonance spectroscopy (1H-MRS). Materials and Methods: A total of 16 individuals diagnosed with NCLBP and 16 healthy individuals volunteers of normal constitution (aged between 20 and 50 years) were recruited. All participants exhibited right-hand dominance. Before commencement of therapeutic intervention and at a 5-week interval thereafter, functional and radiological assessments were undertaken (Oswestry Disability Index, numerical rating scale, and 1H-MRS). The values were compared using independent and paired t tests. Results: Following spinal manipulation, the patients experienced notable reductions in pain and disability (P &lt; 0.05). The treatment group demonstrated significant increases in N-acetyl aspartate (NAA), choline (Cho), myo-inositol (Mio), and glutamate and glutamine (Glx) in the left thalamus region post-treatment compared with the baseline measures (P &lt; 0.05). Before treatment, NAA, Cho, Glx, and Mio levels were significantly lower in the left thalamus of the patients compared with healthy subjects (P &lt; 0.05). However, no significant differences in terms of metabolites were observed between the healthy control group and the patients after the treatment. Conclusion: In patients presenting with NCLBP, spinal manipulation has been observed to exert an effect on the brain, thereby inducing changes in thalamic metabolites.

Additional effect of erenumab for patients with chronic migraine treated with onabotulinumtoxin A-real-world data from a preliminary cohort study.

This preliminary retrospective cohort study investigates the potential additive prophylactic effect of erenumab, a fully human monoclonal antibody that blocks the calcitonin gene-related peptide receptor, in combination with ongoing onabotulinumtoxin A (onaBoNT-A) treatment in patients suffering from chronic migraine. The study included 218 patients and investigated the effects of adding erenumab to the existing treatment regimen. The primary outcome was the MIDAS (Migraine Disability Assessment) score assessed 3 months after the introduction of erenumab. The results indicated a significant improvement of the MIDAS score, suggesting a reduction in migraine-related disability following the addition of erenumab to onaBoNT-A. In the inter group comparison, dual therapy showed a significantly greater reduction of the MIDAS when compared to a switch from onaBoNT-A to erenumab monotherapy, but not compared to initiation of onaBoNT-A monotherapy. It is hypothesized that the observed additive effects are due to the independent modes of action of erenumab and onabotulinumtoxin A. This study suggests that the combination of erenumab with onaBoNT-A may offer an improved approach for the treatment of chronic migraine in selected patients. However, the results highlight the need for prospective, controlled studies to validate these findings and determine the optimal combination of treatments tailored to the individual patient.

Sex differences in response to rehabilitation treatment for musculoskeletal pain: the mediating role of post-traumatic stress symptoms

Aim: Numerous investigations have revealed sex differences in recovery outcomes in individuals who have sustained work-related musculoskeletal injuries (WRMIs). Previous research has also revealed significant sex differences in the prevalence and severity of post-traumatic stress symptoms (PTSS) following musculoskeletal injury. This study investigated whether PTSS mediated sex differences in recovery outcomes in individuals receiving treatment for a work-related musculoskeletal injury. The recovery outcomes of interest in the present study were pain severity and pain-related disability. Methods: The study sample included 137 individuals (68 men; 69 women) with WRMIs who were enrolled in a 7-week physical rehabilitation program. Participants completed measures of pain severity, pain disability and PTSS at admission and termination of the physical rehabilitation program. Results: Consistent with previous research, independent samples t-tests revealed that women obtained significantly higher baseline scores on measures of pain severity (P &lt; 0.01), number of pain sites (P &lt; 0.001), depression (P &lt; 0.001) and PTSS (P &lt; 0.001) compared to men. Also consistent with previous research, the measure of PTSS, assessed at baseline, was prospectively associated with treatment-related disability reduction (P &lt; 0.01), and return to work (P &lt; 0.01). Bootstrap regression analyses revealed that PTSS partially mediated the relation between sex and pain-related disability. Conclusions: The results of the present study suggest that the experience of PTSS might be one of the factors that explain sex differences in recovery outcomes following a WRMI. The results call for greater attention to the assessment and intervention of PTSS in individuals who have sustained WRMIs.

Does combining oro-facial manual therapy with bruxism neuroscience education affect pain and function in cases of awake bruxism? A pilot study.

Although awake bruxism is associated with temporomandibular disorder (TMD) as well as head and neck pain, the effects of physical therapy and bruxism education to address these factors have not been investigated. The aim of this study was to evaluate the effects of oro-facial manual therapy and bruxism neuroscience education (BNE) on awake bruxism over a 3-week period with an open-ended follow-up questionnaire after 3 months. Subjects (n = 28) were randomly allocated to one of two groups, an intervention group and a control group. Data regarding disability, function and pain were collected pre- and post-assessment, with all measures administered in a single-blind fashion. Participants in both groups received six treatment sessions during this period. In addition to manual therapy, participants were provided with information on the neurophysiological mechanisms of bruxism and contributing factors. Individual behavioural guidelines and daily exercises were determined in consultation with the therapist. An introduction to a bruxism specific app (Brux.App) was also provided, which all participants used as an adjunct to their treatment. The intervention group demonstrated notable improvement as indicated by their scores in the Neck Disability Index (NDI) (p = .008), Pain Disability Index (PDI) (p = .007) and Jaw Disability List (JDL) (p = .03). Furthermore, clinical assessments of the temporomandibular joint (TMJ) revealed a significant progress in terms of mouth opening (p = .03) and lateral jaw movement (laterotrusion) (p = .03). The mechanical pain threshold (PTT) of both the masseter (p = .02) and temporalis muscle (p = .05) also showed significant improvement. At 3-month follow-up, the questionnaire revealed that the majority of the intervention group (13/15, 87%) reported a benefit from the treatment. The reduction in pain and disability together with improvement in function and increased coping suggest a potential modification of awake bruxism through specialised musculoskeletal intervention and BNE tailored to the individual patient.