Conduct problems (CPs) in childhood, such as conduct disorder and oppositional defiant disorder, are among the most prevalent mental health disorders in childhood and a leading cause for referral to child and adolescent mental health services ( 1 Fairchild G. Hawes D.J. Frick P.J. Copeland W.E. Odgers C.L. Franke B. et al. Conduct disorder. Nat Rev Dis Primers. 2019; 5: 43 Crossref PubMed Scopus (152) Google Scholar ). The 2019 Global Burden of Disease Study found that for the 0- to 14-year-old age category, CPs have now become the leading cause of burden among mental disorders, in terms of both disability-adjusted life years and years lived with disability ( 2 GBD 2019 Mental Disorders CollaboratorsGlobal, regional, and national burden of 12 mental disorders in 204 countries and territories, 1990-2019: A systematic analysis for the Global Burden of Disease Study 2019. Lancet Psychiatry. 2022; 9: 137-150 Abstract Full Text Full Text PDF PubMed Scopus (502) Google Scholar ). Crucially, various prospective longitudinal studies have shown that the negative outcomes observed in youth persist into adulthood and cover a similar range of domains. Importantly, the worst outcomes in adulthood are experienced by those whose CP symptoms persist ( 1 Fairchild G. Hawes D.J. Frick P.J. Copeland W.E. Odgers C.L. Franke B. et al. Conduct disorder. Nat Rev Dis Primers. 2019; 5: 43 Crossref PubMed Scopus (152) Google Scholar ). SEE CORRESPONDING ARTICLE ON PAGE 50 SEE CORRESPONDING ARTICLE ON PAGE 50 Selective Amygdala Hypoactivity to Fear in Boys With Persistent Conduct Problems After Parent TrainingBiological PsychiatryVol. 94Issue 1PreviewParenting interventions reduce antisocial behavior (ASB) in some children with conduct problems (CPs), but not others. Understanding the neural basis for this disparity is important because persistent ASB is associated with lifelong morbidity and places a huge burden on our health and criminal justice systems. One of the most highly replicated neural correlates of ASB is amygdala hypoactivity to another person’s fear. We aimed to assess whether amygdala hypoactivity to fear in children with CPs is remediated following reduction in ASB after successful treatment and/or if it is a marker for persistent ASB. Full-Text PDF Open Access
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