Reduction Of Overweight Research Articles

Determinants of failure to progress within 2 weeks of delivery: results of a multivariable analysis approach

ObjectiveThe incidence of cesarean section (CS) for failure to progress (FP) has progressively increased; thus, knowing the factors that increase this incidence has become of crucial importance. This study aimed to find the true determinants of CS for FP within 2 weeks of delivery, proposing strategies to reduce its incidence. Material and MethodsA group of 957 term and late preterm (≥34 weeks) singleton pregnancies with a complete gestational follow-up and an ultrasound examination within 2 weeks of delivery were included in a retrospective observational study. Epidemiological, sonographic, and perinatal data were recorded, and multivariable logistic regression analyses were applied to create models to predict the importance of different variables in the explanation of FP. ResultsInduction of labor was by far the most important modifiable factor, followed by smoking and maternal weight, while parity was the most important nonmodifiable factor, followed by maternal age and estimated fetal weight. The difference in days from the actual due date exerted no influence. ConclusionsTo reduce the incidence of CS for FP, inductions of labor should be performed only under evidence-based medicine indications and kept to a minimum. In addition, maternal overweight reduction and maternal smoking cessation should be promoted before the initiation of gestation.

Re-evaluating concurrent training strategies for cardiovascular risk reduction in overweight or obese adults.

Re-evaluating concurrent training strategies for cardiovascular risk reduction in overweight or obese adults.

Adding thread-embedding acupuncture to auricular acupuncture enhances short-term weight reduction in overweight and obesity: A double-blinded, randomized, sham-controlled trial

BackgroundAuricular acupuncture (AA) has been widely used in overweight and obesity management due to its safety and effectiveness. The combination of other acupuncture therapies with thread-embedding acupuncture (TEA) has shown enhanced effects. However, there is a lack of evidence regarding AA plus TEA for overweight and obesity. This study was conducted to address this question. MethodsA randomized placebo-controlled trial was conducted involving 66 overweight or obese participants, divided into two groups: 33 received AA plus TEA, and 33 received AA plus sham TEA over eight weeks. The primary outcome was body weight (BW) reduction. Secondary outcomes included changes in body mass index (BMI) and waist circumference (WC), hip circumference (HC), waist-hip ratio (WHR), food cravings questionnaire-trait-reduced (FCQ-Tr) and food craving visual analog scale (VAS) scores. Safety outcomes were adverse events (AEs). ResultsAfter eight weeks, BW decreased by a mean (SD) of -4.45 (1.29) kg and -2.05 (1.33) kg in the AA plus TEA and AA plus sham TEA groups, respectively (MD [95 % CI]: 2.40 [1.75; 3.05]). BMI, WC, WHR, and food craving VAS score decreased significantly more in the AA plus TEA group than in the AA plus sham TEA group. No significant differences were found in FCQ-Tr and HC between groups. Seven AEs were recorded that were mild and resolved without treatment. ConclusionThe addition of TEA to AA is a safe and effective management of overweight and obesity. Further studies should incorporate dietary and lifestyle modifications and follow-up after the intervention to assess long-term effectiveness. Trial registrationThe study protocol had been registered on ClinicalTrials.gov (NCT06091761).

"Dare to feel full"-A group treatment method for sustainable weight reduction in overweight and obese adults: A randomized controlled trial with 5-years follow-up.

To assess the long-term effects on weight reduction and health of a group-based behavioral weight intervention over six months focusing eating for fulfillment as compared to a control regime with brief intervention. Overweight or obese adults (n = 176, 80% female, mean BMI 33.8 ± 4.7 kg/m2, mean age 55.2 ±10.1 years) were randomized to a group treatment or control receiving a brief intervention. Ninety-three participants (53% of original sample) completed the 5-year follow-up. Anthropometrics, blood pressure and biochemical measurements, self-rated lifestyle habits, quality of life and medication were obtained at baseline, at the end of the 6-month intervention, and once a year for five years following randomization. A per-protocol analysis, performed due to a high drop-out rate, found that weight reduction was small and similar in the two groups after five years. Reduction of waist/hip ratio, total-cholesterol and triglycerides were somewhat larger in the control group than in the treatment group. No changes regarding blood pressure, quality of life or medication use between the treatment and control groups were found. No effect on weight reduction of the group intervention was found as compared to brief intervention but both groups achieved small weight loss over time. Findings indicate that any intervention or merely regular follow-ups might be promotive for weight maintenance in middle age.

A review of an investigational drug retatrutide, a novel triple agonist agent for the treatment of obesity.

Obesity is one of the critical public health problems in our society. It leads to various health conditions, such as type 2 diabetes mellitus, cardiovascular disease, hypertension, dyslipidaemia, and non-alcoholic fatty liver disease. With the rising incidence of obesity, there is a growing demand for new therapies which can effectively manage body weight and improve health. Currently under development, multi-receptor agonist drugs may offer a promising solution to meet this unmet medical need. Retatrutide is a novel triple receptor agonist peptide that targets the glucagon receptor (GCGR), glucose-dependent insulinotropic polypeptide receptor (GIPR), and glucagon-like peptide-1 receptor (GLP-1R). This novel drug has the potential to treat metabolic abnormalities associated with obesity as well as diseases resulting from it due to its distinct mechanism of action. The Phase III trial of this pipeline drug for treating type 2 diabetes mellitus, non-alcoholic fatty liver disease, and obesity started on August 28, 2023. The results of a Phase II clinical trial have demonstrated significant weight reduction in overweight and obese adults. Specifically, the trial reported an average weight loss of 17.5% and 24.4% at 24 and 48 weeks, respectively. These findings hold promise for the development of effective weight loss interventions in this population group. There is a need for more phase III studies to provide sufficient clinical evidence for the effectiveness of retatrutide, as current evidence is limited to phase II studies and has yet to prove its worth in a larger population. Here, we aimed to provide an overview of retatrutide's safety and effectiveness in treating obesity.

Prevalence of Overweight and Obesity among Adolescents: A cross-sectional study in urban area of Kathmandu, Nepal

Background: Overweight and obesity constitute a mounting global public health concern in middle to lower socioeconomic countries like Nepal. The contemporary shifts in nutrition patterns and swift urbanization have introduced overweight and obesity as an additional challenge to the persistently prevalent issue of under nutrition among adolescents. Many low- and middle-income countries are facing a dual burden of disease, struggling to address both under nutrition and over nutrition. Objectives: The objective of this study was to assess the prevalence and factors associated with overweight and obesity among late adolescents. Methods: A cross-sectional study was conducted on two public and two private schools of Tarkeshwor municipality of Kathmandu, Nepal. A random sample of 366 school going students aged 16-19 years and grade 11 and 12 were selected in the Tarkeshwor municipality of Kathmandu, Nepal. Cluster sampling technique was used to reach the respondents. STEPS survey questionnaire, National sleep foundation questionnaire, 24-hour dietary recall were used as data collection tools. Results: The prevalence of overweight and obesity was 16.7% and 10.7% respectively. Factors associated with overweight and obesity included being female (AOR: 1.99,95% CI: 1.21-3.26), junk food intake per week (AOR: 2.73, 95% C.I: 1.34-5.58), and absence of play yard at home (AOR: 2.36, 95% C.I: 1.59-4.09). However, vegetable intake per week (AOR: 0.42, 95% C.I: 0.13-0.80) has been found to be associated with significant reduction of overweight and obesity. Conclusion: Female in gender, junk food and absence of play yard at home were found to be contributing to the overweight and obesity in Nepal. Raising awareness about the negative effects of junk food, promoting healthy diets, implementing policies are key to prevention.

Association between dietary Intake, eating behavior, and childhood obesity among children and adolescents in Ethiopia

IntroductionThe upsurge of overweight/obesity (OW/OB) among children and adolescents is as a result of complex interactions between lifestyle behaviours and socioeconomic factors. The objective of this study was to determine...

Combined Lifestyle Intervention to reduce overweight at the workplace: opinions of stakeholders

Abstract Background Overweight is a risk factor for employee health and sustainable employability. Multifactorial interventions, addressing both the employee's individual lifestyle and the work environment, are expected to be most effective in overweight reduction. In the Netherlands, primary care patients with overweight are referred to Combined Lifestyle Interventions (CLI), but this is not yet common in occupational health. This study explores the attitudes, intentions and perceived facilitators and barriers of three groups of stakeholders (employees, employers and occupational physicians (OP's)). Methods A cross-sectional survey focusing on attitudes, barriers and facilitators was conducted among a convenience sample of, varying in age and gender, Dutch OPs (n = 267), employers (n = 401) and employees (n = 1,023) in 2021/2022. Results Preliminary results indicate that 32% of the employers would offer CLIs if accessible and 25% of the overweight employees intend to participate in a CLI. For employers, the main reasons to offer a CLI were reduction of sick leave (42%) and good employment practice (37%), barriers were the conviction that employees would not be interested (33%), lack of finance (21%) and lack of time (21%). Employee's main reason for attending was boost for good lifestyle (27%), facilitators were alignment with working hours (24%) and employer's payment for the CLI (25%). Barriers were ‘I already do enough for my health’ (22%). The main barriers for OPs to refer to a CLI were lack of knowledge (66%) and a preference for known professionals (40%), while a facilitator was having more time during their consultations. Conclusions Although not yet common in the Netherlands, a relative large portion of participating employers is willing to invest in lifestyle interventions to reduce overweight. The shared barrier of lack of time needs to be tackled in combination with strengthening of attitudes and facilitators to achieve a successful CLI implementation. Key messages • Employers are willing to invest in a combined lifestyle intervention to reduce or prevent employee’s overweight. • Implementation requires sufficient time for referral and participation, employers to pay and OPs to be informed about the combined lifestyle intervention.

Co-creating obesity prevention policies with youth: Policy ideas generated through the CO-CREATE project.

Despite growing recognition of the importance of applying a systemslens to action on obesity, there has only been limited analysis of the extent to which this lens has actually been applied. The CO-CREATE project used a youth-led participatory action research approach to generate policy ideas towards the reduction of adolescent overweight and obesity across Europe. In order to assess the extent to which these youth-generated policy ideas take a systems approach, we analyzed them using the Intervention Level Framework (ILF). The ILF ascribes actions to one of five system levels, from Structural Elements, the least engaged with system change, up to Paradigm, which is the system's deepest held beliefs and thus the most difficult level at which to intervene. Of the 106 policy ideas generated by young people during the CO-CREATE project, 91 (86%) were categorized at the level of Structural Elements. This emphasis on operational rather than systems level responses echoes findings from a previous study on obesity strategies. Analyzing the distribution of systems level responses using the ILF has the potential to support more effective action on obesity by allowing identification of opportunities to strengthen systems level responses overall.

Investment case for the prevention and reduction of childhood and adolescent overweight and obesity in Mexico.

Despite efforts to curb the rise in Mexico's child and adolescent overweight and obesity rates, prevalence in Mexico has grown by 120% since 1990 to 43.3% in 2022. This investment case identifies policies that will produce the largest returns for Mexico. The investment case model builds beyond a cost-of-illness analysis by predicting the health and societal economic impact of implementing child and adolescent overweight and obesity interventions in a cohort aged 0-19 from 2025 to 2090. The Markov model's impacts include healthcare expenditures, years of life lost, and reduced wages and productivity. We projected and compared costs in a status quo scenario to an intervention scenario to estimate cost savings and calculate return-on-investment (ROI). Total lifetime health and economic costs amount to USD 1.8 trillion-USD 30 billion on average per year. Implementing five interventions can reduce lifetime costs by approximately 7%. Each intervention has a low cost per disability-adjusted life year averted over 30-year, 50-year, and lifetime horizons. The findings demonstrate that a package of interventions mitigating child and adolescent overweight and obesity offers a strong ROI. The novel investment case methods should be applied to other countries, particularly low- and middle-income countries.

Tirzepatide, the dual GLP‐1 and GIP agonist showed ground breaking weight loss and HbA1c reduction in overweight or obese people with type 2 diabetes: Result of the SURMOUNT‐2 trial

Tirzepatide, the dual <scp>GLP</scp>‐1 and <scp>GIP</scp> agonist showed ground breaking weight loss and <scp>HbA1c</scp> reduction in overweight or obese people with type 2 diabetes: Result of the SURMOUNT‐2 trial

Potential for optimizing management of overweight and obesity in patients with established atherosclerotic coronary artery disease

Abstract Funding Acknowledgements Type of funding sources: None. Obesity and overweight play a key role in the development of cardiovascular disease or myocardial ischemia, particularly today, as does their relationship to traditional and non-traditional risk factors. Despite, diet and weight management are grossly under-met per desired body mass index (BMI) threshold goals among very high-risk patients with established atherosclerotic cardiovascular disease (ASCVD). Thus, we aimed to investigate the presence of overweight and obesity in patients with established atherosclerotic cardiovascular disease who were admitted to our center. Patients and methods: Out of 790 patients admitted in our center between May and October 2021, we analyzed 341 patients who underwent isolated coronary artery by-pass surgery. Risk factors were noted as well as previous drug therapy, previous COVID 19 infection and vaccination. Anthropometric data were measured and BMI was determined. Obesity was defined as a BMI &amp;gt;_30 kg/m2 and overweight as a BMI between 25 and 30 kg/m2 . Patients with a BMI &amp;gt;_40 kg/m2 were considered morbidly obese. Early cardiac rehabilitation (phase 1) was performed by using personalized approach in all patients. Results Out of 341 patients (64.68±7.91 years of age), 275 were males (80.6%). The total of 97 (28.44%) had previous myocardial infarction. Blood pressure was well controlled. Majority of the patients reached the step 2 goals according to EAPC Guidelines on prevention (130.7±6.45/75.27±6.54mmHg), and were adherent to prescribed drugs. Mean heart rate was 65±5.65/minute. Only 27% of females and 22% of males had normal weight with BMI between 18.5 and 24.9.kg/m2. The mean BMI was 27.76 kg/m2. 50% of males and females were overweight. Obesity was noted in 23% of females and 27% of males (0.7% morbidly obese. Early cardiac rehabilitation was performed in all patients and they were all referred to participate the phase 2 programs. Conclusions Diet and body weight reduction in overweight and obese ASCVD patients should continue to be a priority given the impact on cardiovascular risk. There is a potential for optimizing management of overweight and obesity in patients. In addition to a better risk factor profile, weight loss also leads to a better quality of life. Cardiovascular prevention and rehabilitation programs should include weight loss intervention. Different forms of self-support and use of digital health might be used as a specific component of a comprehensive intervention to reduce total cardiovascular risk, extend life expectancy, and improve quality of life.

Assessment of the Impact of Increased Physical Activity on Body Mass and Adipose Tissue Reduction in Overweight and Obese Children.

(1) Background: Within the last 30 years, growing rates of child overweight and obesity have been observed as a very concerning phenomenon in most countries worldwide. The research aim was to assess what effect increased physical activity has on reducing body mass and adipose tissue in children between 10 and 11 years of age as well as to answer the question of whether physical activity could be considered as a factor in preventing child overweight and obesity when maintaining their existing diet and lifestyle. (2) Material and methods: There were 419 sports class primary school pupils in the experimental group who, in addition to four obligatory weekly physical education hours, attended six training hours. The control group comprised 485 children from parallel non-sports classes. In all pupils, height and weight measurements as well as physical fitness measurements were taken twice, at the beginning and end of the school year. Cole's method was used to assess the children's normal body weight. With the help of this method, children with excessive body weight were selected from the entire study group (N = 904), who additionally had skinfolds and adipose tissue measured using the BIA electrical bioimpedance method. The obtained results were interpreted using the variance analysis for repeated measurements and LSD test. (3) Results: The number of children with excessive body mass after 10 months of increased physical activity decreased (in the case of overweight: p = 0.0014, obesity: p = 0.0022), as did their skinfolds (p ≤ 0.001) and body fat (p ≤ 0.001), while their physical fitness considerably improved compared to the control group. (4) Conclusions: The introduction of increased physical activity in the experimental group children when maintaining their existing diet and lifestyle contributed to reducing their obesity and overweight and, at the same time, proved to be an effective factor in the process of decreasing their excessive body mass.

Ketogenic Diet Applied in Weight Reduction of Overweight and Obese Individuals with Progress Prediction by Use of the Modified Wishnofsky Equation.

Ketogenic diet is often used as diet therapy for certain diseases, among other things, its positive effect related to weight loss is highlighted. Precisely because of the suggestion that KD can help with weight loss, visceral obesity, and appetite control, 100 respondents joined the weight loss program (of which 31% were men and 69% were women). The aforementioned respondents were interviewed in order to determine their eating habits, the amount of food consumed, and the time when they consume meals. Basic anthropometric data (body height, body mass, chest, waist, hips, biceps, and thigh circumferences) were also collected, in order to be able to monitor their progress during the different phases of the ketogenic diet. Important information is the expected body mass during the time frame of a certain keto diet phase. This information is important for the nutritionist, medical doctor, as well as for the participant in the reduced diet program; therefore, the model was developed that modified the original equation according to Wishnofsky. The results show that women lost an average of 22.7 kg (average number of days in the program 79.5), and for men the average weight loss was slightly higher, 29.7 kg (with an average of 76.8 days in the program). The prediction of expected body mass by the modified Wishnofsky's equation was extremely well aligned with the experimental values, as shown by the Bland-Altman graph (bias for women 0.021 kg and -0.697 kg for men) and the coefficient of determination of 0.9903. The modification of the Wishnofsky equation further shed light on the importance of controlled energy reduction during the dietetic options of the ketogenic diet.

Effects of a Physical Exercise Program on the Physical Capacities of Older Adults: A Quasi-Experimental Study.

To measure the effects of an exercise program on the physical capacities of older adults such as strength, flexibility, balance, and aerobic capacity. This was a quasi-experimental study on a population of 5550 older adults and a sample of 4830 participants in an active aging program designed by the Municipal Health Secretary. The exercise program lasted 12 months, and pre-and post-program intervention measures were recorded using the senior fitness test. Most participants were women (92.4%) and their mean age was 70.7 years (standard deviation, 7.3 years; range, 60-97 years). All areas showed significant differences before and after the program in terms of the participants' physical capabilities (p < 0.05), muscular strength and flexibility had a more significant mean difference and a large effect (>0.80), except for aerobic capacity, which had a small effect. The present study revealed that a supervised physical exercise program at the community level has positive effects on the physical capacities of coordination, balance, flexibility, strength, and aerobic capacity, which are essential components for a better functional capacity at this stage of life, with improvements that encompassed the improved self-perception of their health status, a reduction of overweight and obesity. The reinforcement of these programs is recommended, consequently, promoting pre-sport games and sports championships among the elderly population, as a public health strategy.

Assessing effects of diet alteration on selected parameters of chronically mentally ill residents of a 24-hour Nursing Home. Part 2. Effects of nutritional changes on anthropometric parameters and composition of the body.

The study was aimed at finding out whether, and how, changes in dietary habits would be reflected in anthropometric parameters and body composition. Anthropometric measurements (Martin's technique) were taken on 52 chronically mentally ill patients, twice: before and a year after diet correction. The patients' body composition was examined, directly after the measurements, by bioelectric impedance analysis (BIA) in tetragonal arrangement, using a Bodystat ®1500MDD device. Changes in dietary habits were reflected in a significant reduction of body weight, BMI, and waist circumference in schizophrenic women; WHR in men with other diseases increased significantly. BMI analysis showed an increase in the percentage of normal-weight schizophrenic women and men, a decrease in the proportion of underweight women and men, and an increase in the proportion of individuals with normal weight suffering from other diseases. Both groups showed beneficial changes in body composition (increased content and percentage of fatless body weight and water, reduced content and percentage of fat tissue). These changes were statistically significant only in men suffering from other diseases and concerned the increased content of fatless body weight. Changes in dietary habits enhanced body weight reduction in overweight and obese individuals and resulted in desired changes in BMI, WHR, and body composition. The body fat content was distinctly reduced, with no concurrent changes in the fatless body weight and/or water content. Changes in dietary habits were beneficial for the nutritional status of undernourished patients or those with low body weight.

P070 Does exercise reduce fat free mass loss during very low energy diet-induced rapid weight loss? A systematic review and meta-analysis

Abstract A bi-directional relationship exists between obstructive sleep apnoea and obesity. Very low energy diets (VLEDs) have been show to significantly reduce weight in overweight and obese patients. However, they can cause excessive fat free mass (FFM) loss, which adversely impacts health. Concurrent exercise training is a potential method of mitigating FFM loss. This systematic review and meta-analysis aims to assess the impact of exercise on FFM loss during VLED-induced weight loss in the overweight and obese. Medline, Embase, Cochrane Register of Controlled Trials and CINAHL were searched from inception to December 2021 for studies that compared VLED groups with and without concurrent exercise in overweight and obese adults. Studies were included if they reported changes in FFM, VLED was restricted to less than 800kcal/day and exercise programmes were at least low intensity. Following duplicate removal, 6516 studies were screened and 63 full text articles were reviewed, of which 7 were included. The primary outcome is change in FFM between groups and a meta-analysis is planned if deemed appropriate. Results will be available in September. This review will provide evidence regarding the impact of exercise on FFM loss when undertaken concurrently with a VLED. Furthermore, it will help inform practice guidelines around exercise prescription for preserving FFM while undertaking a VLED to ensure better patient health outcomes. It will also help inform translational studies for weight reduction in overweight and obese sleep apnoeics.

Impact of a School-Based Nutrition Intervention in Preventing Overweight and Obesity in Children in Thailand.

This study evaluated the impact of a school-based nutrition program on preventing overweight and obesity in children in Thailand from 2014 to 2019. We used difference-in-differences with matched comparison group to evaluate program impact. Treatment schools were categorized into those that participated in phase 1 only, and those that participated in phase 1 and 2. We matched 311 treatment schools in phase 1 only with 1504 comparison schools, and 75 treatment schools in both phases with 216 comparison schools. Administrative data from Thailand Office of Basic Education Commission were used from 2014 (baseline), 2016 (first follow-up), and 2019 (second follow-up). Program resulted in a 0.6-1.1 percentage point reduction in the students' probability of overweight by the end of phase 1, and 1.7 percentage points by the end of phase 2. Impact on obesity was found only for schools participating in both phases (0.4 and 0.9 percentage points by the end of phase 1 and 2, respectively). Program continuity and intensity are key to achieve a reduction in overweight and obesity in schoolchildren. The program was successful in reducing overweight and/or obesity given appropriate level of continuity and intensity.

Effects Of An Online Weight Management Program On Weight And Physical Activity Changes.

PURPOSE: To compare the effectiveness of an online weight management program through only online education(OO) or tailored video feedback with online education (OF) or control(CO). METHODS: This intervention included 60 overweight and obese Korean women aged 19 -39 years old. Participants are randomly allocated to one of three groups: (1) 20 women in OO group (online education video and self-monitoring application), (2) 20 women in OF group (online education video, self-monitoring application, and 1:1 tailored video feedback), and (3) 20 women in CO group (only self-monitoring application). Online education included nutrition, physical activity, psychological factors, and medical knowledge for weight loss, goal-setting, and cognitive/behavioral strategies. Tailored feedback helped to motivate weight loss and give solutions for weight loss through real-time video coaching once a week for 10 minutes per session. Effectiveness was assessed using repeated measure ANOVA to compare outcome changes between groups and Tukey’s post-hoc tests were performed. RESULTS: After 6-weeks, a total of 17(85%) of OO group, 17(85%) of OF group, and 19(95%) of CO group completed the post-measurement at 6 weeks. In the intention-to-treat analysis including all 60 participants, there was a significant difference in weight change at 6 weeks in OO and OF groups with a mean weight change of -0.86 kg (95%CI, -1.72 to -0.1) in OO group and -2.23 kg (95%CI, -2.93 to -1.52) in OF group, while no significant change was observed in CO group with a mean weight change of 0.08 kg (95%CI, -0.65 to 0.8). Changes in waist circumference were -2.29 cm (95% CI, -3.48 to -1.11) in OF group, -1.64 cm (95 CI, -3.14 to -0.09) in OO group, and 0.03 cm (95% CI, -1.05 to 1.11) in CO group. In the post-hoc analysis, there was a significant difference only between OF group and CO group in body weight and waist circumference (P > 0.001, P = 0.039, respectively). However, no significant group × time effects were found for the moderate to vigorous physical activity and sedentary behavior (P = 0.979, P = 0.578, respectively). CONCLUSION: Our online weight management program showed significant weight loss and waist circumference reduction in overweight or obese Korean women. Further research is needed to track the long term effects.

Effect of MED-02 Containing Two Probiotic Strains, Limosilactobacillus fermentum MG4231 and MG4244, on Body Fat Reduction in Overweight or Obese Subjects: A Randomized, Multicenter, Double-Blind, Placebo-Controlled Study.

MED-02 is a complex supplement containing two probiotic strains, Limosilactobacillus fermentum MG4231 and MG4244, isolated from humans. The anti-obesity effects and safety profile of MED-02 were assessed in overweight and obese subjects. In this randomized, double-blinded, placebo-controlled, multicenter study, 100 healthy obese and overweight subjects aged 19–65 years with a body mass index (BMI) between 25 and 31.9 kg/m2 were recruited and randomized to receive a placebo or MED-02 (5 × 109 CFU/day). After 12 weeks of consumption, body fat mass (−1166.82 g vs. −382.08 g; p = 0.024) and body fat percentage (−0.85% vs. −0.11%; p = 0.030), as evaluated by dual-energy X-ray absorptiometry (DEXA) and body weight (−2.06 kg vs. −1.22 kg; p = 0.041), were significantly reduced in the MED-02 group compared to the placebo group. The safety profile did not differ among the groups. No serious adverse effects were observed in either group. These results suggest that MED-02 is a safe and beneficial probiotics that reduces body fat and body weight in overweight or obese individuals.