Normal-pressure shale gas is an important object of shale gas reserves and production increase with broad resource prospects in China, but its large-scale benefit development is still confronted with technical bottlenecks. To promote the large-scale benefit development of normal-pressure shale gas, this paper systematically sorts out and summarizes the research achievements and technological progresses related to normal-pressure shale gas from the aspects of accumulation mechanism, enrichment theory, percolation mechanism, development technology, and low-cost engineering technology, and points out the difficulties and challenges to the benefit development of normal-pressure shale gas in the complex structure zones of southern China, by taking the shale gas in the Southeast Chongqing Area of the Sichuan Basin as the research object. In addition, the research direction of normal-pressure shale gas exploration and development is discussed in terms of sweet spot selection, development technology policy, low-cost drilling technology and high-efficiency fracturing technology. And the following research results are obtained. First, the accumulation mechanism of normal-pressure shale gas is clarified from the perspective of geological exploration theory; the hydrocarbon accumulation model of generation, expulsion, retention and accumulation is established; the enrichment theory of “three-factor controlling reservoir” is put forward; and the comprehensive sweetspot target evaluation system is formed. Second, as for development technology, the development technology policies of “multiple series of strata, variable well spacing, long horizontal section, small included angle, low elevation difference, strong stimulation and pressure difference controlling” are formulated. Third, as for drilling engineering, the optimal fast drilling and completion technology with “secondary structure + radical parameter + integrated guidance + unpressured leak-proof cementing” as the core is formed. Fourth, as for fracturing engineering, the low-cost and high-efficiency fracturing technology with “multi-cluster small-stage + limited-entry perforating + double temporary blocking + high-intensity sand injection + fully electric” as the core is formed. Fifth, normal-pressure shale gas is characterized by complex geological conditions, low pressure coefficient and gas content, poor resource endowment and so on, but its resource utilization still faces a series of challenges, such as uncertain productivity construction positions, low single-well productivity and ultimate recoverable reserve, high investment cost and poor economic benefit. In conclusion, the key research directions to realize the large-scale benefit development of low-grade normal-pressure shale gas are to deepen the research on the enrichment and high yield mechanism and sweet spot selection of normal-pressure shale gas, strengthen the research on the benefit development technology policy based on percolation mechanism and the key technologies for low-cost drilling, accelerate the research and development of the key technologies for low-cost and high-efficiency fracturing, and implement cost reduction and efficiency improvement continuously.