The heat generation and aging characteristics of power batteries exhibit a strong coupling relationship, and thus designing liquid cooling plates (LCPs) requires considering both aspects to achieve optimal thermal management. In this study, an electric-thermal-aging model (ETAM) correlating internal resistance, capacity, and temperature was developed. Based on this model, the effects of a serpentine LCP on the heat generation and aging characteristics of battery pack under different operating conditions were investigated using a combined simulation of zero-dimensional numerical model and three-dimensional CFD methods. Furthermore, the LCP channel widths in the length and width directions and the number of channels were optimized using orthogonal tests, artificial neural networks, and genetic algorithms, aiming to minimize battery capacity degradation. Results showed that increasing the mass flow rate of the coolant reduced the maximum temperature, temperature difference, capacity loss, and aging inconsistency of the battery pack. Conversely, reducing the coolant inlet temperature could decrease the maximum temperature and capacity loss but increased the temperature difference and aging inconsistency of the battery pack. The orthogonal test results indicated that the number of channels had the greatest impact on the heat generation and aging characteristics of the battery pack, followed by the channel width in the length direction, and the channel width in the width direction had the least impact. After optimization, the maximum temperature of the battery pack decreased by 0.57 %, the maximum temperature difference increased by 1.41 %, and the average capacity degradation decreased by 0.20 %. Moreover, with the increasing mass flow rate, the pressure drop reduction improved from 27.90 % to 33.90 %. This study may provide guidance for the design of LCPs that take battery aging into account.