Abstract Introduction Multiple sclerosis (MS), like many other chronic diseases, may impact the whole life situation. MS is more common among women than men, in addition, women tend to report worse health status. We aimed to explore the self-reported impact of MS on different dimensions of life such as work, family, leisure activities and, contact with friends and acquaintances. Methods All individuals 20-50 years of age listed in the Swedish MS Registry were invited to answer a survey in 2021. Responses from 2659 working women regarding impact of MS in different dimensions (1, not at all; 2-3, occasionally; 4-5, frequently; 6-7 to a high extend) were explored with descriptive statistics. Results Reported impact of MS varied across the different life dimensions. Working women reported that MS had a greater impact on their leisure activities (20.7% - responding to ‘to a high extent’), followed by contact with friends and acquaintances (15.8%), work (15.5%) and family (11.7%). This despite the fact that 77.1% had mild levels of disability. Further, the MS diagnosis was reported to have contributed to reduced working time (31.4%), refrained from changing job (28.8%), changed jobs (20.5%) or changed career track (20.4%). When questioned about positive life-changing experiences due to MS diagnosis, a majority of the women stated that it had contributed to learning how to adapt to things one cannot change (59.2%) and being grateful for everyday (51.7%). Conclusions An MS diagnosis can significantly impact various aspects of life. While work is notably affected, leisure activities also undergo substantial changes after MS diagnosis. However, acceptance, adaptability and finding meaning, among other, can be important parts of the journey. Key messages • At early stages of MS, the disease tend to affect leisure activities more than other dimensions of life. • Finding coping mechanisms to handle MS may contribute to compensate the impact of MS.