Ultrasonic drilling is a suitable process to enhance the generated surfaces by additive manufacturing. In this study, polylactic acid was selected as the workpiece. The examination parameters were thrust force, delamination, geometrical tolerance, chip adhesion, hole wall morphology and surface roughness. It was explained that the harmonic movement of drill bit in ultrasonic drilling reduced thrust force, delamination, circularity, cylindricality and surface roughness up to 14.5%, 3.7%, 44%, 38%, 20% respectively and removed chip adhesion. Furthermore, number of end-mill flutes was examined and observed that 4-flutes compared to 2-flutes induced reduction in thrust force, delamination, circularity, cylindricality and surface roughness up to 15.2%, 2%, 7.5%, 18.9%, 12.5% respectively. Besides, analysis of variance was established to determine the significant parameters. Finally, non-dominated sorting genetic algorithm-II technique was implemented in order to carry out multi-response optimization.