Redness Research Articles

Systematic characterization of new EBT4 radiochromic films in clinical x-ray beams

Objective. We aim to characterize kinetics of radiation-induced optical density in newly released EBT4 radiochromic films exposed to clinical x-rays. Several film models and batches were evaluated for the film sensitivity, optical signal increasing with time, relative film noise, and minimum detectable limits (MDL).Approach. Radiochromic film pieces from a single batch of EBT3 and three batches of EBT4 were exposed to doses of 77.38 cGy, 386.92 cGy, and 773.84 cGy using a 6 MV x-ray beam. The films were scanned with a flatbed scanner at specific time intervals up to 120 h. The time-series net optical density of red, green and blue colors was corrected for response of the scanner with time and studied to establish the saturation characteristics of film polymerization process. Dose-response from 3.86 cGy to 1935 cGy was also determined for each color. MDL of the films was quantitatively defined as the dose that would double the net optical density of red color above the standard deviation of the residual signal at zero dose. The relative noise characteristics of EBT3 versus EBT4 were studied as a function of time, dose and scanner resolution.Main Results. For doses ≥ 100 cGy, analysis revealed a stability of optical density beyond 48 h post-exposure for EBT3 and EBT4 films. EBT3 films attained 80%-90% of their net optical density at 48 h within minutes of irradiation, compared to 72%-88% for EBT4 films. The rate of growth was slowest for blue color, fastest for red, while green was in between the two. The MDL for EBT4 averaged 15 cGy for three batches, whereas EBT3 films reliably detected doses as low as 8.5 cGy.Significance. Several batches of the new EBT4 film showed slightly lower response compared to its predecessor over 3.86 cGy to 1935 Gy range. For all practical purposes, the post-irradiation growth of polymers ceases between 48 to 60 h for both EBT films. Overall, the EBT4 film exhibited noise characteristics similar to EBT3, except for lower doses where the noise was observed to be higher than its predecessor.

Microbial Biodiversity in Sediment from the Amuyo Ponds: Three Andean Hydrothermal Lagoons in Northern Chile

The Amuyo Ponds (APs) are a group of three brackish hydrothermal lagoons located at 3700 m above sea level in a pre-Andean setting in the Atacama Desert. Each pond shows a conspicuous green (GP), red (RP), or yellow (YP) coloration, and discharges water rich in arsenic and boron into the Caritaya River (Camarones Basin, northern Chile). Microorganisms are subjected to harsh environmental conditions in these ponds, and the microbial composition and diversity in the Amuyo Ponds’ sediments are unknown. The microbial life colonizing AP sediments was explored by metagenomics analyses, showing a diverse microbial life dominated by members of the bacterial domain, with nearly 800 bacterial genome sequences, and sequences associated with Archaea, Eukarya, and viruses. The genus Pseudomonas was more abundant in GP and YP sediments, while the genera Pseudomonas, Aeromonas, and Shewanella were enriched in RP sediments. Archaeal composition was similar in all sediments, and enriched with methanogens sequences from the Archaeoglobi and Halobacteria classes. Abundant fungi sequences were detected in all sediments from the phyla Blastocladiomycota and Ascomycota. We also report putative functional capabilities related to virulence and defense genes, the biosynthesis of secondary metabolites, and tolerance to arsenic. Thirteen bacterial and fourteen viral metagenome-assembled genomes were reconstructed and informed here. This work expands our knowledge on the richness of the microorganisms in the APs and open further studies on the ecology and genomics of this striking Andean geosite.

Ethnonutritional study of fruits of Solanum aethiopicum L. and Solanum melongena L. in the district of Galim (Bamboutos) in West Cameroon

Solanum aethiopicum L. and Solanum melongena L. are endemic plants whose fruits are used in the composition of cultural dishes in West Cameroon including Yellow, Black, Eggplant, Nkui and Okra sauces. This work aims to conduct an ethnonutritional study based on the knowledge and consumption of these dishes. Surveys were carried out including 480 persons of the district of Galim (Kieneghang I and Mbezaté) in the Bamboutos division in West Cameroon and the results revealed that the vernacular and common names for Solanum aethiopicum L. and Solanum melongena L. are respectively “Shusshui” and “sweet egglant”; “Nzuinzuiè” and “bitter eggplant”. These fruits are rounded and spindle in shape. The fruits of Solanum aethiopicum L. exist in green, yellow and red colors with a mild flavor, while those of Solanum melongena L. are red and bitter. These fruits are preserved by sun-drying, smoking, and parboiled before drying. Their cultivation is traditional with a duration of 3–7 months using organic and chemical fertilizers. The age group 41–50 years had a good knowledge of fruits while the age group over 60 years had a better consumption frequency of eggplant-dishes. In addition, these fruits have important cultural values during traditional ceremonies at births, weddings, funerals, symbolisms such as acceptance, reconciliation, hospitality, consideration, and valorisation. These populations had knowledge for the prevention and or treatment of diabetes (6.66%), high blood pressure (25%), obesity (13.54%), cancers (1.66%) and mouth ulcers (2.70%). The valorization of these fruits could constitute a means of preserving cultural heritage.

Study on artificial intelligence recognition pre-processing algorithm for cervical cancer

INTRODUCTION: Cervical cancer is the most common malignant tumor in the female reproductive system, with the number of deaths due to cervical cancer in developing countries accounting for 80% of the global total. In China, the incidence rate of cervical cancer is increasing year by year. At present, the commonly used methods for cervical cancer screening include TCT, HPV testing, TCT+HPV combined testing, FRD, and VIA/VILI. Among them, although TCT+HPV combined testing has high sensitivity and specificity, it is costly and time-consuming. VIA/VILI screening is cost-effective, easy to operate, and suitable for promotion in economically underdeveloped areas.However, VIA/VILI screening relies on the subjective judgment of doctors, so its accuracy is relatively low in rural areas of China with a large population and a lack of well-trained doctors. To address this issue, computer-aided diagnosis (CAD) technology is needed to improve the accuracy and reliability of VIA/VILI screening. OBJECTIVES: The implementation of artificial intelligence (AI)-based Visual Inspection with Acetic acid (VIA) screening and computer-aided diagnosis has the potential to significantly reduce the cost of cervical cancer screenings and increase the coverage rate of cervical cancer screenings, thus reducing the incidence rate of the disease. To this end, we have developed an AI preprocessing algorithm aimed at improving the accuracy of AI in detecting cervical cancer. METHODS: Initially, the algorithm maps images to the YCrCb and Lab color spaces. Unlike traditional enhancement methods that mainly focus on the luminance channel, our method primarily enhances the Cr channel in the YCrCb color space and a channel in the Lab color space. This paper innovatively proposes the LT_CLAHE algorithm to enhance the Cr channel, obtaining an enhanced image with a bias towards blue-green colors, and uses the WLS algorithm to enhance the a channel, obtaining an enhanced image with a bias towards red colors. Subsequently, the enhanced images from both color spaces are fused to eliminate color distortion. RESULTS: Experimental results show that our method significantly enhances the texture of lesions and outperforms traditional methods across various objective indicators. When the enhanced images from this paper are used as input for neural networks, there is also a significant increase in the accuracy of neural network detection.

Spread of yellow-bill-color alleles favored by selection in the long-tailed finch hybrid system.

Carotenoid pigments produce the yellow and red colors of birds and other vertebrates. Despite their importance in social signaling and sexual selection, our understanding of how carotenoid ornamentation evolves in nature remains limited. Here, we examine the long-tailed finch Poephila acuticauda, an Australian songbird with a yellow-billed western subspecies acuticauda and a red-billed eastern subspecies hecki, which hybridize where their ranges overlap. We found that yellow bills can be explained by the loss of C(4)-oxidation, thus preventing yellow dietary carotenoids from being converted to red. Combining linked-read genomic sequencing and reflectance spectrophotometry measurements of bill color collected from wild-sampled finches and laboratory crosses, we identify four loci that together explain 53% of variance in this trait. The two loci of largest effect contain the genes CYP2J19, an essential enzyme for producing red carotenoids, and TTC39B, an enhancer of carotenoid metabolism. A paucity of protein-coding changes and an enrichment of associated upstream variants suggest that the loss of C(4)-oxidation results from cis-regulatory evolution. Evolutionary genealogy reconstruction indicates that the red-billed phenotype is ancestral and that yellow alleles at CYP2J19 and TTC39B first arose and fixed in acuticauda approximately 100 kya. Yellow alleles subsequently introgressed into hecki less than 5 kya. Across all color loci, acuticauda-derived variants show evidence of selective sweeps, implying that yellow bill coloration has been favored by natural selection. Our study illustrates how evolutionary transitions between yellow and red coloration can be achieved by successive selective events acting on regulatory changes at a few interacting genes.

Candidates for Substellar Members of the Orion Nebula Cluster from JWST/NIRCam ∗ ∗ Based on observations made with the Gaia mission and the NASA/ESA/CSA James Webb Space Telescope.

In 2022, the James Webb Space Telescope (JWST) obtained 1–5 μm images of the center of the Orion Nebula Cluster (ONC). I have analyzed these data in an attempt to search for substellar members of the cluster. Using a pair of color–color diagrams, I have identified >200 brown dwarf candidates that lack spectral classifications. Some of the candidates could be protostars (either stellar or substellar) given their very red colors. Based on the age of the ONC and the photometry predicted by theoretical evolutionary models, the faintest candidates could have masses of 1–2 M Jup. This sample of candidates may prove to be valuable for studying various aspects of young brown dwarfs, including their mass function and minimum mass. However, spectroscopy is needed to confirm the membership (via signatures of youth) and late spectral types of the candidates. Finally, I note that most of the “Jupiter-mass binary objects” that have been previously identified with these JWST images are absent from my sample of candidates because their colors are indicative of reddened background sources rather than young brown dwarfs, or their photometry is inadequate for assessing their nature because of very low signal-to-noise ratios and/or detections in only a few bands.

Bar Presence in Local Galaxies: Dependence on Morphology in Field Galaxies

We analyzed the fractions of barred galaxies in the local Universe using a volume-limited sample of galaxies from the Sloan Digital Sky Survey Data Release 3. We examined 116 field galaxies with redshifts between 0.0207 and 0.030, using r and z-band images. Overall, the bar fraction was 26% in the r-band and 19% in the z-band. For distinct morphological groups, barred spiral galaxies had fractions of 33% in the r-band and 22% in the z-band, while barred lenticular galaxies had 25% in the r-band and 12% in the z-band. We observed that the bar fraction in spiral galaxies increases for stellar masses log (M */M ⊙) > 10.5 and for galaxies with red colors (u − r) > 2.0. Additionally, most barred galaxies have a bulge-to-total ratio B/T ≤ 0.2. Our results indicate that the bar fraction is more dependent on internal morphology than on the galaxy environment.

Ppbbx24-del mutant positively regulates light-induced anthocyanin accumulation in the ‘Red Zaosu’ pear (Pyrus pyrifolia White Pear Group)

Red fruit peel is one of the most valuable economic traits in pear and is mainly determined by anthocyanins. Many pear cultivars with a red peel originated from bud sports; however, little is known about the genetic mechanisms underlying this trait. We have previously identified a mutant PpBBX24 containing a 14-nucleotide deletion in the coding region (Ppbbx24-del) as the only known variant associated with the red coloration of the mutant ‘Red Zaosu’ pear (Pyrus pyrifolia White Pear Group). Herein, we analyzed the role of the mutant gene in red coloration and its mechanism of action. The results showed that light promoted red <pg=>peel coloration in ‘Red Zaosu’ pear, and Ppbbx24-del had positive effects on light-induced anthocyanin biosynthesis, while normal PpBBX24 had the opposite effects. Transient and stable <pg=>transformation experiments confirmed that Ppbbx24-del could promote anthocyanin accumulation in pear fruit peels, calli, and tobacco flowers. Due to the loss of NLS and VP domains, Ppbbx24-del co-localized in the nucleus and cytoplasm, whereas PpBBX24 localized only in the nucleus. Real-time PCR and transcriptome analyses indicated that PpMYB10 and PpHY5 is highly expressed in ‘Red Zaosu’ pear. In yeast one-hybrid and dual luciferase assays, Ppbbx24-del and PpHY5 independently promoted the expression of PpCHS, PpCHI, and PpMYB10 by binding to their promoters; however, PpBBX24 did not affect the expression of these genes. Additionally, we found that Ppbbx24-del and PpHY5 had additive effects on the expression of PpCHS, PpCHI, and PpMYB10, as they promote the expression of anthocyanin synthesis genes separately. The co-expression of PpBBX24 and PpHY5 inhibited the activation of downstream genes by PpHY5, and this was attributed to the interaction between the two loci. In conclusion, our results clarify the molecular mechanism by which mutant Ppbbx24-del and PpBBX24 exert opposite effects in the regulation of anthocyanin accumulation in pear. These findings lay an important theoretical foundation for the use of Ppbbx24-del to create red pear cultivars.

Solar active region evolution and imminent flaring activity through color-coded visualization of photospheric vector magnetograms

Context. The emergence of magnetic flux, its transition to complex configurations, and the pre-eruptive state of active regions are probed using photospheric magnetograms. Aims. Our aim is to pinpoint different evolutionary stages in emerging active regions, explore their differences, and produce parameters that could advance flare prediction using color-coded maps of the photospheric magnetic field. Methods. The three components of the photospheric magnetic field vector are combined to create color-combined magnetograms (COCOMAGs). From these, the areas occupied by different color hues are extracted, creating appropriate time series (color curves). These COCOMAGs and color curves are used as proxies of the active region evolution and its complexity. Results. The morphology of COCOMAGs showcases typical features of active regions, such as sunspots, plages, and sheared polarity inversion lines. The color curves represent the area occupied by photospheric magnetic field of different orientation and contain information pertaining to the evolutionary stages of active regions. During emergence, most of the region area is dominated by horizontal or highly inclined magnetic field, which is gradually replaced by more vertical magnetic field. In complex regions, large parts are covered by highly inclined magnetic fields, appearing as abrupt color changes in COCOMAGs. The decay of a region is signified by a domination of vertical magnetic field, indicating a gradual relaxation of the magnetic field configuration. The color curves exhibit a varying degree of correlation with active region complexity. Particularly the red and magenta color curves, which represent strong, purely horizontal magnetic field, are good indicators of future flaring activity. Conclusions. Color-combined magnetograms facilitate a comprehensive view of the evolution of active regions and their complexity. They offer a framework for the treatment of complex observations and can be used in pattern recognition, feature extraction, and flare-prediction schemes.

Optimizing Bleaching Process Parameters of Distillers Corn Oil for Edible Applications Using a Response Surface Methodology

The bleaching process is aimed at removing pigments, traces of metals, and residual phospholipids to improve the color, stability, and quality of the oil. Distillers corn oil (DCO) contains lots of β-carotene that are beneficial but no study has focused on optimizing the removal of pigments while minimizing the loss of β-carotene. Hence, a response surface methodology with the Box-Behnken design was used to study the effect of the process parameters during bleaching. The process parameters were dosage of bleaching clay (1 − 3%), time (5 − 25 min), and temperature (90 − 110 ºC) for neutralized DCO on the laboratory scale. The optimal parameters were bleaching clay dosage of 1.2%, time of 23.2 min, and temperature of 99.1 °C. The β-carotene reduced from 0.2% − 36%, red color reduced from 27% − 88%, and yellow color reduced from 0% − 83%. The PV values of the bleached oil sample ranged from 1.7 to 9.4 meq O2 /kg. The quality of DCO at the optimal bleaching level was compared with conventional edible corn oil. The models developed was used to identify the precise balance between enhancing color removal and maintaining beneficial nutritional values.

Assessing the Impact of Elevated Day and Night Temperatures on Flesh Red Coloration and Diminished Quality in Peaches

Assessing the Impact of Elevated Day and Night Temperatures on Flesh Red Coloration and Diminished Quality in Peaches

Exploration of Strawberry Fruit Quality During Harvest Season Under a Semi-Forcing Culture with Plants Nursed Without Chilling

Strawberry, a profitable crop, adapts well to diverse environments. This study evaluated the stability of fruit quality in different strawberry varieties produced as green plants without chilling during the harvest season in northern Uruguay. The focus was on understanding the impact of harvest date versus agricultural practices (different orchards and growers) on key fruit quality variables such as color, firmness, sugars, and acidity. Results indicated that the INIA Yrupé variety showed greater stability in external coloration and sugar content across harvest dates, suggesting that standardizing fruit coloration is viable under challenging conditions. INIA Guapa consistently met minimum requirements for soluble solids and ratio, with stable acidity and red coloration. Firmness was positively correlated with ratio (r = 0.81) and negatively impacted by rainfall 2–3 days before harvest. The findings suggest that harvest date has a more significant impact on INIA Yrupé fruit quality than growing conditions or practices, with variability observed in firmness and ratio but minimal variation in fruit coloration. These insights highlight the importance of harvest timing for maintaining stable fruit quality traits, which is crucial for breeding programs and ensuring consistent sensory quality and crop profitability.

A colorimetric paper based on curcumin-loaded CD-MOFs and CNFs for visual monitoring of strawberry freshness

Curcumin is a natural yellow colorant, but the color variation occurs only under alkaline conditions, limiting the monitoring range for food freshness. In this study, curcumin obtained the property of acid-responsive color transition from red to yellow by encapsulating in alkaline CD-MOFs. Then, the curcumin-loaded CD-MOFs (CD-MOFs-Cur) with red color was incorporated in cellulose nanofibrils (CNFs)/ethanol suspensions forming a colorimetric paper through the wet-forming process. Results showed that the cubic CD-MOFs-Cur was evenly distributed in the network of CNFs. With the increase amount of CD-MOFs-Cur, the paper exhibited a redder color, but all exhibited high color stability. In pH 5–10 buffer solutions, the paper showed obvious color change from red to yellow with the pH decreased, but the pH that induced the color of the paper turn to yellow was lower with the increase of CD-MOFs-Cur amount. Similar color alteration also occurred when CD-MOFs-Cur was exposed to CO2. Based on this, the CNFs/CD-MOFs-Cur composite paper was successfully used for visual monitoring of strawberry freshness. This work provides the possibility for curcumin to detect the freshness of foods that release acid gases during spoilage.

Hedgehog: An Isolated Quiescent Dwarf Galaxy at 2.4 Mpc

It is well known that almost all isolated dwarf galaxies are actively forming stars. We report the discovery of dw1322m2053 (nicknamed Hedgehog), an isolated quiescent dwarf galaxy at a distance of 2.40 ± 0.15 Mpc with a stellar mass of M ⋆ ≈ 105.8 M ⊙. The distance is measured using surface brightness fluctuations with both Legacy Surveys and deep Magellan/IMACS imaging data. Hedgehog is 1.7 Mpc from the nearest galaxy group, Centaurus A, and has no neighboring galaxies within 1 Mpc, making it one of the most isolated quiescent dwarf galaxies at this stellar mass. It has a red optical color and early-type morphology and shows no UV emission. This indicates that Hedgehog has an old stellar population and no ongoing star formation. Compared with other quiescent dwarfs in the Local Group and Local Volume, Hedgehog appears smaller in size for its luminosity but is consistent with the mass–size relations. Hedgehog might be a backsplash galaxy from the Centaurus A group, but it could also have been quenched in the field by ram pressure stripping in the cosmic web, reionization, or internal processes such as supernova and stellar feedback. Future observations are needed to fully unveil its formation, history, and quenching mechanisms.

Large-scale high purity and brightness structural color generation in layered thin film structures via coupled cavity resonance

Abstract Structural colors, resulting from the interaction of light with nanostructured materials rather than pigments, present a promising avenue for diverse applications ranging from ink-free printing to optical anti-counterfeiting. Achieving structural colors with high purity and brightness over large areas and at low costs is beneficial for many practical applications, but still remains a challenge for current designs. Here, we introduce a novel approach to realizing large-scale structural colors in layered thin film structures that are characterized by both high brightness and purity. Unlike conventional designs relying on single Fabry–Pérot cavity resonance, our method leverages coupled resonance between adjacent cavities to achieve sharp and intense transmission peaks with significantly suppressed sideband intensity. We demonstrate this approach by designing and experimentally validating transmission-type red, green, and blue colors using an Ag/SiO2/Ag/SiO2/Ag configuration on fused silica substrate. The measured spectra exhibit narrow resonant linewidths (full width at half maximum ∼60 nm), high peak efficiencies (&gt;40 %), and well-suppressed sideband intensities (∼0 %). In addition, the generated color can be easily tuned by adjusting the thickness of SiO2 layer, and the associated color gamut coverage shows a wider range than many existing standards. Moreover, the proposed design method is versatile and compatible with various choices of dielectric and metallic layers. For instance, we demonstrate the production of angle-robust structural colors by utilizing high-index Ta2O5 as the dielectric layer. Finally, we showcase a series of printed color images based on the proposed structures. The coupled-cavity-resonance architecture presented here successfully mitigates the trade-off between color brightness and purity in conventional layered thin film structures and provides a novel and cost-effective route towards the realization of large-scale and high-performance structural colors.

Discovery of Electrochemical Indicators upon Sarcoplasmic Meat Discoloration.

Meat discoloration is one of the challenges facing the food industry, which affects both quality and shelf life. In this report, we present our groundbreaking discovery of electrochemically probing specific redox peaks associated with meat discoloration and successfully monitor its delay when controlled biochemically with added antioxidants. We have validated the redox features by spectrophotometry measurements of the relative levels of oxymyoglobin, which gives meat its cherry red color, and metmyoglobin, which causes the meat to turn brown in relation to discoloration. The insights from this research open up new avenues for the development of innovative electroanalytical tools for studying meat color and quality. These new tools could potentially minimize nutritious beef waste, lessen the environmental burden associated with waste disposal, and reduce CO2 emissions linked to discoloration issues.

The Metallicity Dilution in Local Massive Early-type Galaxies

We derive a sample of 114 Baldwin–Phillips–Terlevich-diagram star-forming and Wide-field Infrared Survey Explorer (WISE) low-star-formation-rate early-type galaxies (ETGs) by utilizing the criterion W2 − W3 < 2.5 (where W2 and W3 are the wavelengths of 4.6 and 12 μm in the WISE four bands) and cross matching the Galaxy Zoo 1 and the catalog of the Sloan Digital Sky Survey (SDSS) Data Release 7 Max Planck Institute for Astrophysics-Johns Hopkins University emission-line measurements. We find that ∼28% of our ETGs exhibit a metallicity that is at least 2 standard deviation (0.26 dex) below the mass–metallicity (MZ) relation of star-forming galaxies (SFGs) from the SDSS. We demonstrate that almost all of our ETGs locate below the “main sequence” of SFGs. We find that these ETGs with larger metallicity deviation from the MZ relation tend to have lower SFR and redder color. By exploring the dilution properties of these massive ETGs, we report that the dilution effect may be mainly attributed to the inflow of metal-poor gas from mergers/interaction or the intergalactic medium.

"Artificial intelligence Reading Digital Mammogram: Enhancing Detection and Differentiation of Suspicious Microcalcifications".

To investigate the impact of artificial intelligence (AI) on enhancing the sensitivity of digital mammograms in the detection and specification of grouped microcalcifications. The study is a retrospective analysis of grouped microcalcifications for 447 patients. Grouped microcalcifications detected were correlated with AI, which was applied to the initial mammograms. AI provided a heat map, demarcation, and quantitative evaluation for abnormalities according to the degree of suspicion of malignancy. Histopathology was the standard for confirmation of malignancy. AI showed a high correlation percentage of 67.5% between the red color of the color hue bar and malignant microcalcifications (p value <0.001). The scoring of probable cancer was suggested (ie, more than 50% abnormality scoring) in 39.5% of true cancer lesions. The diagnostic performance of mammography for grouped microcalcifications revealed a sensitivity of 94.7% and a negative predictive value of 82.1%. False negatives were only 12 out of 228 that proved malignant calcifications. The agreement of cancer probability between standard mammograms and examinations read by AI presented a Kappa value of -0.094 and a p value of < 0.001. The used AI system enhanced the sensitivity of mammograms in detecting suspicious microcalcifications, yet an expert human reader is required for proper specification. Grouped calcifications could be early breast cancer on a mammogram. The morphology and distribution are correlated with the nature of breast diseases. AI is a potential decision support for the detection and classification of grouped microcalcifications and thus positively affects the control of breast cancer.

Factors involved in gastroesophageal varix-related events in patients with hepatitisC virus-related compensated and decompensated cirrhosis after direct-acting antiviral therapy.

The incidence of and factors involved in gastroesophageal varix-related events in hepatitisC virus-related cirrhosis patients, including decompensated cirrhosis, after direct-acting antiviral therapy are unclear. We conducted a multicenter study using prospective data from 478 hepatitisC virus-related cirrhosis patients treated with direct-acting antiviral therapy from February 2019 to December 2021 at 33 Japanese hospitals. Gastroesophageal varices were classified as F1 (small-caliber), F2 (moderately enlarged), or F3 (markedly enlarged) according to the Japanese criteria. Patients without varix or with F1 without red color signs were defined as low-risk varix, and patients with ≥F2 or red color signs or a history of rupture were defined as high-risk varix. Varix-related events were defined as prophylactic treatment or rupture of gastroesophageal varix. The median age was 70years, 43% of patients had decompensated cirrhosis, and 16% had high-risk varices (13% in compensated and 33% in decompensated, p<0.001). Sustained virologic response rates were 94.9% for compensated cirrhosis and 91.3% for decompensated cirrhosis (p=0.120). Across 35.7months, 25 patients received prophylactic treatment, and four experienced varix rupture. The 3-year incidence rate of varix-related events was 6.2% (3.5% in compensated and 9.9% in decompensated, p=0.001). In the multivariate analysis, high-risk varix (p<0.001), high baseline gamma-glutamyl transpeptidase levels (p<0.001), and virologic failure (p=0.004) were significantly involved in varix-related events. The cumulative incidence rate of varix-related events was significantly higher in decompensated cirrhosis than in compensated cirrhosis. Baseline varix status, baseline gamma-glutamyl transpeptidase levels, and virologic response were related to varix-related events after direct-acting antiviral therapy.

Switchable Camouflage via Reflective Display

In nature, dynamic camouflage is performed by cephalopods and reptiles. Humans attempt to perform dynamic camouflage by employing display devices to show the surrounding background. In this work, a switchable camouflage device based on an electrophoretic display (EPD) is proposed. Color‐filter EPDs display colors by reflecting light through the color filters and black‐and‐white EPDs. The number of subpixels is found to be an important factor on color performance. To improve the poor saturation of color‐filter EPDs, the number of color filter subpixels is reduced. Compared with filters with three and four subpixels, a dual‐subpixel filter proposed in this work significantly improves the average saturation of red, green, and blue colors, with increases of 49% and 112%, respectively. Subsequently, the spectral characteristics of the color filter and black‐and‐white EPD are optimized by using genetic algorithm to reduce the average color difference between the display and the switchable target color, which can be reduced as low as 0.18. To visually demonstrate the color reproduction capability of the dual‐subpixel EPD, sample applications including the switchable vegetation and digital camouflages are designed and have a high degree of agreement with the background. In this work, an innovative and effective approach is introduced to dynamic camouflage.