Recursive Feature Elimination Algorithm Research Articles

Matrix metalloproteinase 9 expression and glioblastoma survival prediction using machine learning on digital pathological images

This study aimed to apply pathomics to predict Matrix metalloproteinase 9 (MMP9) expression in glioblastoma (GBM) and investigate the underlying molecular mechanisms associated with pathomics. Here, we included 127 GBM patients, 78 of whom were randomly allocated to the training and test cohorts for pathomics modeling. The prognostic significance of MMP9 was assessed using Kaplan–Meier and Cox regression analyses. PyRadiomics was used to extract the features of H&E-stained whole slide images. Feature selection was performed using the maximum relevance and minimum redundancy (mRMR) and recursive feature elimination (RFE) algorithms. Prediction models were created using support vector machines (SVM) and logistic regression (LR). The performance was assessed using ROC analysis, calibration curve assessment, and decision curve analysis. MMP9 expression was elevated in patients with GBM. This was an independent prognostic factor for GBM. Six features were selected for the pathomics model. The area under the curves (AUCs) of the training and test subsets were 0.828 and 0.808, respectively, for the SVM model and 0.778 and 0.754, respectively, for the LR model. The C-index and calibration plots exhibited effective estimation abilities. The pathomics score calculated using the SVM model was highly correlated with overall survival time. These findings indicate that MMP9 plays a crucial role in GBM development and prognosis. Our pathomics model demonstrated high efficacy for predicting MMP9 expression levels and prognosis of patients with GBM.

Correlation of disulfidptosis and periodontitis: New insights and clinical significance

ObjectivesThis study aims to investigate and predict the therapeutic agents associated with disulfidptosis in periodontitis. DesignThe dataset GSE10334 was downloaded from the Gene Expression Omnibus (GEO) database and used to train a least absolute shrinkage and selection operator (LASSO) regression and support vector machine recursive feature elimination (SVM–RFE) algorithm to identify genes associated with disulfidptosis in periodontitis. GSE16134 validation sets, polymerase chain reaction (PCR), and gingival immunofluorescence were used to verify the results.Single-gene Gene Set Enrichment Analysis (GSEA) was performed to explore the potential mechanisms and functions of the characterized genes. Immune infiltration and correlation analyses were performed, and competing endogenous RNA (ceRNA) networks were constructed. Effective therapeutic drugs were then predicted using the DGIdb database, and molecular docking was used to validate binding affinity. ResultsSix genes (SLC7A11, SLC3A2, RPN1, NCKAP1, LRPPRC, and NDUFS1) associated with disulfidptosis in periodontitis were obtained. Validation results from external datasets and experiments were consistent with the screening results. Single-gene GSEA analysis was mainly enriched for antigen presentation and immune-related pathways and functions.Immune infiltration and correlation analyses revealed significant regulatory relationships between these genes and plasma cells, resting dendritic cell, and activated NK cells. The ceRNA network was visualized. And ME-344, NV-128, and RILUZOLE, which have good affinity to target genes, were identified as promising agents for the treatment of periodontitis. ConclusionsSLC7A11, SLC3A2, RPN1, NCKAP1, LRPPRC, and NDUFS1 are targets associated with disulfidptosis in periodontitis, and ME-344, NV-128, and RILUZOLE are promising agents for the treatment of periodontitis.

Soil organic carbon sequestration potential explained by mineralogical and microbiological activity using spectral transfer functions

The ability of soil to sequester carbon and reduce atmospheric CO2 concentrations is limited and depends on the soil minerals and their interaction with the microbiota. Microbial activities are closely associated with the types and amounts of soil organic matter (SOM) and clay minerals that have functional groups that interact with energy in Vis NIR-SWIR and Mid-IR wavelengths. The main objective of this research was to determine, based on these spectral ranges, the relation between mineralogical and organic compounds, as their sequestration and specialization in soils from Brazil. It was possible to map microbiological activity by spectral transfer functions and digital soil mapping reaching R2 from 0.77 to 0.85. Multiple regression equations were constructed to quantify enzymatic activity, microbial biomass carbon (MBC), particulate organic matter (POM), and resistant forms of carbon, and SOM associated with the mineral fraction (MAOM). All these properties were detected by specific bands obtained with the recursive feature elimination (RFE) algorithm, reaching correlations from 0.64 to 0.98 in specific ranges. The prediction model of the carbon sequestration potential was adjusted with microbiological and mineralogical variables from Vis-NIR-SWIR and the Mid-IR spectral range. A SARAR double autoregressive model was adjusted with r 0.61 and to a spatial error model (SEM) with r 0.7. The explanatory variables were associated with kaolinite, hematite, goethite, gibbsite, and the abundance of fungi, actinomycetes, vesico-arbuscular mycorrhizal fungi, enzymatic activity of beta-glucosidase, urease and phosphatase, and POM. Among the microbiological variables, the general abundance of fungi was the most important, in contrast to enzymatic activity that was the least important. The interaction between the different maps constructed and historical land use allowed the identification of areas that contribute to sequestering new carbon and could be the key to climate change mitigation strategies.

Exploring potential neuroimaging biomarkers for the response to non-steroidal anti-inflammatory drugs in episodic migraine

BackgroundNon-steroidal anti-inflammatory drugs (NSAIDs) are considered first-line medications for acute migraine attacks. However, the response exhibits considerable variability among individuals. Thus, this study aimed to explore a machine learning model based on the percentage of amplitude oscillations (PerAF) and gray matter volume (GMV) to predict the response to NSAIDs in migraine treatment.MethodsPropensity score matching was adopted to match patients having migraine with response and nonresponse to NSAIDs, ensuring consistency in clinical characteristics and migraine-related features. Multimodal magnetic resonance imaging was employed to extract PerAF and GMV, followed by feature selection using the least absolute shrinkage and selection operator regression and recursive feature elimination algorithms. Multiple predictive models were constructed and the final model with the smallest predictive residuals was chosen. The model performance was evaluated using the area under the receiver operating characteristic (ROCAUC) curve, area under the precision-recall curve (PRAUC), balance accuracy (BACC), sensitivity, F1 score, positive predictive value (PPV), and negative predictive value (NPV). External validation was performed using a public database. Then, correlation analysis was performed between the neuroimaging predictors and clinical features in migraine.ResultsOne hundred eighteen patients with migraine (59 responders and 59 non-responders) were enrolled. Six features (PerAF of left insula and left transverse temporal gyrus; and GMV of right superior frontal gyrus, left postcentral gyrus, right postcentral gyrus, and left precuneus) were observed. The random forest model with the lowest predictive residuals was selected and model metrics (ROCAUC, PRAUC, BACC, sensitivity, F1 score, PPV, and NPV) in the training and testing groups were 0.982, 0.983, 0.927, 0.976, 0.930, 0.889, and 0.973; and 0.711, 0.648, 0.639, 0.667,0.649, 0.632, and 0.647, respectively. The model metrics of external validation were 0.631, 0.651, 0.611, 0.808, 0.656, 0.553, and 0.706. Additionally, a significant positive correlation was found between the GMV of the left precuneus and attack time in non-responders.ConclusionsOur findings suggest the potential of multimodal neuroimaging features in predicting the efficacy of NSAIDs in migraine treatment and provide novel insights into the neural mechanisms underlying migraine and its optimized treatment strategy.

Mapping Soil Properties in the Haihun River Sub-Watershed, Yangtze River Basin, China, by Integrating Machine Learning and Variable Selection.

Mapping soil properties in sub-watersheds is critical for agricultural productivity, land management, and ecological security. Machine learning has been widely applied to digital soil mapping due to a rapidly increasing number of environmental covariates. However, the inclusion of many environmental covariates in machine learning models leads to the problem of multicollinearity, with poorly understood consequences for prediction performance. Here, we explored the effects of variable selection on the prediction performance of two machine learning models for multiple soil properties in the Haihun River sub-watershed, Jiangxi Province, China. Surface soils (0-20 cm) were collected from a total of 180 sample points in 2022. The optimal covariates were selected from 40 environmental covariates using a recursive feature elimination algorithm. Compared to all-variable models, the random forest (RF) and extreme gradient boosting (XGBoost) models with variable selection improved in prediction accuracy. The R2 values of the RF and XGBoost models increased by 0.34 and 0.47 for the soil organic carbon, by 0.67 and 0.62 for the total phosphorus, and by 0.43 and 0.62 for the available phosphorus, respectively. The models with variable selection presented reduced global uncertainty, and the overall uncertainty of the RF model was lower than that of the XGBoost model. The soil properties showed high spatial heterogeneity based on the models with variable selection. Remote sensing covariates (particularly principal component 2) were the major factors controlling the distribution of the soil organic carbon. Human activity covariates (mainly land use) and organism covariates (mainly potential evapotranspiration) played a predominant role in driving the distribution of the soil total and soil available phosphorus, respectively. This study indicates the importance of variable selection for predicting multiple soil properties and mapping their spatial distribution in sub-watersheds.

Feature engineering and machine learning for electrochemical detection of rabies virus in graphene-based biosensors

Electrochemical biosensors are small analytical devices that convert a biological response into a processable signal with high sensitivity, ease of operation, cost-effectiveness, and miniaturization capability. The current study proposes enhancing the reliability of the electrochemical detection of enveloped viruses, such as the rabies virus using feature engineering and machine learning. Portable detection was achieved using a graphene-based microfluidic sensor and the current was recorded from electrochemical experiments using a portable potentiostat. After data mining and feature engineering, a dataset obtained from staircase cyclic voltammetry was used in different machine learning models. The features from the voltammogram were extracted following theoretic aspects to build a dataset with uncovering patterns and valuable information. Correlation-based and recursive feature elimination algorithms were used for feature engineering. Our analysis showed that the best F-measure score a model trained was obtained through a support vector machine with 0.9830 for the diagnostic tasks following the proposed feature engineering pipeline. On the other hand, the preprocessing pipeline which is commonly used in many studies obtained a score of 0.9394 using a decision tree model. In addition, the proposed method generates features with higher interpretability and lower model complexity than conventional feature reduction methods such as PCA. Our study shows the potential of machine learning models in the field of electrochemical biosensor development with a focus on feature engineering based on electroanalytical analysis, which can be extended to develop new tools for disease diagnosis in the future.

Exploratory Study of Differentially Expressed Genes of Peripheral Blood Monocytes in Patients with Carotid Atherosclerosis.

The abundance of circulating monocytes is closely associated with the development of atherosclerosis in humans. This study aimed to further research into diagnostic biomarkers and targeted treatment of carotid atherosclerosis (CAS). We performed transcriptomics analysis through weighted gene co-expression network analysis (WGCNA) of monocytes from patients in public databases with and without CAS. Differentially expressed genes (DEGs) were screened by R package limma. Diagnostic molecules were derived by the least absolute shrinkage and selection operator (LASSO) and support vector machine recursive feature elimination (SVM-RFE) algorithms. NetworkAnalyst, miRWalk, and StarBase databases assisted in the construction of diagnostic molecule regulatory networks. The DrugBank database predicted drugs targeting the diagnostic molecules. RT-PCR tested expression profiles. From 14,369 hub genes and 61 DEGs, six differentially expressed monocyte-related hub genes were significantly associated with immune cells, immune responses, monocytes, and lipid metabolism. LASSO and SVM-RFE yielded five genes for CAS prediction. RT-PCR of these genes showed HMGB1 was upregulated, and CCL3, CCL3L1, CCL4, and DUSP1 were down-regulated in CAS versus controls. Then, we constructed and visualized the regulatory networks of 9 transcription factors (TFs), which significantly related to 5 diagnostic molecules. About 11 miRNAs, 19 lncRNAs, and 39 edges centered on four diagnostic molecules (CCL3, CCL4, DUSP1, and HMGB1) were constructed and displayed. Eleven potential drugs were identified, including ibrutinib, CTI-01, roflumilast etc. Conclusion: A set of five biomarkers were identified for the diagnosis of CAS and for the study of potential therapeutic targets.

Identification of Airline Turbulence Using WOA-CatBoost Algorithm in Airborne Quick Access Record (QAR) Data

Turbulence is a significant operational aviation safety hazard during all phases of flight. There is an urgent need for a method of airline turbulence identification in aviation systems to avoid turbulence hazards to aircraft during flight. Integrating flight data and machine learning significantly enhances the efficacy of turbulence identification. Nevertheless, present studies encounter issues including unstable model performance, challenges in data feature extraction, and parameter optimization. Hence, it is imperative to propose a superior approach to enhance the accuracy of turbulence identification along airline. The paper presents a combined swarm intelligence and machine learning model based on data mining for identifying airline turbulence. Based on the theory of swarm-intelligence-based optimization algorithm, the optimal parameters of Categorical Boosting (CatBoost) are obtained by introducing the whale optimization algorithm (WOA), and the corresponding WOA-CatBoost fusion model is established. Then, the Recursive Feature Elimination algorithm (RFE) is used to eliminate the data with lower feature weights, extract the effective features of the data, and the combination with the WOA brings robust optimization effects, whereby the accuracy of CatBoost increased by 11%. The WOA-CatBoost model can perform accurate turbulence identification from QAR data, comparable to that with established EDR approaches and outperforms traditional machine learning models. This discovery highlights the effectiveness of combining swarm intelligence and machine learning algorithms in turbulence monitoring systems to improve aviation safety.

Identification of disease-specific genes related to immune infiltration in nonalcoholic steatohepatitis using machine learning algorithms.

To identify disease signature genes associated with immune infiltration in nonalcoholic steatohepatitis (NASH), we downloaded 2 publicly available gene expression profiles, GSE164760 and GSE37031, from the gene expression omnibus database. These profiles represent human NASH and control samples and were used for differential genes (DEGs) expression screening. Two machine learning methods, the Least Absolute Shrinkage and Selection Operator regression model and Support Vector Machine Recursive Feature Elimination, were used to identify candidate disease signature genes. The CIBERSORT deconvolution algorithm was employed to analyze the infiltration of 22 immune cell types in NASH. Additionally, we constructed a NASH cell model using HepG2 cells treated with oleic acid and free fatty acids. The construction of the cell model was verified using oil red O staining, and Western blotting was used to detect the protein expression of the disease signature genes in both control and model groups. As a result, a total of 262 DEGs were identified. These DEGs were primarily associated with metal ion transmembrane transporter activity, sodium ion transmembrane transporter protein activity, calcium ion, and neuroactive ligand-receptor interactions. FOS, IGFBP2, dual-specificity phosphatase 1 (DUSP1), and IKZF3 were identified as disease signature genes of NASH by the least absolute shrinkage and selection operator and Support Vector Machine Recursive Feature Elimination algorithms for DEGs analysis. The receiver operating characteristic curves showed that FOS, IGFBP2, DUSP1, and IKZF3 had good diagnostic value (area under receiver operating characteristic curve > 0.8). These findings were validated in the GSE89632 dataset and through cellular assays. Immunocyte infiltration analysis revealed that NASH was associated with CD8 T cells, CD4 T cells, follicular helper T cells, resting NK cells, eosinophils, regulatory T cells, and γδ T cells. The FOS, IGFBP2, DUSP1, and IKZF3 genes were specifically associated with follicular helper T cells. Lipid droplet aggregation significantly increased in HepG2 cells treated with oleic acid and free fatty acids, indicating successful construction of the cell model. In this model, the expression of FOS, IGFBP2, and DUSP1 was significantly decreased, while that of IKZF3 was significantly elevated (P < .01, P < .001) compared with the control group. Therefore, FOS, IGFBP2, DUSP1, and IKZF3 can be considered as disease signature genes associated with immune infiltration in NASH.

Examining nonlinear effects of socioecological drivers on urban solar energy development in China using machine learning and high-dimensional data

In the context of carbon neutrality target, renewable energy sources have been transforming from “supplementary energy” to “main energy”, which have promoted the green and low-carbon transition of global energy supply system. In-depth analyzing the spatial patterns and driving mechanisms of renewable energy expansion are of significance for optimizing the spatial layout of clean power, and avoiding the phenomenon of wind and solar power curtailment. In this paper, we proposed an ensemble learning model to examine the nonlinear effects of physical geography, resource endowment, and socio-economic factors on solar photovoltaic (PV) capacity at the prefecture-level city scale in China. Using the city-level multi-sources geospatial big data, we extensively collected a total of 175 related explanatory variables and cumulative installed capacity of solar PV power for 295 prefecture-level cities of China. The recursive feature elimination algorithm (SVM-REF) is firstly used to extract the optimal feature subset of urban PV capacity from multi-dimensional features variables. Furthermore, three advanced machine learning models (random forest, decision tree, extreme gradient boosting) are developed to identify the key influencing factors and nonlinear driving effect of urban solar PV power expansion in China. The results show that China's PV installation capacity is highly concentrated in Northern and Northwest parts of China, with the occupancy over 70% in 2019. Moreover, the XGBoost model has the best prediction accuracy (R2 = 0.97) among three methods. We also found that total amount of urban water resources, average solar radiation, and population density are the most important controlling factors for urban solar PV capacity expansion in China, with contribution of 35.6%, 17.7%, and 13.3%, respectively. We suggested that urban solar PV layout mode in China is recommended to gradually shift from resource orientation to the “resource-environment-demand” comprehensive orientation. The paper provides a replicable, scalable machine learning models for simulating solar PV power capacity at the prefecture-level city scale, and serves as a motivation for decision-making reference of the macro siting optimization and sustainable development of China's green power industry.

Precise prediction of CO2 separation performance of metal–organic framework mixed matrix membranes based on feature selection and machine learning

Nowadays, the price of fossil fuels keeps setting new records, escalating continuing concerns about global warming from CO2 production from fuel combustion. As a promising membrane separation technique dealing with carbon capture, metal–organic framework (MOF) mixed matrix membranes (MMMs) have been extensively studied. Herein, a genetic algorithm (GA) optimized artificial neural network (ANN) was developed to form prediction model of MOF MMMs performances towards CO2/N2 separation. The MOF properties, polymer properties, and the operating conditions were used as the characteristic variables. To overcome the limitation, molecular descriptors were incorporated to reflect the physicochemical properties of polymers and target encoding was applied to digitalize the MOF and polymer types. In addition, recursive feature elimination algorithm was used to filter the optimal feature subset and Shapley additive explanations was utilized to analyze the feature importance. The results demonstrated that the model has a dramatically improved prediction performance than other machine learning methods.

Soil moisture retrieval at high spatial resolution over alpine ecosystems on Nagqu-Tibetan plateau: A comparative study on semiempirical and machine learning approaches

Soil moisture (SM) is an essential climate variable that directly and indirectly affects vegetation growth and survival through land‒atmosphere interactions. Alpine vegetation on the Tibetan Plateau is part of a unique ecosystem that is vulnerable to changes in environmental factors such as SM; consequently, this makes this ecosystem extremely sensitive to climate change. This study investigated the potential of synthetic aperture radar (SAR) vegetation indices based on Sentinel-1 data for retrieving SM at high spatial resolution (10 m) over an alpine grassland ecosystem in the Nagqu region. Several SAR vegetation indices, including the dual polarization SAR vegetation index (DPSVI), modified dual polarization SAR vegetation index (mDPSVI), dual polarimetric radar vegetation index (DpRVI), polarimetric radar vegetation index (PRVI), and radar vegetation index (RVI), were used in the semiempirical water cloud model (WCM) to determine which indices provide better SM retrievals in this alpine ecosystem. In addition, the potential of the distributed random forest (DRF) machine learning algorithm was explored using the same variables as the WCM together with several ecohydrological parameters from different data sources. The recursive feature elimination algorithm was used to establish the optimized DRF model. Among the vegetation indices based on SAR data, DPSVI, DpRVI, and PRVI showed similar results, with DPSVI performing slightly better than the other SAR indices, with a correlation coefficient (R2) of 0.70 and root mean squared error (RMSE) of 0.04 m3m-3. A comparison of the optimized DRF with the best fitted WCM reveals that the DRF algorithm outperformed the WCM, including having more predictors (10 variables) in the model. The results show that the overall accuracies in terms of the R2 values and the RMSEs of both the WCMs and the DRF models were 0.52–0.75 and 0.08 m3 m−3 to 0.04 m3 m−3, respectively, which was validated over in situ SM measurements in the Nagqu region.

Bioinformatics to Identify Biomarkers of Diabetic Nephropathy based on Sphingolipid Metabolism and their Molecular Mechanisms.

Diabetes mellitus (DM) frequently results in Diabetic Nephropathy (DN), which has a significant negative impact on the quality of life of diabetic patients. Sphingolipid metabolism is associated with diabetes, but its relationship with DN is unclear. Therefore, screening biomarkers related to sphingolipid metabolism is crucial for treating DN. To identify Differentially Expressed Genes (DEGs) in the GSE142153 dataset, we conducted a differential expression analysis (DN samples versus control samples). The intersection genes were obtained by overlapping DEGs and Sphingolipid Metabolism-Related Genes (SMRGs). Furthermore, The Least Absolute Shrinkage and Selection Operator (LASSO) and Support Vector Machine Recursive Feature Elimination (SVM-RFE) algorithms were used to filter biomarkers. We further analyzed the Gene Set Enrichment analysis (GSEA) and the immunoinfiltrational analysis based on biomarkers. We identified 2,186 DEGs associated with DN. Then, five SMR-DEGs were obtained. Subsequently, biomarkers associated with sphingolipid metabolism (S1PR1 and SELL) were identified by applying machine learning and expression analysis. In addition, GSEA showed that these biomarkers were correlated with cytokine cytokine receptor interaction'. Significant variations in B cells, DCs, Tems, and Th2 cells between the two groups suggested that these cells might have a role in DN. Overall, we obtained two sphingolipid metabolism-related biomarkers (S1PR1 and SELL) associated with DN, which laid a theoretical foundation for treating DN.

A hierarchical recursive feature elimination algorithm to develop brain computer interface application of user behavior for statistical reasoning and decision making

BackgroundWith the aid of a brain computer interface (BCI), users can communicate and receive signals wirelessly or over wired connections to operate smart devices. A BCI classifier's architecture is quite difficult since numerous elements should be combined. These elements are made up of brain signals, which also include high levels of weak sounds that could provide reliable participant recordings of daily activities. We must use computer vision techniques to create a model in order to control those information. The high dimension and volume of signals present the classification classifier with its primary obstacles. New methodDue to this, we extracted and classified the brain activity in this study, and we also presented a novel hierarchical recursive feature elimination method that we refer to as HRFE embracing noisy additions. HRFE makes a variety of categorization suggestions to eliminate bias in classifying BCI systems of different types. We put the HRFE to the test on two BCI signal data sets—specifically, dataset I and BCI contests III—using shallow and deep convolution network classification techniques. Just a grid of assets is used to create electrocorticography (ECoG) signals on the contralateral (right) motor cortex, and these signals are recorded in the BCI contests III database. ResultsUsing ECoG signals, we choose the top 20 features that have the biggest effects on distortion and classification selection. Comparison with existing methodsThe simulation findings show that HRFE has a significant computer vision enhancement when compared to comparable feature selection methods in the literature, particularly for ECoG signal, which achieves about 93% reliability.

Estimation of the rice aboveground biomass based on the first derivative spectrum and Boruta algorithm.

Aboveground biomass (AGB) is regarded as a critical variable in monitoring crop growth and yield. The use of hyperspectral remote sensing has emerged as a viable method for the rapid and precise monitoring of AGB. Due to the extensive dimensionality and volume of hyperspectral data, it is crucial to effectively reduce data dimensionality and select sensitive spectral features to enhance the accuracy of rice AGB estimation models. At present, derivative transform and feature selection algorithms have become important means to solve this problem. However, few studies have systematically evaluated the impact of derivative spectrum combined with feature selection algorithm on rice AGB estimation. To this end, at the Xiaogang Village (Chuzhou City, China) Experimental Base in 2020, this study used an ASD FieldSpec handheld 2 ground spectrometer (Analytical Spectroscopy Devices, Boulder, Colorado, USA) to obtain canopy spectral data at the critical growth stage (tillering, jointing, booting, heading, and maturity stages) of rice, and evaluated the performance of the recursive feature elimination (RFE) and Boruta feature selection algorithm through partial least squares regression (PLSR), principal component regression (PCR), support vector machine (SVM) and ridge regression (RR). Moreover, we analyzed the importance of the optimal derivative spectrum. The findings indicate that (1) as the growth stage progresses, the correlation between rice canopy spectrum and AGB shows a trend from high to low, among which the first derivative spectrum (FD) has the strongest correlation with AGB. (2) The number of feature bands selected by the Boruta algorithm is 19~35, which has a good dimensionality reduction effect. (3) The combination of FD-Boruta-PCR (FB-PCR) demonstrated the best performance in estimating rice AGB, with an increase in R² of approximately 10% ~ 20% and a decrease in RMSE of approximately 0.08% ~ 14%. (4) The best estimation stage is the booting stage, with R2 values between 0.60 and 0.74 and RMSE values between 1288.23 and 1554.82 kg/hm2. This study confirms the accuracy of hyperspectral remote sensing in estimating vegetation biomass and further explores the theoretical foundation and future direction for monitoring rice growth dynamics.

Deciphering peri-implantitis: Unraveling signature genes and immune cell associations through bioinformatics and machine learning.

Early diagnosis of peri-implantitis (PI) is crucial to understand its pathological progression and prevention. This study is committed to investigating the signature genes, relevant signaling pathways and their associations with immune cells in PI. We analyzed differentially expressed genes (DEGs) from a PI dataset in the gene expression omnibus database. Functional enrichment analysis was conducted for these DEGs. Weighted Gene Co-expression Network Analysis was used to identify specific modules. Least absolute shrinkage and selection operator and support vector machine recursive feature elimination were ultimately applied to identify the signature genes. These genes were subsequently validated in an external dataset. And the immune cells infiltration was classified using CIBERSORT. A total of 180 DEGs were screened from GSE33774. Weighted Gene Co-expression Network Analysis revealed a significant association between the MEturquoise module and PI (cor = 0.6, P < .0001). Least absolute shrinkage and selection operator and support vector machine recursive feature elimination algorithms were applied to select the signature genes, containing myeloid-epithelial-reproductive tyrosine kinase, microfibrillar-associated protein 5, membrane-spanning 4A 4A, tribbles homolog 1. In the validation on the external dataset GSE106090, all these genes achieved area under curve values exceeding 0.95. GSEA analysis showed that these genes were correlated with the NOD-like receptor signaling pathway, metabolism of xenobiotics by cytochrome P450, and arachidonic acid metabolism. CIBERSORT revealed elevated levels of macrophage M2 and activated mast cells in PI. This study provides novel insights into understanding the molecular mechanisms of PI and contributes to advancements in its early diagnosis and prevention.

Carbon emission price point-interval forecasting based on multivariate variational mode decomposition and attention-LSTM model

Accurate forecasting of carbon emission prices is a crucial yet challenging task, given the complexity of the trading market and the variability of influencing factors. To comprehensively address factors related to carbon prices while considering interval forecasts associated with uncertainty, this study introduces a novel multistep ahead point-interval forecasting framework for carbon emission prices. This framework integrates multifactor selection, multivariate decomposition and reconstruction, an intelligent point and interval forecasting network, and an evaluation system. First, influencing factors are selected using a recursive feature elimination algorithm based on the extreme gradient boosting estimator. Second, original carbon prices and related influencing factors are decomposed into a set of multimode components (MMCs) using multivariate variational mode decomposition and sample entropy reconstruction techniques. Third, each row of MMCs is predicted using a long short-term memory model with an attention mechanism, and final point predictions are produced through simple addition. Finally, interval predictions are derived using enhanced kernel density estimation (KDE), which can expand the upper and lower bounds of the prediction interval. The stability and robustness have been tested in European Union Allowance (EUA) price forecasting. The results show that the proposed model is superior to other benchmark models, with MAPEs of 0.83%, 3.54%, and 3.82% in 1-step, 15-step, and 30-step ahead forecasting, respectively. Additionally, the proposed enhanced KDE demonstrates excellent performance; in 1-step ahead forecasting, the F-value is 1.86, 1.82, and 1.75 at the 80%, 90%, and 95% confidence levels, respectively. This proves that the proposed framework can effectively improve the point forecasting performance of EUA prices and quantify the prediction uncertainty.

Application of Ensemble Learning and Feature Selection Models in Energy Expenditure Estimation of Fitness Tracking Devices

The use of fitness tracking devices to monitor energy expenditure (EE) is becoming increasingly popular among consumers. However, the accuracy of EE estimation still needs to be improved due to the lack of accurate data filtering and more efficient data analysis models. To address this issue, we designed an energy expenditure estimation (EEE) model based on smart tracking devices. This paper proposes an algorithm for data reconstruction called PC-DF-RFECV: firstly, Pearson correlation analysis (PC) is used for initial data screening, then Feature Derivation (DF) is applied to reconstruct new features, and finally, the Recursive Feature Elimination algorithm based on cross-validation (RFECV) is employed to select the new features. Furthermore, the EEE model adopts a weighted average (Wei-Voting) strategy to enhance the robustness of the model by integrating the predictions of multiple base learners (XGBoost, LightGBM, Random Forest). During algorithm optimization, a Bayesian hyperparameter optimization technique is employed to fine-tune the model's hyperparameters. Empirical findings indicate that the EEE model, when applied to the dataset collected from motion tracking devices, attains an score of 0.9985, of 1.033, and of 0.865. These results demonstrate superior performance compared to current state-of-the-art research and conventional algorithms including random forests, gradient boosting, and bagging.

Driver state recognition with physiological signals: Based on deep feature fusion and feature selection techniques

Driver state constitutes a significant factor affecting traffic safety, and accurate detection of driver state can significantly enhance driving safety. Therefore, the objective of this investigation is to develop a high accuracy driver state recognition model driven by physiological data. Firstly, expert knowledge and deep learning algorithms were used to extract the shallow and deep features of the driver's electroencephalogram (EEG) and electrodermal activity (EDA) data, respectively; secondly, the principal component analysis (PCA) technique was employed to reduce dimensionality of deep features, enabling fusion with the shallow features; thirdly, an improved recursive feature elimination (RFE) algorithm based on Shapley additive explanation (SHAP) value was proposed for the issue of redundant features in the fused features, and a hybrid feature selection algorithm was devised in conjunction with the chi-square test; finally, the driver state was recognized based on machine learning algorithms. The findings demonstrate superior performance of the driver state recognition model built on the fused features compared to models constructed solely with shallow or deep features. Moreover, the application of the hybrid feature selection algorithm further improved the performance of the driver state recognition model, resulting in a satisfactory accuracy (94.88 %) and F1 score (94.86 %). This study highlights the efficacy of fusing deep features and conducting feature selection in enhancing the accuracy of the driver state recognition model.

CD6 and CCR7 as Genetic Biomarkers in Evaluating Intracranial Aneurysm Rupture Risk.

This study used bioinformatics combined with statistical methods to identify plasma biomarkers that can predict intracranial aneurysm (IA) rupture and provide a strong theoretical basis for the search for new IA rupture prevention methods. We downloaded gene expression profiles in the GSE36791 and GSE122897 datasets from the Gene Expression Omnibus (GEO) database. Data were normalized using the "sva" R package and differentially expressed genes (DEGs) were identified using the "limma" R package. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were used for DEG function analysis. Univariate logistic regression analysis, least absolute shrinkage and selection operator (LASSO) regression modeling, and the support vector machine recursive feature elimination (SVM-RFE) algorithm were used to identify key biomarker genes. Data from GSE122897 and GSE13353 were extracted to verify our findings. Eight co-DEG mRNAs were identified in the GSE36791 and GSE122897 datasets. Genes associated with inflammatory responses were clustered in the co-DEG mRNAs in IAs. CD6 and C-C chemokine receptor 7 (CCR7) were identified as key genes associated with IA. CD6 and CCR7 were upregulated in patients with IA and their expression levels were positively correlated. There were significant differences in the infiltration of immune cells between IAs and normal vascular wall tissues (p < 0.05). A predictive nomogram was designed using this two-gene signature. Binary transformation of CD6 and CCR7 was performed according to the cut-off value to construct the receiver-operating characteristic (ROC) curve and showed a strong predictive ability of the CD6-CCR7 gene signature (p < 0.01; area under the curve (AUC): 0.90; 95% confidence interval (CI): 0.88-0.92). Furthermore, validation of this two-gene signature using the GSE122897 and GSE13353 datasets proved it to be valuable for clinical application. The identified two-gene signature (CD6-CCR7) for evaluating the risk of IA rupture demonstrated good clinical application value.