ABSTRACTIn this paper, we consider an appropriate ordering of the Laurent monomials , that allows us to study sequences of orthogonal Laurent polynomials of the real variables and with respect to a positive Borel measure defined on such that . This ordering is suitable for considering the multiplication plus inverse multiplication operator on each variable and , and as a result we obtain five‐term recurrence relations, Christoffel–Darboux and confluent formulas for the reproducing kernel and a related Favard's theorem. A connection with the one‐variable case is also presented, along with some applications for future research.