ObjectiveThe primary purpose of this article is to undertake a mathematical investigation into the electro osmotically thermally driven transport of solute particles, which are typically on a micro to nano-meter scale, suspended in blood. The study is conducted within a non-uniform porous channel for a Williamson fluid. The main objective of this research is to explore the interactions and consequences of solute particles and nanoparticles in the Esophagus, particularly regarding their potential applications in drug delivery and biomedical engineering, especially in the context of electroosmotic non-Newtonian fluids. SignificanceThis research also has significant implications for microscale physiological phenomena. In this investigation, blood serves as the base fluid, and a nanofluid is created by introducing Nickel and Cobalt nanoparticles into the blood. Both nanoparticles have critical medical applications, especially in drug delivery and cancer treatment. To delve deeper into the study of nanomedicine delivery, Nickel and Cobalt nanoparticles are introduced into the blood alongside other smaller solute particles. MethodologyThe mathematical modeling is conducted in a rectangular coordinate system, and the governing flow equations are linearized using approximations that consider low Reynolds numbers and large wavelengths. The numerical solution is computed for a coupled set of nonlinear equations that describe the profiles of fluid-particle velocity, temperature, and fluid-particle composition. The study explores the influence of various key parameters and presents these effects through graphical representations. FindingsIt is observed that an increase in the suspension concentration and the Williamson fluid parameter leads to higher fluid velocity, while the temperature distribution exhibits the opposite trend. The introduction of nanoparticles into the fluid decelerates the flow and raises the temperature.