In twenty-first century Uruguay, there are several studies related to the treatment of documents and information related to human rights violations, which occurred in the period of illegitimate action and State terrorism during the period 1968 and 1985. From the information science, issues related to public policies and cultural management institutions are problematized. The general objective of this work has to carry out an approach to cultural mediation developed in information units referring to human rights violations in Uruguay. Concepts are reviewed in an articulated way between culture, heritage and information units, in the context of cultural and memory policies. It introduces a characterization of the institutionalization of human rights as a cultural agent and its role in the democratization of knowledge preserved in heritage information units. Finally, aspects of the social function of access, cultural diffusion, and usability of information, acquired by the National Institution of Human Rights and the Ombudsman’s Office, are described. These, aimed at the reconstruction of historical memory, guarantee the rights to information, truth, justice, reparation, and non-repetition.